Effects of overlap and pass number in CO2 laser skin resurfacing: A study of residual thermal damage, cell death, and wound healing

Newer CO2 laser systems incorporating short pulse and scanning technology have been used effectively to resurface the skin. As the number of resurfacing cases has increased, hypertrophic scarring has been reported more commonly. Previous dermabrasion and continuous wave CO2 studies have suggested that depth of injury and thermal damage are important predictors of scarring for a given anatomic region. To determine whether rapid overlapping of laser pulses/scans significantly altered wound healing, we examined residual thermal damage, cell death, and histologic and clinical wound healing in a farm pig.

[1]  T. Alster Comparison of Two High‐Energy, Pulsed Carbon Dioxide Lasers in the Treatment of Periorbital Rhytides , 1996, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[2]  M. Griffin,et al.  Laser Skin Resurfacing: Pre‐ and Posttreatment Guidelines , 1995, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[3]  R.R. Anderson,et al.  Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. , 1983, Science.

[4]  N. Lowe,et al.  Laser Skin Resurfacing with the Silk Touch Flashscanner for Facial Rhytides , 1995, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[5]  A. Welch,et al.  Time constants in thermal laser medicine , 1989, Lasers in surgery and medicine.

[6]  B. R. Burkhardt,et al.  Are more passes better? Safety versus efficacy with the pulsed CO2 laser. , 1997, Plastic and reconstructive surgery.

[7]  M P Goldman,et al.  Advances in carbon dioxide laser surgery. , 1995, Clinics in dermatology.

[8]  Pulsed Carbon Dioxide Laser Resurfacing of Photoaged Facial Skin , 1996 .

[9]  J. Dover,et al.  Laser skin resurfacing. , 1996, Archives of dermatology.

[10]  J. Penoff Laser skin resurfacing. , 1996, Annals of Plastic Surgery.

[11]  D. Apfelberg The Ultrapulse Carbon Dioxide Laser with Computer Pattern Generator Automatic Scanner for Facial Cosmetic Surgery and Resurfacing , 1996, Annals of plastic surgery.

[12]  S. Thomsen PATHOLOGIC ANALYSIS OF PHOTOTHERMAL AND PHOTOMECHANICAL EFFECTS OF LASER–TISSUE INTERACTIONS , 1991, Photochemistry and photobiology.

[13]  B. Mikic,et al.  The effect of laser parameters on the zone of thermal injury produced by laser ablation of biological tissue. , 1994, Journal of biomechanical engineering.

[14]  L. David,et al.  Rapid Laser Scanning for Facial Resurfacing , 1995, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[15]  R. Anderson,et al.  Pulsed CO2 laser tissue ablation: Effect of tissue type and pulse duration on thermal damage , 1988, Lasers in surgery and medicine.

[16]  A. Welch,et al.  Approximate Solutions for Heat Conduction: Time Constants , 1995 .

[17]  M. Griffin,et al.  Skin Resurfacing with the Ultrapulse Carbon Dioxide Laser: Observations on 100 Patients , 1995, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[18]  B. Mikic,et al.  The effect of CO/sub 2/ laser pulse repetition rate on tissue ablation rate and thermal damage , 1991, IEEE Transactions on Biomedical Engineering.

[19]  T. Schröder,et al.  Lactate dehydrogenase in laser incisions: A comparative analysis of skin wounds made with steel scalpel, electrocautery, superpulse—continuous wave mode carbon‐dioxide lasers, and contact Nd:YAG laser , 1989, Lasers in surgery and medicine.

[20]  M. V. van Gemert,et al.  Temperature response of biological materials to pulsed non‐ablative CO2 laser irradiation , 1991, Lasers in surgery and medicine.

[21]  V. Romano,et al.  Lateral thermal damage along pulsed laser incisions , 1990, Lasers in surgery and medicine.

[22]  A. D. Zweig,et al.  A thermo-mechanical model for laser ablation , 1991 .

[23]  J. Walsh,et al.  Pulsed CO2 laser tissue ablation: Measurement of the ablation rate , 1988, Lasers in surgery and medicine.

[24]  J. Walsh,et al.  Er:YAG laser ablation of tissue: Measurement of ablation rates , 1989, Lasers in surgery and medicine.

[25]  A J Welch,et al.  Time constants in thermal laser medicine: II. Distributions of time constants and thermal relaxation of tissue. , 1996, Physics in medicine and biology.

[26]  M. Swindle,et al.  Swine as models in experimental surgery. , 1988, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

[27]  Yacov Domankevitz,et al.  Effects of CO2 laser pulse duration in ablation and residual thermal damage: Implications for skin resurfacing , 1996, Lasers in surgery and medicine.

[28]  Jennifer K. Barton,et al.  Infrared imaging of CO2 laser ablation: implications for laser skin resurfacing , 1998, Photonics West - Biomedical Optics.