The inhibitory properties of the bovine plasuma amine oxidase activity by procaine and procainamide

The interaction of bovine plasma amine oxidase with local anesthetics, procaine and procainamide has been described. The amine oxidase activity was inhibited by both prc caine and procainamide in a mode noncompetitive inhibition when benzylamine and kynuramine were used as substrates. The components of the inhibitors, p-aminobenzoic acid, N, N-diethylaminoethanol and N, N-diethylaminoethylamine which could be produced by the enzymecatalyzed hydrolysis of the inhibitors in serum failed to exert any effects on the amine oxidase reaction.

[1]  L. Avigliano,et al.  Determination of amine oxidases in tissues by peroxidation-induced chemiluminescence of phthalazines. , 1986, Analytical biochemistry.

[2]  U. Bachrach,et al.  A sensitive, rapid, chemiluminescence-based method for the determination of diamines and polyamines. , 1986, Analytical biochemistry.

[3]  K. Tipton,et al.  The effect of lipophilic compounds upon the activity of rat liver mitochondrial monoamine oxidase-A and -B. , 1980, Biochemical pharmacology.

[4]  E. Neufeld,et al.  An evaluation of three methods for the measurement of diamine oxidase (DAO) activity in amniotic fluid. , 1979, Analytical biochemistry.

[5]  R. Laverty,et al.  Studies on the nature of the increased monoamine oxidase activity in the rat heart after adrenalectomy , 1973, The Journal of pharmacy and pharmacology.

[6]  S. Snyder,et al.  A simple and sensitive fluorescence assay for monoamine oxidase and diamine oxidase. , 1968, The Journal of pharmacology and experimental therapeutics.

[7]  R. Mccaman,et al.  MICRODETERMINATION OF MONOAMINE OXIDASE AND 5‐HYDROXYTRYPTOPHAN DECARBOXYLASE ACTIVITIES IN NERVOUS TISSUES , 1965, Journal of neurochemistry.

[8]  H. Yamada,et al.  MONOAMINE OXIDASE. IV. NATURE OF THE SECOND PROSTHETIC GROUP OF PLASMA MONOAMINE OXIDASE. , 1963, The Journal of biological chemistry.

[9]  H. Yamada,et al.  Monoamine oxidase. I. Purification, crystallization, and properties of plasma monoamine oxidase. , 1962, The Journal of biological chemistry.

[10]  Y. Kobayashi,et al.  Determination of diamine oxidase activity by liquid scintillation counting. , 1961, Archives of biochemistry and biophysics.

[11]  H. Weissbach,et al.  A rapid spectrophotometric assay of mono-amine oxidase based on the rate of disappearance of kynuramine. , 1960, The Journal of biological chemistry.

[12]  C. W. Tabor,et al.  Purification of amine oxidase from beef plasma. , 1954, The Journal of biological chemistry.

[13]  W. Kalow.  Hydrolysis of local anesthetics by human serum cholinesterase. , 1952, The Journal of pharmacology and experimental therapeutics.

[14]  E. Radha,et al.  Murine regional brain monoamine oxidase activity: time- and age-dependent response to inhibitors. , 1984, Gerontology.

[15]  G. Guilbault,et al.  New substrates for the fluorometric determination of oxidative enzymes. , 1968, Analytical chemistry.

[16]  D. N. Kramer,et al.  A new substrate for fluorometric determination of oxidative enzymes. , 1967, Analytical chemistry.