마우스에서 복분자 물추출물의 기억력 감퇴에 대한 개선 효과

In the present study, we examined the effect of the aqueous extract of Rubus coreanus Miquel (RCM-Ex) on scopolamine-induced memory impairment in male ICR mice. Mice were fed the diet containing 100 mg/kg body weight/day of RCM-Ex for 4 weeks. To induce amnesia, scopolamine (an antagonist of muscarinic acetylcholine receptor, 1 mg/kg of body weight) was intraperitoneally injected into mice 30 min before starting the behavior tests. RCM-Ex reversed scopolamine-induced memory impairments in mice as evidence by the passive avoidance test and Morris water maze test. In addition, acetylcholineasterase activities were decreased in the brains of mice treated with RCM-Ex. These results suggest that RCM-Ex may be an effective agent for the prevention of the memory impairment induced by cholinergic dysfunction.

[1]  R. Morris.  Developments of a water-maze procedure for studying spatial learning in the rat , 1984, Journal of Neuroscience Methods.

[2]  신현경,et al.  토종 복분자와 외래종 복분자 추출물의 항염증효과 비교 , 2007 .

[3]  K. Courtney,et al.  A new and rapid colorimetric determination of acetylcholinesterase activity. , 1961, Biochemical pharmacology.

[4]  I. Torok,et al.  Donepezil dose-dependently inhibits acetylcholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptive enzyme-positive structures in the human and rat brain , 2000, Neuroscience.

[5]  Hyun-Kyung Shin,et al.  Induction of apoptosis by the aqueous extract of Rubus coreanum in HT-29 human colon cancer cells. , 2005, Nutrition.

[6]  G. Dawson,et al.  The behavioral effects of heptyl physostigmine, a new cholinesterase inhibitor, in tests of long-term and working memory in rodents , 1991, Pharmacology Biochemistry and Behavior.

[7]  U. Ebert,et al.  Scopolamine model of dementia: electroencephalogram findings and cognitive performance , 1998, European journal of clinical investigation.

[8]  G. Wilcock,et al.  The cholinergic hypothesis of Alzheimer’s disease: a review of progress , 1999, Journal of neurology, neurosurgery, and psychiatry.

[9]  Joseph E. LeDoux,et al.  Emotional memory systems in the brain , 1993, Behavioural Brain Research.

[10]  박근형,et al.  복분자 열매에서 항산화활성을 지닌 quercetin의 분리 및 동정 , 2003 .

[11]  Kim Dong-Hyun,et al.  Memory enhancing properties of the ethanolic extract of black sesame and its ameliorating properties on memory impairments in mice. , 2010 .

[12]  Cherry Tomatoes Ameliorate Scopolamine-induced Amnesia in Mice , 2008 .

[13]  E. Giacobini.  Chapter 34 The cholinergic system in Alzheimer disease , 1990 .

[14]  Mee-Ra Kim,et al.  Antimutagenic and Cytotoxic Activity of Ethanol and Water Extracts from Rubus coreanum , 2009 .

[15]  P. Davies,et al.  SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE , 1976, The Lancet.

[16]  D. Braida,et al.  An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors. , 1996, European journal of pharmacology.

[17]  S. Minoshima,et al.  In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer’s disease , 1999, Neurology.

[18]  차환수,et al.  복분자 딸기의 이화학적 특성 , 2001 .

[19]  T. Kaptchuk,et al.  Chinese Herbal Medicine: Materia Medica , 1986 .

[20]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[21]  Myeon Choe,et al.  Synergistic Effects of extracts from korean red ginseng, saururus chinensis(Lour) Baill. And Rubus coreanus Miq on Antioxidative activities in rats , 2003 .

[22]  R. Bartus,et al.  On Neurodegenerative Diseases, Models, and Treatment Strategies: Lessons Learned and Lessons Forgotten a Generation Following the Cholinergic Hypothesis , 2000, Experimental Neurology.

[23]  H. Chapel,et al.  CLINICAL RELEVANCE OF SPECIFIC IgG ANTIBODIES TO CARDIOLIPIN , 1989, The Lancet.

[24]  박성진,et al.  발효더덕 추출물이 흰쥐의 인지능 회복에 미치는 효과 , 2010 .