Human Monkeypox Virus Severity

Monkeypox is a sylvatic zoonotic sickness that initially affected tropical rainforest areas in the west and vital Africa earlier than spreading to other places. Its miles carried with the aid of the Monkeypox virus member of orthopoxvirus circle of relatives. The clinical features of the infection resembles to smallpox. The primary animal to human transmission is the cause of most people of human Monkeypox ailments. Severe rodent species and non-human primates function hosts for the virus. Transmission can manifest with infected people, animals or objects into contact with bodily fluids, sores on the skin or inner mucosal surfaces just like the mouth or throat, or breathing droplets. The incubation length for Monkeypox usually lasts 6 to 13 days, even though it could last as long as 21 days. The ailment is often self-proscribing, with signs and symptoms generally clearing up on their own inside 14 to 21 days. Signs can range from moderate to extreme, and lesions may be itchy or painful. Due to the discontinuation of recurring smallpox vaccination which supplied some pass- safety in past, populations have become more liable to Monkey pox. The outbreak of Monkeypox virus due to the fact that may additionally, 2022 has created a worldwide risk of the virus. In the present review, Monkeypox epidemiology, severity, therapeutics, vaccination and its transmission to non-endemic countries has been considered. Special care and guidelines may help in the containing in the spread of the infections to the non endemic countries.

[1]  Md. Jamal Hossain,et al.  Repositioning potentials of smallpox vaccines and antiviral agents in monkeypox outbreak: A rapid review on comparative benefits and risks , 2022, Health science reports.

[2]  S. Riley,et al.  Community transmission of monkeypox in the United Kingdom, April to May 2022 , 2022, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[3]  E. Nicastri,et al.  Epidemiological, clinical and virological characteristics of four cases of monkeypox support transmission through sexual contact, Italy, May 2022 , 2022, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[4]  J. Wallinga,et al.  Estimated incubation period for monkeypox cases confirmed in the Netherlands, May 2022 , 2022, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[5]  Elisabeth Mahase Monkeypox: What do we know about the outbreaks in Europe and North America? , 2022, BMJ.

[6]  Jennifer L. Small,et al.  Clinical features and management of human monkeypox: a retrospective observational study in the UK , 2022, The Lancet. Infectious diseases.

[7]  M. Pal,et al.  Human Monkeypox: An Emerging and Re-emerging Infectious Viral Disease , 2022, Acta Scientific Microbiology.

[8]  G. Wortmann,et al.  Imported Monkeypox from International Traveler, Maryland, USA, 2021 , 2022, Emerging infectious diseases.

[9]  Anna M. Mandra,et al.  Exportation of Monkeypox Virus From the African Continent , 2020, The Journal of infectious diseases.

[10]  Florian Thiery,et al.  Linked COVID-19 Data: Johns Hopkins University (JHU) and European Centre for Disease Prevention and Control (ECDC) , 2020 .

[11]  J. Dunning,et al.  Human-to-Human Transmission of Monkeypox Virus, United Kingdom, October 2018 , 2020, Emerging infectious diseases.

[12]  B. Monroe,et al.  Asymptomatic Orthopoxvirus Circulation in Humans in the Wake of a Monkeypox Outbreak among Chimpanzees in Cameroon , 2019, The American journal of tropical medicine and hygiene.

[13]  V. B. Rao,et al.  A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy , 2019, PLoS neglected tropical diseases.

[14]  H. Achdout,et al.  Diagnosis of Imported Monkeypox, Israel, 2018 , 2019, Emerging infectious diseases.

[15]  Sheridan M. Hoy Tecovirimat: First Global Approval , 2018, Drugs.

[16]  Andrew T. Russo,et al.  Effects of Treatment Delay on Efficacy of Tecovirimat Following Lethal Aerosol Monkeypox Virus Challenge in Cynomolgus Macaques , 2018, The Journal of infectious diseases.

[17]  M. Reynolds,et al.  Improving the Care and Treatment of Monkeypox Patients in Low-Resource Settings: Applying Evidence from Contemporary Biomedical and Smallpox Biodefense Research , 2017, Viruses.

[18]  J. Muyembe,et al.  Maternal and Fetal Outcomes Among Pregnant Women With Human Monkeypox Infection in the Democratic Republic of Congo , 2017, The Journal of infectious diseases.

[19]  J. Mokili,et al.  Toward Understanding the Outcomes of Monkeypox Infection in Human Pregnancy , 2017, The Journal of infectious diseases.

[20]  A. Peterson,et al.  Assessing Monkeypox Virus Prevalence in Small Mammals at the Human–Animal Interface in the Democratic Republic of the Congo , 2017, Viruses.

[21]  Nicole A. Hoff,et al.  Varicella Coinfection in Patients with Active Monkeypox in the Democratic Republic of the Congo , 2017, EcoHealth.

[22]  I. Damon Status of human monkeypox: clinical disease, epidemiology and research. , 2011, Vaccine.

[23]  J. Montgomery,et al.  A Silent Enzootic of an Orthopoxvirus in Ghana, West Africa: Evidence for Multi-Species Involvement in the Absence of Widespread Human Disease , 2010, The American journal of tropical medicine and hygiene.

[24]  K. B. Petersen,et al.  A POX‐LIKE DISEASE IN CYNOMOLGUS MONKEYS , 2009 .

[25]  A. MacNeil,et al.  Monkeypox or varicella? Lessons from a rash outbreak investigation in the Republic of the Congo. , 2009, The American journal of tropical medicine and hygiene.

[26]  R. Buller,et al.  Human monkeypox: an emerging zoonotic disease. , 2007, Future microbiology.

[27]  R. Holman,et al.  Clinical manifestations of human monkeypox influenced by route of infection. , 2006, The Journal of infectious diseases.

[28]  I. Damon,et al.  Detection of monkeypox virus with real-time PCR assays , 2006, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[29]  S. Bavari,et al.  Reemergence of monkeypox: prevalence, diagnostics, and countermeasures. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[30]  J. Sejvar,et al.  Clinical characteristics of human monkeypox, and risk factors for severe disease. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[31]  P. Formenty,et al.  A tale of two clades: monkeypox viruses. , 2005, The Journal of general virology.

[32]  C. Drosten,et al.  Rapid detection and differentiation of human pathogenic orthopox viruses by a fluorescence resonance energy transfer real-time PCR assay. , 2004, Clinical chemistry.

[33]  J. P. Davis,et al.  The detection of monkeypox in humans in the Western Hemisphere. , 2004, The New England journal of medicine.

[34]  P. Formenty,et al.  Outbreaks of Disease Suspected of Being Due to Human Monkeypox Virus Infection in the Democratic Republic of Congo in 2001 , 2002, Journal of Clinical Microbiology.

[35]  Grab,et al.  Human monkeypox: confusion with chickenpox. , 1988, Acta tropica.

[36]  P E Fine,et al.  The transmission potential of monkeypox virus in human populations. , 1988, International journal of epidemiology.

[37]  B. Grab,et al.  Human monkeypox: disease pattern, incidence and attack rates in a rural area of northern Zaire. , 1988, Tropical and geographical medicine.

[38]  Z. Ježek,et al.  Human monkeypox: clinical features of 282 patients. , 1987, The Journal of infectious diseases.

[39]  I. Arita,et al.  HUMAN MONKEYPOX TRANSMITTED BY A CHIMPANZEE IN A TROPICAL RAIN-FOREST AREA OF ZAIRE , 1983, The Lancet.

[40]  R. Pebody,et al.  Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997. , 2001, Emerging infectious diseases.

[41]  D. Heymann,et al.  Re-emergence of monkeypox in Africa: a review of the past six years. , 1998, British medical bulletin.

[42]  L. Khodakevich,et al.  Monkeypox virus: ecology and public health significance. , 1988, Bulletin of the World Health Organization.

[43]  B. Grab,et al.  Clinico-epidemiological features of monkeypox patients with an animal or human source of infection. , 1988, Bulletin of the World Health Organization.

[44]  S. Marennikova,et al.  Poxviruses isolated from clinically ill and asymptomatically infected monkeys and a chimpanzee. , 1972, Bulletin of the World Health Organization.