Role of β‐chemokines in mast cell activation and type I hypersensitivity reactions in the conjunctiva: in vivo and in vitro studies

Summary:  Chemokines have a clearly defined role in mobilizing the recruitment of leukocytes to both healthy and inflamed tissues. This review details work from our and other laboratories, indicating that β‐chemokines may play important roles (i) in driving the terminal differentiation of mast cell precursors in mucosal tissues and (ii) in providing priming or costimulatory signals required for mast cell activation, leading to an antigen‐driven inflammatory response. These data stem from in vivo, ex vivo, and in vitro studies. Data are also presented that suggest that FcɛRI:chemokine receptor cross talk may involve spatiotemporal dynamics that may control the strength and nature of the complex activating signals controlling mast cell effector function.

[1]  K. Matsushima,et al.  Corneal Allograft Rejection in CCR5– and/or CXCR3–Deficient Mice , 2006 .

[2]  M. Tsai,et al.  Mast Cell-Associated TNF Promotes Dendritic Cell Migration1 , 2006, The Journal of Immunology.

[3]  Santa Jeremy Ono,et al.  Impact of Engagement of FcϵRI and CC Chemokine Receptor 1 on Mast Cell Activation and Motility* , 2004, Journal of Biological Chemistry.

[4]  J. Marshall,et al.  IgE-Mediated Mast Cell Activation Induces Langerhans Cell Migration In Vivo1 , 2004, The Journal of Immunology.

[5]  D. F. Barber,et al.  Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis , 2004, The Journal of cell biology.

[6]  P. Marrack,et al.  Mast cell–dependent migration of effector CD8+ T cells through production of leukotriene B4 , 2003, Nature Immunology.

[7]  P. Lorenz,et al.  High CXCR3 expression in synovial mast cells associated with CXCL9 and CXCL10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis , 2003, Arthritis research & therapy.

[8]  H. Ochi,et al.  T Helper Cell Type 2 Cytokine–Mediated Comitogenic Responses and Ccr3 Expression during Differentiation of Human Mast Cells in Vitro , 1999, The Journal of experimental medicine.

[9]  J W Sedat,et al.  Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. , 1999, Molecular biology of the cell.

[10]  S. Galli,et al.  Identification of a Committed Precursor for the Mast Cell Lineage , 1996, Science.

[11]  D. Taub,et al.  Bone marrow-derived murine mast cells migrate, but do not degranulate, in response to chemokines. , 1995, Journal of immunology.

[12]  J. Warner,et al.  IgE-mediated anaphylactic degranulation of isolated human skin mast cells. , 1991, Blood.

[13]  P. Lehmann.  Inflammatory properties of human C5a and C5a des Arg in mast cell-depleted human skin. , 1990, The Journal of investigative dermatology.

[14]  M. Kaliner,et al.  Ultrastructural changes in human skin mast cells during antigen-induced degranulation in vivo. , 1988, The Journal of allergy and clinical immunology.

[15]  Santa Jeremy Ono,et al.  Macrophage inflammatory protein-1alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions. , 2005, The Journal of clinical investigation.

[16]  Santa Jeremy Ono,et al.  A specific CCR3 chemokine receptor antagonist inhibits both early and late phase allergic inflammation in the conjunctiva , 2005, Immunologic research.

[17]  G. Marone,et al.  Chapter 36 – Chemokine Receptors on Human Mast Cells , 2000 .

[18]  A. Dvorak.  Basophils and mast cells: piecemeal degranulation in situ and ex vivo: a possible mechanism for cytokine-induced function in disease. , 1992, Immunology series.