Assessment of possible transneuronal changes in the retina of rats with inherited retinal dystrophy: Cell size, number, synapses, and axonal transport by retinal ganglion cells

In pigmented RCS rats with inherited retinal dystrophy, most photoreceptor cells disappear between postnatal days 20 and 100. We have examined the time course of the degeneration of photoreceptor nuclei and synapses and determined whether transneuronal changes occur in the inner nuclear layer (INL), inner plexiform layer (IPL), und retinal ganglion cells following loss of photoreceptor cells in these animals.

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