[18F]FDG‐PET and Whole‐Scalp MEG Localization of Epileptogenic Cortex

Summary: Purpose: To evaluate combined [18F]fluorodeoxy‐glucose (18F‐FDG) positron emission tomography (PET) and 122‐channel whole‐scalp magnetoencephalography (MEG) in lateralizing the epileptogenic cortex in patients whose routine presurgical evaluations gave discordant results about the location of the epileptic focus.

[1]  S Gilman,et al.  Differences between lateral and mesial temporal metabolism interictally in epilepsy of mesial temporal origin , 1990, Neurology.

[2]  M. Newton,et al.  Hippocampal Atrophy Is Not a Major Determinant of Regional Hypometabolism in Temporal Lobe Epilepsy , 1997, Epilepsia.

[3]  W. J. Brown,et al.  Pathological findings underlying focal temporal lobe hypometabolism in partial epilepsy , 1982, Annals of neurology.

[4]  R. Ilmoniemi,et al.  Magnetoencephalography-theory, instrumentation, and applications to noninvasive studies of the working human brain , 1993 .

[5]  A. Pitkänen,et al.  Recurrent seizures may cause hippocambal damage in temporal lobe epilepsy , 1998, Neurology.

[6]  R. Kuzniecky,et al.  Predictive value of magnetic resonance imaging in temporal lobe epilepsy surgery. , 1993, Archives of neurology.

[7]  J. Talairach,et al.  Lesion, "irritative" zone and epileptogenic focus. , 1966, Confinia neurologica.

[8]  J C Mazziotta,et al.  Quantifying Interictal Metabolic Activity in Human Temporal Lobe Epilepsy , 1990, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[9]  K. Hamacher,et al.  Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. , 1986, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[10]  M. Mandelkern,et al.  Neuroimaging in Temporal Lobe Epilepsy: Test Sensitivity and Relationships to Pathology and Postoperative Outcome , 1992, Epilepsia.

[11]  A. Ylinen,et al.  Comparison of[F]FDG-PET, [Tc]-HMPAO-SPECT, and [I]-iomazenil-SPECT in localising the epileptogenic cortex , 1998 .

[12]  Michael E. Phelps,et al.  Comparative localization of foci in partial epilepsy by PCT and EEG , 1982 .

[13]  J. Engel Update on surgical treatment of the epilepsies , 1993, Neurology.

[14]  K Abraham-Fuchs,et al.  Magnetic source localization and morphological changes in temporal lobe epilepsy: comparison of MEG/EEG, ECoG and volumetric MRI in presurgical evaluation of operated patients , 1994, Acta neurologica Scandinavica. Supplementum.

[15]  Riitta Salmelin,et al.  Parietal epileptic mirror focus detected with a whole‐head neuromagnetometer , 1993, Neuroreport.

[16]  N Forss,et al.  Trigeminally triggered epileptic hemifacial convulsions , 1995, Neuroreport.

[17]  G. Barnett,et al.  The value of PET scan (and MRI and Wada test) in patients with bitemporal epileptiform abnormalities. , 1995, Archives of neurology.

[18]  J Beatty,et al.  Neuromagnetic evidence of spatially distributed sources underlying epileptiform spikes in the human brain. , 1984, Science.

[19]  J. Mazziotta,et al.  Clinical evaluation of interictal fluorine-18-fluorodeoxyglucose PET in partial epilepsy. , 1993, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[20]  S. Sato,et al.  FDG-PET and volumetric MRI in the evaluation of patients with partial epilepsy , 1995, Neurology.

[21]  K. A. Frey,et al.  Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy , 1995, Neurology.

[22]  D. Velis,et al.  Quantitative analysis of 18/FDG-PET in the presurgical evaluation of patients suffering from refractory partial epilepsy. Comparison with CT, MRI, and combined subdural and depth. EEG. , 1990, Acta neurochirurgica. Supplementum.

[23]  J M Hoffman,et al.  MR and positron emission tomography in the diagnosis of surgically correctable temporal lobe epilepsy. , 1994, AJNR. American journal of neuroradiology.

[24]  C R Jack,et al.  Magnetic resonance imaging–based volume studies in temporal lobe epilepsy: Pathological correlations , 1991, Annals of neurology.

[25]  Conrad V. Kufta,et al.  FDG‐Positron Emission Tomography and Invasive EEG: Seizure Focus Detection and Surgical Outcome , 1997, Epilepsia.

[26]  G. Jackson,et al.  Hippocampal sclerosis can be reliably detected by magnetic resonance imaging , 1990, Neurology.

[27]  M. Fine,et al.  A Golgi and horseradish peroxidase study of the sonic motor nucleus of the oyster toadfish. , 1995, Brain, behavior and evolution.

[28]  J C Mazziotta,et al.  Interictal cerebral glucose metabolism in partial epilepsy and its relation to EEG changes , 1982, Annals of neurology.

[29]  J. Mazziotta,et al.  Presurgical evaluation for partial epilepsy , 1990, Neurology.

[30]  M. Gilardi,et al.  Physical performance of the latest generation of commercial positron scanner , 1988 .

[31]  K Abraham-Fuchs,et al.  Ictal and Interictal Activity in Partial Epilepsy Recorded with Multichannel Magnetoelectroencephalography: Correlation of Electroencephalography/Electrocorticography, Magnetic Resonance Imaging, Single Photon Emission Computed Tomography, and Positron Emission Tomography Findings , 1992, Epilepsia.

[32]  Conrad V. Kufta,et al.  Temporal lobectomy for uncontrolled seizures: The role of positron emission tomography , 1992, Annals of neurology.

[33]  L. Parkkonen,et al.  122-channel squid instrument for investigating the magnetic signals from the human brain , 1993 .

[34]  I Savic,et al.  Comparison of [11C]flumazenil and [18F]FDG as PET markers of epileptic foci. , 1993, Journal of neurology, neurosurgery, and psychiatry.

[35]  A. Reissell,et al.  Production of 18F from water targets. Specific radioactivity and anionic contaminants , 1988 .

[36]  D. Barth,et al.  Neuromagnetic localization of epileptiform spike activity in the human brain. , 1982, Science.

[37]  C. Patlak,et al.  Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[38]  W W Sutherling,et al.  Neocortical propagation in temporal lobe spike foci on magnetoencephalography and electroencephalography , 1989, Annals of neurology.

[39]  F. Sharbrough,et al.  Depth Electrode Studies in Temporal Lobe Epilepsy: Relation to Quantitative Magnetic Resonance Imaging and Operative Outcome , 1995, Epilepsia.

[40]  Sid Gilman,et al.  Positron emission tomography studies of cerebral glucose metabolism in chronic partial epilepsy , 1987, Annals of neurology.

[41]  C. Nordling,et al.  Wavelengths and energy levels of the 4d95s-4d95p transition array of Xe IX , 1994 .

[42]  P. Crandall,et al.  Comparative localization of epileptic foci in partial epilepsy by PCT and EEG. , 1982, Annals of neurology.

[43]  Michael Channing,et al.  {18F}fluorodeoxyglucose positron emission tomography in refractory complex partial seizures , 1983, Annals of neurology.

[44]  A Connelly,et al.  Detection of hippocampal pathology in intractable partial epilepsy , 1993, Neurology.

[45]  M. Kajola,et al.  Localization of epileptic foci using a large‐area magnetometer and functional brain anatomy , 1990, Annals of neurology.

[46]  W. Theodore,et al.  Patterns of cerebral glucose metabolism in patients with partial seizures , 1988, Neurology.

[47]  D E Kuhl,et al.  In vivo cerebral metabolism and central benzodiazepine‐receptor binding in temporal lobe epilepsy , 1993, Neurology.

[48]  G. Sedvall,et al.  IN-VIVO DEMONSTRATION OF REDUCED BENZODIAZEPINE RECEPTOR BINDING IN HUMAN EPILEPTIC FOCI , 1988, The Lancet.

[49]  M Kajola,et al.  Magnetoencephalography in the study of epilepsy , 1990, Neurophysiologie Clinique/Clinical Neurophysiology.

[50]  H. Soininen,et al.  Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age‐associated memory impairment , 1994, Neurology.

[51]  A. Ylinen,et al.  Comparison of[18F]FDG-PET, [99mTc]-HMPAO-SPECT, and [123I]-iomazenil-SPECT in localising the epileptogenic cortex , 1997, Journal of neurology, neurosurgery, and psychiatry.

[52]  G L Romani,et al.  Biomagnetic measurements of spontaneous brain activity in epileptic patients. , 1982, Electroencephalography and clinical neurophysiology.

[53]  K. Wienhard,et al.  MRI-Guided Flumazenil- and FDG-PET in Temporal Lobe Epilepsy , 1996, NeuroImage.

[54]  J. Mazziotta,et al.  Interictal metabolic anatomy of mesial temporal lobe epilepsy. , 1993, Archives of neurology.

[55]  M Hämäläinen,et al.  Somatosensory evoked cerebral magnetic fields from SI and SII in man. , 1984, Electroencephalography and clinical neurophysiology.