The mutational landscape of early‐ and typical‐onset oral tongue squamous cell carcinoma

The incidence of oral tongue squamous cell carcinoma (OTSCC) is increasing among younger birth cohorts. The etiology of early‐onset OTSCC (diagnosed before the age of 50 years) and cancer driver genes remain largely unknown.

[1]  J. Long,et al.  From tobacco smoking to cancer mutational signature: a mediation analysis strategy to explore the role of epigenetic changes , 2020, BMC Cancer.

[2]  J. Long,et al.  Integrative genomic analyses of APOBEC-mutational signature, expression and germline deletion of APOBEC3 genes, and immunogenicity in multiple cancer types , 2019, BMC Medical Genomics.

[3]  J. Long,et al.  Identifying Putative Susceptibility Genes and Evaluating Their Associations with Somatic Mutations in Human Cancers. , 2019, American journal of human genetics.

[4]  Mulin Jun Li,et al.  WITER: a powerful method for estimation of cancer-driver genes using a weighted iterative regression modelling background mutation counts , 2019, Nucleic acids research.

[5]  Mark Barnes,et al.  SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events , 2019, BMC Genomics.

[6]  R. Fåhraeus,et al.  Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue , 2018, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[7]  Arnoud Boot,et al.  Identification of novel mutational signatures in Asian oral squamous cell carcinomas associated with bacterial infections , 2018, bioRxiv.

[8]  Benjamin R Campbell,et al.  Early onset oral tongue cancer in the United States: A literature review. , 2018, Oral oncology.

[9]  B. L. James,et al.  Detection of High-Risk Human Papillomavirus in Oral Cavity Squamous Cell Carcinoma Using Multiple Analytes and Their Role in Patient Survival , 2018, Journal of global oncology.

[10]  P. Hammerman,et al.  Tumor PD-L1 expression is associated with improved survival and lower recurrence risk in young women with oral cavity squamous cell carcinoma. , 2017, International journal of oral and maxillofacial surgery.

[11]  E. Choi,et al.  Ataxin-1 is involved in tumorigenesis of cervical cancer cells via the EGFR–RAS–MAPK signaling pathway , 2017, Oncotarget.

[12]  Russell Bonneville,et al.  Landscape of Microsatellite Instability Across 39 Cancer Types. , 2017, JCO precision oncology.

[13]  A. Dutt,et al.  Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 as a candidate to predict metastases , 2017, Oral oncology.

[14]  Wendy Cozen,et al.  Rising incidence of oral tongue cancer among white men and women in the United States, 1973-2012. , 2017, Oral oncology.

[15]  Mu-Kuan Chen,et al.  Exome Sequencing of Oral Squamous Cell Carcinoma Reveals Molecular Subgroups and Novel Therapeutic Opportunities , 2017, Theranostics.

[16]  Seongman Kang,et al.  Ataxin-1 regulates epithelial–mesenchymal transition of cervical cancer cells , 2017, Oncotarget.

[17]  Jia Hui Ng,et al.  Changing epidemiology of oral squamous cell carcinoma of the tongue: A global study , 2017, Head & neck.

[18]  F. Calvo,et al.  Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts , 2016, Small GTPases.

[19]  F. Calvo,et al.  The Borg family of Cdc42 effector proteins Cdc42EP1–5 , 2016, Biochemical Society transactions.

[20]  Jeffrey N Myers,et al.  TP53 Mutations in Head and Neck Squamous Cell Carcinoma and Their Impact on Disease Progression and Treatment Response , 2016, Journal of cellular biochemistry.

[21]  N. Johnson,et al.  Global Epidemiology of Head and Neck Cancers: A Continuing Challenge , 2016, Oncology.

[22]  Brian A. King,et al.  Current Cigarette Smoking Among Adults - United States, 2005-2015. , 2016, MMWR. Morbidity and mortality weekly report.

[23]  M. Meyerson,et al.  Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke , 2015, Head & neck.

[24]  Costerwell Khyriem,et al.  Integrated analysis of oral tongue squamous cell carcinoma identifies key variants and pathways linked to risk habits, HPV, clinical parameters and tumor recurrence , 2015, bioRxiv.

[25]  C. Ong,et al.  Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance , 2015, Genome Medicine.

[26]  Carole Fakhry,et al.  Epidemiology of Human Papillomavirus-Positive Head and Neck Squamous Cell Carcinoma. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[27]  Nicolai J. Birkbak,et al.  Clonal status of actionable driver events and the timing of mutational processes in cancer evolution , 2015, Science Translational Medicine.

[28]  Olivier Lichtarge,et al.  Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer. , 2015, Cancer research.

[29]  Gretchen A. Stevens,et al.  Global trends and projections for tobacco use, 1990–2025: an analysis of smoking indicators from the WHO Comprehensive Information Systems for Tobacco Control , 2015, The Lancet.

[30]  Steven J. M. Jones,et al.  Comprehensive genomic characterization of head and neck squamous cell carcinomas , 2015, Nature.

[31]  Brian A. King,et al.  Current cigarette smoking among adults - United States, 2005-2014. , 2015, MMWR. Morbidity and mortality weekly report.

[32]  R. Gibbs,et al.  Squamous Cell Carcinoma of the Oral Tongue in Young Non-Smokers Is Genomically Similar to Tumors in Older Smokers , 2014, Clinical Cancer Research.

[33]  Jacques Ferlay,et al.  Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[34]  R. Gibbs,et al.  Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. , 2013, Cancer discovery.

[35]  B. Perez-Ordonez,et al.  Low etiologic fraction for high-risk human papillomavirus in oral cavity squamous cell carcinomas. , 2013, Oral oncology.

[36]  H. Zoghbi,et al.  ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. , 2011, Developmental cell.

[37]  K. Nakashiro,et al.  Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin. , 2011, Oncology reports.

[38]  Jianjie Ma,et al.  Ataxin‐1 and Brother of ataxin‐1 are components of the Notch signalling pathway , 2011, EMBO reports.

[39]  西川 由希子.  Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin , 2011 .

[40]  H. Hakonarson,et al.  ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data , 2010, Nucleic acids research.

[41]  S. Weed,et al.  Actin cytoskeletal mediators of motility and invasion amplified and overexpressed in head and neck cancer , 2008, Clinical & Experimental Metastasis.

[42]  A. Chaturvedi,et al.  Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[43]  A. Fersht,et al.  Structural basis for understanding oncogenic p53 mutations and designing rescue drugs , 2006, Proceedings of the National Academy of Sciences.

[44]  C. Harris,et al.  The IARC TP53 database: New online mutation analysis and recommendations to users , 2002, Human mutation.