FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent manner
暂无分享,去创建一个
Kyoung-Jin Oh | Ji-Yoon Lee | S. Bae | W. Kim | Sang Chul Lee | Sangok Kim | Haeseung Lee | B. Han | H. Ban | Kwang-Hee Bae | Eun-Woo Lee | Jong Woo Kim | H. Kim | Min-Ju Kim | Tae-Hee Han
[1] B. Henkelmann,et al. A non-canonical vitamin K cycle is a potent ferroptosis suppressor , 2022, Nature.
[2] Weishi Li,et al. The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights , 2022, Experimental & Molecular Medicine.
[3] B. Stockwell. Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications , 2022, Cell.
[4] Dong-Hyun Kim,et al. Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes , 2022, Redox biology.
[5] Yang Xu,et al. Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation , 2022, Redox biology.
[6] Kellen L. Olszewski,et al. A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers , 2022, Nature Communications.
[7] L. Ye,et al. Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer , 2021, Cell death & disease.
[8] S. Dixon,et al. Ferroptosis regulation by the NGLY1/NFE2L1 pathway , 2021, bioRxiv.
[9] S. Lemon,et al. FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication. , 2021, Cell chemical biology.
[10] Y. Huh,et al. Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer. , 2020, Proceedings of the National Academy of Sciences of the United States of America.
[11] Alexander R. Pico,et al. WikiPathways: connecting communities , 2020, Nucleic Acids Res..
[12] Shu-ji Li,et al. ATF6 aggravates acinar cell apoptosis and injury by regulating p53/AIFM2 transcription in Severe Acute Pancreatitis , 2020, Theranostics.
[13] Stephen A. Sastra,et al. Cysteine depletion induces pancreatic tumor ferroptosis in mice , 2020, Science.
[14] F. Ursini,et al. Lipid peroxidation and ferroptosis: The role of GSH and GPx4. , 2020, Free radical biology & medicine.
[15] I. Bahar,et al. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death , 2020, Nature Chemical Biology.
[16] E. Robert McDonald,et al. Quantitative Proteomics of the Cancer Cell Line Encyclopedia , 2020, Cell.
[17] Edward W. Tate,et al. FSP1 is a glutathione-independent ferroptosis suppressor , 2019, Nature.
[18] J. Olzmann,et al. The CoQ oxidoreductase FSP1 acts in parallel to GPX4 to inhibit ferroptosis , 2019, Nature.
[19] G. Sethi,et al. Antioxidant response elements: Discovery, classes, regulation and potential applications , 2018, Redox biology.
[20] Aikseng Ooi,et al. The Roles of NRF2 in Modulating Cellular Iron Homeostasis , 2017, Antioxidants & redox signaling.
[21] G. Kroemer,et al. The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. , 2017, Cell reports.
[22] Akhileshwar Namani,et al. NRF2-regulated metabolic gene signature as a prognostic biomarker in non-small cell lung cancer , 2017, Oncotarget.
[23] Masayuki Yamamoto,et al. The KEAP1–NRF2 System in Cancer , 2017, Front. Oncol..
[24] O. Pardo,et al. Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine , 2017, Cell reports.
[25] Leonard D. Goldstein,et al. Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers. , 2016, Cell reports.
[26] B. Stockwell,et al. Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis , 2016, Proceedings of the National Academy of Sciences.
[27] C. Zappa,et al. Non-small cell lung cancer: current treatment and future advances. , 2016, Translational lung cancer research.
[28] S. Dixon,et al. Mechanisms of ferroptosis , 2016, Cellular and Molecular Life Sciences.
[29] D. Tang,et al. Ferroptosis: process and function , 2016, Cell Death and Differentiation.
[30] D. Tang,et al. Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells , 2016, Hepatology.
[31] D. Ferguson,et al. Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405 , 2015, PloS one.
[32] W. Gu,et al. Ferroptosis as a p53-mediated activity during tumour suppression , 2015, Nature.
[33] Jin Ock Kim,et al. miR-185 Plays an Anti-Hypertrophic Role in the Heart via Multiple Targets in the Calcium-Signaling Pathways , 2015, PloS one.
[34] Steven J. M. Jones,et al. Comprehensive molecular profiling of lung adenocarcinoma , 2014, Nature.
[35] Matthew E. Welsch,et al. Regulation of Ferroptotic Cancer Cell Death by GPX4 , 2014, Cell.
[36] A. Levonen,et al. The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer☆ , 2013, Redox biology.
[37] Hye Eun Lee,et al. Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. , 2013, Cell metabolism.
[38] M. R. Lamprecht,et al. Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death , 2012, Cell.
[39] Michelle R. Campbell,et al. Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha , 2012, Nucleic acids research.
[40] Akira Mogi,et al. TP53 Mutations in Nonsmall Cell Lung Cancer , 2011, Journal of biomedicine & biotechnology.
[41] M. McMahon,et al. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. , 2009, Trends in biochemical sciences.
[42] B. Stockwell,et al. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. , 2008, Chemistry & biology.
[43] J. Herman,et al. Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer , 2006, PLoS medicine.
[44] Tsutomu Ohta,et al. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. , 2006, Molecular cell.
[45] T. Hagen,et al. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[46] Simon C Watkins,et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. , 2017, Nature chemical biology.
[47] A. Walch,et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. , 2017, Nature chemical biology.