Laquinimod ameliorates excitotoxic damage by regulating glutamate re-uptake
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D. Centonze | G. Mandolesi | A. Musella | A. Gentile | D. Fresegna | S. Bullitta | F. De Vito | F. Rizzo
[1] Francesco Mori,et al. miR-142-3p is a key regulator of IL-1β-dependent synaptopathy in neuroinflammation. , 2017, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[2] Ignacio S. Caballero,et al. Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor , 2016, Proceedings of the National Academy of Sciences.
[3] P. Rosenberg,et al. GLT-1: The elusive presynaptic glutamate transporter , 2016, Neurochemistry International.
[4] D. Centonze,et al. Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis , 2016, Journal of Neuroinflammation.
[5] R. Ransohoff. A polarizing question: do M1 and M2 microglia exist? , 2016, Nature Neuroscience.
[6] D. Centonze,et al. Synaptopathy connects inflammation and neurodegeneration in multiple sclerosis , 2015, Nature Reviews Neurology.
[7] A. C. Fontana. Current approaches to enhance glutamate transporter function and expression , 2015, Journal of neurochemistry.
[8] M. Aschner,et al. Transcriptional Regulation of the Astrocytic Excitatory Amino Acid Transporter 1 (EAAT1) via NF-κB and Yin Yang 1 (YY1)* , 2015, The Journal of Biological Chemistry.
[9] Kou Takahashi,et al. Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease , 2015, Cellular and Molecular Life Sciences.
[10] R. Gold,et al. Laquinimod exerts strong clinical and immunomodulatory effects in Lewis rat experimental autoimmune neuritis , 2014, Journal of Neuroimmunology.
[11] S. Nelson,et al. In vivo evidence of glutamate toxicity in multiple sclerosis , 2014, Annals of neurology.
[12] M. O’Banion,et al. Neuroinflammation and M2 microglia: the good, the bad, and the inflamed , 2014, Journal of Neuroinflammation.
[13] W. Brück,et al. Laquinimod reduces neuroaxonal injury through inhibiting microglial activation , 2014, Annals of clinical and translational neurology.
[14] Milos Kostic,et al. The role of glutamate and its receptors in multiple sclerosis , 2014, Journal of Neural Transmission.
[15] D. Arnold,et al. A randomized placebo-controlled phase III trial of oral laquinimod for multiple sclerosis , 2014, Journal of Neurology.
[16] Q. Kan,et al. Matrine regulates glutamate-related excitotoxic factors in experimental autoimmune encephalomyelitis , 2014, Neuroscience Letters.
[17] Kyuwon Lee,et al. Yin Yang 1 Is a Repressor of Glutamate Transporter EAAT2, and It Mediates Manganese-Induced Decrease of EAAT2 Expression in Astrocytes , 2014, Molecular and Cellular Biology.
[18] N. Rothwell,et al. The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial , 2014, Journal of Neuroinflammation.
[19] Rhusheet P Patel,et al. Therapeutic laquinimod treatment decreases inflammation, initiates axon remyelination, and improves motor deficit in a mouse model of multiple sclerosis , 2013, Brain and behavior.
[20] M. Filippi,et al. Placebo-controlled trial of oral laquinimod in multiple sclerosis: MRI evidence of an effect on brain tissue damage , 2013, Journal of Neurology, Neurosurgery & Psychiatry.
[21] S. Hauser,et al. Multiple sclerosis: Prospects and promise , 2013, Annals of neurology.
[22] Kyuwon Lee,et al. cAMP Response Element-binding Protein (CREB) and Nuclear Factor κB Mediate the Tamoxifen-induced Up-regulation of Glutamate Transporter 1 (GLT-1) in Rat Astrocytes* , 2013, The Journal of Biological Chemistry.
[23] D. Centonze,et al. Interleukin-1β Alters Glutamate Transmission at Purkinje Cell Synapses in a Mouse Model of Multiple Sclerosis , 2013, The Journal of Neuroscience.
[24] D. Centonze,et al. Laquinimod prevents inflammation-induced synaptic alterations occurring in experimental autoimmune encephalomyelitis , 2013, Multiple sclerosis.
[25] F. Zipp,et al. Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis. , 2013, Brain : a journal of neurology.
[26] Puneet Kumar,et al. Excitotoxicity: bridge to various triggers in neurodegenerative disorders. , 2013, European journal of pharmacology.
[27] R. Saada,et al. Oral treatment with laquinimod augments regulatory T-cells and brain-derived neurotrophic factor expression and reduces injury in the CNS of mice with experimental autoimmune encephalomyelitis , 2012, Journal of Neuroimmunology.
[28] M. Aschner,et al. Estrogen Attenuates Manganese-Induced Glutamate Transporter Impairment in Rat Primary Astrocytes , 2012, Neurotoxicity Research.
[29] C. Wegner,et al. Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination , 2012, Acta Neuropathologica.
[30] D. Centonze,et al. GABAergic signaling and connectivity on Purkinje cells are impaired in experimental autoimmune encephalomyelitis , 2012, Neurobiology of Disease.
[31] M. Filippi,et al. Placebo-controlled trial of oral laquinimod for multiple sclerosis. , 2012, The New England journal of medicine.
[32] M. Rattray,et al. Riluzole elevates GLT-1 activity and levels in striatal astrocytes , 2012, Neurochemistry International.
[33] P. Fisher,et al. Role of Excitatory Amino Acid Transporter‐2 (EAAT2) and glutamate in neurodegeneration: Opportunities for developing novel therapeutics , 2011, Journal of cellular physiology.
[34] C. Wegner,et al. Insight into the mechanism of laquinimod action , 2011, Journal of the Neurological Sciences.
[35] D. Centonze,et al. The link between inflammation, synaptic transmission and neurodegeneration in multiple sclerosis , 2010, Cell Death and Differentiation.
[36] Camille J. Olechowski,et al. A diminished response to formalin stimulation reveals a role for the glutamate transporters in the altered pain sensitivity of mice with experimental autoimmune encephalomyelitis (EAE) , 2010, PAIN.
[37] J. G. Bjaalie,et al. The concentrations and distributions of three C-terminal variants of the GLT1 (EAAT2; slc1a2) glutamate transporter protein in rat brain tissue suggest differential regulation , 2009, Neuroscience.
[38] S. Ozawa,et al. Functions of glutamate transporters in cerebellar Purkinje cell synapses , 2009, Acta physiologica.
[39] L. Strużyńska,et al. Expression of glutamate transporters GLT-1 and GLAST in different regions of rat brain during the course of experimental autoimmune encephalomyelitis , 2008, Neuroscience.
[40] G. Comi,et al. Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study , 2008, The Lancet.
[41] P. Fisher,et al. Mechanism of Ceftriaxone Induction of Excitatory Amino Acid Transporter-2 Expression and Glutamate Uptake in Primary Human Astrocytes* , 2008, Journal of Biological Chemistry.
[42] J. Sepulcre,et al. Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis , 2008, Journal of Neuroimmunology.
[43] M. Robinson,et al. The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention , 2007, Neurochemistry International.
[44] R. Mutani,et al. Altered Glutamate Reuptake in Relapsing-Remitting and Secondary Progressive Multiple Sclerosis Cortex: Correlation With Microglia Infiltration, Demyelination, and Neuronal and Synaptic Damage , 2007, Journal of neuropathology and experimental neurology.
[45] E. López-Bayghen,et al. Glutamate‐dependent transcriptional regulation of GLAST/EAAT1: a role for YY1 , 2007, Journal of neurochemistry.
[46] W. L. Benedict,et al. Multiple Sclerosis , 2007, Journal - Michigan State Medical Society.
[47] Yuan-Fong Lin,et al. Translational Control of Glial Glutamate Transporter EAAT2 Expression* , 2007, Journal of Biological Chemistry.
[48] A. Hazell,et al. Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury , 2006, Neurochemistry International.
[49] O. Hurtado,et al. A polymorphism in the EAAT2 promoter is associated with higher glutamate concentrations and higher frequency of progressing stroke , 2006, The Journal of experimental medicine.
[50] J. Dunlop. Glutamate-based therapeutic approaches: targeting the glutamate transport system. , 2006, Current opinion in pharmacology.
[51] F. Barkhof,et al. Treatment with laquinimod reduces development of active MRI lesions in relapsing MS , 2005, Neurology.
[52] P. Fisher,et al. β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression , 2005, Nature.
[53] E. López-Bayghen,et al. Glutamate down-regulates GLAST expression through AMPA receptors in Bergmann glial cells. , 2003, Brain research. Molecular brain research.
[54] Masahiko Watanabe,et al. Altered expression of glutamate transporters in experimental autoimmune encephalomyelitis , 2002, Journal of Neuroimmunology.
[55] D. Pitt,et al. Multiple sclerosis: Altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage , 2001, Annals of neurology.
[56] A. Ludolph,et al. The EAAT2 (GLT-1) gene in motor neuron disease: absence of mutations in amyotrophic lateral sclerosis and a point mutation in patients with hereditary spastic paraplegia , 1998, Journal of neurology, neurosurgery, and psychiatry.
[57] P. Rosenberg,et al. Dihydrokainate‐sensitive neuronal glutamate transport is required for protection of rat cortical neurons in culture against synaptically released glutamate , 1998, The European journal of neuroscience.
[58] J. Storm-Mathisen,et al. Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[59] M. Robinson,et al. Transcriptional Regulation of Glutamate Transporters: From Extracellular Signals to Transcription Factors. , 2016, Advances in pharmacology.
[60] G. Comi,et al. Modulation of autoimmune demyelination by laquinimod via induction of brain-derived neurotrophic factor. , 2012, The American journal of pathology.
[61] D. Pitt,et al. Glutamate excitotoxicity in a model of multiple sclerosis , 2000, Nature Medicine.