Accidents with hazardous materials may threaten the lives of people living in the direct environment of the transportation infrastructure. In many countries, fire brigades play a major role in advising the authorities when they are dealing with issues where hazardous materials are involved. Since emergency responders have to deal with injured persons, information concerning the number of injured people and the types of injuries is relevant to them. In response to this need, we developed a method for calculating the number of injured people. This method was applied to the (re)development plans for the largest railway station in the Netherlands, Utrecht Central station. Through this intermodal transfer terminal, both passengers and substantial amounts of hazardous materials are transported. The fire brigades used the injury information to assess the spatial development plans and transportation plans for hazardous materials. Furthermore, the fire brigades used the injury information to determine their suppression tactics and equipment requirements.