may in this suggests Abstract It is reported chronic methamphetamine (MA) use has reper-cussions for the behavioral and neuropsychological aspects. The repeated MA use is associated with altered activation and decreased dopamine concentrations in the striatum, which may contribute to addiction. The aim of the current study is to investigate the changes of the resting-state functional connectivity of the as consequences of chronic administration of MA in nonhuman Abstract The recent development of smartphone has brought about a radical change in the social life. These changes have brought enormous convenience to the modern society, but considering that smartphones are sharing most aspects of the Internet, the addiction to smartphones is highly likely to cause physical and psychosocial problems as well as Internet addiction. The aim of this study is to investigate altered brain functional connectivity in adolescent who overuse their smartphones (SUD) compared with normal control adolescents (NC). with smartphone addiction (mean = 13.45 ± 0.94) and 22 age-matched normal controls (mean = 13.47 ± 1.00) were recruited for fMRI experiments. The groups were classified according to Smartphone Addiction scale (SAS) and The SAS consists of 15 items, which are four-point Likert scale (1: Not at all to 4: Always). A high-resolution T1-weighted MRI data set was obtained from subjects using a Siemens MAGNETOM Verio 3.0T MRI scan-ner with an 8-channel SENSE head coil. For the resting state fMRI scanning, subjects were asked to fixate a cross during resting state without movement for 6 minutes 40 seconds. 200 EPI images were acquired and 5 images were discarded for equilib-rium. For the spatial preprocessing of the EPI images, we applied realigning, coregistering, normalizing and smoothing one by one. In addition, temporal band-pass filtering to the smoothed data, detrending the globally increasing tendency and regress-ing out the motion parameters and the effects from the white matter and cerebral spinal fluid are applied. Then, we analyzed the functional connectivity based on the inferior parietal lobule (IPL) by calculating the Pearson’s correlation coefficients of the time series. In the result, Inferior parietal lobule showed different functional connectivity with two groups. Compared with NC, adolescents with SUD showed decreased functional connectivity in the anterior insula and primary motor cortex. Error! Reference source not found. These results suggest that SUD adolescents’ brain was functionally altered from NC adolescents’ brain in the resting state.
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