Epidemiology of cytomegalovirus Infection among mothers and infants in Colombia

We assessed maternal and infant cytomegalovirus (CMV) infection in Colombia. Maternal serum was tested for CMV immunoglobulin G antibodies at a median of 10 (interquartile range: 8–12) weeks gestation (n = 1501). CMV DNA polymerase chain reaction was performed on infant urine to diagnose congenital (≤21 days of life) and postnatal (>21 days) infection. Maternal CMV seroprevalence was 98.1% (95% confidence interval [CI]: 97.5%–98.8%). Congenital CMV prevalence was 8.4 (95% CI: 3.9%–18.3%; 6/711) per 1000 live births. Among 472 infants without confirmed congenital CMV infection subsequently tested at age 6 months, 258 (54.7%, 95% CI: 50.2%–59.1%) had postnatal infection.

[1]  M. Ospina,et al.  Cohort profile: congenital Zika virus infection and child neurodevelopmental outcomes in the ZEN cohort study in Colombia , 2020, Epidemiology and health.

[2]  M. Gambhir,et al.  Review of Mathematical Models of Vaccination for Preventing Congenital Cytomegalovirus Infection. , 2020, The Journal of infectious diseases.

[3]  J. Schiffer,et al.  Nonprimary Maternal Cytomegalovirus Infection After Viral Shedding in Infants , 2018, The Pediatric infectious disease journal.

[4]  Y. Ville,et al.  Risk Factors for Congenital Cytomegalovirus Infection Following Primary and Nonprimary Maternal Infection: A Prospective Neonatal Screening Study Using Polymerase Chain Reaction in Saliva , 2017, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[5]  Wendy J M van Zuylen,et al.  Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy. , 2017, The Lancet. Infectious diseases.

[6]  S. Gruskin,et al.  Engaging Human Rights in the Response to the Evolving Zika Virus Epidemic , 2017, American journal of public health.

[7]  S. Grosse,et al.  Systematic review of the birth prevalence of congenital cytomegalovirus infection in developing countries. , 2014, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[8]  Cassandra D Josephson,et al.  Breast Milk–Acquired Cytomegalovirus Infection and Disease in VLBW and Premature Infants , 2013, Pediatrics.

[9]  W. Britt.  CHAPTER 23 – Cytomegalovirus , 2011 .

[10]  D. Bernstein,et al.  Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infection. , 2010, JAMA.

[11]  Jane Squires,et al.  Ages & Stages Questionnaires[R], Third Edition (ASQ-3[TM]): A Parent-Completed Child-Monitoring System. , 2009 .