Ovarian Yolk Sac Tumor with Granulomatous Reaction Resembling Tuberculosis: A Unique Presentation

Abstract Yolk sac tumors (endodermal sinus tumors) are an important subgroup of germ cell tumors of the ovary. They are seen in young females and are highly aggressive, but respond well to treatment. Although different morphological patterns can be seen on light microscopy, granulomatous reaction and giant cells are a very rare occurrence. We report the case of a young female with ovarian yolk-sac tumor in which a widespread granulomatous reaction was seen, causing a diagnostic dilemma.

[1]  A. De,et al.  Fine needle aspiration diagnosis of bilateral dysgerminoma with syncytiotrophoblastic giant cells , 2009, Journal of cytology.

[2]  T. K. Dutta,et al.  A ten year clinicopathological study of female genital tuberculosis and impact on fertility. , 2009, JNMA; journal of the Nepal Medical Association.

[3]  A. L. Tohic,et al.  Sarcoïdose péritonéale et ovarienne simulant un cancer de l'ovaire , 2007 .

[4]  P. Panel,et al.  [Ovarian and peritoneal sarcoidosis mimicking an ovarian cancer]. , 2007, Gynecologie, obstetrique & fertilite.

[5]  J. Rabban,et al.  Ovarian Yolk Sac Tumors , 2006 .

[6]  M. Lorentzen.  Giant cell tumor of the ovary , 2004, Virchows Archiv A.

[7]  B. Lim,et al.  The masquerades of female pelvic tuberculosis: Case reports and review of literature on clinical presentations and diagnosis , 2002, The journal of obstetrics and gynaecology research.

[8]  M. Matsuta,et al.  Ovarian serous adenocarcinoma with anaplastic areas containing osteoclast-like multinucleated giant cells , 2000, International Journal of Clinical Oncology.

[9]  D. Allen,et al.  Ovarian granulomas: a report of 32 cases. , 1997, Journal of clinical pathology.

[10]  M. Fukuda,et al.  Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking. , 1991, The Journal of biological chemistry.

[11]  A. Foulis,et al.  Postoperative necrotising granulomas in the ovary. , 1991, Journal of clinical pathology.

[12]  D. Mason,et al.  Distribution of the CD68 macrophage/myeloid associated antigen. , 1990, International immunology.

[13]  T. Parmley,et al.  Foreign body granulomas in normal ovaries , 1985, Obstetrics and gynecology.

[14]  M. Morimatsu,et al.  Anaplastic Giant Cell Tumor With Mucinous Cystadenocarcinoma of The Ovary Origin of the Giant Cells , 1984, Acta pathologica japonica.

[15]  Pace Eh,et al.  Xanthogranulomatous oophoritis: an inflammatory pseudotumor of the ovary. , 1984 .

[16]  R. Scully,et al.  Ovarian sex cord-stromal tumors with bizarre nuclei: a clinicopathologic analysis of 17 cases. , 1983, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[17]  C. Zaloudek,et al.  Dysgerminoma with syncytiotrophoblastic giant cells: A histologically and clinically distinctive subtype of dysgerminoma , 1981, The American journal of surgical pathology.