Splenic diffuse red pulp small B-cell lymphoma displays increased expression of cyclin D3 and recurrent CCND3 mutations.

To the editor: Splenic diffuse red pulp lymphoma (SDRPL) is a rare small B-cell neoplasm provisionally included in the category of unclassifiable splenic B-cell lymphomas/leukemias in the 2008 World Health Organization classification.[1][1] SDRPL is characterized by a diffuse pattern of involvement

[1]  G. Salles,et al.  Splenic diffuse red pulp lymphoma has a distinct pattern of somatic mutations amongst B-cell malignancies , 2017, Leukemia & lymphoma.

[2]  T. Yokote,et al.  Parathyroid hormone-related protein-producing cyclin D3-positive blastoid variant of mantle cell lymphoma with hypercalcemia. , 2016, Blood.

[3]  S. Bens,et al.  NOTCH1, TP53, and MAP2K1 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma Are Associated With Progressive Disease , 2015, The American journal of surgical pathology.

[4]  C. von Kalle,et al.  Recurrent CDKN1B (p27) mutations in hairy cell leukemia. , 2015, Blood.

[5]  K. Stamatopoulos,et al.  Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing , 2015, Clinical Cancer Research.

[6]  S. Pileri,et al.  The Krüppel-like factor 2 transcription factor gene is recurrently mutated in splenic marginal zone lymphoma , 2014, Leukemia.

[7]  L. Staudt,et al.  Oncogenic mechanisms in Burkitt lymphoma. , 2014, Cold Spring Harbor perspectives in medicine.

[8]  Paul S. Meltzer,et al.  High prevalence of MAP2K1 mutations in variant and IGHV4-34 expressing hairy-cell leukemia , 2013, Nature Genetics.

[9]  A. Rosenwald,et al.  CCND2 rearrangements are the most frequent genetic events in cyclin D1(-) mantle cell lymphoma. , 2013, Blood.

[10]  R. Spang,et al.  Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing , 2012, Nature Genetics.

[11]  K. Elenitoba-Johnson,et al.  Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma , 2012, The Journal of experimental medicine.

[12]  S. Pileri,et al.  The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development , 2012, The Journal of experimental medicine.

[13]  L. Staudt,et al.  Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics , 2012, Nature.

[14]  Steven J. M. Jones,et al.  Frequent mutation of histone modifying genes in non-Hodgkin lymphoma , 2011, Nature.

[15]  Raul Rabadan,et al.  Analysis of the Coding Genome of Diffuse Large B-Cell Lymphoma , 2011, Nature Genetics.

[16]  J. Cigudosa,et al.  Splenic diffuse red pulp small B-cell lymphoma: revision of a series of cases reveals characteristic clinico-pathological features , 2010, Haematologica.

[17]  Yasodha Natkunam,et al.  Characterization of D-Cyclin Proteins in Hematolymphoid Neoplasms: Lack of Specificity of Cyclins D2 and D3 Expression in Lymphoma Subtypes , 2009, Modern Pathology.

[18]  H. Pospíšilová,et al.  Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas. , 2008, Blood.

[19]  G. Salles,et al.  Splenic red pulp lymphoma with numerous basophilic villous lymphocytes: a distinct clinicopathologic and molecular entity? , 2008, Blood.

[20]  N. Shinton WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues , 2007 .

[21]  P. Sicinski,et al.  A unique function for cyclin D3 in early B cell development , 2006, Nature Immunology.

[22]  O. Bachs,et al.  P38SAPK2 phosphorylates cyclin D3 at Thr-283 and targets it for proteasomal degradation , 2004, Oncogene.

[23]  F Solé,et al.  Cyclin D3 is a target gene of t(6;14)(p21.1;q32.3) of mature B-cell malignancies. , 2001, Blood.

[24]  J. Climent,et al.  KLF 2 mutation is the most frequent somatic change in splenic marginal zone lymphoma and 1 identifies a subset with distinct genotype 2 3 , 2014 .

[25]  A. Tefferi,et al.  BRAF mutations in hairy-cell leukemia. , 2011, The New England journal of medicine.