Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction.

[1]  Shiou-Chuan Tsai,et al.  Polyketide chain length control by chain length factor. , 2003, Journal of the American Chemical Society.

[2]  B. Moore,et al.  Mutasynthesis of enterocin and wailupemycin analogues. , 2003, Journal of the American Chemical Society.

[3]  Taek Soon Lee,et al.  Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity. , 2003, Biochemistry.

[4]  B. Moore,et al.  Characterization of Benzoyl Coenzyme A Biosynthesis Genes in the Enterocin-Producing Bacterium “Streptomyces maritimus” , 2003, Journal of bacteriology.

[5]  C Richard Hutchinson,et al.  A model of structure and catalysis for ketoreductase domains in modular polyketide synthases. , 2003, Biochemistry.

[6]  B. Moore,et al.  Inactivation, Complementation, and Heterologous Expression ofencP, a Novel Bacterial Phenylalanine Ammonia-Lyase Gene* , 2002, The Journal of Biological Chemistry.

[7]  C. Rock,et al.  Forty years of bacterial fatty acid synthesis. , 2002, Biochemical and biophysical research communications.

[8]  B. Moore,et al.  Mutational analysis of the enterocin favorskii biosynthetic rearrangement. , 2002, Organic letters.

[9]  Bradley S Moore,et al.  Biosynthesis and attachment of novel bacterial polyketide synthase starter units. , 2002, Natural product reports.

[10]  C. Khosla,et al.  In vitro reconstitution and analysis of the chain initiating enzymes of the R1128 polyketide synthase. , 2001, Biochemistry.

[11]  B. Moore,et al.  A Mechanism of Benzoic Acid Biosynthesis in Plants and Bacteria that Mirrors Fatty Acid β‐Oxidation , 2001, Chembiochem : a European journal of chemical biology.

[12]  Michael Müller,et al.  Mutational Analysis and Reconstituted Expression of the Biosynthetic Genes Involved in the Formation of 3-Amino-5-hydroxybenzoic Acid, the Starter Unit of Rifamycin Biosynthesis in Amycolatopsis mediterraneiS699* , 2001, The Journal of Biological Chemistry.

[13]  W R Strohl,et al.  The product of dpsC confers starter unit fidelity upon the daunorubicin polyketide synthase of Streptomyces sp. strain C5. , 2001, Metabolic engineering.

[14]  C Hertweck,et al.  Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase. , 2000, Chemistry & biology.

[15]  B. Moore,et al.  A Plant-like Biosynthesis of Benzoyl-CoA in the Marine Bacterium ‘Streptomyces maritimus’ , 2000 .

[16]  C. Khosla,et al.  Cloning, Nucleotide Sequence, and Heterologous Expression of the Biosynthetic Gene Cluster for R1128, a Non-steroidal Estrogen Receptor Antagonist , 2000, The Journal of Biological Chemistry.

[17]  B. Moore,et al.  Natural metabolic diversity encoded by the enterocin biosynthesis gene cluster , 2000 .

[18]  C. Khosla,et al.  Mechanistic analysis of a type II polyketide synthase. Role of conserved residues in the beta-ketoacyl synthase-chain length factor heterodimer. , 2000, Biochemistry.

[19]  T. Kieser Practical streptomyces genetics , 2000 .

[20]  B. Shen Biosynthesis of Aromatic Polyketides , 2000 .

[21]  C R Hutchinson,et al.  A multiplasmid approach to preparing large libraries of polyketides. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[22]  P. Leadlay,et al.  A chain initiation factor common to both modular and aromatic polyketide synthases , 1999, Nature.

[23]  C. Khosla,et al.  Heterologous expression, purification, reconstitution and kinetic analysis of an extended type II polyketide synthase. , 1999, Chemistry & biology.

[24]  B J Rawlings,et al.  Biosynthesis of polyketides (other than actinomycete macrolides). , 1999, Natural product reports.

[25]  R. Ziermann,et al.  Recombinant polyketide synthesis in Streptomyces: engineering of improved host strains. , 1999, BioTechniques.

[26]  D. Hopwood,et al.  Genetic Contributions to Understanding Polyketide Synthases. , 1997, Chemical reviews.

[27]  William R. Strohl,et al.  Biotechnology of antibiotics , 1997 .

[28]  C R Hutchinson,et al.  Iterative type II polyketide synthases, cyclases and ketoreductases exhibit context-dependent behavior in the biosynthesis of linear and angular decapolyketides. , 1997, Chemistry & biology.

[29]  C. Richard Hutchinson,et al.  RATIONAL DESIGN AND ENGINEERED BIOSYNTHESIS OF A NOVEL 18-CARBON AROMATIC POLYKETIDE , 1997 .

[30]  C R Hutchinson,et al.  Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase. , 1994, Gene.

[31]  C. Khosla,et al.  Engineered biosynthesis of novel polyketides: evidence for temporal, but not regiospecific, control of cyclization of an aromatic polyketide precursor. , 1994, Chemistry & biology.

[32]  J. Lawrence,et al.  Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5 , 1994, Journal of bacteriology.

[33]  C. Khosla,et al.  Relaxed Specificity of the Oxytetracycline Polyketide Synthase for an Acetate Primer in the Absence of a Malonamyl Primer , 1994 .

[34]  S Omura,et al.  Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin. , 1994, Gene.

[35]  C. Khosla,et al.  Engineered Biosynthesis of Novel Polyketides: Dissection of the Catalytic Specificity of the act Ketoreductase , 1994 .

[36]  K. O'Brien,et al.  Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp. , 1992, Gene.

[37]  P. Bartel,et al.  Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions , 1990, Journal of Bacteriology.

[38]  A. Pühler,et al.  A Broad Host Range Mobilization System for In Vivo Genetic Engineering: Transposon Mutagenesis in Gram Negative Bacteria , 1983, Bio/Technology.

[39]  B. Rudd,et al.  Genetics of actinorhodin biosynthesis by Streptomyces coelicolor A3(2). , 1979, Journal of general microbiology.