FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent manner

[1]  B. Henkelmann,et al.  A non-canonical vitamin K cycle is a potent ferroptosis suppressor , 2022, Nature.

[2]  Weishi Li,et al.  The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights , 2022, Experimental & Molecular Medicine.

[3]  B. Stockwell Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications , 2022, Cell.

[4]  Dong-Hyun Kim,et al.  Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes , 2022, Redox biology.

[5]  Yang Xu,et al.  Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation , 2022, Redox biology.

[6]  Kellen L. Olszewski,et al.  A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers , 2022, Nature Communications.

[7]  L. Ye,et al.  Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer , 2021, Cell death & disease.

[8]  S. Dixon,et al.  Ferroptosis regulation by the NGLY1/NFE2L1 pathway , 2021, bioRxiv.

[9]  S. Lemon,et al.  FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication. , 2021, Cell chemical biology.

[10]  Y. Huh,et al.  Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer. , 2020, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Alexander R. Pico,et al.  WikiPathways: connecting communities , 2020, Nucleic Acids Res..

[12]  Shu-ji Li,et al.  ATF6 aggravates acinar cell apoptosis and injury by regulating p53/AIFM2 transcription in Severe Acute Pancreatitis , 2020, Theranostics.

[13]  Stephen A. Sastra,et al.  Cysteine depletion induces pancreatic tumor ferroptosis in mice , 2020, Science.

[14]  F. Ursini,et al.  Lipid peroxidation and ferroptosis: The role of GSH and GPx4. , 2020, Free radical biology & medicine.

[15]  I. Bahar,et al.  Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death , 2020, Nature Chemical Biology.

[16]  E. Robert McDonald,et al.  Quantitative Proteomics of the Cancer Cell Line Encyclopedia , 2020, Cell.

[17]  Edward W. Tate,et al.  FSP1 is a glutathione-independent ferroptosis suppressor , 2019, Nature.

[18]  J. Olzmann,et al.  The CoQ oxidoreductase FSP1 acts in parallel to GPX4 to inhibit ferroptosis , 2019, Nature.

[19]  G. Sethi,et al.  Antioxidant response elements: Discovery, classes, regulation and potential applications , 2018, Redox biology.

[20]  Aikseng Ooi,et al.  The Roles of NRF2 in Modulating Cellular Iron Homeostasis , 2017, Antioxidants & redox signaling.

[21]  G. Kroemer,et al.  The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. , 2017, Cell reports.

[22]  Akhileshwar Namani,et al.  NRF2-regulated metabolic gene signature as a prognostic biomarker in non-small cell lung cancer , 2017, Oncotarget.

[23]  Masayuki Yamamoto,et al.  The KEAP1–NRF2 System in Cancer , 2017, Front. Oncol..

[24]  O. Pardo,et al.  Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine , 2017, Cell reports.

[25]  Leonard D. Goldstein,et al.  Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers. , 2016, Cell reports.

[26]  B. Stockwell,et al.  Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis , 2016, Proceedings of the National Academy of Sciences.

[27]  C. Zappa,et al.  Non-small cell lung cancer: current treatment and future advances. , 2016, Translational lung cancer research.

[28]  S. Dixon,et al.  Mechanisms of ferroptosis , 2016, Cellular and Molecular Life Sciences.

[29]  D. Tang,et al.  Ferroptosis: process and function , 2016, Cell Death and Differentiation.

[30]  D. Tang,et al.  Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells , 2016, Hepatology.

[31]  D. Ferguson,et al.  Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405 , 2015, PloS one.

[32]  W. Gu,et al.  Ferroptosis as a p53-mediated activity during tumour suppression , 2015, Nature.

[33]  Jin Ock Kim,et al.  miR-185 Plays an Anti-Hypertrophic Role in the Heart via Multiple Targets in the Calcium-Signaling Pathways , 2015, PloS one.

[34]  Steven J. M. Jones,et al.  Comprehensive molecular profiling of lung adenocarcinoma , 2014, Nature.

[35]  Matthew E. Welsch,et al.  Regulation of Ferroptotic Cancer Cell Death by GPX4 , 2014, Cell.

[36]  A. Levonen,et al.  The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer☆ , 2013, Redox biology.

[37]  Hye Eun Lee,et al.  Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. , 2013, Cell metabolism.

[38]  M. R. Lamprecht,et al.  Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death , 2012, Cell.

[39]  Michelle R. Campbell,et al.  Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha , 2012, Nucleic acids research.

[40]  Akira Mogi,et al.  TP53 Mutations in Nonsmall Cell Lung Cancer , 2011, Journal of biomedicine & biotechnology.

[41]  M. McMahon,et al.  NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. , 2009, Trends in biochemical sciences.

[42]  B. Stockwell,et al.  Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. , 2008, Chemistry & biology.

[43]  J. Herman,et al.  Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer , 2006, PLoS medicine.

[44]  Tsutomu Ohta,et al.  Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. , 2006, Molecular cell.

[45]  T. Hagen,et al.  Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[46]  Simon C Watkins,et al.  Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. , 2017, Nature chemical biology.

[47]  A. Walch,et al.  ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. , 2017, Nature chemical biology.