Topiramate for Treatment in Patients With Migraine and Epilepsy

Antiepileptic drugs (AED) are often considered first line for monotherapy in treatment of patients with migraines, and also those with comorbid migraine and epilepsy. Topiramate, a newer generation AED, has broad mechanism of action and evidence of benefit in patients with either episodic or chronic migraine along with epilepsy, both generalized and focal.

[1]  D. Mccrory,et al.  Antiepileptics in migraine prophylaxis: An updated Cochrane review , 2015, Cephalalgia : an international journal of headache.

[2]  Elizabeth Salisbury-Afshar,et al.  Topiramate for the prophylaxis of episodic migraine in adults. , 2014, American family physician.

[3]  E. Chronicle,et al.  Antiepileptics other than gabapentin, pregabalin, topiramate, and valproate for the prophylaxis of episodic migraine in adults. , 2013, The Cochrane database of systematic reviews.

[4]  P. Patsalos.  Drug Interactions with the Newer Antiepileptic Drugs (AEDs)—Part 2: Pharmacokinetic and Pharmacodynamic Interactions Between AEDs and Drugs Used to Treat Non-Epilepsy Disorders , 2013, Clinical Pharmacokinetics.

[5]  P. Patsalos.  Drug Interactions with the Newer Antiepileptic Drugs (AEDs)—Part 1: Pharmacokinetic and Pharmacodynamic Interactions Between AEDs , 2013, Clinical Pharmacokinetics.

[6]  V. Martinelli,et al.  Migralepsy: a new case confirming the existence of this migraine complication and proposing therapy , 2013, Neurological Sciences.

[7]  Y. Ng,et al.  Update on the management of Lennox-Gastaut syndrome. , 2012, Pediatric neurology.

[8]  W. Hauser,et al.  Comparative safety of antiepileptic drugs during pregnancy , 2012, Neurology.

[9]  S. Silberstein,et al.  Evidence-based guideline update: Pharmacologic treatment for episodic migraine prevention in adults , 2012, Neurology.

[10]  S. E. Mohammadianinejad,et al.  Zonisamide Versus Topiramate in Migraine Prophylaxis: A Double-Blind Randomized Clinical Trial , 2011, Clinical neuropharmacology.

[11]  G. Sette,et al.  Zonisamide for Migraine Prophylaxis in Topiramate‐Intolerant Patients: An Observational Study , 2011, Headache.

[12]  J. Hulihan,et al.  A multicenter, outpatient, open-label study to evaluate the dosing, effectiveness, and safety of topiramate as monotherapy in the treatment of epilepsy in clinical practice , 2009, Epilepsy & Behavior.

[13]  M. Martinez-frias,et al.  TOPIRAMATE IN PREGNANCY: PRELIMINARY EXPERIENCE FROM THE UK EPILEPSY AND PREGNANCY REGISTER , 2009, Neurology.

[14]  Ferrari,et al.  Are Migraineurs at Increased Risk of Adverse Drug Responses?: A Meta‐Analytic Comparison of Topiramate‐Related Adverse Drug Reactions in Epilepsy and Migraine , 2009, Clinical pharmacology and therapeutics.

[15]  V. Shaygannejad,et al.  A double‐blind, randomized trial of low‐dose topiramate vs propranolol in migraine prophylaxis , 2008, Acta neurologica Scandinavica.

[16]  Josemir W Sander,et al.  Topiramate monotherapy in the treatment of newly or recently diagnosed epilepsy. , 2008, Clinical therapeutics.

[17]  B. Uthman,et al.  Topiramate in older patients with partial‐onset seizures: A pilot double‐blind, dose‐comparison study , 2008, Epilepsia.

[18]  G. Comi,et al.  Headache therapy with neuronal stabilising drugs , 2008, Neurological Sciences.

[19]  M. Ferrari,et al.  A Review of the Genetic Relation Between Migraine and Epilepsy , 2008, Cephalalgia : an international journal of headache.

[20]  D. Capobianco,et al.  Headache and Other Craniofacial Pain , 2008 .

[21]  H. Diener,et al.  Topiramate Reduces Headache Days in Chronic Migraine: A Randomized, Double-Blind, Placebo-Controlled Study , 2007, Cephalalgia : an international journal of headache.

[22]  Jing Shen,et al.  The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial , 2007, The Lancet.

[23]  M. Dickson,et al.  Topiramate prescribing patterns among medicaid patients: diagnosis, comorbidities, and dosing. , 2007, Clinical therapeutics.

[24]  G. Shukla,et al.  Low‐Dose Topiramate Versus Lamotrigine in Migraine Prophylaxis (The Lotolamp Study) , 2006, Headache.

[25]  K. Haynes,et al.  Use of Antiepileptic Drugs in Patients with Kidney Disease , 2006, Seminars in dialysis.

[26]  S. Silberstein,et al.  Efficacy and tolerability of topiramate 200 mg/d in the prevention of migraine with/without aura in adults: a randomized, placebo-controlled, double-blind, 12-week pilot study. , 2006, Clinical therapeutics.

[27]  V. Shaygannejad,et al.  Comparison of the Effect of Topiramate and Sodium Valporate in Migraine Prevention: A Randomized Blinded Crossover Study , 2006, Headache.

[28]  R. Wenzel,et al.  Topiramate for Migraine Prevention , 2006, Pharmacotherapy.

[29]  E. Bromfield,et al.  A Case of “Migralepsy” , 2005, Epilepsia.

[30]  D. Naritoku,et al.  Randomized dose‐controlled study of topiramate as first‐line therapy in epilepsy , 2005, Acta neurologica Scandinavica.

[31]  G. Bussone,et al.  Topiramate in migraine prophylaxis , 2005, Neurological Sciences.

[32]  S. Silberstein.  Topiramate in Migraine Prevention , 2005, Headache.

[33]  E. Ben-Menachem,et al.  Topiramate monotherapy in epilepsy and migraine prevention. , 2005, Clinical therapeutics.

[34]  E. Perucca,et al.  Topiramate Pharmacokinetics in Children and Adults with Epilepsy , 2005, Clinical pharmacokinetics.

[35]  P. Goadsby,et al.  Topiramate Inhibits Trigeminovascular Neurons in the Cat , 2004, Cephalalgia : an international journal of headache.

[36]  H. Diener,et al.  Research Letters , 2012, Indian Pediatrics.

[37]  S. Silberstein,et al.  Anticonvulsants in migraine , 2004, Current pain and headache reports.

[38]  B. Bourgeois,et al.  Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new onset epilepsy , 2004, Neurology.

[39]  B. Bourgeois,et al.  CME Efficacy and tolerability of the new antiepileptic drugs I : Treatment of new onset epilepsy Report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society , 2004 .

[40]  S. Silberstein,et al.  Topiramate in Migraine Prevention: Results of a Large Controlled Trial , 2004 .

[41]  J. Saper,et al.  Topiramate for migraine prevention: a randomized controlled trial. , 2004, JAMA.

[42]  E. Perucca,et al.  Influence of Dosage, Age, and Co-medication on Plasma Topiramate Concentrations in Children and Adults with Severe Epilepsy and Preliminary Observations on Correlations with Clinical Response , 2003, Therapeutic drug monitoring.

[43]  R. Mattson,et al.  Topiramate, carbamazepine and valproate monotherapy: double‐blind comparison in newly diagnosed epilepsy , 2003, Acta neurologica Scandinavica.

[44]  G. Pledger,et al.  A dose-comparison trial of topiramate as monotherapy in recently diagnosed partial epilepsy , 2003, Neurology.

[45]  H. Cross,et al.  Treatment of Lennox-Gastaut syndrome. , 2003, The Cochrane database of systematic reviews.

[46]  J R Storey,et al.  Topiramate in Migraine Prevention: A Double‐Blind, Placebo‐Controlled Study , 2001, Headache.

[47]  E. Perucca,et al.  Is There a Role for Therapeutic Drug Monitoring of New Anticonvulsants? , 2000, Clinical pharmacokinetics.

[48]  S. Skradski,et al.  Topiramate Blocks Kainate‐Evoked Cobalt Influx into Cultured Neurons , 2000, Epilepsia.

[49]  S. Sombati,et al.  Effects of Topiramate on Sustained Repetitive Firing and Spontaneous Recurrent Seizure Discharges in Cultured Hippocampal Neurons , 2000, Epilepsia.

[50]  S. Sombati,et al.  Cellular Actions of Topiramate: Blockade of Kainate‐Evoked Inward Currents in Cultured Hippocampal Neurons , 2000, Epilepsia.

[51]  R. Shank,et al.  An Overview of the Preclinical Aspects of Topiramate: Pharmacology, Pharmacokinetics, and Mechanism of Action , 2000, Epilepsia.

[52]  P. Carlen,et al.  Modulation of High‐Voltage–Activated Calcium Channels in Dentate Granule Cells by Topiramate , 2000, Epilepsia.

[53]  G. Pledger,et al.  A randomized, placebo-controlled study of topiramate in primary generalized tonic-clonic seizures , 1999, Neurology.

[54]  S. Brown,et al.  Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold , 1997, Epilepsy Research.

[55]  E. Ben-Menachem,et al.  Double‐Blind, Placebo‐Controlled Trial of Topiramate as Add‐on Therapy in Patients with Refractory Partial Seizures , 1996, Epilepsia.

[56]  G. Pledger,et al.  Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-, 800-, and 1,000-mg daily dosages , 1996, Neurology.

[57]  G. Pledger,et al.  Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages , 1996, Neurology.

[58]  S. Silberstein,et al.  Migraine prophylaxis with divalproex. , 1995, Archives of neurology.

[59]  Richard B. Lipton,et al.  Comorbidity of migraine and epilepsy , 1994, Neurology.

[60]  J. Olesen,et al.  Sodium valproate has a prophylactic effect in migraine without aura , 1994, Neurology.

[61]  R. Hering,et al.  Sodium Valproate in The Prophylactic Treatment of Migraine: A Double-Blind Study Versus Placebo , 1992, Cephalalgia : an international journal of headache.

[62]  L. Badalian,et al.  [Epilepsy and migraine]. , 1969, Klinicheskaia meditsina.