Inference to the Best Manipulation - a case study of qualitative reasoning in neuropharmacy. Special Issue on Scientific Discovery and Creativity: Case Studies and Computational Approaches. Guest Editors: J. Meheus and T. Nickles

How can new drug lead suggestions beinferred from neurophysiological models? This paperaddresses this question based on a case study ofresearch into Parkinson's disease at the GroningenUniversity Department of Pharmacy. It is argued thatneurophysiological box-and-arrow models can beunderstood as qualitative differential equationmodels. An inference task is defined to helpunderstand and possibly aid the discovery andexplanation of new drug lead suggestions.