Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management

Fungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. SUMMARY Fungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high degree of clinical suspicion coupled with the judicious use of diagnostic tests is required for diagnosis. In addition to microbiological diagnostics (e.g., blood culture for Candida spp. or galactomannan testing and PCR for Aspergillus spp.), echocardiography remains critical for evaluation of potential infective endocarditis, although radionuclide imaging modalities such as 18F-fluorodeoxyglucose positron emission tomography/computed tomography are increasingly being used. A multimodal treatment approach is necessary: surgery is usually required and should be accompanied by long-term systemic antifungal therapy, such as echinocandin therapy for Candida endocarditis or voriconazole therapy for Aspergillus endocarditis.

[1]  M. Hoenigl,et al.  Treatment of Invasive Aspergillosis: How It’s Going, Where It’s Heading , 2023, Mycopathologia.

[2]  T. Hohl,et al.  Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap. , 2023, The Lancet. Microbe.

[3]  M. Hoenigl,et al.  Salvage Treatment for Invasive Aspergillosis and Mucormycosis: Challenges, Recommendations and Future Considerations. , 2023, Infection and drug resistance.

[4]  B. Barker,et al.  Review of Clinical and Laboratory Diagnostics for Coccidioidomycosis , 2023, Journal of clinical microbiology.

[5]  Sevval Nur Bektas,et al.  COVID-19–associated mucormycosis: a systematic review and meta-analysis of 958 cases , 2023, Clinical Microbiology and Infection.

[6]  Eelco F. J. Meijer,et al.  Guideline adherence and survival of patients with candidaemia in Europe: results from the ECMM Candida III multinational European observational cohort study. , 2023, The Lancet. Infectious diseases.

[7]  M. Hoenigl,et al.  Race and ethnicity: Risk factors for fungal infections? , 2023, PLoS pathogens.

[8]  H. Badali,et al.  The current state of laboratory mycology in Asia/Pacific: A survey from the European Confederation of Medical Mycology (ECMM) and International Society for Human and Animal Mycology (ISHAM). , 2023, International journal of antimicrobial agents.

[9]  M. Hoenigl,et al.  The current state of laboratory mycology and access to antifungal treatment in Europe: a European Confederation of Medical Mycology survey. , 2022, The Lancet. Microbe.

[10]  M. Hoenigl,et al.  Liposomal amphotericin B—the future , 2022, The Journal of antimicrobial chemotherapy.

[11]  Fu Lee Wang,et al.  Rezafungin versus caspofungin for treatment of candidaemia and invasive candidiasis (ReSTORE): a multicentre, double-blind, double-dummy, randomised phase 3 trial , 2022, The Lancet.

[12]  M. Ghannoum,et al.  Ibrexafungerp, a Novel Triterpenoid Antifungal in Development for the Treatment of Mold Infections , 2022, Journal of fungi.

[13]  D. Seidel,et al.  COVID-19-associated fungal infections , 2022, Nature Microbiology.

[14]  C. Thornton,et al.  Development of a Monoclonal Antibody and a Serodiagnostic Lateral-Flow Device Specific to Rhizopus arrhizus (Syn. R. oryzae), the Principal Global Agent of Mucormycosis in Humans , 2022, Journal of fungi.

[15]  C. Deming,et al.  Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria. , 2022, Cell host & microbe.

[16]  M. Hoenigl,et al.  Let's talk about sex characteristics—As a risk factor for invasive fungal diseases , 2022, Mycoses.

[17]  J. Perfect,et al.  Noninvasive Testing and Surrogate Markers in Invasive Fungal Diseases , 2022, Open forum infectious diseases.

[18]  E. Cinteză,et al.  Disseminated Cunninghamella spp. Endocarditis in a Beta-Thalassemia Patient after Asymptomatic COVID-19 Infection , 2022, Diagnostics.

[19]  Carmen Tse,et al.  Trichosporon mucoides prosthetic valve endocarditis managed with antifungal suppression therapy , 2022, Medical mycology case reports.

[20]  L. Millon,et al.  An overview of using fungal DNA for the diagnosis of invasive mycoses , 2022, Expert review of molecular diagnostics.

[21]  Z. Beckerman,et al.  Early diagnosis with sequencing and successful treatment of Bipolaris prosthetic valve endocarditis , 2022, Medical mycology case reports.

[22]  C. d’Enfert,et al.  Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins , 2022, mBio.

[23]  J. Perfect,et al.  The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries , 2022, The Lancet Microbe.

[24]  J. Guinea,et al.  Aspergillus endocarditis in the recent years, report of cases of a multicentric national cohort and literature review , 2021, Mycoses.

[25]  M. Garg,et al.  Clinical features, diagnosis and treatment outcome of fungal endocarditis: A systematic review of reported cases , 2021, Mycoses.

[26]  Jo-Anne H. Young,et al.  Aspergillus Infections. , 2021, The New England journal of medicine.

[27]  M. Hoenigl,et al.  The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin , 2021, Drugs.

[28]  J. Perfect,et al.  Global guideline for the diagnosis and management of rare yeast infections: an initiative of the ECMM in cooperation with ISHAM and ASM. , 2021, The Lancet. Infectious diseases.

[29]  Sarah K. Parker,et al.  Time to Blood Culture Positivity by Pathogen and Primary Service. , 2021, Hospital pediatrics.

[30]  N. Ampel,et al.  Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology. , 2021, The Lancet. Infectious diseases.

[31]  R. Vuento,et al.  Fungemia and Other Fungal Infections Associated with Use of Saccharomyces boulardii Probiotic Supplements , 2021, Emerging infectious diseases.

[32]  D. Raoult,et al.  Sexual Dimorphism and Gender in Infectious Diseases , 2021, Frontiers in Immunology.

[33]  B. Boyanton,et al.  Native vs Prosthetic Valve Histoplasma capsulatum Infective Endocarditis: A Case Report and Systemic Literature Review Comparing Patient Presentation, Treatment Modalities, Clinical Outcomes, and Diagnostic Laboratory Testing , 2021, Open forum infectious diseases.

[34]  T. Masai,et al.  Successful surgical treatment of delayed left ventricular pseudoaneurysm related to Candida albicans infection after repair of ventricular septal rupture complicating acute myocardial infarction , 2021, Journal of cardiology cases.

[35]  C. Marboe,et al.  Cryptococcus neoformans infective endocarditis after lung transplantation: a case report and review of the literature. , 2021, Infectious diseases in clinical practice.

[36]  T. Patterson,et al.  Aspergillosis: Epidemiology, Diagnosis, and Treatment. , 2021, Infectious disease clinics of North America.

[37]  F. Vandenesch,et al.  Malassezia Restricta: An Underdiagnosed Causative Agent of Blood Culture-Negative Infective Endocarditis. , 2021, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[38]  A. Toland,et al.  Acute Aortic Valve Insufficiency Due to Disseminated Trichosporon Fungemia in a Non-Neutropenic Patient , 2021 .

[39]  J. Mascaro,et al.  Trichosporonosis Causing Mycotic Aortic Root Pseudoaneurysm after Cardiac Transplantation , 2021 .

[40]  P. Sharma,et al.  Integration of 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in Diagnostic Algorithm of Prosthetic Valve Endocarditis: A Case Report and Review of Literature , 2021, Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India.

[41]  J. Tolentino,et al.  Endocarditis due to Trichosporon beigelii 11 years after mitral valve replacement. , 2021, Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology.

[42]  A. Caliendo,et al.  Aspergillus Polymerase Chain Reaction-An Update on Technical Recommendations, Clinical Applications, and Justification for Inclusion in the Second Revision of the EORTC/MSGERC Definitions of Invasive Fungal Disease. , 2021, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[43]  U. Rosendahl,et al.  Don’t Stop Beleafing , 2021, JACC. Case reports.

[44]  P. Woo,et al.  Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology. , 2021, The Lancet. Infectious diseases.

[45]  C. Lass‐Flörl,et al.  Serology anno 2021 - fungal infections: from invasive to chronic. , 2021, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[46]  Francisca Alves Cardoso,et al.  Relapsing Candida parapsilosis Endocarditis With Septic Embolization: A Case Report , 2021, Cureus.

[47]  M. Finkelman Specificity Influences in (1→3)-β-d-Glucan-Supported Diagnosis of Invasive Fungal Disease , 2020, Journal of fungi.

[48]  S. Hohmann,et al.  Candida Infective Endocarditis: A Retrospective Study of Patient Characteristics and Risk Factors for Death in 703 United States Cases, 2015–2019 , 2020, Open forum infectious diseases.

[49]  Sheng-hu He,et al.  Cryptococcal endocarditis of native valves without immunodeficiency or drug abuse: a case report , 2020, The Journal of international medical research.

[50]  D. Seidel,et al.  Characterization and outcome of invasive infections due to Paecilomyces variotii: analysis of patients from the FungiScope® registry and literature reports , 2020, The Journal of antimicrobial chemotherapy.

[51]  B. Griffin,et al.  Diagnostic performance of cardiac computed tomography versus transesophageal echocardiography in infective endocarditis: A contemporary comparative meta-analysis. , 2020, Journal of cardiovascular computed tomography.

[52]  F. Dondi,et al.  Meta-Analysis of the Diagnostic Performance of 18F-FDG-PET/CT Imaging in Native Valve Endocarditis. , 2020, JACC. Cardiovascular imaging.

[53]  I. Ramírez-Sánchez,et al.  Endocarditis by Fusarium keratoplasticum , 2020, Mycopathologia.

[54]  M. Veve,et al.  Candida spp. infective endocarditis: Characteristics and outcomes of twenty patients with a focus on injection drug use as a predisposing risk factor , 2020, Mycoses.

[55]  C. Sag,et al.  Candida Endocarditis in Patients with Candidemia: A Single-Center Experience of 14 Cases , 2020, Mycopathologia.

[56]  John O. Prior,et al.  COVID-19 Pandemics: A Surprising Link to Bread Flour With Collateral Damage to a Prosthetic Heart Valve. , 2020, Circulation. Cardiovascular imaging.

[57]  Â. Chaves-Markman,et al.  Antifungal Efficacy of Amphotericin B in Candida Albicans Endocarditis Therapy: Systematic Review , 2020, Brazilian journal of cardiovascular surgery.

[58]  G. Samonis,et al.  Candida parapsilosis endocarditis. Report of cases and review of the literature. , 2020, Germs.

[59]  H. Benamer,et al.  Acute ischemic stroke treated with mechanical thrombectomy and fungal endocarditis: A case report and systematic review of the literature. , 2020, Journal of neuroradiology. Journal de neuroradiologie.

[60]  M. Hoenigl,et al.  Diagnosis of Breakthrough Fungal Infections in the Clinical Mycology Laboratory: An ECMM Consensus Statement , 2020, Journal of fungi.

[61]  J. Routy,et al.  Glucan rich nutrition does not increase gut translocation of beta‐glucan , 2020, Mycoses.

[62]  T. Ferraro,et al.  Epidemiological study of Trichosporon asahii infections over the past 23 years , 2020, Epidemiology and Infection.

[63]  R. Siegel,et al.  Right‐Sided Infective Endocarditis 2020: Challenges and Updates in Diagnosis and Treatment , 2020, Journal of the American Heart Association.

[64]  M. Hoenigl,et al.  T2Candida magnetic resonance in patients with invasive candidiasis: Strengths and limitations. , 2020, Medical mycology.

[65]  G. Walther,et al.  First case of fatal Rhizomucor miehei endocarditis in an immunocompromised patient. , 2020, Diagnostic microbiology and infectious disease.

[66]  B. Griffin,et al.  Diagnosis of Infective Endocarditis by Subtype Using 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography , 2020, Circulation. Cardiovascular imaging.

[67]  J. Branda,et al.  Disseminated Intravascular Infection Caused by Paecilomyces variotii: Case Report and Review of the Literature , 2020, Open forum infectious diseases.

[68]  M. Martínez‐Sellés,et al.  Infective endocarditis in patients with cardiac implantable electronic devices: a nationwide study. , 2020, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[69]  H. Jneid,et al.  Prosthetic Valve Endocarditis From Trichosporon asahii in an Immunocompetent Patient , 2020, JACC. Case reports.

[70]  J. P. Telles,et al.  Pseudozyma spp. human infections: A systematic review. , 2020, Medical mycology.

[71]  N. Sankar,et al.  Candida Infective Endocarditis During the Infectious Diseases and Substance Use Disorder Syndemic: A Six-Year Case Series , 2020, Open forum infectious diseases.

[72]  C. Barnett,et al.  Embolic ST-elevation Myocardial Infarction from Candida Endocarditis , 2020, Cureus.

[73]  K. K. Sahu,et al.  Systemic embolization following fungal Infective endocarditis. , 2020, QJM : monthly journal of the Association of Physicians.

[74]  M. Christner,et al.  Clinical characteristics and outcomes of invasive Lomentospora prolificans infections: Analysis of patients in the FungiScope® registry , 2020, Mycoses.

[75]  D. Andes,et al.  Contributions of the Biofilm Matrix to Candida Pathogenesis , 2020, Journal of fungi.

[76]  C. Fong Guideline , 2020, Definitions.

[77]  G. Satta,et al.  Brewer’s Yeast as a cause of infective endocarditis , 2020 .

[78]  U. Kim,et al.  Clinical Characteristics and Risk Factors for Complications of Candidaemia in Adults: Focus on Endophthalmitis, Endocarditis, and Osteoarticular Infections. , 2020, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[79]  Alexander B. Granok Successful Treatment of Malassezia furfur Endocarditis , 2020, Open forum infectious diseases.

[80]  R. Rajani,et al.  Infective endocarditis: A contemporary update. , 2020, Clinical medicine.

[81]  Xuedong Zhou,et al.  The regulation of hyphae growth in Candida albicans , 2020, Virulence.

[82]  G. Butler,et al.  High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis , 2020, Nature Medicine.

[83]  Jon J Hiles,et al.  Evaluation of a Rapid Fungal Detection Panel for Identification of Candidemia at an Academic Medical Center , 2019, Journal of Clinical Microbiology.

[84]  G. Butler,et al.  High-resolution mycobiota analysis reveals dynamic intestinal translocation prior to invasive candidiasis , 2019, Nature Medicine.

[85]  H. Badali,et al.  Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. , 2019, The Lancet. Infectious diseases.

[86]  M. Fukunami,et al.  Cryptococcus endocarditis: A case report and review of the literature. , 2019, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

[87]  R. Neves,et al.  Large Aortic Prosthesis Fungal Vegetation Due to Candida parapsilosis: An Uncommon Presentation , 2019, Mycopathologia.

[88]  W. Powderly,et al.  Risk factors predicting Candida infective endocarditis in patients with candidemia. , 2019, Medical mycology.

[89]  D. Kontoyiannis,et al.  Defining breakthrough invasive fungal infection–Position paper of the mycoses study group education and research consortium and the European Confederation of Medical Mycology , 2019, Mycoses.

[90]  C. Rotstein,et al.  Candida infections in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice , 2019, Clinical transplantation.

[91]  A. Odermatt,et al.  Posaconazole Serum Drug Levels Associated with Pseudohyperaldosteronism. , 2019, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[92]  D. Brotman,et al.  Infective endocarditis: Beyond the usual tests , 2019, Cleveland Clinic Journal of Medicine.

[93]  A. Wanhainen,et al.  Systematic Review of the Management of Mycotic Aortic Aneurysms. , 2019, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[94]  Ganesh Kumar K. Ammannaya,et al.  Fungal endocarditis: what do we know in 2019? , 2019, Kardiologia polska.

[95]  R. Mohiaddin,et al.  Unusual Complicated Fungal Endocarditis in a Patient With Vascular Ehlers-Danlos Syndrome. , 2019, The Annals of thoracic surgery.

[96]  E. Louie,et al.  Combination antifungal therapy for treatment of Candida parapsilosis prosthetic valve endocarditis and utility of T2Candida Panel®: A case series , 2019, IDCases.

[97]  Sarah Fagundes Grobe,et al.  ENDOCARDITE FÚNGICA POR TRICHOSPORON ASAHII: RELATO DE UM CASO RARO EM IMUNOCOMPETENTES , 2019, Revista da Sociedade de Cardiologia do Estado de São Paulo.

[98]  F. Lanternier,et al.  Disease Entities in Mucormycosis , 2019, Journal of fungi.

[99]  F. Queiroz-Telles,et al.  Sporotrichosis In Immunocompromised Hosts , 2019, Journal of fungi.

[100]  H. Carneiro,et al.  Fungal prosthetic aortic valve endocarditis and endarteritis: An unusual cause of aortic root vegetations , 2018, Echocardiography.

[101]  L. Pagano,et al.  Rhodotorula infection in haematological patient: Risk factors and outcome , 2018, Mycoses.

[102]  A. Mansur,et al.  Outcomes in patients with fungal endocarditis: A multicenter observational cohort study. , 2018, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[103]  M. Lederman,et al.  Soluble Urokinase Plasminogen Activator Receptor (suPAR) is predictive of Non-AIDS Events during Antiretroviral Therapy-mediated Viral Suppression. , 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[104]  M. Hoenigl,et al.  Serum 1,3-Beta-D-Glucan Values During and After Laparoscopic and Open Intestinal Surgery , 2018, Open forum infectious diseases.

[105]  V. Dilsizian,et al.  Merits of FDG PET/CT and Functional Molecular Imaging Over Anatomic Imaging With Echocardiography and CT Angiography for the Diagnosis of Cardiac Device Infections. , 2018, JACC. Cardiovascular imaging.

[106]  F. Kong,et al.  Five-year China Hospital Invasive Fungal Surveillance Net (CHIF-NET) study of invasive fungal infections caused by noncandidal yeasts: species distribution and azole susceptibility , 2018, Infection and drug resistance.

[107]  Shivaprakash,et al.  Candida parapsilosis endocarditis in an intravenous drug abuser: an autopsy report. , 2018, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[108]  K. Said,et al.  Aspergillus endocarditis: Diagnostic criteria and predictors of outcome, A retrospective cohort study , 2018, PloS one.

[109]  A. Caliendo,et al.  Detecting Infections Rapidly and Easily for Candidemia Trial, Part 2 (DIRECT2): A Prospective, Multicenter Study of the T2Candida Panel , 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[110]  B. Kullberg,et al.  Invasive Candidiasis. , 2019, The New England journal of medicine.

[111]  C. Beigelman-Aubry,et al.  Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline. , 2018, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[112]  C. Thornton Molecular Imaging of Invasive Pulmonary Aspergillosis Using ImmunoPET/MRI: The Future Looks Bright , 2018, Front. Microbiol..

[113]  Supradip Ghosh,et al.  Native valve endocarditis, fusarium and end-stage renal disease , 2018, BMJ Case Reports.

[114]  S. Touray,et al.  Reemergence of Intravenous Drug Use as Risk Factor for Candidemia, Massachusetts, USA , 2018, Emerging infectious diseases.

[115]  T. Boekhout,et al.  Malassezia ecology, pathophysiology, and treatment. , 2018, Medical mycology.

[116]  Moni Roy,et al.  Cryptococcus neoformans infective endocarditis of native valves in an immunocompetent host , 2018, IDCases.

[117]  C. Castillo,et al.  Prosthetic Valve Candida spp. Endocarditis: New Insights Into Long-term Prognosis—The ESCAPE Study , 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[118]  C. Clancy,et al.  Diagnosing Invasive Candidiasis , 2018, Journal of Clinical Microbiology.

[119]  T. Bajwa,et al.  Not just another Wisconsin case of blastomycosis. , 2017, European heart journal cardiovascular Imaging.

[120]  A. Mattos-Guaraldi,et al.  Endocarditis due to Rhodotorula mucilaginosa in a kidney transplanted patient: case report and review of medical literature , 2017, JMM case reports.

[121]  Felix Bongomin,et al.  Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision , 2017, Journal of fungi.

[122]  B. Alexander,et al.  A Mycoses Study Group International Prospective Study of Phaeohyphomycosis: An Analysis of 99 Proven/Probable Cases , 2017, Open forum infectious diseases.

[123]  M. Bassetti,et al.  Candida endocarditis: systematic literature review from 1997 to 2014 and analysis of 29 cases from the Italian Study of Endocarditis , 2017, Expert review of anti-infective therapy.

[124]  R. Relich,et al.  The Brief Case: Scopulariopsis Endocarditis—a Case of Mistaken Takayasu's Arteritis , 2017, Journal of Clinical Microbiology.

[125]  R. Relich,et al.  Closing the Brief Case: Scopulariopsis Endocarditis—a Case of Mistaken Takayasu's Arteritis , 2017, Journal of Clinical Microbiology.

[126]  A. Freire,et al.  Candida Endocarditis Presenting as Acute Myocardial Infarction. , 2017, American journal of respiratory and critical care medicine.

[127]  Gagandeep Singh,et al.  Geotrichum candidum in Infective Endocarditis , 2017, Journal of global infectious diseases.

[128]  P. Vaideeswar,et al.  Zygomycotic infective endocarditis in pregnancy. , 2017, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[129]  U. Sarwar,et al.  Exophiala (Wangiella) dermatitidis Prosthetic Aortic Valve Endocarditis and Prosthetic Graft Infection in an Immune Competent Patient , 2017, Case reports in infectious diseases.

[130]  Anupam Pande,et al.  Pseudozyma and other non‐Candida opportunistic yeast bloodstream infections in a large stem cell transplant center , 2017, Transplant infectious disease : an official journal of the Transplantation Society.

[131]  D. Seidel,et al.  Invasive infections due to Saprochaete and Geotrichum species: Report of 23 cases from the FungiScope Registry , 2017, Mycoses.

[132]  M. Azar,et al.  Laboratory Diagnostics for Histoplasmosis , 2017, Journal of Clinical Microbiology.

[133]  Y. Taur Intestinal microbiome changes and stem cell transplantation: Lessons learned , 2016, Virulence.

[134]  M. Al Mohajer,et al.  Fungal Endocarditis: Update on Diagnosis and Management. , 2016, The American journal of medicine.

[135]  D. Denning,et al.  Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. , 2016, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[136]  E. Cota,et al.  Candidalysin is a fungal peptide toxin critical for mucosal infection , 2016, Nature.

[137]  J. Sobel,et al.  Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. , 2016, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[138]  R. Hammami,et al.  Fusarium solani endocarditis in an acute leukemia patient. , 2016, Medecine et maladies infectieuses.

[139]  P. Rajagopalan,et al.  Acute ischemia of bilateral lower extremities as a presenting feature of disseminated mucormycosis endocarditis: A case report , 2016, Journal of community hospital internal medicine perspectives.

[140]  P. Konecny,et al.  Lomentospora prolificans endocarditis - case report and literature review , 2015, BMC Infectious Diseases.

[141]  Susanna Price,et al.  2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). , 2015, European heart journal.

[142]  T. Sugita,et al.  Molecular evidence that the opportunistic fungal pathogen Trichosporon asahii is part of the normal fungal microbiota of the human gut based on rRNA genotyping. , 2015, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[143]  K. Amarjeet,et al.  Surviving a recurrent Scedosporium prolificans endocarditis : A case report , 2015, Indian journal of medical microbiology.

[144]  C. Kauffman Complications of Candidemia in ICU Patients: Endophthalmitis, Osteomyelitis, Endocarditis , 2015, Seminars in Respiratory and Critical Care Medicine.

[145]  C. Tribble,et al.  Recurrent candida prosthetic endocarditis over fifteen years managed with medical therapy and four valvular surgeries: a case report and review of literature , 2015, Journal of Cardiothoracic Surgery.

[146]  J. Perfect,et al.  Scedosporium apiosermum infection of the “Native” valve: Fungal endocarditis in an orthotopic heart transplant recipient , 2015, Medical mycology case reports.

[147]  R. Behrouz Preoperative Cerebrovascular Evaluation in Patients With Infective Endocarditis , 2015, Clinical cardiology.

[148]  J. Wingard,et al.  Aspergillus Polymerase Chain Reaction: Systematic Review of Evidence for Clinical Use in Comparison With Antigen Testing , 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[149]  M. Göker,et al.  Towards an integrated phylogenetic classification of the Tremellomycetes , 2015, Studies in mycology.

[150]  Q. Abid,et al.  Systemic aspergilloma post aortic root surgery following coronary artery stenting: diagnostic and management dilemma , 2015, BMJ Case Reports.

[151]  T. Peláez,et al.  The search for endocarditis in patients with candidemia: a systematic recommendation for echocardiography? A prospective cohort , 2015, European Journal of Clinical Microbiology & Infectious Diseases.

[152]  Xiaowei Zhan,et al.  Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization , 2015, Nature Medicine.

[153]  L. Baddour,et al.  A Case of Scopulariopsis brevicaulis Endocarditis with Mycotic Aneurysm in an Immunocompetent Host , 2015, Case reports in medicine.

[154]  K. Garey,et al.  T2 magnetic resonance assay for the rapid diagnosis of candidemia in whole blood: a clinical trial. , 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[155]  P. Vaideeswar Candidial Endocarditis: A Single-Institute Pathological Analysis , 2015, Mycopathologia.

[156]  J. Miro,et al.  Candida Infective Endocarditis: an Observational Cohort Study with a Focus on Therapy , 2015, Antimicrobial Agents and Chemotherapy.

[157]  B. Prendergast,et al.  Guidelines for the diagnosis, prevention and management of implantable cardiac electronic device infection. Report of a joint Working Party project on behalf of the British Society for Antimicrobial Chemotherapy (BSAC, host organization), British Heart Rhythm Society (BHRS), British Cardiovascular S , 2015, The Journal of antimicrobial chemotherapy.

[158]  Reinhard Guthke,et al.  Defining the transcriptomic landscape of Candida glabrata by RNA-Seq , 2015, Nucleic acids research.

[159]  B. Shakhsheer,et al.  Membership and Behavior of Ultra-Low-Diversity Pathogen Communities Present in the Gut of Humans during Prolonged Critical Illness , 2014, mBio.

[160]  M. Hoenigl,et al.  The role of surgical debridement in different clinical manifestations of invasive aspergillosis , 2014, Mycoses.

[161]  S. Antinori,et al.  Fungal Endocarditis Observed Over an 8-Year Period and a Review of the Literature , 2014, Mycopathologia.

[162]  H. Jungwirth,et al.  Systematic Phenotyping of a Large-Scale Candida glabrata Deletion Collection Reveals Novel Antifungal Tolerance Genes , 2014, PLoS pathogens.

[163]  J. Miranda,et al.  Aspergillus endocarditis in a paediatric patient after a cardiac surgery, associated with septic pulmonary embolism and pulmonary hypertension , 2014, Cardiology in the Young.

[164]  J. Aguado,et al.  Epidemiology and predictive factors for early and late mortality in Candida bloodstream infections: a population-based surveillance in Spain. , 2014, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[165]  M. Hoenigl,et al.  Performance of Galactomannan, Beta-d-Glucan, Aspergillus Lateral-Flow Device, Conventional Culture, and PCR Tests with Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis , 2014, Journal of Clinical Microbiology.

[166]  M. J. Buitrago,et al.  Performance of Panfungal- and Specific-PCR-Based Procedures for Etiological Diagnosis of Invasive Fungal Diseases on Tissue Biopsy Specimens with Proven Infection: a 7-Year Retrospective Analysis from a Reference Laboratory , 2014, Journal of Clinical Microbiology.

[167]  M. Castresana,et al.  A rare case of multi-chambered fungal endocarditis from a virulent Cunninghamella infection. , 2014, European heart journal.

[168]  B. Wickes,et al.  Endocarditis Caused by Rhodotorula Infection , 2013, Journal of Clinical Microbiology.

[169]  H. Badali,et al.  Endocarditis due to a co-infection of Candida albicans and Candida tropicalis in a drug abuser. , 2013, Journal of medical microbiology.

[170]  D. Packham,et al.  Thermomyces lanuginosus infective endocarditis: Case report and a review of endocarditis due to uncommon moulds , 2013, Medical mycology case reports.

[171]  J. Mainardi,et al.  Aspergillus endocarditis in the era of new antifungals: major role for antigen detection. , 2013, The Journal of infection.

[172]  D. Lewinski,et al.  Fungal endocarditis of a bioprosthetic aortic valve , 2013, Herz.

[173]  A. Chakrabarti,et al.  Exophiala dermatitidis endocarditis on native aortic valve in a postrenal transplant patient and review of literature on E. dermatitidis infections , 2013, Mycoses.

[174]  Jacobo A Silva,et al.  Clinical significance of congestive heart failure in prosthetic valve endocarditis. A multicenter study with 257 patients. , 2013, Revista espanola de cardiologia.

[175]  C. Clancy,et al.  Finding the "missing 50%" of invasive candidiasis: how nonculture diagnostics will improve understanding of disease spectrum and transform patient care. , 2013, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[176]  M. Mubeen,et al.  Aspergillus pacemaker lead endocarditis , 2013, Asian cardiovascular & thoracic annals.

[177]  Duncan W. Wilson,et al.  Candida albicans pathogenicity mechanisms , 2013, Virulence.

[178]  T. Calandra,et al.  ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients. , 2012, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[179]  R. C. Ferreira,et al.  Molecular Identification, Antifungal Susceptibility Profile, and Biofilm Formation of Clinical and Environmental Rhodotorula Species Isolates , 2012, Antimicrobial Agents and Chemotherapy.

[180]  C. Barr,et al.  Recurrent Candida parapsilosis infective endocarditis aortic root replacement. , 2012, British journal of hospital medicine.

[181]  P. Iwen,et al.  Invasive Scopulariopsis brevicaulis infection in an immunocompromised patient and review of prior cases caused by Scopulariopsis and Microascus species. , 2012, Medical mycology.

[182]  F. D. De Rosa,et al.  Anidulafungin for Candida glabrata Infective Endocarditis , 2012, Antimicrobial Agents and Chemotherapy.

[183]  J. Sobel,et al.  Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials. , 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[184]  M. Wolff,et al.  Diagnosis, management and outcome of Candida endocarditis. , 2012, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[185]  K. Ferreira-Paim,et al.  Disseminated Sporothrix brasiliensis infection with endocardial and ocular involvement in an HIV-infected patient. , 2012, The American journal of tropical medicine and hygiene.

[186]  R. Zancopé-Oliveira,et al.  Sporotrichosis in HIV-infected patients: report of 21 cases of endemic sporotrichosis in Rio de Janeiro, Brazil. , 2012, Medical mycology.

[187]  Alexander D. Johnson,et al.  A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans , 2012, Cell.

[188]  M. Hantschke,et al.  The Malassezia Genus in Skin and Systemic Diseases , 2012, Clinical Microbiology Reviews.

[189]  C. Wattal,et al.  Scopulariopsis brevicaulis infection of prosthetic valve resembling aspergilloma on histopathology. , 2011, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[190]  T. Ferrari,et al.  Fatal right‐sided endocarditis caused by Fusarium in an immunocompromised patient: a case report , 2011, Mycoses.

[191]  J. Sobel,et al.  Ocular manifestations of candidemia. , 2011, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[192]  H. Ahmad,et al.  The Role of Fluconazole in the Treatment of Candida Endocarditis: A Meta-Analysis , 2011, Medicine.

[193]  B. Stausbøl‐Grøn,et al.  Successful management of invasive aspergillosis presenting as pericarditis in an adult patient with chronic granulomatous disease , 2011, Mycoses.

[194]  L. Baddour,et al.  Fungal prosthetic valve endocarditis: Mayo Clinic experience with a clinicopathological analysis , 2011, Mycoses.

[195]  T. Bisdas,et al.  Mycotic or infected aneurysm? Time to change the term. , 2011, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[196]  E. Askari,et al.  Emerging infectious endocarditis due to Scedosporium prolificans: a model of therapeutic complexity , 2011, European Journal of Clinical Microbiology & Infectious Diseases.

[197]  J. McCormack,et al.  Aspergillus endocarditis 2003-2009. , 2011, Medical mycology.

[198]  T. Calandra,et al.  The use of mannan antigen and anti-mannan antibodies in the diagnosis of invasive candidiasis: recommendations from the Third European Conference on Infections in Leukemia , 2010, Critical care.

[199]  K. Workowski,et al.  Aspergillus endocarditis: a review of the literature. , 2010, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[200]  L. Leibovici,et al.  PCR Diagnosis of Invasive Candidiasis: Systematic Review and Meta-Analysis , 2010, Journal of Clinical Microbiology.

[201]  A. Sarwari,et al.  Scedosporium prolificans endocarditis: case report and review of literature. , 2010, The West Virginia medical journal.

[202]  W. Weiwei,et al.  Isolation, identification, and antifungal susceptibility test for Kodamaea ohmeri: a case report on endocarditis , 2010 .

[203]  E. Çiftçi,et al.  PP-003 FATAL FUNGAL ENDOCARDITIS DUE TO TRICHOSPORON ASAHII IN AN ADOLESCENT BOY , 2010 .

[204]  J. Blair,et al.  Coccidioides Fungemia in Six Patients, with a Review of the Literature , 2010, Mycopathologia.

[205]  S. Filler,et al.  Interactions of Candida albicans with epithelial cells , 2010, Cellular microbiology.

[206]  T. Patterson,et al.  In vitro activity of isavuconazole against Trichosporon, Rhodotorula, Geotrichum, Saccharomyces and Pichia species. , 2009, The Journal of antimicrobial chemotherapy.

[207]  P. Hsueh,et al.  Invasive trichosporonosis caused by Trichosporon asahii and other unusual Trichosporon species at a medical center in Taiwan. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[208]  A. Kamarulzaman International Collaboration on Endocarditis Prospective Cohort Study Group.Current features of infective endocarditis in elderly patients: results of theInternational Collaboration on Endocarditis Prospective Cohort Study , 2009 .

[209]  R. Betts,et al.  A Multicenter, double-blind trial of a high-dose caspofungin treatment regimen versus a standard caspofungin treatment regimen for adult patients with invasive candidiasis. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[210]  C. Saldarriaga,et al.  Endocarditis infecciosa por Paecilomyces variotii , 2009 .

[211]  J. Laurini,et al.  Tricuspid Valve and Pacemaker Endocarditis Due to Pseudallescheria boydii (Scedosporium apiospermum) , 2009, Southern medical journal.

[212]  C. Viscoli,et al.  Candida Infective Endocarditis: Report of 15 Cases From a Prospective Multicenter Study , 2009, Medicine.

[213]  Andrew Wang,et al.  Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study. , 2009, Archives of internal medicine.

[214]  S. Ooi,et al.  Scedosporium apiospermum pacemaker endocarditis. , 2009, International journal of cardiology.

[215]  M. Burgueros,et al.  Galactomannan detection as a tool for the diagnosis and management of cardiac aspergillosis in 2 immunocompetent patients. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[216]  E. Kazakos,et al.  A fatal case of pacemaker lead endocarditis caused by Mucor spp. , 2008, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[217]  R. Lerch,et al.  Subaortic aneurysm caused by Paecilomyces lilacinus endocarditis. , 2008, Archives of cardiovascular diseases.

[218]  F. Tuon,et al.  Rhodotorula infection. A systematic review of 128 cases from literature. , 2008, Revista iberoamericana de micologia.

[219]  V. Fowler,et al.  Candida infective endocarditis , 2008, European Journal of Clinical Microbiology & Infectious Diseases.

[220]  J. Lopez-Ribot,et al.  Use of a Genetically Engineered Strain To Evaluate the Pathogenic Potential of Yeast Cell and Filamentous Forms during Candida albicans Systemic Infection in Immunodeficient Mice , 2007, Infection and Immunity.

[221]  R. Betts,et al.  Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[222]  M. A. Gurrutxaga,et al.  Endocarditis fúngica en un paciente portador de prótesis valvular , 2007 .

[223]  R. Betts,et al.  Caspofungin for the treatment of less common forms of invasive candidiasis. , 2007, The Journal of antimicrobial chemotherapy.

[224]  F. Tuon,et al.  Central venous catheter-associated fungemia due to Rhodotorula spp. --a systematic review. , 2007, Medical mycology.

[225]  D. Pittet,et al.  Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: a phase III randomised double-blind trial , 2007, The Lancet.

[226]  S. Filler,et al.  Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells , 2007, PLoS biology.

[227]  C. Tascini,et al.  Pacemaker Endocarditis with Pulmonary Cavitary Lesion Due to Scedosporium Prolificans , 2006, Journal of chemotherapy.

[228]  T. Sorrell,et al.  Development and Clinical Application of a Panfungal PCR Assay To Detect and Identify Fungal DNA in Tissue Specimens , 2006, Journal of Clinical Microbiology.

[229]  D. Denning,et al.  Post-operative aspergillosis. , 2006, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[230]  P. McCluskey,et al.  Endogenous Candida endophthalmitis , 2006, Expert review of anti-infective therapy.

[231]  H. Rutenberg,et al.  Fungal prosthetic mitral valve endocarditis caused by Scopulariopsis species: case report and review of the literature. , 2006, The Journal of thoracic and cardiovascular surgery.

[232]  H. Abdollah,et al.  Aspergillus fumigatus pacemaker lead endocarditis: a case report and review of the literature. , 2006, The Canadian journal of cardiology.

[233]  L. Sirota,et al.  Candida endocarditis in neonates: report of five cases and review of the literature , 2006, Mycoses.

[234]  A. Zaas,et al.  A meta-analysis of medical versus surgical therapy for Candida endocarditis. , 2005, The Journal of infection.

[235]  P. Nayar,et al.  Prosthetic valve endocarditis caused by Scedosporium apiospermum. , 2005, Indian journal of medical microbiology.

[236]  O. Velazquez,et al.  Successful treatment of Aspergillus prosthetic valve endocarditis with oral voriconazole. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[237]  M. García-Fernández,et al.  Aspergillus Endocarditis , 2005, Echocardiography.

[238]  M. Carrier,et al.  Aspergillus endocarditis after cardiac surgery. , 2005, The Annals of thoracic surgery.

[239]  R. Tight,et al.  Histoplasma endocarditis: clinical and mycologic features and outcomes. , 2005, The Journal of infection.

[240]  K. Leslie,et al.  Endocarditis caused by Coccidioides species. , 2004, Mayo Clinic proceedings.

[241]  E. Chadwick,et al.  Fusarium solani endocarditis successfully treated with liposomal amphotericin B and voriconazole. , 2004, The Pediatric infectious disease journal.

[242]  J. Berman,et al.  The distinct morphogenic states of Candida albicans. , 2004, Trends in microbiology.

[243]  R. Digumarti,et al.  Fungal Endocarditis: An Autopsy Study , 2004, Asian cardiovascular & thoracic annals.

[244]  M. Sheppard,et al.  Candida endocarditis with mycotic pulmonary emboli following re-do Rastelli operation , 2004, Heart.

[245]  M. Cuenca‐Estrella,et al.  Clinical Case of Endocarditis due to Trichosporon inkin and Antifungal Susceptibility Profile of the Organism , 2004, Journal of Clinical Microbiology.

[246]  M. Sutton,et al.  Native aortic valve vegetative endocarditis with Cunninghamella. , 2004, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology.

[247]  T. Scarabelli,et al.  Fungal endocarditis due to Scopulariopsis. , 2003, Annals of internal medicine.

[248]  G. Gottlieb,et al.  Disseminated sporotrichosis associated with treatment with immunosuppressants and tumor necrosis factor-alpha antagonists. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[249]  M. J. Buitrago,et al.  Scopulariopsis brevicaulis, a Fungal Pathogen Resistant to Broad-Spectrum Antifungal Agents , 2003, Antimicrobial Agents and Chemotherapy.

[250]  H. Günthard,et al.  Aortic Homograft Endocarditis Caused by Rhodotorula mucilaginosa , 2003, Infection.

[251]  J. Perfect,et al.  Comparison of caspofungin and amphotericin B for invasive candidiasis. , 2002, The New England journal of medicine.

[252]  B. Wickes,et al.  In Vitro Pharmacodynamic Properties of Three Antifungal Agents against Preformed Candida albicans Biofilms Determined by Time-Kill Studies , 2002, Antimicrobial Agents and Chemotherapy.

[253]  Jing Zhang,et al.  Endocarditis and hemorrhagic stroke caused by Cunninghamella bertholletiae infection after kidney transplantation. , 2002, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[254]  H. ElbaWu,et al.  Endocarditis verrucosa secundaria a Saccharomyces cerevisiae: Caso clínico , 2002 .

[255]  C. Cotrim,et al.  Native valve endocarditis due to Pichia ohmeri , 2002, Heart and Vessels.

[256]  L. Baddour,et al.  Fungal endocarditis, 1995-2000. , 2002, Chest.

[257]  M. Ghannoum,et al.  Antifungal Susceptibility of Candida Biofilms: Unique Efficacy of Amphotericin B Lipid Formulations and Echinocandins , 2002, Antimicrobial Agents and Chemotherapy.

[258]  Thomas A O'Bryan,et al.  Scedosporium apiospermum (Pseudallescheria boydii) endocarditis. , 2002, The Journal of infection.

[259]  M. Ghannoum,et al.  Comparison of Biofilms Formed by Candidaalbicans and Candidaparapsilosis on Bioprosthetic Surfaces , 2002, Infection and Immunity.

[260]  M. Guéguen,et al.  Diversity of Geotrichum candidumStrains Isolated from Traditional Cheesemaking Fabrications in France , 2001, Applied and Environmental Microbiology.

[261]  E. Donal,et al.  Echocardiographic features of Candidaspecies endocarditis: 12 cases and a review of published reports , 2001, Heart.

[262]  D. Noyola,et al.  Ophthalmologic, visceral, and cardiac involvement in neonates with candidemia. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[263]  G. Araj,et al.  A Case of Trichosporon beigelii Endocarditis , 2001, European Journal of Clinical Microbiology and Infectious Diseases.

[264]  D. Cosgrove,et al.  Aspergillus Valve Endocarditis in Patients without Prior Cardiac Surgery , 2000, Medicine.

[265]  V. Fowler,et al.  Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. , 2000, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[266]  F. Vandenesch,et al.  Early Microascus cinereus endocarditis of a prosthetic valve implanted after Staphylococcus aureus endocarditis of the native valve. , 1999, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[267]  M. Arvanitidou,et al.  The occurrence of fungi in hospital and community potable waters , 1999, Letters in applied microbiology.

[268]  I. Sobottka,et al.  Fatal Native Valve Endocarditis due to Scedosporium apiospermum (Pseudallescheria boydii) Following Trauma , 1999, European Journal of Clinical Microbiology and Infectious Diseases.

[269]  A. Bolger,et al.  Diagnosis and management of infective endocarditis and its complications. , 1998, Circulation.

[270]  R. Guillemain,et al.  Disseminated Fusarium solani infection with endocarditis in a lung transplant recipient , 1998, Mycoses.

[271]  G. Fink,et al.  Nonfilamentous C. albicans Mutants Are Avirulent , 1997, Cell.

[272]  P. Vaitkus,et al.  The ability of vegetation size on echocardiography to predict clinical complications: a meta-analysis. , 1997, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[273]  N. Nesher,et al.  [Acute fungal endocarditis due to Trichosporon beigelli]. , 1997, Harefuah.

[274]  B. Lytle,et al.  Fungal Prosthetic Valve Endocarditis in 16 Patients An 11‐Year Experience in a Tertiary Care Hospital , 1997, Medicine.

[275]  M. Martín,et al.  Comparison of voriconazole (UK-109,496) and itraconazole in prevention and treatment of Aspergillus fumigatus endocarditis in guinea pigs , 1997, Antimicrobial agents and chemotherapy.

[276]  R. Wiesner,et al.  Risk factors of invasive Candida and non-Candida fungal infections after liver transplantation. , 1996, Transplantation.

[277]  C. Douchet,et al.  Trichosporon inkin endocarditis: short-term evolution and clinical report. , 1996, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[278]  V. Blanc,et al.  Postoperative Cryptococcus neoformans endocarditi. , 1996, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[279]  V. Yu,et al.  Candida prosthetic valve endocarditis: prospective study of six cases and review of the literature. , 1996, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[280]  J. Guarro,et al.  Fungal endocarditis in premature infants: case report and review. , 1996, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[281]  B. Lytle,et al.  Surgical and long-term antifungal therapy for fungal prosthetic valve endocarditis. , 1995, The Annals of thoracic surgery.

[282]  R. Migrino,et al.  Deep tissue infections caused by Scopulariopsis brevicaulis: report of a case of prosthetic valve endocarditis and review. , 1995, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[283]  L. Baddour Long-term suppressive therapy for Candida parapsilosis-induced prosthetic valve endocarditis. , 1995, Mayo Clinic proceedings.

[284]  Chin‐Yun Lee,et al.  Fatal Fusarium endocarditis complicated by hemolytic anemia and thrombocytopenia in an infant. , 1994, The Pediatric infectious disease journal.

[285]  J. Granados,et al.  Recurrent Trichosporon Beigelii Endocarditis after Aortic Valve Replacement , 1994, Cardiovascular surgery.

[286]  J. Miro,et al.  Disseminated candidiasis in addicts who use brown heroin: report of 83 cases and review. , 1992, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[287]  A. Chignell Endogenous Candida Endophthalmitis , 1992, Journal of the Royal Society of Medicine.

[288]  I. Polacheck,et al.  Endocarditis caused by Blastoschizomyces capitatus and taxonomic review of the genus , 1992, Journal of clinical microbiology.

[289]  M. O'Reilly,et al.  A case of trichosporon beigelii endocarditis 8 years after aortic valve replacement , 1992, Clinical cardiology.

[290]  D. Denning,et al.  Endocarditis due to Trichosporon beigelii: in vitro susceptibility of isolates and review. , 1991, Reviews of infectious diseases.

[291]  D. Denning,et al.  Antifungal and surgical treatment of invasive aspergillosis: review of 2,121 published cases. , 1990, Reviews of infectious diseases.

[292]  V. Dato,et al.  Candidemia in children with central venous catheters: role of catheter removal and amphotericin B therapy , 1990, The Pediatric infectious disease journal.

[293]  F. Mandelli,et al.  Catheter-related right-sided endocarditis in bone marrow transplant recipients. , 1990, Reviews of infectious diseases.

[294]  G. Phillips,et al.  Invasive hyalohyphomycosis caused by Scopulariopsis brevicaulis in a patient undergoing allogeneic bone marrow transplant. , 1989, Diagnostic microbiology and infectious disease.

[295]  H. Krishnaswami,et al.  Experience with fungal infections affecting the heart in necropsies at an Indian hospital. , 1989, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[296]  J. Sobel,et al.  Prosthetic valve endocarditis caused by Trichosporon beigelii. , 1988, The American journal of medicine.

[297]  J. Miro,et al.  Systemic candidiasis in Spanish heroin addicts: a possible source of infection. , 1987, The Journal of infectious diseases.

[298]  G. Alpert,et al.  Malassezia furfur Fungemia in Infancy , 1987, Clinical pediatrics.

[299]  W. Pierce,et al.  Disseminated Trichosporon beigelii (cutaneum) infection in an artificial heart recipient. , 1986, JAMA.

[300]  W. Scheld,et al.  Yeast adhesion in the pathogenesis of endocarditis due to Candida albicans: studies with adherence-negative mutants. , 1985, The Journal of infectious diseases.

[301]  M. Stanley,et al.  Trichosporon beigelii endocarditis as a complication of peritoneovenous shunt. , 1985, Human pathology.

[302]  P. A. Leonard,et al.  Trichosporon cutaneum endocarditis: a sequela of intravenous drug abuse. , 1982, American journal of clinical pathology.

[303]  G. Wilner,et al.  Infective endocarditis caused by Paecilomyces varioti. , 1982, American journal of clinical pathology.

[304]  M. Sande,et al.  Yeast Adherence in the Pathogenesis of Candida Endocarditis 1 , 1981, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[305]  A. Prince,et al.  Aspergillus endocarditis in children: case report and review of the literature. , 1981, Pediatrics.

[306]  A. Prince,et al.  Aspergillus Endocarditis in Childen: Case Report and Review of the Literature , 1981, Pediatrics.

[307]  G. Lemole,et al.  Successful management of Penicillium endocarditis. , 1980, The Journal of thoracic and cardiovascular surgery.

[308]  H. D. Rose Venous catheter-associated candidemia. , 1978, The American journal of the medical sciences.

[309]  M. Rotondo,et al.  Candida albicans Endocarditis: Ultrastructural Studies of Vegetation Formation , 1978, Infection and immunity.

[310]  M. Sande,et al.  Experimental Candida albicans endocarditis: characterization of the disease and response to therapy , 1977, Infection and immunity.

[311]  J. McClellan,et al.  Paecilomyces varioti endocarditis on a prosthetic aortic valve. , 1976, The Journal of thoracic and cardiovascular surgery.

[312]  J. Rahal,et al.  FUNGAL ENDOCARDITIS: ANALYSIS OF 24 CASES AND REVIEW OF THE LITERATURE , 1975, Medicine.

[313]  Y. Naveh,et al.  Endocarditis caused by Rhodotorula successfully treated with 5-fluorocytosine. , 1975, British heart journal.

[314]  C. Upshaw Penicillium endocarditis of aortic valve prosthesis. , 1974, The Journal of thoracic and cardiovascular surgery.

[315]  J. Valone,et al.  EXPERIMENTAL ENDOCARDITIS * , 1974, Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases.

[316]  W. Hall Penicillium endocarditis following open heart surgery and prosthetic valve insertion. , 1974, American heart journal.

[317]  M. Levison,et al.  Cure of Aspergillus ustus endocarditis on a prosthetic valve. , 1974, Archives of internal medicine.

[318]  L. R. Freedman,et al.  Experimental endocarditis. IV. Tricuspid and aortic valve infection with Candida albicans in rabbits. , 1972, The Yale journal of biology and medicine.

[319]  D. Speller,et al.  Endocarditis caused by a Coprinus species: a fungus of the toadstool group. , 1971, Journal of medical microbiology.

[320]  M. Silver,et al.  Endocarditis caused by Paecilomyces varioti affecting an aortic valve allograft. , 1971, The Journal of thoracic and cardiovascular surgery.

[321]  J. Enders,et al.  Infectious Diseases Society of America. , 1969, Antimicrobial agents and chemotherapy.

[322]  R. Colmers,et al.  Cryptococcus neoformans endocarditis cured by amphotericin B. , 1967, JAMA.

[323]  R. Carey,et al.  Rhodotorula fungemia complicating staphylococcal endocarditis. , 1962, JAMA.

[324]  W. Roberts,et al.  Candida endocarditis. Clinical and pathologic studies. , 1962, The American journal of medicine.

[325]  S. M. Greenberg,et al.  Fungemia caused by certain nonpathogenic strains of the family Cryptococcaceae. Report of two cases due to Rhodotorula and Torulopsis glabrata. , 1960, The New England journal of medicine.

[326]  H. Dodge,et al.  Mycotic endocarditis; report of a case due to Cryptococcus neoformans. , 1957, The American journal of medicine.

[327]  N. Pond,et al.  Blastomycosis with cardiac involvement and peripheral embolization. , 1952, American heart journal.

[328]  W. D. Forbus,et al.  Coccidioidomycosis; a study of 95 cases of the disseminated type with special reference to the pathogenesis of the disease. , 1946, Military surgeon.

[329]  Eelco F. J. Meijer,et al.  Guideline Adherence Predicts Survival of Candidemia in Europe: Results from the ECMM Candida III Multinational European Study , 2022, SSRN Electronic Journal.

[330]  R. Sehgal,et al.  Disseminated Blastomycosis Presenting with Spontaneous Coronary Artery Dissection. , 2021, European journal of case reports in internal medicine.

[331]  E. Natour,et al.  Diagnostic value of imaging in infective endocarditis: a systematic review. , 2017, The Lancet. Infectious diseases.

[332]  M. Hoenigl,et al.  1,3-ß-d-Glucan testing is highly specific in patients undergoing dialysis treatment. , 2017, The Journal of infection.

[333]  A. Alrifai,et al.  Lower limb ischemia, Candida parapsilosis and prosthetic valve endocarditis. , 2016, QJM : monthly journal of the Association of Physicians.

[334]  S. Yuan Fungal Endocarditis , 2016, Brazilian journal of cardiovascular surgery.

[335]  S. Hatakeyama,et al.  Scedosporium prolificans Endocarditis: Case Report and Literature Review. , 2016, Internal medicine.

[336]  V. Fowler,et al.  Infective endocarditis , 2016, Nature Reviews Disease Primers.

[337]  J. Zamorano,et al.  [2015 ESC Guidelines for the management of infective endocarditis]. , 2015, Kardiologia polska.

[338]  P. Fournier,et al.  Update on blood culture-negative endocarditis. , 2015, Medecine et maladies infectieuses.

[339]  B. Kullberg,et al.  Invasive Candidiasis. , 2015, The New England journal of medicine.

[340]  M. Venditti Clinical Aspects of Invasive Candidiasis , 2012, Drugs.

[341]  S. Bijulal,et al.  Kodamaea ohmeri tricuspid valve endocarditis with right ventricular inflow obstruction in a neonate with structurally normal heart , 2011, Annals of pediatric cardiology.

[342]  C. Saldarriaga,et al.  [Endocarditis due to infection by Paecilomyces variotii]. , 2009, Biomedica : revista del Instituto Nacional de Salud.

[343]  Mónica Saiz Camín,et al.  [Fungal endocarditis in a patient bearing a valve prosthesis]. , 2007, Enfermedades infecciosas y microbiologia clinica.

[344]  Nina Singh,et al.  Infections due to Scedosporium apiospermum and Scedosporium prolificans in transplant recipients: clinical characteristics and impact of antifungal agent therapy on outcome. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[345]  B. Labar,et al.  [Risk factors for invasive fungal infections during intensive chemotherapy of acute leukemia--retrospective study]. , 2004, Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti.

[346]  T J Walsh,et al.  Infections due to emerging and uncommon medically important fungal pathogens. , 2004, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[347]  M E Ellis,et al.  Fungal endocarditis: evidence in the world literature, 1965-1995. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[348]  J. Pemán,et al.  [Endocarditis caused by Saccharomyces cerevisiae on the prosthetic valve]. , 2000, Enfermedades infecciosas y microbiologia clinica.

[349]  V. Fowler,et al.  Proposed Modifications to the Duke Criteria for the Diagnosis of Infective Endocarditis , 2000 .

[350]  A. Carpentier,et al.  Postoperative Cryptococcus neoformans endocarditis. , 1996, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[351]  L. Gentry,et al.  Scopulariopsis endocarditis associated with Duran ring valvuloplasty. , 1995, Texas Heart Institute journal.

[352]  E. Grebel,et al.  The cases of the , 1994 .

[353]  E. Haponik,et al.  Candida endocarditis. A treatable form of pacemaker infection. , 1993, Chest.

[354]  M. Terpenning Infective endocarditis. , 1992, Clinics in geriatric medicine.

[355]  J. Martínez-Lacasa,et al.  Long-term survival of a patient with prosthetic valve endocarditis due to Trichosporon beigelii. , 1991, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.

[356]  D. Thomas,et al.  Prosthetic valve endocarditis caused by Trichosporon cutaneum. , 1984, International journal of cardiology.

[357]  R. Marier,et al.  Trichosporon cutaneum endocarditis. , 1978, Scandinavian journal of infectious diseases.

[358]  J. Valone,et al.  Experimental endocarditis. , 1974, Annals of the New York Academy of Sciences.

[359]  P. Stein,et al.  Saccharomyces fungemia. , 1970, Chest.

[360]  D. Leeber,et al.  Rhodotorula fungemia presenting as "endotoxic" shock. , 1969, Archives of internal medicine.