OUTCOME OF CORONARY ENDARTECTOMY OF THE LEFT ANTERIOR DESCENDING ARTERY: OPEN VERSUS CLOSED TECHNIQUE. COMPARISON AT A TERTIARY CARDIAC CARE FACILITY

Objective: To compare the outcome of Coronary Artery Bypass Graft surgery (CABG) after Coronory Endartectomy (CE) of the Left Anterior Descending Artery (LAD) using the open technique with that employing the closed technique. Study Design: Reterospective Comparative cross sectional study. Place and Duration of Study: Department of Adult Cardiac surgery of Armed Forces institute of Cardiology, Rawalpindi, from September 2011 to June 2015. Material and Methods: Total 52 patients with diffuse atheromatous disease of the LAD who underwent CABG surgery necessitating CE of the LAD were investigated retrospectively. These were divided into 2 groups on the basis of technique of CE utilized: Group (Gp) I underwent open CE of the LAD and GpII had closed CE. All patients were followed up for evaluation of peri-operative mortality and morbidity and freedom from recurrentangina, myocardial infarction (MI) and death at 18 months. Results: There was no peri-operative mortality in group I whereas there were two (7.69%) early deaths in Group II. One patient (3.84%) in Gp I had a non-fatal peri-operative MI as compared to two (7.69%) in Gp II. At 18 months follow-up there was no late death or fresh MI in either group. Two patients (7.69%) in Gp II and none in Gp I had recurrent angina. Conclusion: We conclude from this study that both the open and closed techniques of CE and equally safe in the short and medium- term after CABG surgery in a sub-group of patients with diffuse CAD who are otherwise at a high risk of fatal outcome if left untreated.

[1]  S. Takanashi,et al.  Ten-Year Experience of Coronary Endarterectomy for the Diffusely Diseased Left Anterior Descending Artery. , 2017, The Annals of thoracic surgery.

[2]  K. Taylor,et al.  Outcome of coronary endarterectomy: a case-control study. , 1999, The Annals of thoracic surgery.

[3]  S. Takanashi,et al.  Long segmental reconstruction of diffusely diseased left anterior descending coronary artery with left internal thoracic artery with or without endarterectomy. , 2005, The Annals of thoracic surgery.

[4]  D. Ngaage,et al.  To graft or not to graft? Do coronary artery characteristics influence early outcomes of coronary artery bypass surgery? Analysis of coronary anastomoses of 5171 patients. , 2010, The Journal of thoracic and cardiovascular surgery.

[5]  Peter W. Jones,et al.  Coronary endarterectomy: impact on morbidity and mortality when combined with coronary artery bypass surgery. , 2005, The Annals of thoracic surgery.

[6]  S. Takanashi,et al.  Optimal method of coronary endarterectomy for diffusely diseased coronary arteries. , 2005, The Annals of thoracic surgery.

[7]  L. Cohn,et al.  Left anterior descending coronary endarterectomy: early and late results in 196 consecutive patients. , 2004, The Annals of thoracic surgery.

[8]  F. Wahab,et al.  In hospital outcome of patients undergoing coronary endarterectomy: comparison between off-pump vs on pump CABG. , 2008, Journal of Ayub Medical College, Abbottabad : JAMC.

[9]  S. Moncada,et al.  Nitric oxide: physiology, pathophysiology, and pharmacology. , 1991, Pharmacological reviews.

[10]  R. Habib,et al.  Survival and graft patency after coronary artery bypass grafting with coronary endarterectomy: role of arterial versus vein conduits. , 2007, The Annals of thoracic surgery.

[11]  I. Iakovou,et al.  Multiple overlapping drug-eluting stents to treat diffuse disease of the left anterior descending coronary artery. , 2005, Journal of the American College of Cardiology.

[12]  W. Boyd,et al.  Left anterior descending endarterectomy and internal thoracic artery bypass for diffuse coronary disease. , 1998, The Annals of thoracic surgery.

[13]  N. Resnick,et al.  Hemodynamic forces are complex regulators of endothelial gene expression , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[14]  Wen Cheng,et al.  In the current era, complete revascularization improves survival after coronary artery bypass surgery. , 2005, The Journal of thoracic and cardiovascular surgery.

[15]  V. Parsonnet,et al.  Results of coronary artery endarterectomy and coronary artery bypass grafting for diffuse coronary artery disease. , 2005, The Annals of thoracic surgery.

[16]  G. Couper,et al.  Extensive endarterectomy and reconstruction of the left anterior descending artery: early and late outcomes. , 2012, The Journal of thoracic and cardiovascular surgery.

[17]  S. Garcia,et al.  Outcomes after complete versus incomplete revascularization of patients with multivessel coronary artery disease: a meta-analysis of 89,883 patients enrolled in randomized clinical trials and observational studies. , 2013, Journal of the American College of Cardiology.

[18]  V. Walley,et al.  A study of the sequential morphologic changes after manual coronary endarterectomy. , 1991, The Journal of thoracic and cardiovascular surgery.

[19]  高梨 秀一郎 Coronary endarterectomy in the left anterior descending artery , 2010 .