Composition and structure of articular cartilage: a template for tissue repair.

The authors review the structure and composition of articular cartilage. This tissue is composed of an extensive extracellular matrix synthesized by chondrocytes. It contains different zones with respect to depth from the articular surface and has a regional organization around the chondrocytes. Its composition varies regionally and zonally in its collagen and proteoglycan contents and those of other matrix molecules. There is a macrofibrillar collagen network and a microfilamentous network about which other noncollagenous molecules are organized. Its structure and composition are reflective of its special mechanical properties that primarily reflect its tensile strength (collagens) and compressive stiffness (proteoglycan aggrecan) and cell-matrix interactions (noncollagenous proteins).

[1]  G E Kempson,et al.  The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans. , 1973, Biochimica et biophysica acta.

[2]  V C Mow,et al.  Tensile properties of human knee joint cartilage: I. Influence of ionic conditions, weight bearing, and fibrillation on the tensile modulus , 1986, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[3]  E. Eikenberry,et al.  Collagen XI Nucleates Self-assembly and Limits Lateral Growth of Cartilage Fibrils* , 2000, The Journal of Biological Chemistry.

[4]  R. Timpl,et al.  Recombinant expression and structural and binding properties of α1(VI) and α2(VI) chains of human collagen type VI , 1994 .

[5]  G. Chow,et al.  Antisense inhibition of chondrocyte CD44 expression leading to cartilage chondrolysis. , 1998, Arthritis and rheumatism.

[6]  R. Loeser,et al.  Articular-cartilage matrix gamma-carboxyglutamic acid-containing protein. Characterization and immunolocalization. , 1992, The Biochemical journal.

[7]  The structure of anchorin CII, a collagen binding protein isolated from chondrocyte membrane. , 1988, The Journal of biological chemistry.

[8]  R. Timpl,et al.  Perlecan Maintains the Integrity of Cartilage and Some Basement Membranes , 1999, The Journal of cell biology.

[9]  A R Poole,et al.  An immunoelectron microscope study of the organization of proteoglycan monomer, link protein, and collagen in the matrix of articular cartilage , 1982, The Journal of cell biology.

[10]  D. Heinegård,et al.  Binding of fibromodulin and decorin to separate sites on fibrillar collagens. , 1993, The Journal of biological chemistry.

[11]  W. Koopman.  Arthritis and allied conditions;: A textbook of rheumatology , 1972 .

[12]  D. Eyre,et al.  Identification of cross-linking sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type IX bonding. , 1992, The Journal of biological chemistry.

[13]  P. Roughley,et al.  Contents and distributions of the proteoglycans decorin and biglycan in normal and osteoarthritic human articular cartilage , 1996, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[14]  M. Venn.  Variation of chemical composition with age in human femoral head cartilage. , 1978, Annals of the rheumatic diseases.

[15]  R. Glanville,et al.  Ultrastructure of type VI collagen in human skin and cartilage suggests an anchoring function for this filamentous network , 1988, The Journal of cell biology.

[16]  Hugh C Burry,et al.  Adult Articular Cartilage , 1974 .

[17]  B. Steinmann,et al.  The structure of human collagen type IX and its organization in fetal and infant cartilage fibrils. , 1988, The Journal of biological chemistry.

[18]  R. Behringer,et al.  Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein , 1997, Nature.

[19]  R. Timpl,et al.  Binding of the proteoglycan decorin to collagen type VI. , 1992, The Journal of biological chemistry.

[20]  D. Keene,et al.  Fibrillin-1 in Human Cartilage: Developmental Expression and Formation of Special Banded Fibers , 1997, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[21]  D. Salter,et al.  Integrin-interleukin-4 mechanotransduction pathways in human chondrocytes. , 2001, Clinical orthopaedics and related research.

[22]  C. McDevitt,et al.  Interaction of intact type VI collagen with hyaluronan , 1991, FEBS letters.

[23]  Terry Magnuson,et al.  Lumican Regulates Collagen Fibril Assembly: Skin Fragility and Corneal Opacity in the Absence of Lumican , 1998, The Journal of cell biology.

[24]  L. Tang,et al.  Localization of proteoglycan monomer and link protein in the matrix of bovine articular cartilage: An immunohistochemical study. , 1980, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[25]  M. Quintero,et al.  Cell density of adult human femoral condylar articular cartilage. Joints with normal and fibrillated surfaces. , 1983, Laboratory investigation; a journal of technical methods and pathology.

[26]  J. Turnay,et al.  Collagen binding activity of recombinant and N‐terminally modified annexin V (anchorin CII) , 1995, Journal of cellular biochemistry.

[27]  廣畑 和志,et al.  Cartilage in health and disease , 1985 .

[28]  H. Kuivaniemi,et al.  Mutations in fibrillar collagens (types I, II, III, and XI), fibril‐associated collagen (type IX), and network‐forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels , 1997, Human mutation.

[29]  C. Kielty,et al.  Type VI collagen microfibrils: evidence for a structural association with hyaluronan , 1992, The Journal of cell biology.

[30]  B. Schumacher,et al.  Immunodetection and partial cDNA sequence of the proteoglycan, superficial zone protein, synthesized by cells lining synovial joints , 1999, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[31]  D. Heinegård,et al.  Integrin α2β1 Is a Receptor for the Cartilage Matrix Protein Chondroadherin , 1997, The Journal of cell biology.

[32]  L. Rosenberg,et al.  Localization of a dermatan sulfate proteoglycan (DS-PGII) in cartilage and the presence of an immunologically related species in other tissues. , 1986, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[33]  G. Pringle,et al.  Immunoelectron microscopic localization of the core protein of decorin near the d and e bands of tendon collagen fibrils by use of monoclonal antibodies. , 1990, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[34]  L. Vaughan,et al.  Cartilage contains mixed fibrils of collagen types II, IX, and XI , 1989, The Journal of cell biology.

[35]  L. Ala‐Kokko,et al.  Mutations in Cartilage Oligomeric Matrix Protein Causing Pseudoachondroplasia and Multiple Epiphyseal Dysplasia Affect Binding of Calcium and Collagen I, II, and IX* , 2001, The Journal of Biological Chemistry.