Comparative in vitro efficacy of a hyaluronic acid (HA) matrix ingredient containing HA, dermatan sulphate and collagen (Dermial®) versus pure HA from extraction or fermentation origin

Hyaluronic acid (HA) is a high‐molecular‐weight polysaccharide composed of glucuronic acid and N‐acetylglucosamine. HA constitutes a major component of the extracellular matrix (ECM) of the skin. With aging, the amount of HA in skin decreases, which implies a loss of skin moisture causing wrinkles, sagging and aging of the skin. Oral supplementation with HA has been widely studied in order to provide an anti‐aging effect on the skin. There are mainly two types of HA: HA of fermentation and HA of extraction from a natural source. Dermial® is a HA matrix ingredient composed of HA and other naturally occurring components such as, dermatan sulphate and collagen, which have been shown to exert beneficial effects for skin health.