Lightweight fuzzy processes in clinical computing

In spite of advances in computing hardware, many hospitals still have a hard time finding extra capacity in their production clinical information system to run artificial intelligence (AI) modules, for example: to support real-time drug-drug or drug-lab interactions; to track infection trends; to monitor compliance with case specific clinical guidelines; or to monitor/ control biomedical devices like an intelligent ventilator. Historically, adding AI functionality was not a major design concern when a typical clinical system is originally specified. AI technology is usually retrofitted 'on top of the old system' or 'run off line' in tandem with the old system to ensure that the routine work load would still get done (with as little impact from the AI side as possible). To compound the burden on system performance, most institutions have witnessed a long and increasing trend for intramural and extramural reporting, (e.g. the collection of data for a quality-control report in microbiology, or a meta-analysis of a suite of coronary artery bypass grafts techniques, etc.) and these place an ever-growing burden on typical the computer system's performance. We discuss a promising approach to adding extra AI processing power to a heavily-used system based on the notion 'lightweight fuzzy processing (LFP)', that is, fuzzy modules designed from the outset to impose a small computational load. A formal model for a useful subclass of fuzzy systems is defined below and is used as a framework for the automated generation of LFPs. By seeking to reduce the arithmetic complexity of the model (a hand-crafted process) and the data complexity of the model (an automated process), we show how LFPs can be generated for three sample datasets of clinical relevance.

[1]  Claude E. Shannon,et al.  The Mathematical Theory of Communication , 1950 .

[2]  Mark Plutowski,et al.  Selecting concise training sets from clean data , 1993, IEEE Trans. Neural Networks.

[3]  Ferdinand Hergert,et al.  Improving model selection by nonconvergent methods , 1993, Neural Networks.

[4]  R. Detrano,et al.  International application of a new probability algorithm for the diagnosis of coronary artery disease. , 1989, The American journal of cardiology.

[5]  Irving S. Reed,et al.  Including Hints in Training Neural Nets , 1991, Neural Computation.

[6]  M. Cohen,et al.  Comparative Approaches to Medical Reasoning , 1995 .

[7]  Jorma Rissanen,et al.  Stochastic Complexity in Statistical Inquiry , 1989, World Scientific Series in Computer Science.

[8]  Padhraic Smyth,et al.  An Information Theoretic Approach to Rule Induction from Databases , 1992, IEEE Trans. Knowl. Data Eng..

[9]  J A Parker,et al.  Fuzzy logic, sharp results. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[10]  F. Steimann,et al.  Fuzzy support for serodiagnosis: the ONSET program , 1994, IEEE Engineering in Medicine and Biology Magazine.

[11]  T Tsubokura,et al.  Fuzzy realization in clinical test database system. , 1991, International journal of bio-medical computing.

[12]  Padhraic Smyth,et al.  Rule-Based Neural Networks for Classification and Probability Estimation , 1992, Neural Computation.

[13]  A Brai,et al.  An expert system for the analysis and interpretation of evoked potentials based on fuzzy classification: application to brainstem auditory evoked potentials. , 1994, Computers and biomedical research, an international journal.

[14]  C. E. SHANNON,et al.  A mathematical theory of communication , 1948, MOCO.

[15]  John F. Hurdle The synthesis of compact fuzzy neural circuits , 1997, IEEE Trans. Fuzzy Syst..

[16]  Tal Grossman,et al.  Use of Bad Training Data for Better Predictions , 1993, NIPS.

[17]  J M Goldman,et al.  Advanced clinical monitoring: considerations for real-time hemodynamic diagnostics. , 1994, Proceedings. Symposium on Computer Applications in Medical Care.

[18]  R M Peters,et al.  Fuzzy cluster analysis of positive stress tests, a new method of combining exercise test variables to predict extent of coronary artery disease. , 1995, The American journal of cardiology.

[19]  R.J. Roy,et al.  Multiple drug hemodynamic control by means of a supervisory-fuzzy rule-based adaptive control system: validation on a model , 1995, IEEE Transactions on Biomedical Engineering.

[20]  F. Ji,et al.  Fuzzy classification of nucleotide sequences and bacterial evolution. , 1995, Bulletin of mathematical biology.

[21]  Patrick K. Simpson,et al.  Fuzzy min-max neural networks. I. Classification , 1992, IEEE Trans. Neural Networks.

[22]  C. Bassøe,et al.  Semantic Analysis of Medical Records , 1993, Methods of Information in Medicine.

[23]  R. Palmer,et al.  Introduction to the theory of neural computation , 1994, The advanced book program.