Epigenetic regulation of ageing: linking environmental inputs to genomic stability

[1]  Aaron C. Daugherty,et al.  H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency , 2014, Cell.

[2]  B. Kennedy,et al.  H3K36 methylation promotes longevity by enhancing transcriptional fidelity , 2015, Genes & development.

[3]  Howard Y. Chang,et al.  Single-cell chromatin accessibility reveals principles of regulatory variation , 2015, Nature.

[4]  F. Tang,et al.  A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging , 2015, Science.

[5]  Andrew C. Adey,et al.  Multiplex single-cell profiling of chromatin accessibility by combinatorial cellular indexing , 2015, Science.

[6]  Shunmin He,et al.  N6-Methyladenine DNA Modification in Drosophila , 2015, Cell.

[7]  L. Doré,et al.  N 6-Methyldeoxyadenosine Marks Active Transcription Start Sites in Chlamydomonas , 2015, Cell.

[8]  L. Aravind,et al.  DNA Methylation on N6-Adenine in C. elegans , 2015, Cell.

[9]  D. Moazed,et al.  Epigenetic inheritance uncoupled from sequence-specific recruitment , 2015, Science.

[10]  Haiyuan Yu,et al.  Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span , 2015, Genes & development.

[11]  Liuping Zhang,et al.  Aging alters histone H3 lysine 4 methylation in mouse germinal vesicle stage oocytes. , 2015, Reproduction, fertility, and development.

[12]  Steve Horvath,et al.  Accelerated epigenetic aging in Down syndrome , 2015, Aging cell.

[13]  S. Horvath,et al.  DNA methylation age of blood predicts all-cause mortality in later life , 2015, Genome Biology.

[14]  D. Schübeler Function and information content of DNA methylation , 2015, Nature.

[15]  V. Robert,et al.  The SET-2/SET1 histone H3K4 methyltransferase maintains pluripotency in the Caenorhabditis elegans germline. , 2014, Cell reports.

[16]  Steve Horvath,et al.  Obesity accelerates epigenetic aging of human liver , 2014, Proceedings of the National Academy of Sciences.

[17]  J. Goodrich Faculty Opinions recommendation of Gene repression. H3K27me and PRC2 transmit a memory of repression across generations and during development. , 2014 .

[18]  S. Strome,et al.  H3K27me and PRC2 transmit a memory of repression across generations and during development , 2014, Science.

[19]  Anthony J. Geneva,et al.  SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age , 2014, Nature Communications.

[20]  R. Johnstone,et al.  Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders , 2014, Nature Reviews Drug Discovery.

[21]  Antoine H. F. M. Peters,et al.  In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism , 2014, Science.

[22]  Aaron C. Daugherty,et al.  H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency , 2014, Cell.

[23]  M. Platzer,et al.  RNA-seq of the aging brain in the short-lived fish N. furzeri – conserved pathways and novel genes associated with neurogenesis , 2014, Aging cell.

[24]  O. Hobert,et al.  Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans , 2014, Cell.

[25]  A. Salminen,et al.  Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process , 2014, Ageing Research Reviews.

[26]  B. Cairns,et al.  Age-Associated Sperm DNA Methylation Alterations: Possible Implications in Offspring Disease Susceptibility , 2014, PLoS genetics.

[27]  Joshua W. Francis,et al.  SPR-5 and MET-2 function cooperatively to reestablish an epigenetic ground state during passage through the germ line , 2014, Proceedings of the National Academy of Sciences.

[28]  Gao-Xia Wei,et al.  Acute Aerobic Exercise Increases Cortical Activity during Working Memory: A Functional MRI Study in Female College Students , 2014, PloS one.

[29]  B. Bartholomew,et al.  Regulating the chromatin landscape: structural and mechanistic perspectives. , 2014, Annual review of biochemistry.

[30]  Christopher J. Murakami,et al.  Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. , 2014, Cell metabolism.

[31]  P. Sassone-Corsi,et al.  Circadian clock: linking epigenetics to aging. , 2014, Current opinion in genetics & development.

[32]  Pengda Liu,et al.  SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation. , 2014, American journal of cancer research.

[33]  Hilary A. Godwin,et al.  The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR , 2014, Nature.

[34]  Leonard D. Goldstein,et al.  Reduced insulin/IGF-1 signaling restores germ cell immortality to Caenorhabditis elegans Piwi mutants. , 2014, Cell reports.

[35]  J. A. Parker,et al.  Heritable Transmission of Stress Resistance by High Dietary Glucose in Caenorhabditis elegans , 2014, PLoS genetics.

[36]  B. Göttgens,et al.  Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. , 2014, Cell stem cell.

[37]  Wei Wang,et al.  A histone methylation network regulates transgenerational epigenetic memory in C. elegans. , 2014, Cell reports.

[38]  Liewei Wang,et al.  AMPK regulates histone H2B O-GlcNAcylation , 2014, Nucleic acids research.

[39]  W. G. Kelly Transgenerational epigenetics in the germline cycle of Caenorhabditis elegans , 2014, Epigenetics & Chromatin.

[40]  H. Blom,et al.  Cytosine DNA Methylation Is Found in Drosophila melanogaster but Absent in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Other Yeast Species , 2014, Analytical chemistry.

[41]  C. Allis,et al.  Every amino acid matters: essential contributions of histone variants to mammalian development and disease , 2014, Nature Reviews Genetics.

[42]  Wei Li,et al.  Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging , 2014, Genes & development.

[43]  Thomas W. Mühleisen,et al.  Aging of blood can be tracked by DNA methylation changes at just three CpG sites , 2014, Genome Biology.

[44]  R. Mostoslavsky,et al.  Chromatin and beyond: the multitasking roles for SIRT6. , 2014, Trends in biochemical sciences.

[45]  Cheng Shi,et al.  Mating Induces Shrinking and Death in Caenorhabditis Mothers , 2014, Science.

[46]  A. Brunet,et al.  Males Shorten the Life Span of C. elegans Hermaphrodites via Secreted Compounds , 2014, Science.

[47]  J. Yew,et al.  Drosophila Life Span and Physiology Are Modulated by Sexual Perception and Reward , 2014, Science.

[48]  Martin J. Aryee,et al.  Epigenome-wide association studies without the need for cell-type composition , 2014, Nature Methods.

[49]  Haifan Lin,et al.  PIWI proteins and PIWI-interacting RNAs in the soma , 2014, Nature.

[50]  S. Helfand,et al.  Chromatin structure and transposable elements in organismal aging , 2013, Front. Genet..

[51]  N. Neretti,et al.  Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues , 2013, Aging.

[52]  Peter D. Adams,et al.  Senescent cells harbour features of the cancer epigenome , 2013, Nature Cell Biology.

[53]  Stacy M Alvares,et al.  H3K4 demethylase activities repress proliferative and postmitotic aging , 2013, Aging cell.

[54]  Kristian Helin,et al.  Histone lysine demethylases as targets for anticancer therapy , 2013, Nature Reviews Drug Discovery.

[55]  F. Gage,et al.  The Role of Transposable Elements in Health and Diseases of the Central Nervous System , 2013, The Journal of Neuroscience.

[56]  S. Helfand,et al.  Dietary and genetic effects on age-related loss of gene silencing reveal epigenetic plasticity of chromatin repression during aging , 2013, Aging.

[57]  Eric Verdin,et al.  The nexus of chromatin regulation and intermediary metabolism , 2013, Nature.

[58]  K. Rakshit,et al.  Cryptochrome restores dampened circadian rhythms and promotes healthspan in aging Drosophila , 2013, Aging cell.

[59]  S. Horvath DNA methylation age of human tissues and cell types , 2013, Genome Biology.

[60]  Philipp Oberdoerffer,et al.  Metabolic modulation of chromatin: implications for DNA repair and genomic integrity , 2013, Front. Genet..

[61]  D. Absher,et al.  Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape , 2013, Genome Biology.

[62]  Erik D Herzog,et al.  Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. , 2013, Cell metabolism.

[63]  Lei Zhong,et al.  SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling. , 2013, Molecular cell.

[64]  Kajia Cao,et al.  Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape , 2013, Genes & development.

[65]  Matthew D. Schultz,et al.  Global Epigenomic Reconfiguration During Mammalian Brain Development , 2013, Science.

[66]  E. Mercken,et al.  Metformin improves healthspan and lifespan in mice , 2013, Nature Communications.

[67]  Kevin N. Lu,et al.  Estrogen represses gene expression through reconfiguring chromatin structures , 2013, Nucleic acids research.

[68]  Tom H. Cheung,et al.  Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging , 2013, Cell reports.

[69]  M. Sigvardsson,et al.  An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state. , 2013, Blood.

[70]  G. Ruvkun,et al.  DAF-16/FOXO employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity , 2013, Nature Cell Biology.

[71]  J. Dubnau,et al.  Activation of transposable elements during aging and neuronal decline in Drosophila , 2013, Nature Neuroscience.

[72]  Zachary D. Smith,et al.  Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging. , 2013, Cell stem cell.

[73]  P. Sassone-Corsi,et al.  The circadian epigenome: how metabolism talks to chromatin remodeling. , 2013, Current opinion in cell biology.

[74]  Sara Hillenmeyer,et al.  Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements , 2013, Aging cell.

[75]  Donald L Riddle,et al.  Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1 , 2013, Proceedings of the National Academy of Sciences.

[76]  John Canfield,et al.  Malate and Fumarate Extend Lifespan in Caenorhabditis elegans , 2013, PloS one.

[77]  A. Brunet,et al.  Bridging the transgenerational gap with epigenetic memory. , 2013, Trends in genetics : TIG.

[78]  Tom Misteli,et al.  Functional implications of genome topology , 2013, Nature Structural &Molecular Biology.

[79]  J. Vijg,et al.  Genome instability and aging. , 2013, Annual review of physiology.

[80]  T. Ideker,et al.  Genome-wide methylation profiles reveal quantitative views of human aging rates. , 2013, Molecular cell.

[81]  Paolo Sassone-Corsi,et al.  Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1 , 2013, Proceedings of the National Academy of Sciences.

[82]  H. Masumoto,et al.  A Reduction in Age-Enhanced Gluconeogenesis Extends Lifespan , 2013, PloS one.

[83]  J. Graff,et al.  Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. , 2013, Cell metabolism.

[84]  A. Brunet,et al.  Aging and reprogramming: a two-way street. , 2012, Current opinion in cell biology.

[85]  Vincent Gremeaux,et al.  Exercise and longevity. , 2012, Maturitas.

[86]  T. Misteli,et al.  DNA damage, chromatin, and transcription: the trinity of aging. , 2012, Current opinion in cell biology.

[87]  Naama Barkai,et al.  Expression noise and acetylation profiles distinguish HDAC functions. , 2012, Molecular cell.

[88]  Scott Kennedy,et al.  A nuclear Argonaute promotes multi-generational epigenetic inheritance and germline immortality , 2012, Nature.

[89]  Raymond K. Auerbach,et al.  An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.

[90]  Chuan He,et al.  5-Formyl- and 5-carboxyl-cytosine reduce the rate and substrate specificity of RNA polymerase II transcription , 2012, Nature Structural &Molecular Biology.

[91]  L. Guarente,et al.  Deviation of innate circadian period from 24 h reduces longevity in mice , 2012, Aging cell.

[92]  Amy Tsurumi,et al.  Global heterochromatin loss , 2012, Epigenetics.

[93]  A. Shilatifard The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. , 2012, Annual review of biochemistry.

[94]  Yoav Soen,et al.  Epigenetically heritable alteration of fly development in response to toxic challenge. , 2012, Cell reports.

[95]  E. Young,et al.  Snf1/AMPK regulates Gcn5 occupancy, H3 acetylation and chromatin remodelling at S. cerevisiae ADY2 promoter. , 2012, Biochimica et biophysica acta.

[96]  E. Greer,et al.  Histone methylation: a dynamic mark in health, disease and inheritance , 2012, Nature Reviews Genetics.

[97]  Siu Sylvia Lee,et al.  Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans , 2012, Aging cell.

[98]  J. Tyler,et al.  Histone exchange and histone modifications during transcription and aging. , 2012, Biochimica et biophysica acta.

[99]  J. Priess,et al.  C. elegans Germ Cells Show Temperature and Age-Dependent Expression of Cer1, a Gypsy/Ty3-Related Retrotransposon , 2012, PLoS pathogens.

[100]  Ziv Bar-Joseph,et al.  The sirtuin SIRT6 regulates lifespan in male mice , 2012, Nature.

[101]  S. Haggarty,et al.  An epigenetic blockade of cognitive functions in the neurodegenerating brain , 2012, Nature.

[102]  Waddington Ch,et al.  The epigenotype. 1942. , 2012 .

[103]  E. Greer,et al.  The H3K27 demethylase UTX‐1 regulates C. elegans lifespan in a germline‐independent, insulin‐dependent manner , 2011, Aging cell.

[104]  W. Burhans,et al.  Retrotransposition is associated with genome instability during chronological aging , 2011, Proceedings of the National Academy of Sciences.

[105]  E. Greer,et al.  Transgenerational Epigenetic Inheritance of Longevity in C. elegans , 2011, Nature.

[106]  Jianhua Huang,et al.  The Spatial Association of Gene Expression Evolves from Synchrony to Asynchrony and Stochasticity with Age , 2011, PloS one.

[107]  Zheng Yan,et al.  Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. , 2011, Cell metabolism.

[108]  Oren Froy,et al.  Circadian rhythms, aging, and life span in mammals. , 2011, Physiology.

[109]  Matt Kaeberlein,et al.  Absence of effects of Sir2 over-expression on lifespan in C. elegans and Drosophila , 2011, Nature.

[110]  Zhongjun Zhou,et al.  Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice , 2011, Proceedings of the National Academy of Sciences.

[111]  Jason Feser,et al.  Chromatin structure as a mediator of aging , 2011, FEBS letters.

[112]  G. Hager,et al.  Control of nuclear receptor function by local chromatin structure , 2011, The FEBS journal.

[113]  Ryoichi Nakamura,et al.  Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change , 2011, Cell.

[114]  Steve Horvath,et al.  Epigenetic Predictor of Age , 2011, PloS one.

[115]  R. Evans,et al.  Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis , 2011, Cell.

[116]  H. Korswagen,et al.  Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells , 2011, Proceedings of the National Academy of Sciences.

[117]  Zhiping Weng,et al.  Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals , 2010, Cell.

[118]  I. Manosalva,et al.  Aging changes the chromatin configuration and histone methylation of mouse oocytes at germinal vesicle stage. , 2010, Theriogenology.

[119]  R. Eisenman,et al.  Essential Functions of the Histone Demethylase Lid , 2010, PLoS genetics.

[120]  M. Schaefer,et al.  Lack of evidence for DNA methylation of Invader4 retroelements in Drosophila and implications for Dnmt2-mediated epigenetic regulation , 2010, Nature Genetics.

[121]  L. Wells,et al.  Intracellular protein glycosylation modulates insulin mediated lifespan in C. elegans , 2010, Aging.

[122]  T. Mikkelsen,et al.  The NIH Roadmap Epigenomics Mapping Consortium , 2010, Nature Biotechnology.

[123]  J. Kieft,et al.  Elevated histone expression promotes life span extension. , 2010, Molecular cell.

[124]  David Carling,et al.  Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation , 2010, Science.

[125]  Stuart L Schreiber,et al.  Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres , 2010, Nature Structural &Molecular Biology.

[126]  Brian K. Kennedy,et al.  Progeria syndromes and ageing: what is the connection? , 2010, Nature Reviews Molecular Cell Biology.

[127]  L. B. Snoek,et al.  Genome-wide gene expression regulation as a function of genotype and age in C. elegans. , 2010, Genome research.

[128]  Or Gozani,et al.  Members of the Histone H3 Lysine 4 Trimethylation Complex Regulate Lifespan in a Germline-dependent Manner in C. elegans , 2010, Nature.

[129]  M. Götz,et al.  Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. , 2010, Cell stem cell.

[130]  Lennart Opitz,et al.  Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice , 2010, Science.

[131]  Linda Partridge,et al.  Extending Healthy Life Span—From Yeast to Humans , 2010, Science.

[132]  C. Wolkow,et al.  Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity , 2010, Proceedings of the National Academy of Sciences.

[133]  Wolfgang Wagner,et al.  Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. , 2010, Genome research.

[134]  C. Kenyon The genetics of ageing , 2010, Nature.

[135]  Nianxiang Zhang,et al.  Widespread and Tissue Specific Age-related Dna Methylation Material Supplemental Related Content a Hallmark of Cancer Age-dependent Dna Methylation of Genes That Are Suppressed in Stem Cells Is , 2022 .

[136]  M. Atalay,et al.  Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats , 2010, Mechanisms of Ageing and Development.

[137]  Rakhee Banerjee,et al.  Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance , 2009, Proceedings of the National Academy of Sciences.

[138]  Lucinda K. Southworth,et al.  Aging Mice Show a Decreasing Correlation of Gene Expression within Genetic Modules , 2009, PLoS genetics.

[139]  Tanja Diemer,et al.  Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO‐dependent pathway , 2009, Aging cell.

[140]  A. Garnham,et al.  Exercise‐induced histone modifications in human skeletal muscle , 2009, The Journal of physiology.

[141]  S. Panda,et al.  AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation , 2009, Science.

[142]  T. Elston,et al.  A quantitative model for age-dependent expression of the p16INK4a tumor suppressor , 2009, Proceedings of the National Academy of Sciences.

[143]  D. Reinberg,et al.  Calorie restriction and the exercise of chromatin. , 2009, Genes & development.

[144]  A. Edison Caenorhabditis elegans pheromones regulate multiple complex behaviors , 2009, Current Opinion in Neurobiology.

[145]  R. Medzhitov,et al.  Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation , 2009, Cell.

[146]  G. Reuter,et al.  Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2 , 2009, Nature Genetics.

[147]  Justin R. Cross,et al.  ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation , 2009, Science.

[148]  A. Shilatifard,et al.  Histone H4 lysine-16 acetylation regulates cellular lifespan , 2009, Nature.

[149]  W. G. Kelly,et al.  A C. elegans LSD1 Demethylase Contributes to Germline Immortality by Reprogramming Epigenetic Memory , 2009, Cell.

[150]  E. Greer,et al.  Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans , 2009, Aging cell.

[151]  M. Hatta,et al.  Acetylation curtails nucleosome binding, not stable nucleosome remodeling, by FoxO1. , 2009, Biochemical and biophysical research communications.

[152]  F. Alt,et al.  SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging , 2008, Cell.

[153]  X. Wang,et al.  Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. , 2008, Cancer cell.

[154]  Florian Kreppel,et al.  SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation , 2008, Cell.

[155]  Paolo Sassone-Corsi,et al.  The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control , 2008, Cell.

[156]  K. Hughes,et al.  Evolution and mechanisms of long life and high fertility in queen honey bees , 2008, AGE.

[157]  Kaushik Sengupta,et al.  Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin. , 2008, Genes & development.

[158]  B. Kemp,et al.  AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5 , 2008, Diabetes.

[159]  Howard Y. Chang,et al.  SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin , 2008, Nature.

[160]  M. McBurney,et al.  SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice , 2008, PloS one.

[161]  I. Weissman,et al.  Transcriptional instability is not a universal attribute of aging , 2007, Aging cell.

[162]  A. Shilatifard,et al.  Covalent modifications of histones during development and disease pathogenesis , 2007, Nature Structural &Molecular Biology.

[163]  A. Richardson,et al.  Caloric restriction and genomic stability , 2007, Nucleic acids research.

[164]  A. Owen,et al.  AGEMAP: A Gene Expression Database for Aging in Mice , 2007, PLoS genetics.

[165]  R. Busuttil,et al.  Intra-Organ Variation in Age-Related Mutation Accumulation in the Mouse , 2007, PloS one.

[166]  T. Duhamel,et al.  Muscle sarcoplasmic reticulum calcium regulation in humans during consecutive days of exercise and recovery. , 2007, Journal of applied physiology.

[167]  D. L. Jones,et al.  Aging and the Germ Line: Where Mortality and Immortality Meet , 2007, Stem Cell Reviews.

[168]  S. Chong,et al.  Heritable germline epimutation is not the same as transgenerational epigenetic inheritance , 2007, Nature Genetics.

[169]  C. Allis,et al.  Epigenetics: A Landscape Takes Shape , 2007, Cell.

[170]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[171]  Jan Vijg,et al.  Increased cell-to-cell variation in gene expression in ageing mouse heart , 2006, Nature.

[172]  Paolo Sassone-Corsi,et al.  Circadian Regulator CLOCK Is a Histone Acetyltransferase , 2006, Cell.

[173]  K. Korach,et al.  Estrogen receptors and human disease. , 2006, The Journal of clinical investigation.

[174]  Pingfang Liu,et al.  Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6 , 2006, Cell.

[175]  K. S. Rao,et al.  DNA double strand break repair in brain: Reduced NHEJ activity in aging rat neurons , 2006, Neuroscience Letters.

[176]  E. Greer,et al.  FOXO transcription factors at the interface between longevity and tumor suppression , 2005, Oncogene.

[177]  C. Shen,et al.  DNA Methyltransferase Gene dDnmt2 and Longevity of Drosophila* , 2005, Journal of Biological Chemistry.

[178]  E. Epel,et al.  Accelerated telomere shortening in response to life stress. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[179]  B. Rogina,et al.  Sir2 mediates longevity in the fly through a pathway related to calorie restriction. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[180]  A. Sharov,et al.  Age-associated alteration of gene expression patterns in mouse oocytes. , 2004, Human molecular genetics.

[181]  Matt Kaeberlein,et al.  Sir2-Independent Life Span Extension by Calorie Restriction in Yeast , 2004, PLoS biology.

[182]  R. Roeder,et al.  S Phase Activation of the Histone H2B Promoter by OCA-S, a Coactivator Complex that Contains GAPDH as a Key Component , 2003, Cell.

[183]  Gary Ruvkun,et al.  DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism , 2003, Science.

[184]  M. G. Kidwell,et al.  Transposable elements and the evolution of genome size in eukaryotes , 2002, Genetica.

[185]  C. Allis,et al.  Translating the Histone Code , 2001, Science.

[186]  T. Kirkwood,et al.  If you would live long, choose your parents well. , 2001, Trends in genetics : TIG.

[187]  L. Guarente,et al.  Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase , 2000, Nature.

[188]  M. McVey,et al.  The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. , 1999, Genes & development.

[189]  M. Ralph,et al.  The Significance of Circadian Organization for Longevity in the Golden Hamster , 1998, Journal of biological rhythms.

[190]  R Holliday,et al.  The inheritance of epigenetic defects. , 1987, Science.

[191]  V. J. Simpson,et al.  Caenorhabditis elegans DNA does not contain 5-methylcytosine at any time during development or aging. , 1986, Nucleic acids research.

[192]  V. L. Wilson,et al.  DNA methylation decreases in aging but not in immortal cells. , 1983, Science.

[193]  T. Kirkwood,et al.  The evolution of ageing and longevity , 1979, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[194]  M. Thakur,et al.  Modulation of acetylation of histones and transcription of chromatin by butyric acid and 17beta-estradiol in the brain of rats of various ages. , 1979, Biochemical and biophysical research communications.

[195]  S. Blair,et al.  Years of life gained due to leisure-time physical activity in the U.S. , 2013, American journal of preventive medicine.