Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression*
暂无分享,去创建一个
[1] C. B. Pickett,et al. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. , 2003, Annual review of pharmacology and toxicology.
[2] H. Huang,et al. Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element , 2003, The Journal of Biological Chemistry.
[3] J. Alam,et al. Degradation of Transcription Factor Nrf2 via the Ubiquitin-Proteasome Pathway and Stabilization by Cadmium* , 2003, The Journal of Biological Chemistry.
[4] Hongyu Wang,et al. Electrophile Response Element-mediated Induction of the Cystine/Glutamate Exchange Transporter Gene Expression* , 2002, The Journal of Biological Chemistry.
[5] C. B. Pickett,et al. Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription* , 2002, The Journal of Biological Chemistry.
[6] M. Freeman,et al. Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2 , 2002, Oncogene.
[7] L. Zipper,et al. The Keap1 BTB/POZ Dimerization Function Is Required to Sequester Nrf2 in Cytoplasm* , 2002, The Journal of Biological Chemistry.
[8] S. Biswal,et al. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. , 2002, Cancer research.
[9] R. Cole,et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[10] Takafumi Suzuki,et al. Identification of the interactive interface and phylogenic conservation of the Nrf2‐Keap1 system , 2002, Genes to cells : devoted to molecular & cellular mechanisms.
[11] M. Carmo-Fonseca,et al. Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. , 2002, Molecular biology of the cell.
[12] C. Wolf,et al. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. , 2002, The Biochemical journal.
[13] James Douglas Engel,et al. Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. , 2002, Gene.
[14] Ken Itoh,et al. Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 Promoter , 2002, Molecular and Cellular Biology.
[15] A. Ciechanover,et al. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. , 2002, Physiological reviews.
[16] K. Itoh,et al. A Sulforaphane Analogue That Potently Activates the Nrf2-dependent Detoxification Pathway* , 2002, The Journal of Biological Chemistry.
[17] Jiang Li,et al. Microarray Analysis Reveals an Antioxidant Responsive Element-driven Gene Set Involved in Conferring Protection from an Oxidative Stress-induced Apoptosis in IMR-32 Cells* , 2002, The Journal of Biological Chemistry.
[18] E Yoshida,et al. Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription , 2001, Genes to cells : devoted to molecular & cellular mechanisms.
[19] D. Wolf,et al. Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4 , 2001, The EMBO journal.
[20] J. Hayes,et al. Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. , 2001, Cancer research.
[21] S. Dhakshinamoorthy,et al. Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene , 2001, Oncogene.
[22] Freya Q. Schafer,et al. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. , 2001, Free radical biology & medicine.
[23] H. Masutani,et al. Hemin-induced Activation of the Thioredoxin Gene by Nrf2 , 2001, The Journal of Biological Chemistry.
[24] C. Wolf,et al. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. , 2001, Cancer research.
[25] M. Kwak,et al. Role of Transcription Factor Nrf2 in the Induction of Hepatic Phase 2 and Antioxidative Enzymes in vivo by the Cancer Chemoprotective Agent, 3H-1, 2-Dithiole-3-thione , 2001 .
[26] T. Sommer,et al. Ubiquitin-mediated Proteolysis of a Short-lived Regulatory Protein Depends on Its Cellular Localization* , 2000, The Journal of Biological Chemistry.
[27] C Longaretti,et al. Nuclear‐specific degradation of Far1 is controlled by the localization of the F‐box protein Cdc4 , 2000, The EMBO journal.
[28] C. Pickart,et al. Ubiquitin in chains. , 2000, Trends in biochemical sciences.
[29] Alexander Varshavsky,et al. The ubiquitin system. , 1998, Annual review of biochemistry.
[30] G. Géraud,et al. In mouse myoblasts nuclear prosomes are associated with the nuclear matrix and accumulate preferentially in the perinucleolar areas. , 2000, Journal of cell science.
[31] Ken Itoh,et al. Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages* , 2000, The Journal of Biological Chemistry.
[32] C. B. Pickett,et al. Transcriptional Regulation of the Antioxidant Response Element , 2000, The Journal of Biological Chemistry.
[33] F. Domann,et al. Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase. , 2000, Biochemical and biophysical research communications.
[34] B. Futcher,et al. Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis , 2000 .
[35] K. Tanaka,et al. Subcellular localization of proteasomes and their regulatory complexes in mammalian cells. , 2000, The Biochemical journal.
[36] J. Hayes,et al. Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver. , 2000, Cancer research.
[37] L. Cooley,et al. The kelch repeat superfamily of proteins: propellers of cell function. , 2000, Trends in cell biology.
[38] Dean P. Jones,et al. Glutathione redox potential in response to differentiation and enzyme inducers. , 1999, Free radical biology & medicine.
[39] J. Hayes,et al. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. , 1999, Free radical research.
[40] Moinova Hr,et al. Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element. , 1999 .
[41] A. Puga,et al. Regulation of gene expression by reactive oxygen. , 1999, Annual review of pharmacology and toxicology.
[42] J. D. Engel,et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. , 1999, Genes & development.
[43] Aaron Ciechanover,et al. The ubiquitin–proteasome pathway: on protein death and cell life , 1998, The EMBO journal.
[44] Wolfgang Baumeister,et al. The Proteasome: Paradigm of a Self-Compartmentalizing Protease , 1998, Cell.
[45] K. Itoh,et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. , 1997, Biochemical and biophysical research communications.
[46] Y. Kan,et al. NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[47] A. Varshavsky,et al. The N-end rule: functions, mysteries, uses. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[48] J. Alam,et al. The heme-responsive element of the mouse heme oxygenase-1 gene is an extended AP-1 binding site that resembles the recognition sequences for MAF and NF-E2 transcription factors. , 1996, Biochemical and biophysical research communications.
[49] L. Staszewski,et al. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain , 1994, Cell.
[50] P. Talalay,et al. Chemical and molecular regulation of enzymes that detoxify carcinogens. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[51] C. B. Pickett,et al. Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants. , 1991, The Journal of biological chemistry.
[52] E. Farber. The biochemistry of preneoplastic liver: a common metabolic pattern in hepatocyte nodules. , 1984, Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire.