A Homologation Approach to the Synthesis of Difluorinated Cycloalkynes.
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The starting material (I) is synthesized beginning with the difluorination of cycloheptane-1,3-dione using Selectfluor, mono-Wittig olefination and hydrogenation of the olefin moiety.
[1] C. Bertozzi,et al. A Homologation Approach to the Synthesis of Difluorinated Cycloalkynes , 2014, Organic letters.