Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.

[1]  R. Geahlen,et al.  Cross-linking of integrins induces tyrosine phosphorylation of the proto-oncogene product Vav and the protein tyrosine kinase Syk in human factor-dependent myeloid cells. , 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[2]  M. Tremblay,et al.  Protein Tyrosine Phosphatase-PEST Regulates Focal Adhesion Disassembly, Migration, and Cytokinesis in Fibroblasts , 1999, The Journal of cell biology.

[3]  K. Burridge,et al.  Focal adhesion assembly. , 1997, Trends in cell biology.

[4]  K. Burridge,et al.  Vav2 Activates Rac1, Cdc42, and RhoA Downstream from Growth Factor Receptors but Not β1 Integrins , 2000, Molecular and Cellular Biology.

[5]  J. Settleman,et al.  Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation , 1996, Molecular and cellular biology.

[6]  M. K. Magnússon,et al.  Lysophosphatidic acid and microtubule-destabilizing agents stimulate fibronectin matrix assembly through Rho-dependent actin stress fiber formation and cell contraction. , 1997, Molecular biology of the cell.

[7]  G. Rinnerthaler Cytostructural dynamics of contact formation during fibroblast locomotion in vitro , 1985 .

[8]  A. Hall,et al.  Rho GTPases and the actin cytoskeleton. , 1998, Science.

[9]  G. Johnson,et al.  Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly (*) , 1995, The Journal of Biological Chemistry.

[10]  Yi Zheng,et al.  Inhibition of RhoA by p120 catenin , 2000, Nature Cell Biology.

[11]  M. Schwartz,et al.  Integrins: emerging paradigms of signal transduction. , 1995, Annual review of cell and developmental biology.

[12]  M. Schwartz,et al.  Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK , 2000, The EMBO journal.

[13]  K. Rottner,et al.  Interplay between Rac and Rho in the control of substrate contact dynamics , 1999, Current Biology.

[14]  A. Woods,et al.  Control of morphology, cytoskeleton and migration by syndecan-4. , 1999, Journal of cell science.

[15]  R. Hynes,et al.  Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[16]  H. Saito,et al.  Syndecan-4 Deficiency Impairs Focal Adhesion Formation Only under Restricted Conditions* , 2000, The Journal of Biological Chemistry.

[17]  Y. Emori,et al.  Morphological Changes and Detachment of Adherent Cells Induced by p122, a GTPase-activating Protein for Rho* , 1999, The Journal of Biological Chemistry.

[18]  J. Guan,et al.  Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. , 1996, Journal of cell science.

[19]  C. Turner,et al.  Paxillin LD4 Motif Binds PAK and PIX through a Novel 95-kD Ankyrin Repeat, ARF–GAP Protein: A Role in Cytoskeletal Remodeling , 1999, The Journal of cell biology.

[20]  Michael P. Sheetz,et al.  Selective regulation of integrin–cytoskeleton interactions by the tyrosine kinase Src , 1999, Nature Cell Biology.

[21]  T. Miki,et al.  Human Ect2 Is an Exchange Factor for Rho Gtpases, Phosphorylated in G2/M Phases, and Involved in Cytokinesis , 1999, The Journal of cell biology.

[22]  A. Woods,et al.  Syndecan-4 and integrins: combinatorial signaling in cell adhesion. , 1999, Journal of cell science.

[23]  David A. Calderwood,et al.  Integrins and Actin Filaments: Reciprocal Regulation of Cell Adhesion and Signaling* , 2000, The Journal of Biological Chemistry.

[24]  G. Gundersen,et al.  Rho Guanosine Triphosphatase Mediates the Selective Stabilization of Microtubules Induced by Lysophosphatidic Acid , 1998, The Journal of cell biology.

[25]  J. Taylor,et al.  Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho. , 1999, Journal of cell science.

[26]  Jonathan A. Cooper,et al.  ASAP1, a Phospholipid-Dependent Arf GTPase-Activating Protein That Associates with and Is Phosphorylated by Src , 1998, Molecular and Cellular Biology.

[27]  B A Danowski,et al.  Fibroblast contractility and actin organization are stimulated by microtubule inhibitors. , 1989, Journal of cell science.

[28]  B. Seed,et al.  αLβ2 Integrin/LFA-1 Binding to ICAM-1 Induced by Cytohesin-1, a Cytoplasmic Regulatory Molecule , 1996, Cell.

[29]  R L Juliano,et al.  Integrin signaling and cell growth control. , 1998, Current opinion in cell biology.

[30]  M. Mattei,et al.  A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion , 1998, The Journal of cell biology.

[31]  K. Jacobson,et al.  Maturation of cell-substratum focal adhesions induced by depolymerization of microtubules is mediated by increased cortical tension. , 1998, Cell adhesion and communication.

[32]  D R Critchley,et al.  Focal adhesions - the cytoskeletal connection. , 2000, Current opinion in cell biology.

[33]  R. Lefkowitz,et al.  GIT Proteins, A Novel Family of Phosphatidylinositol 3,4,5-Trisphosphate-stimulated GTPase-activating Proteins for ARF6* , 2000, The Journal of Biological Chemistry.

[34]  A. Debant,et al.  The LAR transmembrane protein tyrosine phosphatase and a coiled‐coil LAR‐interacting protein co‐localize at focal adhesions. , 1995, The EMBO journal.

[35]  T. Enomoto,et al.  Microtubule disruption induces the formation of actin stress fibers and focal adhesions in cultured cells: possible involvement of the rho signal cascade. , 1996, Cell structure and function.

[36]  K. Jakobs,et al.  Rho‐specific binding and guanine nucleotide exchange catalysis by KIAA0380, a Dbl family member , 1999, FEBS letters.

[37]  Jonathan A. Cooper,et al.  Src family kinases are required for integrin but not PDGFR signal transduction , 1999, The EMBO journal.

[38]  R. Geahlen,et al.  Phosphorylation- and Activation-independent Association of the Tyrosine Kinase Syk and the Tyrosine Kinase Substrates Cbl and Vav with Tubulin in B-Cells* , 1999, The Journal of Biological Chemistry.

[39]  M. Frame,et al.  The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility , 1998, The EMBO journal.

[40]  L. Smilenov,et al.  Focal adhesion motility revealed in stationary fibroblasts. , 1999, Science.

[41]  B. Geiger,et al.  Contact formation during fibroblast locomotion: involvement of membrane ruffles and microtubules , 1988, The Journal of cell biology.

[42]  A. Horwitz,et al.  Dynamics of beta 1 integrin-mediated adhesive contacts in motile fibroblasts , 1992, The Journal of cell biology.

[43]  P C Sternweis,et al.  Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. , 1998, Science.

[44]  D. Helfman,et al.  Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions. , 1999, Molecular biology of the cell.

[45]  K. Burridge,et al.  P120 Catenin Regulates the Actin Cytoskeleton via Rho Family Gtpases , 2000, The Journal of cell biology.

[46]  K. Burridge,et al.  Microtubule depolymerization induces stress fibers, focal adhesions, and DNA synthesis via the GTP-binding protein Rho. , 1998, Cell adhesion and communication.

[47]  M. Mann,et al.  Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[48]  Irina Kaverina,et al.  Microtubule Targeting of Substrate Contacts Promotes Their Relaxation and Dissociation , 1999, The Journal of cell biology.

[49]  Alan Hall,et al.  Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement , 1999, The Journal of cell biology.

[50]  M. Schwartz,et al.  Integrin-dependent tyrosine phosphorylation and growth regulation by Vav. , 1999, Cell adhesion and communication.

[51]  V. Brunton,et al.  Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins , 1996, The Journal of cell biology.

[52]  A. Horwitz,et al.  Tyrosine phosphorylation and cytoskeletal tension regulate the release of fibroblast adhesions , 1995, The Journal of cell biology.

[53]  F. Echtermeyer,et al.  Syndecan-4 core protein is sufficient for the assembly of focal adhesions and actin stress fibers. , 1999, Journal of cell science.

[54]  K. Nagayama,et al.  A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration. , 2000, Molecular biology of the cell.

[55]  Frederick W. Alt,et al.  Vav Family Proteins Couple to Diverse Cell Surface Receptors , 2000, Molecular and Cellular Biology.

[56]  Y. Kaziro,et al.  G Protein βγ Subunits Induce Stress Fiber Formation and Focal Adhesion Assembly in a Rho-dependent Manner in HeLa Cells* , 2000, The Journal of Biological Chemistry.

[57]  A. Ullrich,et al.  The Carboxyl-terminal Tyrosine Residue of Protein-tyrosine Phosphatase α Mediates Association with Focal Adhesion Plaques* , 2000, The Journal of Biological Chemistry.

[58]  A. Huttenlocher,et al.  Adhesion in cell migration. , 1995, Current opinion in cell biology.

[59]  T. Pawson,et al.  Role of P120 Ras-Gap in Directed Cell Movement , 2000, The Journal of cell biology.

[60]  A. Mercurio,et al.  Rhoa Function in Lamellae Formation and Migration Is Regulated by the α6β4 Integrin and Camp Metabolism , 2000, The Journal of cell biology.

[61]  W. Arthur,et al.  Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism , 2000, Current Biology.

[62]  P. Scambler,et al.  RhoE Regulates Actin Cytoskeleton Organization and Cell Migration , 1998, Molecular and Cellular Biology.

[63]  A. Hall,et al.  The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts , 1997, The Journal of cell biology.

[64]  E. Salmon,et al.  Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts , 1999, Nature Cell Biology.

[65]  M. Schwartz,et al.  Signaling networks linking integrins and rho family GTPases. , 2000, Trends in biochemical sciences.

[66]  K. Burridge,et al.  Focal adhesions, contractility, and signaling. , 1996, Annual review of cell and developmental biology.

[67]  M. Rothkegel,et al.  The molecular architecture of focal adhesions. , 1995, Annual review of cell and developmental biology.

[68]  A. Ridley,et al.  Monocyte Adhesion and Spreading on Human Endothelial Cells Is Dependent on Rho-regulated Receptor Clustering , 1999, The Journal of cell biology.

[69]  Richard O. Hynes,et al.  Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases , 1998, The Journal of cell biology.

[70]  L. Shaw,et al.  RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion , 2000, Oncogene.

[71]  Kozo Kaibuchi,et al.  Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase) , 1996, Science.

[72]  Jonathan A. Cooper,et al.  The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[73]  L. Van Aelst,et al.  ADP-Ribosylation Factor 6 Regulates Actin Cytoskeleton Remodeling in Coordination with Rac1 and RhoA , 2000, Molecular and Cellular Biology.

[74]  K. Burridge,et al.  Rho-stimulated contractility drives the formation of stress fibers and focal adhesions , 1996, The Journal of cell biology.

[75]  Kenneth M. Yamada,et al.  Molecular interactions in cell adhesion complexes. , 1997, Current opinion in cell biology.

[76]  Sean P. Palecek,et al.  Integrin dynamics on the tail region of migrating fibroblasts. , 1996, Journal of cell science.

[77]  S. Kuroda,et al.  Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. , 1999, Annual review of biochemistry.

[78]  T. Kozasa,et al.  G13α-mediated PYK2 Activation , 2000, The Journal of Biological Chemistry.

[79]  S. Hanks,et al.  Dissociation of FAK/p130CAS/c-Src Complex during Mitosis: Role of Mitosis-specific Serine Phosphorylation of FAK , 1999, The Journal of cell biology.

[80]  C. Der,et al.  Vav2 Is an Activator of Cdc42, Rac1, and RhoA* , 2000, The Journal of Biological Chemistry.

[81]  Klemens Rottner,et al.  Targeting, Capture, and Stabilization of Microtubules at Early Focal Adhesions , 1998, The Journal of cell biology.

[82]  E. Elson,et al.  Contraction due to microtubule disruption is associated with increased phosphorylation of myosin regulatory light chain. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[83]  C. Der,et al.  Dbl family proteins. , 1997, Biochimica et biophysica acta.

[84]  K. Schuebel,et al.  Phosphorylation‐dependent and constitutive activation of Rho proteins by wild‐type and oncogenic Vav‐2 , 1998, The EMBO journal.

[85]  S. Aizawa,et al.  Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice , 1995, Nature.

[86]  S. Barry,et al.  Requirement for Rho in integrin signalling. , 1997, Cell adhesion and communication.

[87]  A. Hall,et al.  The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases , 1995, The Journal of cell biology.

[88]  J. Settleman,et al.  c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation , 1995, The Journal of cell biology.

[89]  John G. Collard,et al.  Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition , 2000, The Journal of cell biology.

[90]  J. Brugge,et al.  Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1 , 1998, Current Biology.

[91]  K. Burridge,et al.  Bidirectional signaling between the cytoskeleton and integrins. , 1999, Current opinion in cell biology.

[92]  John G. Collard,et al.  Rac Downregulates Rho Activity: Reciprocal Balance between Both Gtpases Determines Cellular Morphology and Migratory Behavior , 1999 .

[93]  L. Zheng,et al.  Antibody-induced engagement of beta 2 integrins on adherent human neutrophils triggers activation of p21ras through tyrosine phosphorylation of the protooncogene product Vav. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[94]  A. Ridley,et al.  Signal transduction pathways regulating Rho‐mediated stress fibre formation: requirement for a tyrosine kinase. , 1994, The EMBO journal.

[95]  J. Gutkind,et al.  A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho* , 1999, The Journal of Biological Chemistry.

[96]  S. Aota,et al.  Molecular diversity of cell-matrix adhesions. , 1999, Journal of cell science.

[97]  H. Radhakrishna,et al.  ADP-Ribosylation Factor 6 Regulates a Novel Plasma Membrane Recycling Pathway , 1997, The Journal of cell biology.

[98]  K. Burridge,et al.  Evidence for a Calpeptin-sensitive Protein-tyrosine Phosphatase Upstream of the Small GTPase Rho , 1999, The Journal of Biological Chemistry.

[99]  Y. Zheng,et al.  Cloning and Characterization of GEF-H1, a Microtubule-associated Guanine Nucleotide Exchange Factor for Rac and Rho GTPases* , 1998, The Journal of Biological Chemistry.

[100]  G. Bokoch,et al.  Inhibition of myosin light chain kinase by p21-activated kinase. , 1999, Science.

[101]  P. Gönczy,et al.  Cyk-4 , 2000, The Journal of cell biology.

[102]  Richard O. Hynes,et al.  Integrins: Versatility, modulation, and signaling in cell adhesion , 1992, Cell.

[103]  Kenneth M. Yamada,et al.  Physical state of the extracellular matrix regulates the structure and molecular composition of cell-matrix adhesions. , 2000, Molecular biology of the cell.

[104]  Yoshiharu Matsuura,et al.  Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)* , 1996, The Journal of Biological Chemistry.

[105]  G. Feng,et al.  Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion* , 1998, The Journal of Biological Chemistry.

[106]  W. Kiosses,et al.  Regulation of the small GTP‐binding protein Rho by cell adhesion and the cytoskeleton , 1999, The EMBO journal.

[107]  Anne J. Ridley,et al.  The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors , 1992, Cell.

[108]  S. Barry,et al.  ARF1 Mediates Paxillin Recruitment to Focal Adhesions and Potentiates Rho-stimulated Stress Fiber Formation in Intact and Permeabilized Swiss 3T3 Fibroblasts , 1998, The Journal of cell biology.

[109]  L. Van Aelst,et al.  Rho GTPases and signaling networks. , 1997, Genes & development.

[110]  B. Geiger,et al.  Involvement of microtubules in the control of adhesion-dependent signal transduction , 1996, Current Biology.

[111]  W. Kolanus,et al.  Phosphoinositide 3-OH Kinase Activates the β2Integrin Adhesion Pathway and Induces Membrane Recruitment of Cytohesin-1* , 1998, The Journal of Biological Chemistry.

[112]  M. Kinch,et al.  Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells. , 1997, Molecular biology of the cell.