Killing Me Softly: The Fetal Origins Hypothesis.

In the epidemiological literature, the fetal origins hypothesis associated with David J. Barker posits that chronic, degenerative conditions of adult health, including heart disease and type 2 diabetes, may be triggered by circumstance decades earlier, in utero nutrition in particular. Economists have expanded on this hypothesis, investigating a broader range of fetal shocks and circumstances and have found a wealth of later-life impacts on outcomes including test scores, educational attainment, and income, along with health. In the process, they have provided some of the most credible observational evidence in support of the hypothesis. The magnitude of the impacts is generally large. Thus, the fetal origins hypothesis has not only survived contact with economics, but has flourished.

[1]  T. Lehner,et al.  Low birth weight and health expenditures from birth to late adolescence , 2014, The European Journal of Health Economics.

[2]  M. Lindeboom,et al.  Early Life Conditions and Later Life Inequality in Health , 2013 .

[3]  M. Lindeboom,et al.  The impact of early-life economic conditionson cause-specific mortality during adulthood , 2013 .

[4]  Shige Song Identifying the intergenerational effects of the 1959-1961 Chinese Great Leap Forward Famine on infant mortality. , 2013, Economics and human biology.

[5]  Dan-yang Li,et al.  Moving to the Right Place at the Right Time: The Economic Consequence of the Manchuria Plague of 1910-11 on Migrants , 2013 .

[6]  Daniel L. Millimet,et al.  The origins of early childhood anthropometric persistence , 2013, Empirical Economics.

[7]  Erin C. Lentz,et al.  The Economics and Nutritional Impacts of Food Assistance Policies and Programs , 2013 .

[8]  J. Currie,et al.  What Do We Know About Short and Long Term Effects of Early Life Exposure to Pollution? , 2013 .

[9]  A. Burlando,et al.  Transitory Shocks and Birth Weights: Evidence from a Blackout in Zanzibar , 2013 .

[10]  Individual Behavior as a Pathway between Early-Life Shocks and Adult Health: Evidence from Hunger Episodes in Post-War Germany , 2013 .

[11]  James P. Smith,et al.  Individual Behaviour as a Pathway between Early�?Life Shocks and Adult Health: Evidence from Hunger Episodes in Post�?War Germany , 2013, SSRN Electronic Journal.

[12]  A. Geronimus Deep integration: letting the epigenome out of the bottle without losing sight of the structural origins of population health. , 2013, American journal of public health.

[13]  Bulent Unel,et al.  The Impact of Mothers' Earnings on Health Inputs and Infant Health , 2013 .

[14]  Marie T Ruel,et al.  Nutrition-sensitive interventions and programmes: how can they help to accelerate progress in improving maternal and child nutrition? , 2013, The Lancet.

[15]  Hannah Landecker,et al.  From Social Structure to Gene Regulation, and Back: A Critical Introduction to Environmental Epigenetics for Sociology , 2013 .

[16]  C. Barrett,et al.  The Economics of Poverty Traps and Persistent Poverty: Empirical and Policy Implications , 2013 .

[17]  Shinsuke Tanaka Does Abolishing User Fees Lead to Improved Health Status? Evidence from Post-Apartheid South Africa , 2013 .

[18]  E. K. Adams,et al.  Tobacco Control Policies, Birth Outcomes, and Maternal Human Capital , 2013, Journal of Human Capital.

[19]  S. Phipps,et al.  From Parent to Child: Emerging Inequality in Outcomes for Children in Canada and the U.S. , 2013 .

[20]  Marco Manacorda,et al.  The Effect of Violence on Birth Outcomes: Evidence from Homicides in Rural Brazil , 2013 .

[21]  Maya Rossin-Slater WIC in Your Neighborhood: New Evidence on the Impacts of Geographic Access to Clinics. , 2013, Journal of public economics.

[22]  J. Klugman,et al.  Maternal health: a missed opportunity for development , 2013, The Lancet.

[23]  J. Graff Zivin,et al.  Environment, Health, and Human Capital , 2013 .

[24]  W. Schlenker,et al.  Something in the Water: Contaminated Drinking Water and Infant Health , 2013, The Canadian journal of economics. Revue canadienne d'economique.

[25]  Daniel Kuehnle The Causal Effect of Family Income on Child Health: A Re-Examination Using an Instrumental Variables Approach , 2013 .

[26]  S. Hsiang,et al.  Destruction, Disinvestment, and Death: Economic and Human Losses Following Environmental Disaster , 2013 .

[27]  M. McEniry Early-life conditions and older adult health in low- and middle-income countries: a review. , 2013, Journal of developmental origins of health and disease.

[28]  D. Himmelgreen Using a life course approach and a bio-cultural perspective to understand the food insecurity and obesity paradox. , 2013, Cadernos de saude publica.

[29]  P. Bharadwaj,et al.  Discrimination Begins in the Womb: Evidence of Sex-Selective Prenatal Investments , 2013, The Journal of Human Resources.

[30]  T. Norström,et al.  The use of epidemiology in alcohol research , 2012, Addiction.

[31]  Abhijeet Singh,et al.  School Meals as a Safety Net: An Evaluation of the Midday Meal Scheme in India , 2012, Economic Development and Cultural Change.

[32]  Maya Rossin-Slater,et al.  Weathering the Storm: Hurricanes and Birth Outcomes , 2012, Journal of health economics.

[33]  Hendrik Jürges Collateral damage: the German food crisis, educational attainment and labor market outcomes of German post-war cohorts. , 2013, Journal of health economics.

[34]  G. Ridder,et al.  Health, Height, Height Shrinkage and Ses at Older Ages: Evidence from China , 2013, American economic journal. Applied economics.

[35]  D. Almond,et al.  Long Run Impacts of Childhood Access to the Safety Net , 2012 .

[36]  R. Lutter,et al.  Fetal and Early Childhood Undernutrition, Mortality, and Lifelong Health , 2012, Science.

[37]  D. Rees,et al.  Armed conflict and birth weight: Evidence from the al-Aqsa Intifada , 2012 .

[38]  J. Currie,et al.  Early-Life Health and Adult Circumstance in Developing Countries , 2012 .

[39]  Thomas Pogge,et al.  Ethical and Economic Perspectives on Global Health Interventions , 2012 .

[40]  J. W. Reyes Lead Policy and Academic Performance: Insights from Massachusetts , 2012 .

[41]  H. Strulik,et al.  The Genesis of the Golden Age - Accounting for the Rise in Health and Leisure , 2012 .

[42]  A. Venkataramani Early life exposure to malaria and cognition in adulthood: evidence from Mexico. , 2012, Journal of health economics.

[43]  Nicholas J. Sanders What Doesn't Kill You Makes You Weaker: Prenatal Pollution Exposure and Educational Outcomes , 2012 .

[44]  Hendrik Jürges Collateral Damage: Educational Attainment and Labor Market Outcomes Among German War and Post-War Cohorts , 2012 .

[45]  Joshua Goodman,et al.  The Wages of Sinistrality: Handedness, Brain Structure and Human Capital Accumulation , 2012 .

[46]  Pia R. Pinger,et al.  Instrumental Variable Estimation of the Causal Effect of Hunger Early in Life on Health Later In Life , 2016, SSRN Electronic Journal.

[47]  S. Bhalotra,et al.  War and Stature: Growing Up During the Nigerian Civil War , 2012, SSRN Electronic Journal.

[48]  S. Bhalotra,et al.  Health and the Political Agency of Women , 2011, SSRN Electronic Journal.

[49]  Mariesa A. Herrmann,et al.  From Infant to Mother: Early Disease Environment and Future Maternal Health , 2011 .

[50]  S. Bhalotra,et al.  The Captain of the Men of Death and His Shadow: Long-Run Impacts of Early Life Pneumonia Exposure , 2011, SSRN Electronic Journal.

[51]  E. Kelly The Scourge of Asian Flu: In utero Exposure to Pandemic Influenza and the Development of a Cohort of British Children , 2011 .

[52]  D. Almond,et al.  Health Capital and the Prenatal Environment: The Effect of Ramadan Observance during Pregnancy , 2011 .

[53]  J. Strauss,et al.  Intergenerational Correlations of Health Among Older Adults: Empirical Evidence from Indonesia , 2011 .

[54]  Marianne E. Page,et al.  Can targeted transfers improve birth outcomes?: Evidence from the introduction of the WIC program , 2011 .

[55]  P. Muennig,et al.  The effect of small class sizes on mortality through age 29 years: evidence from a multicenter randomized controlled trial. , 2011, American journal of epidemiology.

[56]  Achyuta R. Adhvaryu,et al.  Endowments and Investments within the Household: Evidence from Iodine Supplementation in Tanzania , 2011 .

[57]  Long-Run Effects of Prenatal Influenza-Exposure: Evidence from Switzerland , 2011 .

[58]  Seonghoon Kim,et al.  Long-Term Effects of Early Childhood Malaria Exposure on Education and Health: Evidence from Colonial Taiwan , 2011, SSRN Electronic Journal.

[59]  Janet Currie,et al.  Inequality at Birth: Some Causes and Consequences , 2011 .

[60]  John N. Friedman,et al.  How Does Your Kindergarten Classroom Affect Your Earnings? Evidence from Project Star , 2010, The quarterly journal of economics.

[61]  A. Deaton,et al.  Adult height and childhood disease , 2009, Demography.

[62]  K. Simon,et al.  Prenatal health investment decisions: Does the child’s sex matter? , 2008, Demography.

[63]  D. Almond,et al.  Inside the War on Poverty: The Impact of Food Stamps on Birth Outcomes , 2008 .

[64]  M. Kilburn,et al.  Endowments and parental investments in infancy and early childhood , 2006, Demography.

[65]  Robert W. Fogel,et al.  A theory of technophysio evolution, with some implications for forecasting population, health care costs, and pension costs , 1997, Demography.

[66]  S. Gahagan,et al.  Overweight and Obesity , 2011 .

[67]  S. Bhalotra,et al.  Intergenerational Persistence in Health in Developing Countries: The Penalty of Gender Inequality? , 2011, SSRN Electronic Journal.

[68]  A. Banerjee,et al.  Long-Run Health Impacts of Income Shocks: Wine and Phylloxera in Nineteenth-Century France , 2010, The Review of Economics and Statistics.

[69]  Alan Barreca The Long-Term Economic Impact of In Utero and Postnatal Exposure to Malaria , 2010, The Journal of Human Resources.

[70]  M. Emran,et al.  General Equilibrium Effects of Land Market Restrictions on Labor Market: Evidence from Wages in Sri Lanka , 2010 .

[71]  R. Nelson Testing the Fetal Origins Hypothesis in a developing country: evidence from the 1918 Influenza Pandemic. , 2010, Health economics.

[72]  L. Schulz The Dutch Hunger Winter and the developmental origins of health and disease , 2010, Proceedings of the National Academy of Sciences.

[73]  D. Ludwig,et al.  The association between pregnancy weight gain and birthweight: a within-family comparison , 2010, The Lancet.

[74]  Christopher A. Neilson,et al.  Do Initial Endowments Matter Only Initially? The Persistent Effect of Birth Weight on School Achievement , 2010 .

[75]  J. Beyene,et al.  Overweight and obesity in mothers and risk of preterm birth and low birth weight infants: systematic review and meta-analyses , 2010, BMJ : British Medical Journal.

[76]  Arturas Petronis,et al.  Epigenetics as a unifying principle in the aetiology of complex traits and diseases , 2010, Nature.

[77]  M. Kremer,et al.  Early-Life Malaria Exposure and Adult Outcomes: Evidence from Malaria Eradication in India , 2010 .

[78]  D. Almond,et al.  Human Capital Development Before Age Five , 2010 .

[79]  Laura Stroud,et al.  Education, Knowledge and the Evolution of Disparities in Health , 2010 .

[80]  J. Currie,et al.  Child Health and Young Adult Outcomes , 2008, The Journal of Human Resources.

[81]  Luojia Hu,et al.  Does sex-selective abortion improve girls' well-being? Evidence from India , 2010 .

[82]  Susanne M. Schennach,et al.  Web Appendix for \Estimating the Technology of Cognitive and Noncognitive Skill Formation" , 2010 .

[83]  Marianne Page,et al.  Is a WIC Start a Better Start? Evaluating Wic&Apos;S Impact on Infant Health Using Program Introduction , 2009 .

[84]  M. Torero,et al.  Iodine Deficiency and Schooling Attainment in Tanzania , 2009 .

[85]  J. Ermisch,et al.  Birth Weight and the Dynamics of Early Cognitive and Behavioural Development , 2009, SSRN Electronic Journal.

[86]  M. Greenstone,et al.  Climate Change and Birth Weight. , 2009, The American economic review.

[87]  A. Case,et al.  Early Life Health and Cognitive Function in Old Age. , 2009, The American economic review.

[88]  Dean Yang,et al.  Under the Weather: Health, Schooling, and Socioeconomic Consequences of Early-Life Rainfall , 2006 .

[89]  Heather Royer Separated at Girth: US Twin Estimates of the Effects of Birth Weight , 2009 .

[90]  James J. Heckman,et al.  Estimating the Technology of Cognitive and Noncognitive Skill Formation , 2010, Econometrica : journal of the Econometric Society.

[91]  D. Almond,et al.  Health Capital and the Prenatal Environment: The Effect of Maternal Fasting During Pregnancy , 2008 .

[92]  Enrico Moretti,et al.  The Demand for Sons , 2008 .

[93]  A. Siow,et al.  Large Shocks and Small Changes in the Marriage Market for Famine Born Cohorts in , 2008 .

[94]  P. Nilsson,et al.  Does a pint a day affect your child's pay? The effect of prenatal alcohol exposure on adult outcomes , 2008 .

[95]  J. Currie Healthy, Wealthy, and Wise: Socioeconomic Status, Poor Health in Childhood, and Human Capital Development , 2008 .

[96]  J. Birchenall Escaping high mortality , 2007 .

[97]  John DiNardo,et al.  Interesting Questions in Freakonomics , 2007 .

[98]  P. Dunn Perinatal lessons from the past: Sir Norman Gregg, ChM, MC, of Sydney (1892–1966) and rubella embryopathy , 2007, Archives of Disease in Childhood Fetal and Neonatal Edition.

[99]  H. Voth Poor, Hungry and Stupid: Numeracy and the Impact of High Food Prices in Industrializing Britain, 1780-1850 , 2007 .

[100]  Lena Edlund,et al.  Long-Term Effects of the 1959-1961 China Famine: Mainland China and Hong Kong , 2007 .

[101]  D. Cutler,et al.  Evidence on early-life income and late-life health from America's Dust Bowl era , 2007, Proceedings of the National Academy of Sciences.

[102]  D. Almond,et al.  Chernobyl's Subclinical Legacy: Prenatal Exposure to Radioactive Fallout and School Outcomes in Sweden. NBER Working Paper No. 13347. , 2007 .

[103]  Yuyu Chen,et al.  The long-term health and economic consequences of the 1959-1961 famine in China. , 2007, Journal of health economics.

[104]  A. Stein,et al.  Anthropometric measures in middle age after exposure to famine during gestation: evidence from the Dutch famine. , 2007, The American journal of clinical nutrition.

[105]  A. Deaton,et al.  Child Mortality, Income and Adult Height , 2007 .

[106]  Hoyt Bleakley,et al.  Disease and Development: Evidence from Hookworm Eradication in the American South. , 2007, The quarterly journal of economics.

[107]  Enrico Moretti,et al.  California Center for Population Research On-Line Working Paper Series NBER WORKING PAPER SERIES BIOLOGY AS DESTINY? SHORT AND LONG-RUN DETERMINANTS OF INTERGENERATIONAL TRANSMISSION OF BIRTH WEIGHT , 2005 .

[108]  J. Currie,et al.  Healthy , Wealthy , and Wise : Is there a Causal Relationship Between Child Health and Human Capital Development ? , 2007 .

[109]  A. Stein,et al.  Exposure to famine during gestation, size at birth, and blood pressure at age 59 y: evidence from the dutch famine , 2006, European Journal of Epidemiology.

[110]  D. Almond,et al.  Is the 1918 Influenza Pandemic Over? Long‐Term Effects of In Utero Influenza Exposure in the Post‐1940 U.S. Population , 2006, Journal of Political Economy.

[111]  R. Walld,et al.  Short, Medium, and Long Term Consequences of Poor Infant Health: An Analysis Using Siblings and Twins , 2006 .

[112]  Gerard J. van den Berg,et al.  Economic Conditions Early in Life and Individual Mortality. , 2006, The American economic review.

[113]  R. Walld,et al.  Short-, Medium-, and Long-Term Consequences of Poor Infant Health: An Analysis Using Siblings and Twins , 2006 .

[114]  C. Finch,et al.  Infection, inflammation, height, and longevity. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[115]  Sandra E. Black,et al.  From the Cradle to the Labor Market? The Effect of Birth Weight on Adult Outcomes , 2005, SSRN Electronic Journal.

[116]  Douglas L. Miller,et al.  Does Head Start Improve Children's Life Chances? Evidence from a Regression Discontinuity Design , 2005, SSRN Electronic Journal.

[117]  P. Sham,et al.  Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961. , 2005, JAMA.

[118]  Dora L. Costa,et al.  PREDICTING OLDER AGE MORTALITY TRENDS , 2005 .

[119]  Peter Gluckman,et al.  The Fetal Matrix: Evolution, Development and Disease , 2004 .

[120]  W. O. Kermack,et al.  Death-rates in Great Britain and Sweden. Some general regularities and their significance , 2001 .

[121]  J. Vaupel,et al.  Lifespan depends on month of birth , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[122]  D. Barker Fetal and infant origins of adult disease , 2001, Monatsschrift Kinderheilkunde.

[123]  W. O. Kermack,et al.  Death-rates in Great Britain and Sweden. Some general regularities and their significance. , 1934, International journal of epidemiology.

[124]  K. Rasmussen,et al.  The "fetal origins" hypothesis: challenges and opportunities for maternal and child nutrition. , 2001, Annual review of nutrition.

[125]  Duncan C. Thomas,et al.  Longer Term Effects of Head Start , 2000 .

[126]  J. Currie,et al.  Is the Impact of Health Shocks Cushioned by Socioeconomic Status? the Case of Low Birthweight , 1999 .

[127]  James P. Smith,et al.  Healthy bodies and thick wallets: the dual relation between health and economic status. , 1999, The journal of economic perspectives : a journal of the American Economic Association.

[128]  John Fox,et al.  A Life Course Approach to Chronic Disease Epidemiology , 1998, BMJ.

[129]  E. Susser,et al.  The Dutch Famine and schizophrenia spectrum disorders , 1998, Social Psychiatry and Psychiatric Epidemiology.

[130]  J S Yudkin,et al.  Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study , 1997, BMJ.

[131]  D J Barker,et al.  Fetal origins of coronary heart disease , 1995, BMJ.

[132]  J. Vaupel,et al.  No increased mortality in later life for cohorts born during famine. , 1997, American journal of epidemiology.

[133]  B. de Visser,et al.  Fetal brain sparing is associated with accelerated shortening of visual evoked potential latencies during early infancy. , 1996, American journal of obstetrics and gynecology.

[134]  Jonathan Gruber,et al.  Health Insurance Eligibility, Utilization of Medical Care, and Child Health , 1995 .

[135]  M. Susser,et al.  Early origin of coronary heart disease (the “Barker hypothesis”) , 1995, BMJ.

[136]  Q. Qazi,et al.  Fetal alcohol syndrome at the turn of the 20th century. An unexpected explanation of the Kallikak family. , 1995, Archives of pediatrics & adolescent medicine.

[137]  Z. Stein,et al.  Timing in prenatal nutrition: a reprise of the Dutch Famine Study. , 2009, Nutrition reviews.

[138]  Paul Taubman,et al.  Endowments and the Allocation of Schooling in the Family and in the Marriage Market: The Twins Experiment , 1994, Journal of Political Economy.

[139]  W. J. Milne The Economic Consequences of Demographic Change , 1991 .

[140]  D. Freedman Statistical models and shoe leather , 1989 .

[141]  M. Gupta Selective Discrimination against Female Children in Rural Punjab, India , 1987 .

[142]  C. Osmond,et al.  INFANT MORTALITY, CHILDHOOD NUTRITION, AND ISCHAEMIC HEART DISEASE IN ENGLAND AND WALES , 1986, The Lancet.

[143]  A. Forsdahl,et al.  Are poor living conditions in childhood and adolescence an important risk factor for arteriosclerotic heart disease? , 1977, International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation.

[144]  A. Forsdahl,et al.  Living conditions in childhood and subsequent development of risk factors for arteriosclerotic heart disease. The cardiovascular survey in Finnmark 1974-75. , 1978, Journal of epidemiology and community health.

[145]  M. Susser,et al.  Obesity in young men after famine exposure in utero and early infancy. , 1976, The New England journal of medicine.

[146]  J. L. Smart Famine and Human Development. The Dutch Hunger Winter of 1944-1945.Zena Stein , Mervyn Susser , Gerhart Saenger , Francis Marolla , 1976 .

[147]  Clement A. Smith Famine and Human Development: The Dutch Hunger Winter 1944-1945 , 1976 .

[148]  A. Streissguth,et al.  Pattern of Malformation in Offspring of Chronic Alcoholic Mothers , 1995, Alcohol health and research world.

[149]  M. Grossman On the Concept of Health Capital and the Demand for Health , 1972, Journal of Political Economy.

[150]  W. Lenz,et al.  Die Thalidomid-Embryopathie* , 1962 .

[151]  M. Joseph THALIDOMIDE AND CONGENITAL ABNORMALITIES , 1962, Developmental medicine and child neurology.