Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
暂无分享,去创建一个
Sasikanth Manne | John P. Reilly | Allison R. Greenplate | E. Wherry | M. Betts | S. Cherry | A. Greenplate | D. Oldridge | S. Hensley | H. Ramage | A. Baxter | J. Giles | N. Meyer | S. Gouma | J. Reilly | S. Manne | Zeyu Chen | A. Huang | K. D’Andrea | L. Vella | C. Alanio | E. John Wherry | S. Lacey | Jennifer E. Wu | Fang Chen | Nuala J. Meyer | Kurt D’Andrea | Amy E. Baxter | Sigrid Gouma | Fang Chen | Zeyu Chen | Derek A. Oldridge | Cécile Alanio | Simon F. Lacey | Scott E. Hensley | C. Ittner | E. Goodwin | Sara Cherry | Michael R. Betts | Leticia Kuri-Cervantes | Alexander C. Huang | D. Mathew | Divij Mathew | Josephine R. Giles | M. Betina Pampena | Yinghui Jane Huang | Ariel R. Weisman | Caroline A. G. Ittner | Oliva Kuthuru | Jeanette Dougherty | Kito Nzingha | Nicholas Han | Justin Kim | Ajinkya Pattekar | Eileen C. Goodwin | Elizabeth M. Anderson | Madison E. Weirick | Claudia P. Arevalo | Marcus J. Bolton | Holly Ramage | Sokratis A. Apostolidis | Laura A. Vella | A. Pattekar | E. Anderson | M. Weirick | M. Bolton | S. Apostolidis | L. Kuri-Cervantes | A. Weisman | O. Kuthuru | J. Dougherty | Justin Kim | N. Han | Kito Nzingha | Y. J. Huang | M. Pampena | C. P. Arevalo | Justin Y. Kim | E. M. Anderson | Zeyu Chen | Cécile Alanio | Sasikanth Manne
[1] U. Reimer,et al. Presence of SARS-CoV-2 reactive T cells in COVID-19 patients and healthy donors , 2020, medRxiv.
[2] D. Dolfi,et al. Circulating CXCR5+PD-1+ Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults , 2014, The Journal of Immunology.
[3] Jedd D. Wolchok,et al. T-cell invigoration to tumour burden ratio associated with anti-PD-1 response , 2017, Nature.
[4] Jay B. Varkey,et al. Human Ebola virus infection results in substantial immune activation , 2015, Proceedings of the National Academy of Sciences.
[5] M. Merad,et al. Immunology of COVID-19: Current State of the Science , 2020, Immunity.
[6] Jing Yuan,et al. Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma. , 2020, JAMA.
[7] Taojiao Wang,et al. Clinical and immunologic features in severe and moderate Coronavirus Disease 2019. , 2020, The Journal of clinical investigation.
[8] G. Walther,et al. Earth Mover’s Distance (EMD): A True Metric for Comparing Biomarker Expression Levels in Cell Populations , 2016, PloS one.
[9] Carl H. June,et al. Cytokine release syndrome in severe COVID-19 , 2020, Science.
[10] Jianmin Li,et al. Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing , 2020, Cell Discovery.
[11] Chuan Qin,et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[12] G. Alexe,et al. Origin and differentiation of human memory CD8 T cells after vaccination , 2017, Nature.
[13] Jeffrey S. Morris,et al. SARS-CoV-2 seroprevalence among parturient women in Philadelphia , 2020, Science Immunology.
[14] Y. Wen,et al. Neutralizing antibody responses to SARS-CoV-2 in a COVID-19 recovered patient cohort and their implications , 2020, medRxiv.
[15] E. Walsh,et al. Circulating Human Antibody-Secreting Cells during Vaccinations and Respiratory Viral Infections Are Characterized by High Specificity and Lack of Bystander Effect , 2011, The Journal of Immunology.
[16] S. Crotty. T Follicular Helper Cell Biology: A Decade of Discovery and Diseases. , 2019, Immunity.
[17] Richard Molenkamp,et al. Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome , 2020, medRxiv.
[18] M. Netea,et al. Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure , 2020, Cell Host & Microbe.
[19] Yuan Shi,et al. Convalescent plasma as a potential therapy for COVID-19 , 2020, The Lancet Infectious Diseases.
[20] Bin Li,et al. Tocilizumab treatment in severe COVID-19 patients attenuates the inflammatory storm incited by monocyte centric immune interactions revealed by single-cell analysis , 2020 .
[21] Susan A. Doyle,et al. Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cells , 2017, Science Immunology.
[22] F. Schmidt. Meta-Analysis , 2008 .
[23] C. Hillyer,et al. Neutralizing Antibodies against SARS-CoV-2 and Other Human Coronaviruses , 2020, Trends in Immunology.
[24] Aaron M. Rosenfeld,et al. Comprehensive mapping of immune perturbations associated with severe COVID-19 , 2020, Science Immunology.
[25] J. Greenbaum,et al. Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals , 2020, Cell.
[26] M. Tay,et al. The trinity of COVID-19: immunity, inflammation and intervention , 2020, Nature Reviews Immunology.
[27] J. Altman,et al. Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines. , 2008, Immunity.
[28] H. Deng,et al. The clinical and immunological features of pediatric COVID-19 patients in China , 2020, Genes & Diseases.
[29] R. Schwartz,et al. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 , 2020, Cell.
[30] Susan A. Doyle,et al. Vaccine-induced ICOS+CD38+ cTfh are sensitive biosensors of age-related changes in inflammatory pathways , 2019, bioRxiv.
[31] Yong-tang Zheng,et al. Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients , 2020, Cellular & Molecular Immunology.
[32] Hengcheng Zhu,et al. Clinical characteristics of 82 death cases with COVID-19 , 2020, medRxiv.
[33] Y. Hu,et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China , 2020, The Lancet.
[34] Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing. , 2020, Cell discovery.
[35] Lei Liu,et al. Exuberant elevation of IP-10, MCP-3 and IL-1ra during SARS-CoV-2 infection is associated with disease severity and fatal outcome , 2020, medRxiv.
[36] J. Mason,et al. A dynamic COVID-19 immune signature includes associations with poor prognosis , 2020, Nature Medicine.
[37] Lin Cheng,et al. Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 , 2020, Nature Medicine.
[38] G. Blanchard-Rohner,et al. Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans. , 2009, Blood.
[39] J. Mason,et al. A consensus Covid-19 immune signature combines immuno-protection with discrete sepsis-like traits associated with poor prognosis , 2020, medRxiv.
[40] Nikesh Kotecha,et al. Web‐Based Analysis and Publication of Flow Cytometry Experiments , 2010, Current protocols in cytometry.
[41] E. Wherry,et al. CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. , 2019, Annual review of immunology.
[42] Zhigang Tian,et al. Functional exhaustion of antiviral lymphocytes in COVID-19 patients , 2020, Cellular & Molecular Immunology.
[43] J. Oxford,et al. Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans , 2012, Nature Medicine.
[44] N. Watkins,et al. Evaluation of antibody testing for SARS-Cov-2 using ELISA and lateral flow immunoassays , 2020, medRxiv.
[45] F. A. Lagunas-Rangel. Neutrophil‐to‐lymphocyte ratio and lymphocyte‐to‐C‐reactive protein ratio in patients with severe coronavirus disease 2019 (COVID‐19): A meta‐analysis , 2020, Journal of medical virology.
[46] C. Agrati,et al. Longitudinal characterization of dysfunctional T cell-activation during human acute Ebola infection , 2016, Cell Death and Disease.
[47] Li Yang,et al. Lymphopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A systemic review and meta-analysis , 2020, International Journal of Infectious Diseases.
[48] Sara Invitto,et al. Current state of the science , 2015 .
[49] Douglas B. Johnson,et al. Computational Immune Monitoring Reveals Abnormal Double-Negative T Cells Present across Human Tumor Types , 2018, Cancer Immunology Research.
[50] Xinquan Wang,et al. Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals , 2020, Immunity.
[51] A. Sette,et al. Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome , 2020, Science Immunology.
[52] Jiyuan Zhang,et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome , 2020, The Lancet Respiratory Medicine.
[53] K. Shekhar,et al. Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point. , 2015, Immunity.
[54] P. Jahrling,et al. Depletion of peripheral blood T lymphocytes and NK cells during the course of ebola hemorrhagic Fever in cynomolgus macaques. , 2004, Viral immunology.
[55] E. Iype,et al. Understanding the asymmetric spread and case fatality rate (CFR) for COVID-19 among countries , 2020, medRxiv.
[56] Piet Demeester,et al. FlowSOM: Using self‐organizing maps for visualization and interpretation of cytometry data , 2015, Cytometry. Part A : the journal of the International Society for Analytical Cytology.
[57] Andrew Pollard,et al. Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel , 2020, Wellcome open research.
[58] Yajuan Li,et al. COVID-19 diagnosis and study of serum SARS-CoV-2 specific IgA, IgM and IgG by a quantitative and sensitive immunoassay , 2020, medRxiv.
[59] Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19) , 2020, Frontiers in Immunology.
[60] Ying Wang,et al. COVID-19 infection: the perspectives on immune responses , 2020, Cell Death & Differentiation.
[61] K. Qu,et al. Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm , 2020, Nature Communications.
[62] P. Klenerman,et al. CD39 Expression Identifies Terminally Exhausted CD8+ T Cells , 2015, PLoS pathogens.
[63] B. Pulendran,et al. Rapid and Massive Virus-Specific Plasmablast Responses during Acute Dengue Virus Infection in Humans , 2012, Journal of Virology.
[64] Y. Yazdanpanah,et al. Severe Acute Respiratory Syndrome Coronavirus 2−Specific Antibody Responses in Coronavirus Disease Patients , 2020, Emerging infectious diseases.
[65] SARS-CoV-2 Seroprevalence Among Parturient Women , 2020, medRxiv.
[66] Peipei Xu,et al. A systemic review and meta-analysis , 2017 .
[67] D. Rader,et al. SARS-CoV-2 Seroprevalence Among Parturient Women , 2020, medRxiv.
[68] Steven Y. C. Tong,et al. Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19 , 2020, Nature Medicine.
[69] Zhigang Tian,et al. Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus , 2020, bioRxiv.