Dual carbamoylations on the polyketide and glycosyl moiety by asm21 result in extended ansamitocin biosynthesis.

[1]  Q. Kang,et al.  Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS. , 2011, Molecular bioSystems.

[2]  Q. Kang,et al.  N‐Methylation of the Amide Bond by Methyltransferase Asm10 in Ansamitocin Biosynthesis , 2011, Chembiochem : a European journal of chemical biology.

[3]  H. Floss,et al.  The Biosynthesis of 3-Amino-5-hydroxybenzoic Acid (AHBA), the Precursor of mC7N Units in Ansamycin and Mitomycin Antibiotics , 2011 .

[4]  T. Knobloch,et al.  Mutational Biosynthesis of Ansamitocin Antibiotics: A Diversity‐Oriented Approach to Exploit Biosynthetic Flexibility , 2011, Chembiochem : a European journal of chemical biology.

[5]  Guozhu Wei,et al.  A new antitumour ansamitocin from Actinosynnema pretiosum , 2010, Natural product research.

[6]  Z. Deng,et al.  Two pHZ1358-derivative vectors for efficient gene knockout in streptomyces. , 2010, Journal of microbiology and biotechnology.

[7]  Z. Deng,et al.  Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins. , 2008, Chemistry & biology.

[8]  R. Chari.  Targeted cancer therapy: conferring specificity to cytotoxic drugs. , 2008, Accounts of chemical research.

[9]  J. Gilbert,et al.  The ansacarbamitocins: polar ansamitocin derivatives. , 2007, Journal of natural products.

[10]  Yue-Mao Shen,et al.  New amide N-glycosides of ansamitocins identified fromActinosynnema pretiosum , 2007, Archives of pharmacal research.

[11]  Ruth H Flatman,et al.  Structure-Activity Relationships of Aminocoumarin-Type Gyrase and Topoisomerase IV Inhibitors Obtained by Combinatorial Biosynthesis , 2006, Antimicrobial Agents and Chemotherapy.

[12]  P. Leadlay,et al.  Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449. , 2005, Microbiology.

[13]  Kenneth K. Chan,et al.  Recent Developments in the Maytansinoid Antitumor Agents , 2004 .

[14]  L. Heide,et al.  New aminocoumarin antibiotics formed by a combined mutational and chemoenzymatic approach utilizing the carbamoyltransferase NovN. , 2004, Chemistry & biology.

[15]  L. Bai,et al.  A novel amide N-glycoside of ansamitocins from Actinosynnema pretiosum. , 2004, The Journal of antibiotics.

[16]  L. Bai,et al.  The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema pretiosum. , 2003, Journal of the American Chemical Society.

[17]  G. Challis,et al.  PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[18]  L. Bai,et al.  The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[19]  L. Rebhun,et al.  Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids. , 2002, Journal of medicinal chemistry.

[20]  L. Heide,et al.  Identification of the Novobiocin Biosynthetic Gene Cluster of Streptomyces spheroides NCIB 11891 , 2000, Antimicrobial Agents and Chemotherapy.

[21]  M. Beeby,et al.  Crystal structure of 3-amino-5-hydroxybenzoic acid (AHBA) synthase. , 1999, Biochemistry.

[22]  J. Ishikawa,et al.  FramePlot: a new implementation of the frame analysis for predicting protein-coding regions in bacterial DNA with a high G + C content. , 1999, FEMS microbiology letters.

[23]  A. Neumann,et al.  Purification and Characterization of Tetrachloroethene Reductive Dehalogenase from Dehalospirillum multivorans* , 1996, The Journal of Biological Chemistry.

[24]  C V Smith,et al.  The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X‐ray crystallography. , 1996, The EMBO journal.

[25]  H. Kinashi,et al.  Isolation and characterization of concanamycins A, B and C. , 1984, The Journal of antibiotics.

[26]  M. Winters,et al.  Effects of novobiocin, coumermycin A1, clorobiocin, and their analogs on Escherichia coli DNA gyrase and bacterial growth , 1982, Antimicrobial Agents and Chemotherapy.

[27]  M. Turner,et al.  An adenosine triphosphate-dependent carbamoylphosphate--3-hydroxymethylcephem O-carbamoyltransferase from Streptomyces clavuligerus. , 1980, The Biochemical journal.

[28]  T. Hasegawa,et al.  Ansamitocin, a group of novel maytansinoid antibiotics with antitumour properties from Nocardia , 1977, Nature.

[29]  M. Gellert,et al.  Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[30]  T. Miller,et al.  Cephamycins, a New Family of β-Lactam Antibiotics II. Isolation and Chemical Characterization , 1972, Antimicrobial Agents and Chemotherapy.

[31]  Ramanathan Nagarajan,et al.  Beta-lactam antibiotics from Streptomyces. , 1971, Journal of the American Chemical Society.

[32]  C. Walsh,et al.  Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring. , 2004, Angewandte Chemie.

[33]  Kenneth K. Chan,et al.  Recent developments in the maytansinoid antitumor agents. , 2004, Chemical & pharmaceutical bulletin.

[34]  T. Kieser.  Practical streptomyces genetics , 2000 .