Challenges and emerging technologies in the immunoisolation of cells and tissues.

[1]  Dong Yun Lee,et al.  Highly poly(ethylene) glycolylated islets improve long-term islet allograft survival without immunosuppressive medication. , 2007, Tissue engineering.

[2]  Nalinkanth G. Veerabadran,et al.  Nanoencapsulation of stem cells within polyelectrolyte multilayer shells. , 2007, Macromolecular bioscience.

[3]  Lara Leoni,et al.  Biocompatibility of nanoporous alumina membranes for immunoisolation. , 2007, Biomaterials.

[4]  M. Taniguchi,et al.  Successful Islet Transplantation to Two Recipients From a Single Donor by Targeting Proinflammatory Cytokines in Mice , 2007, Transplantation.

[5]  S. Nagel,et al.  Immunoisolating pancreatic islets by encapsulation with selective withdrawal. , 2007, Small.

[6]  Jean-Luc Dulong,et al.  A theoretical study of oxygen transfer including cell necrosis for the design of a bioartificial pancreas , 2007, Biotechnology and bioengineering.

[7]  Youngro Byun,et al.  Functional and histological evaluation of transplanted pancreatic islets immunoprotected by PEGylation and cyclosporine for 1 year. , 2007, Biomaterials.

[8]  C. Nastruzzi,et al.  Encapsulation, in vitro characterization, and in vivo biocompatibility of Sertoli cells in alginate-based microcapsules. , 2007, Tissue engineering.

[9]  A. Sambanis,et al.  Modeling of encapsulated cell systems. , 2007, Journal of theoretical biology.

[10]  E. Chaikof,et al.  In vivo biocompatibility and stability of a substrate-supported polymerizable membrane-mimetic film. , 2007, Biomaterials.

[11]  S. Sugiura,et al.  Microfabricated airflow nozzle for microencapsulation of living cells into 150 micrometer microcapsules , 2007, Biomedical microdevices.

[12]  H. Iwata,et al.  Encapsulation of islets with ultra-thin polyion complex membrane through poly(ethylene glycol)-phospholipids anchored to cell membrane. , 2006, Biomaterials.

[13]  Y. Tabata,et al.  Maintenance of Neovascularization at the Implantation Site of an Artificial Device by bFGF and Endothelial Cell Transplant , 2006, Cell transplantation.

[14]  P. de Vos,et al.  Alginate-based microcapsules for immunoisolation of pancreatic islets. , 2006, Biomaterials.

[15]  Maryam Tabrizian,et al.  Biorecognition through layer-by-layer polyelectrolyte assembly: in-situ hybridization on living cells. , 2006, Biomacromolecules.

[16]  A. Gliozzi,et al.  Multilayer nanoencapsulation. New approach for immune protection of human pancreatic islets. , 2006, Nano letters.

[17]  E. Vasheghani-Farahani,et al.  A method to optimize PEG-coating of red blood cells. , 2006, Bioconjugate chemistry.

[18]  J. Pedraz,et al.  Biocompatibility of alginate-poly-L-lysine microcapsules for cell therapy. , 2006, Biomaterials.

[19]  K. Anseth,et al.  Synthesis of immunoisolation barriers that provide localized immunosuppression for encapsulated pancreatic islets. , 2006, Bioconjugate chemistry.

[20]  C. Ricordi,et al.  Reversal of Diabetes by Pancreatic Islet Transplantation into a Subcutaneous, Neovascularized Device , 2006, Transplantation.

[21]  Denis Dufrane,et al.  Six-Month Survival of Microencapsulated Pig Islets and Alginate Biocompatibility in Primates: Proof of Concept , 2006, Transplantation.

[22]  Seungpyo Hong,et al.  Interaction of polycationic polymers with supported lipid bilayers and cells: nanoscale hole formation and enhanced membrane permeability. , 2006, Bioconjugate chemistry.

[23]  E. Chaikof,et al.  Catalytic efficiency of a thrombomodulin-functionalized membrane-mimetic film in a flow model. , 2006, Biomaterials.

[24]  R. Bretzel,et al.  Ischaemia is linked to inflammation and induction of angiogenesis in pancreatic islets , 2006, Clinical and experimental immunology.

[25]  H. Drexler,et al.  Cell-based therapy for heart failure , 2006, Current opinion in cardiology.

[26]  E. Jansen,et al.  A Novel Method of Monitoring Response to Islet Transplantation: Bioluminescent Imaging of an NF-kB Transgenic Mouse Model , 2006, Transplantation.

[27]  E. Chaikof,et al.  Membrane-mimetic films containing thrombomodulin and heparin inhibit tissue factor-induced thrombin generation in a flow model. , 2006, Biomaterials.

[28]  E. Chaikof,et al.  Fabrication and characterization of heparin functionalized membrane-mimetic assemblies. , 2006, Biomaterials.

[29]  Tatsuya Kin,et al.  Survival of Microencapsulated Islets at 400 Days Posttransplantation in the Omental Pouch of NOD Mice , 2006, Cell transplantation.

[30]  Dong Yun Lee,et al.  A new strategy toward improving immunoprotection in cell therapy for diabetes mellitus: long-functioning PEGylated islets in vivo. , 2006, Tissue engineering.

[31]  G. Remuzzi,et al.  Biocompatibility and function of microencapsulated pancreatic islets. , 2006, Acta biomaterialia.

[32]  Mathias Winterhalter,et al.  Protection of mammalian cell used in biosensors by coating with a polyelectrolyte shell. , 2006, Biosensors & bioelectronics.

[33]  Carol Tucker-Burden,et al.  Immune responses to an encapsulated allogeneic islet beta-cell line in diabetic NOD mice. , 2006, Biochemical and biophysical research communications.

[34]  Dong Yun Lee,et al.  A combination therapy of PEGylation and immunosuppressive agent for successful islet transplantation. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[35]  A. Gliozzi,et al.  Interaction of polyelectrolytes and their composites with living cells. , 2005, Nano letters.

[36]  A. Khademhosseini,et al.  Conformal coating of mammalian cells immobilized onto magnetically driven beads. , 2005, Tissue engineering.

[37]  Carlo Rossi,et al.  Ketoprofen controlled release from composite microcapsules for cell encapsulation: effect on post-transplant acute inflammation. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[38]  L. Nielsen,et al.  Emulsion strategies in the microencapsulation of cells: pathways to thin coherent membranes. , 2005, Biotechnology and bioengineering.

[39]  A. Vasconcellos,et al.  Intraperitoneal alginate-encapsulated neonatal porcine islets in a placebo-controlled study with 16 diabetic cynomolgus primates. , 2005, Transplantation proceedings.

[40]  Eduardo Bracho-Blanchet,et al.  Xenotransplantation of porcine neonatal islets of Langerhans and Sertoli cells: a 4-year study. , 2005, European journal of endocrinology.

[41]  L. Shapiro,et al.  Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[42]  R. Robitaille,et al.  Inflammatory response to peritoneal implantation of alginate-poly-L-lysine microcapsules. , 2005, Biomaterials.

[43]  Liping Tang,et al.  Molecular determinants of biocompatibility , 2005, Expert review of medical devices.

[44]  R. Perfetti,et al.  Intrasplenic Transplantation of Encapsulated Genetically Engineered Mouse Insulinoma Cells Reverses Streptozotocin-Induced Diabetes in Rats , 2005, Cell transplantation.

[45]  K. Ekdahl,et al.  Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation. , 2005 .

[46]  P. de Vos,et al.  Deletion of the tissue response against alginate-pll capsules by temporary release of co-encapsulated steroids. , 2005, Biomaterials.

[47]  N. Barshes,et al.  islet transplantation: implications for intrahepatic grafts , 2022 .

[48]  J. Gaglia,et al.  Islet transplantation: progress and challenge. , 2005, Archives of medical research.

[49]  C. Esmon,et al.  Coagulation inhibitors in inflammation. , 2005, Biochemical Society transactions.

[50]  Liping Su,et al.  A novel approach to tumor suppression using microencapsulated engineered J558/TNF-alpha cells. , 2005, Experimental oncology.

[51]  T. Matsuda,et al.  Inhibition of p38 Pathway Suppresses Human Islet Production of Pro‐Inflammatory Cytokines and Improves Islet Graft Function , 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[52]  B. Manjula,et al.  Surface decoration of red blood cells with maleimidophenyl‐polyethylene glycol facilitated by thiolation with iminothiolane: an approach to mask A, B, and D antigens to generate universal red blood cells , 2005, Transfusion.

[53]  Heiko Zimmermann,et al.  Long-term graft function of adult rat and human islets encapsulated in novel alginate-based microcapsules after transplantation in immunocompetent diabetic mice. , 2005, Diabetes.

[54]  B. Hering,et al.  Inhibition of Cellular Immune Responses to Encapsulated Porcine Islet Xenografts by Simultaneous Blockade of Two Different Costimulatory Pathways , 2005, Transplantation.

[55]  D. Hunkeler,et al.  Effect of Microcapsule Composition and Short-Term Immunosuppression on Intraportal Biocompatibility , 2005, Cell transplantation.

[56]  J. Contreras,et al.  Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation. , 2005, Biomaterials.

[57]  J. Bromberg,et al.  Role of donor-derived monocyte chemoattractant protein-1 in murine islet transplantation. , 2005, Journal of the American Society of Nephrology : JASN.

[58]  M. Doser,et al.  Encapsulation of Islets in Rough Surface, Hydroxymethylated Polysulfone Capillaries Stimulates VEGF Release and Promotes Vascularization after Transplantation , 2005, Cell transplantation.

[59]  G. Weir,et al.  Long-Term Normoglycemia in Rats Receiving Transplants with Encapsulated Islets , 2005, Transplantation.

[60]  P. Brunetti,et al.  Optimized parameters for microencapsulation of pancreatic islet cells: an in vitro study clueing on islet graft immunoprotection in type 1 diabetes mellitus. , 2004, Transplant immunology.

[61]  G. Weir,et al.  Survival of Microencapsulated Adult Pig Islets in Mice In Spite of an Antibody Response , 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[62]  Michael V Sefton,et al.  In Vivo Recognition by the Host Adaptive Immune System of Microencapsulated Xenogeneic Cells , 2004, Transplantation.

[63]  E. Bonifacio,et al.  Tissue factor and CCL2/monocyte chemoattractant protein-1 released by human islets affect islet engraftment in type 1 diabetic recipients. , 2004, The Journal of clinical endocrinology and metabolism.

[64]  José A Fernández,et al.  Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death. , 2004, Diabetes.

[65]  P Aebischer,et al.  Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study. , 2004, Human gene therapy.

[66]  R. Bottino,et al.  Response of human islets to isolation stress and the effect of antioxidant treatment. , 2004, Diabetes.

[67]  C. Esmon Interactions between the innate immune and blood coagulation systems , 2004, Trends in Immunology.

[68]  Y. Bae,et al.  Prolonged Glucose Normalization of Streptozotocin-Induced Diabetic Mice by Transplantation of Rat Islets Coencapsulated with Crosslinked Hemoglobin , 2004, Transplantation.

[69]  Dong Yun Lee,et al.  Immune reactions of lymphocytes and macrophages against PEG-grafted pancreatic islets. , 2004, Biomaterials.

[70]  P. de Vos,et al.  University of Groningen Factors influencing functional survival of microencapsulated islet grafts , 2004 .

[71]  J. Contreras,et al.  NOVEL APPROACH TO XENOTRANSPLANTATION COMBINING SURFACE ENGINEERING AND GENETIC MODIFICATION OF ISOLATED ADULT PORCINE ISLETS. , 2004, Surgery.

[72]  K. M. Faucher,et al.  A membrane-mimetic barrier for islet encapsulation. , 2004, Transplantation proceedings.

[73]  C. Esmon Crosstalk between inflammation and thrombosis. , 2004, Maturitas.

[74]  A. Gliozzi,et al.  Nanocapsules: coating for living cells , 2004, IEEE Transactions on NanoBioscience.

[75]  R. Georgieva,et al.  Permeability and conductivity of red blood cell templated polyelectrolyte capsules coated with supplementary layers. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[76]  J. Holgersson,et al.  Adult porcine islets produce MCP‐1 and recruit human monocytes in vitro , 2004, Xenotransplantation.

[77]  R. Robertson Islet transplantation as a treatment for diabetes - a work in progress. , 2004, The New England journal of medicine.

[78]  Tejal A Desai,et al.  Micromachined biocapsules for cell-based sensing and delivery. , 2004, Advanced drug delivery reviews.

[79]  Gorka Orive,et al.  History, challenges and perspectives of cell microencapsulation. , 2004, Trends in biotechnology.

[80]  M. Scott,et al.  Beyond the red cell: pegylation of other blood cells and tissues. , 2004, Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine.

[81]  Y. Bae,et al.  Protection of insulin secreting cells from nitric oxide induced cellular damage by crosslinked hemoglobin. , 2004, Biomaterials.

[82]  Dong Yun Lee,et al.  Effect of polyethylene glycol grafted onto islet capsules on prevention of splenocyte and cytokine attacks , 2004, Journal of biomaterials science. Polymer edition.

[83]  B. Rollins,et al.  Blocking the Monocyte Chemoattractant Protein-1/CCR2 Chemokine Pathway Induces Permanent Survival of Islet Allografts through a Programmed Death-1 Ligand-1-Dependent Mechanism 1 , 2003, The Journal of Immunology.

[84]  R. van Schilfgaarde,et al.  Macrophage overgrowth affects neighboring nonovergrown encapsulated islets. , 2003, The Journal of surgical research.

[85]  T. Orłowski,et al.  The influence of intraperitoneal transplantation of free and encapsulated Langerhans islets on the second set phenomenon. , 2003, Artificial organs.

[86]  Paul A. De Bank,et al.  Chemical modification of mammalian cell surfaces. , 2003, Chemical Society reviews.

[87]  M. Scott,et al.  Immunocamouflage: prevention of transfusion-induced graft-versus-host disease via polymer grafting of donor cells. , 2003, Journal of biomedical materials research. Part A.

[88]  P. Kann,et al.  Intraportal transplantation of allogenic pancreatic islets encapsulated in barium alginate beads in diabetic rats. , 2003, Artificial organs.

[89]  C. Ricordi,et al.  Edmonton's islet success has indeed been replicated elsewhere , 2003, The Lancet.

[90]  P. de Vos,et al.  Factors Influencing Insulin Secretion from Encapsulated Islets , 2003, Cell transplantation.

[91]  S. Sigrist,et al.  Influence of VEGF on the Viability of Encapsulated Pancreatic Rat Islets after Transplantation in Diabetic Mice , 2003, Cell transplantation.

[92]  U. Johansson,et al.  Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation. , 2003, Biochemical and biophysical research communications.

[93]  C. Nastruzzi,et al.  Multifunctional microcapsules for pancreatic islet cell entrapment: design, preparation and in vitro characterization. , 2003, Biomaterials.

[94]  C. Mathieu,et al.  Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agents , 2003, Diabetologia.

[95]  C. Esmon Inflammation and thrombosis , 2003, Journal of thrombosis and haemostasis : JTH.

[96]  S. Sigrist,et al.  Induction of Angiogenesis in Omentum with Vascular Endothelial Growth Factor: Influence on the Viability of Encapsulated Rat Pancreatic Islets during Transplantation , 2003, Journal of Vascular Research.

[97]  M. Tabrizian,et al.  Nanocoatings onto arteries via layer-by-layer deposition: toward the in vivo repair of damaged blood vessels. , 2003, Journal of the American Chemical Society.

[98]  P. Vos,et al.  Association between macrophage activation and function of micro-encapsulated rat islets , 2003, Diabetologia.

[99]  G. Korbutt,et al.  Immunoprotection of rat islet xenografts by cotransplantation with sertoli cells and a single injection of antilymphocyte serum1 , 2003, Transplantation.

[100]  P. de Vos,et al.  Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats , 2003, Xenotransplantation.

[101]  Y. Tabata,et al.  Bioartificial Pancreas Transplantation at Prevascularized Intermuscular Space: Effect of Angiogenesis Induction on Islet Survival , 2003, Pancreas.

[102]  P. Aebischer,et al.  Prevention of the initial host immuno-inflammatory response determines the long-term survival of encapsulated myoblasts genetically engineered for erythropoietin delivery. , 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

[103]  F. Ris,et al.  Intra-portal injection of 400-µm microcapsules in a large-animal model , 2003, Transplant international : official journal of the European Society for Organ Transplantation.

[104]  K. M. Faucher,et al.  Fabrication and Characterization of Glycocalyx-Mimetic Surfaces † , 2003 .

[105]  G. Korbutt,et al.  Harnessing the Immunomodulatory Properties of Sertoli Cells to Enable Xenotransplantation in Type I Diabetes , 2003, Immunological investigations.

[106]  K. Ekdahl,et al.  Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation , 2002, The Lancet.

[107]  Dong Yun Lee,et al.  Optimization of monomethoxy-polyethylene glycol grafting on the pancreatic islet capsules. , 2002, Journal of biomedical materials research.

[108]  P. de Vos,et al.  Tissue responses against immunoisolating alginate-PLL capsules in the immediate posttransplant period. , 2002, Journal of biomedical materials research.

[109]  Narendra P. Singh,et al.  Cell membrane modification for rapid display of proteins as a novel means of immunomodulation: FasL-decorated cells prevent islet graft rejection. , 2002, Immunity.

[110]  K. M. Faucher,et al.  Functional Reconstitution of Thrombomodulin within a Substrate-Supported Membrane-Mimetic Polymer Film , 2002 .

[111]  J. Kapp,et al.  Proliferative and Cytokine Responses in CTLA4-Ig-Treated Diabetic NOD Mice Transplanted with Microencapsulated Neonatal Porcine ICCs , 2002, Cell transplantation.

[112]  J. Pedraz,et al.  Biocompatibility of microcapsules for cell immobilization elaborated with different type of alginates. , 2002, Biomaterials.

[113]  P. de Vos,et al.  Encapsulation of pancreatic islets for transplantation in diabetes: the untouchable islets. , 2002, Trends in molecular medicine.

[114]  Tatsuya Kin,et al.  Xenotransplantation of Pig Islets in Diabetic Dogs with Use of a Microcapsule Composed of Agarose and Polystyrene Sulfonic Acid Mixed Gel , 2002, Pancreas.

[115]  Y. Bae,et al.  Effect of cross-linked hemoglobin on functionality and viability of microencapsulated pancreatic islets. , 2002, Tissue engineering.

[116]  Randy S. Lewis,et al.  Free Radical Profiles in an Encapsulated Pancreatic Cell Matrix Model , 2002, Annals of Biomedical Engineering.

[117]  A. Gliozzi,et al.  Single living cell encapsulation in nano-organized polyelectrolyte shells , 2002 .

[118]  J. Corbett,et al.  Interleukin-1 Plus γ-Interferon-Induced Pancreatic β-Cell Dysfunction Is Mediated by β-Cell Nitric Oxide Production , 2002 .

[119]  K. M. Faucher,et al.  A membrane-mimetic barrier for cell encapsulation , 2002 .

[120]  P. de Vos,et al.  Considerations for successful transplantation of encapsulated pancreatic islets , 2002, Diabetologia.

[121]  D. Hunkeler,et al.  Improving cell encapsulation through size control , 2002, Journal of biomaterials science. Polymer edition.

[122]  P. Chang,et al.  Development of small alginate microcapsules for recombinant gene product delivery to the rodent brain , 2002, Journal of biomaterials science. Polymer edition.

[123]  A. King,et al.  The effect of host factors and capsule composition on the cellular overgrowth on implanted alginate capsules. , 2001, Journal of biomedical materials research.

[124]  D. Gray An Overview of the Immune System with Specific Reference to Membrane Encapsulation and Islet Transplantation , 2001, Annals of the New York Academy of Sciences.

[125]  J. Nordenström,et al.  Survival of Macroencapsulated Allogeneic Parathyroid Tissue One Year after Transplantation in Nonimmunosuppressed Humans , 2001, Cell transplantation.

[126]  G. Weir,et al.  Complete protection of islets against allorejection and autoimmunity by a simple barium-alginate membrane. , 2001, Diabetes.

[127]  R. Bjerkvig,et al.  Cell Encapsulation Technology as a Therapeutic Strategy for Cns Malignancies 1 Immunoisolation Technology Address Correspondence and Reprint Requests To , 2001 .

[128]  M. Löhr,et al.  Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma , 2001, The Lancet.

[129]  P. de Vos,et al.  C-Peptide responses after meal challenge in mice transplanted with microencapsulated rat islets , 2001, Diabetologia.

[130]  L. Gelbert,et al.  Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis* , 2001, The Journal of Biological Chemistry.

[131]  C. Mathieu,et al.  Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1β-exposed human and rat islet cells , 2001, Diabetologia.

[132]  A. Lew,et al.  Protection of Xenografts by a Combination of Immunoisolation and a Single Dose of Anti-CD4 Antibody , 2001, Cell transplantation.

[133]  P. Aebischer,et al.  INDUCING HOST ACCEPTANCE TO ENCAPSULATED XENOGENEIC MYOBLASTS , 2001, Transplantation.

[134]  G M Steil,et al.  ISLETS IN ALGINATE MACROBEADS REVERSE DIABETES DESPITE MINIMAL ACUTE INSULIN SECRETORY RESPONSES1 , 2001, Transplantation.

[135]  C. Ricordi,et al.  ENDOTOXIN-MEDIATED DELAYED ISLET GRAFT FUNCTION IS ASSOCIATED WITH INCREASED INTRA-ISLET CYTOKINE PRODUCTION AND ISLET CELL APOPTOSIS1 , 2001, Transplantation.

[136]  C. Mathieu,et al.  Early graft failure of xenogeneic islets in NOD mice is accompanied by high levels of interleukin-1 and low levels of transforming growth factor-beta mRNA in the grafts. , 2000, Diabetes.

[137]  K. Stecker,et al.  ICAM-1 Antisense Oligodeoxynucleotide Improves Islet Allograft Survival and Function , 2000, Cell transplantation.

[138]  S. Coughlin,et al.  Thrombin signalling and protease-activated receptors , 2000, Nature.

[139]  M. Shoichet,et al.  Cell delivery to the central nervous system. , 2000, Advanced drug delivery reviews.

[140]  E. Edelman,et al.  Endothelial cell delivery for cardiovascular therapy. , 2000, Advanced drug delivery reviews.

[141]  B. Říhová Immunocompatibility and biocompatibility of cell delivery systems. , 2000, Advanced drug delivery reviews.

[142]  Y. Bae,et al.  Cell transplantation for endocrine disorders. , 2000, Advanced drug delivery reviews.

[143]  A. King,et al.  Cytokine-induced functional suppression of microencapsulated rat pancreatic islets in vitro. , 2000, Transplantation.

[144]  P. Aebischer,et al.  Long-term host unresponsiveness to encapsulated xenogeneic myoblasts after transient immunosuppression. , 2000, Transplantation.

[145]  R. Robitaille,et al.  Studies on small (<350 microm) alginate-poly-L-lysine microcapsules. V. Determination of carbohydrate and protein permeation through microcapsules by reverse-size exclusion chromatography. , 2000, Journal of biomedical materials research.

[146]  A. Russell,et al.  Treatment of rat pancreatic islets with reactive PEG. , 2000, Biomaterials.

[147]  M. Sefton,et al.  Viability of HEMA-MMA microencapsulated model hepatoma cells in rats and the host response. , 2000, Tissue engineering.

[148]  M. Sefton,et al.  Making microencapsulation work: conformal coating, immobilization gels and in vivo performance. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[149]  G. Steil,et al.  Improved Vascularization of Planar Membrane Diffusion Devices following Continuous Infusion of Vascular Endothelial Growth Factor , 2000, Cell transplantation.

[150]  G. Elgue,et al.  Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation? , 1999, Diabetes.

[151]  J. Eaton,et al.  Stealth cells: prevention of major histocompatibility complex class II-mediated T-cell activation by cell surface modification. , 1999, Blood.

[152]  K. Stuhlmeier,et al.  Camouflaging endothelial cells: does it prolong graft survival? , 1999, Biochimica et biophysica acta.

[153]  P. de Vos,et al.  Why do microencapsulated islet grafts fail in the absence of fibrotic overgrowth? , 1999, Diabetes.

[154]  Jeffrey A. Hubbell,et al.  Thin Polymer Layers Formed by Polyelectrolyte Multilayer Techniques on Biological Surfaces , 1999 .

[155]  M. Sefton,et al.  Conformal Coating of Small Particles and Cell Aggregates at a Liquid‐Liquid Interface , 1999, Annals of the New York Academy of Sciences.

[156]  RONALD G. Gilla Antigen Presentation Pathways for Immunity to Islet Transplants: Relevance to Immunoisolation , 1999 .

[157]  P. Brunetti,et al.  Transplantation of Pancreatic Islets Contained in Minimal Volume Microcapsules in Diabetic High Mammalians , 1999, Annals of the New York Academy of Sciences.

[158]  J. Kapp,et al.  Evaluation of Graft‐Host Response for Various Tissue Sources and Animal Models , 1999, Annals of the New York Academy of Sciences.

[159]  F. Chang,et al.  The Rescue Effect of 15-Deoxyspergualin on Intraperitoneal Microencapsulated Xenoislets , 1999, Cell transplantation.

[160]  J. Hubbell,et al.  In Vitro and in Vivo Performance of Porcine Islets Encapsulated in Interfacially Photopolymerized Poly(Ethylene Glycol) Diacrylate Membranes , 1999, Cell transplantation.

[161]  H. Yang,et al.  Co-encapsulation of Sertoli enriched testicular cell fractions further prolongs fish-to-mouse islet xenograft survival. , 1999, Transplantation.

[162]  T Ohyama,et al.  Long-term normalization of diabetes by xenotransplantation of newly developed encapsulated pancreatic islets. , 1998, Transplantation proceedings.

[163]  Y. Ikada,et al.  Microencapsulation of islets and model beads with a thin alginate–ba2+ gel layer using centrifugation , 1998 .

[164]  R. Holman,et al.  Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. , 1998 .

[165]  Anderson,et al.  Host response to tissue engineered devices. , 1998, Advanced drug delivery reviews.

[166]  Li,et al.  Materials for immunoisolated cell transplantation. , 1998, Advanced drug delivery reviews.

[167]  Bowie,et al.  Development of engineered cells for implantation in gene therapy. , 1998, Advanced drug delivery reviews.

[168]  S. Efrat Development of engineered pancreatic β-cell lines for cell therapy of diabetes , 1998 .

[169]  W. Suarez-Pinzon,et al.  Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. , 1998, Biochemical pharmacology.

[170]  J. Hubbell,et al.  A sensitivity study of the key parameters in the interfacial photopolymerization of poly(ethylene glycol) diacrylate upon porcine islets. , 1998, Biotechnology and bioengineering.

[171]  C. Ricordi,et al.  Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation. , 1998, Diabetes.

[172]  Y. Mullen,et al.  Pravastatin prevents primary nonfunction of canine islet autografts. , 1998, Transplantation proceedings.

[173]  G. Korbutt,et al.  Coencapsulation of allogeneic islets with allogeneic Sertoli cells prolongs graft survival without systemic immunosuppression. , 1998, Transplantation proceedings.

[174]  M. Monden,et al.  Protection of islet allografts transplanted together with Fas ligand expressing testicular allografts , 1998, Diabetologia.

[175]  C. Colton,et al.  Effect of External Oxygen Mass Transfer Resistances on Viability of Immunoisolated Tissue a , 1997, Annals of the New York Academy of Sciences.

[176]  J. Hubbell,et al.  Immunoisolation of Adult Porcine Islets for the Treatment of Diabetes Mellitus , 1997, Annals of the New York Academy of Sciences.

[177]  P. Brunetti,et al.  Alginate/Polyaminoacidic Coherent Microcapsules for Pancreatic Islet Graft Immunoisolation in Diabetic Recipients , 1997, Annals of the New York Academy of Sciences.

[178]  R. C. Johnson,et al.  Use of an Immunoisolation Device for Cell Transplantation and Tumor Immunotherapy , 1997, Annals of the New York Academy of Sciences.

[179]  R. Bretzel,et al.  Alginate‐based Microcapsules for Immunoprotected Islet Transplantation a , 1997, Annals of the New York Academy of Sciences.

[180]  M. Dallman,et al.  Cytokine gene expression in pancreatic islet grafts in the rat. , 1997, Transplantation.

[181]  Y. Ikada,et al.  Characterization and transplantation of agarose microencapsulated canine islets of Langerhans. , 1997, Annals of Transplantation.

[182]  P. Linsley,et al.  CTLA4-Ig prolongs survival of microencapsulated neonatal porcine islet xenografts in diabetic NOD mice. , 1997, Cell transplantation.

[183]  Gero Decher,et al.  Fuzzy Nanoassemblies: Toward Layered Polymeric Multicomposites , 1997 .

[184]  J W Eaton,et al.  Chemical camouflage of antigenic determinants: stealth erythrocytes. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[185]  F. Bach,et al.  Immunobiology and therapeutic applications of protein c/protein s/thrombomodulin in human and experimental allotransplantation and xenotransplantation. , 1997, Trends in cardiovascular medicine.

[186]  B. Kulseng,et al.  Alginate polylysine microcapsules as immune barrier: permeability of cytokines and immunoglobulins over the capsule membrane. , 1997, Cell transplantation.

[187]  D. Hanahan,et al.  Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction , 1997, Nature Medicine.

[188]  L. Tibell,et al.  Characterization of the heparin-binding domain of human extracellular superoxide dismutase. , 1997, Biochimica et biophysica acta.

[189]  D. Vaux,et al.  Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[190]  A. Anilkumar,et al.  An encapsulation system for the immunoisolation of pancreatic islets , 1997, Nature Biotechnology.

[191]  P. de Vos,et al.  Efficacy of a prevascularized expanded polytetrafluoroethylene solid support system as a transplantation site for pancreatic islets. , 1997, Transplantation.

[192]  G. Korbutt,et al.  Cotransplantation of Allogeneic Islets With Allogeneic Testicular Cell Aggregates Allows Long-Term Graft Survival Without Systemic Immunosuppression , 1997, Diabetes.

[193]  K. Takatsuki,et al.  Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production. , 1997, The American journal of physiology.

[194]  P. de Vos,et al.  Impaired glucose tolerance in recipients of an intraperitoneally implanted microencapsulated islet allograft is caused by the slow diffusion of insulin through the peritoneal membrane. , 1997, Transplantation proceedings.

[195]  P. De Vos,et al.  Improved biocompatibility but limited graft survival after purification of alginate for microencapsulation of pancreatic islets , 1997, Diabetologia.

[196]  V. Karsten,et al.  Cytotoxicity of peritoneal murine macrophages against encapsulated pancreatic rat islets: in vivo and in vitro studies , 1996, Journal of leukocyte biology.

[197]  P. Sanberg,et al.  Testis-derived Sertoli cells survive and provide localized immunoprotection for xenografts in rat brain , 1996, Nature Biotechnology.

[198]  P. de Vos,et al.  Factors influencing the adequacy of microencapsulation of rat pancreatic islets. , 1996, Transplantation.

[199]  P. de Vos,et al.  Association between capsule diameter, adequacy of encapsulation, and survival of microencapsulated rat islet allografts. , 1996, Transplantation.

[200]  A. Sun,et al.  Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression. , 1996, The Journal of clinical investigation.

[201]  K. Dohi,et al.  Intermittent intraperitoneal implantation of islets in rat islet transplantation. , 1996, Cell transplantation.

[202]  Y. Ikada,et al.  A newly developed three-layer agarose microcapsule for a promising biohybrid artificial pancreas: rat to mouse xenotransplantation. , 1996, Cell transplantation.

[203]  R. Lanza,et al.  Encapsulated cell technology , 1996, Nature Biotechnology.

[204]  T. Chang,et al.  Microencapsulated genetically engineered live E. coli DH5 cells administered orally to maintain normal plasma urea level in uremic rats , 1996, Nature Medicine.

[205]  C. Stoeckert,et al.  Prevention of Islet Allograft Rejection with Engineered Myoblasts Expressing FasL in Mice , 1996, Science.

[206]  S K Young,et al.  Local inflammatory response around diffusion chambers containing xenografts. Nonspecific destruction of tissues and decreased local vascularization. , 1996, Transplantation.

[207]  T. Loudovaris,et al.  CD4+ T cell mediated destruction of xenografts within cell-impermeable membranes in the absence of CD8+ T cells and B cells. , 1996, Transplantation.

[208]  Myriam Schluep,et al.  Intrathecal delivery of CNTF using encapsulated genetically modifiedxenogeneic cells in amyotrophic lateral sclerosis patients , 1996, Nature Medicine.

[209]  A. Abbas,et al.  Role of Fas-mediated cell death in the regulation of immune responses. , 1996, Current opinion in immunology.

[210]  F. Gentile,et al.  Transport characterization of hydrogel matrices for cell encapsulation , 1996, Biotechnology and bioengineering.

[211]  K. Takatsuki,et al.  Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats. , 1996, Blood.

[212]  S. Grey,et al.  Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signaling and monocyte-dependent proliferative responses. , 1995, Transplantation.

[213]  R. C. Johnson,et al.  Neovascularization of synthetic membranes directed by membrane microarchitecture. , 1995, Journal of biomedical materials research.

[214]  D. Ecker,et al.  Xenotransplantation of porcine and bovine islets without immunosuppression using uncoated alginate microspheres. , 1995, Transplantation.

[215]  W. Baldwin,et al.  Complement in organ transplantation. Contributions to inflammation, injury, and rejection. , 1995, Transplantation.

[216]  A. Sambanis,et al.  Tissue Engineering of a Bioartificial Pancreas: Modeling the Cell Environment and Device Function , 1995, Biotechnology progress.

[217]  S. Grey,et al.  Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester. , 1994, Journal of immunology.

[218]  D. Rogers,et al.  The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus , 1994 .

[219]  R. Lanza,et al.  Xenogenic humoral responses to islets transplanted in biohybrid diffusion chambers. , 1994, Transplantation.

[220]  P. Soon-Shiong,et al.  Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation , 1994, The Lancet.

[221]  R. Hermann,et al.  Human protein C inhibits selectin-mediated cell adhesion: role of unique fucosylated oligosaccharide. , 1994, Glycobiology.

[222]  R. Bretzel,et al.  Transplantation of microencapsulated islets in rats: evidence for induction of fibrotic overgrowth by islet alloantigens released from microcapsules. , 1994, Transplantation proceedings.

[223]  F T Gentile,et al.  Poly(ethylene oxide)‐grafted thermoplastic membranes for use as cellular hybrid bio‐artificial organs in the central nervous system , 1994, Biotechnology and bioengineering.

[224]  J. Weiler,et al.  Heparin and derivatized heparin inhibit zymosan and cobra venom factor activation of complement in serum. , 1994, Immunopharmacology.

[225]  V. Kolb-Bachofen,et al.  Macrophage-generated nitric oxide as cytotoxic factor in destruction of alginate-encapsulated islets. Protection by arginine analogs and/or coencapsulated erythrocytes. , 1993, Transplantation.

[226]  S. Genuth,et al.  The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. , 1993, The New England journal of medicine.

[227]  M. Pangburn,et al.  Identification of multiple sites of interaction between heparin and the complement system. , 1993, Molecular immunology.

[228]  D. Cameron,et al.  Sertoli Cell-Enriched Fractions in Successful Islet Cell Transplantation , 1993, Cell transplantation.

[229]  R. Bretzel,et al.  Transplantation of Free and Microencapsulated Islets in Rats: Evidence for the Requirement of An Increased Islet Mass for Transplantation into the Peritoneal Site , 1993, The International journal of artificial organs.

[230]  C. Colton,et al.  Effect of Hypoxia on Insulin Secretion by Isolated Rat and Canine Islets of Langerhans , 1993, Diabetes.

[231]  A. Sun,et al.  Xenografts of rat islets into diabetic mice. An evaluation of new smaller capsules. , 1992, Transplantation.

[232]  J. Baird,et al.  Microencapsulated islet grafts in the BB/E rat: a possible role for cytokines in graft failure , 1992, Diabetologia.

[233]  A. Sun,et al.  Prolonged Reversal of Diabetic State in NOD Mice by Xenografts of Microencapsulated Rat Islets , 1991, Diabetes.

[234]  P. Vos,et al.  THE EFFICACY OF INTRAPERITONEAL PANCREATIC ISLET ISOGRAFTS IN THE REVERSAL OF DIABETES IN RATS , 1991, Transplantation.

[235]  M. Frank,et al.  The role of complement in inflammation and phagocytosis. , 1991, Immunology today.

[236]  R. Bergman,et al.  Determination of Portal Insulin Absorption From Peritoneum via Novel Nonisotopic Method , 1990, Diabetes.

[237]  D. Dunn,et al.  Differential roles of Mac-1+ cells, and CD4+ and CD8+ T lymphocytes in primary nonfunction and classic rejection of islet allografts , 1990, The Journal of experimental medicine.

[238]  V. D’Agati,et al.  The role of CD4+ helper T cells in the destruction of microencapsulated islet xenografts in nod mice. , 1990, Transplantation.

[239]  K. Tatarkiewicz New membrane for cell encapsulation. , 1988, Artificial organs.

[240]  M. Kazatchkine,et al.  Structure-function relationships in the inhibitory effect of heparin on complement activation: independency of the anti-coagulant and anti-complementary sites on the heparin molecule. , 1988, Molecular immunology.

[241]  J M Anderson,et al.  Inflammatory response to implants. , 1988, ASAIO transactions.

[242]  G. Reach,et al.  In vitro kinetics of insulin release by microencapsulated rat islets: effect of the size of the microcapsules , 1988, Diabetologia.

[243]  L. Dijkhuizen,et al.  Diffusion of oxygen in alginate gels related to the kinetics of methanol oxidation by immobilized Hansenula polymorpha cells , 1983, European journal of applied microbiology and biotechnology.

[244]  K. Polonsky,et al.  Differences in the hepatic and renal extraction of insulin and glucagon in the dog: evidence for saturability of insulin metabolism. , 1983, Acta endocrinologica.

[245]  F. Lim,et al.  Microencapsulated islets as bioartificial endocrine pancreas. , 1980, Science.

[246]  W. Chick,et al.  Beta cell culture on synthetic capillaries: an artificial endocrine pancreas , 1975, Science.

[247]  G. H. Algire,et al.  Growth of cells in vivo in diffusion chambers. I. Survival of homografts in immunized mice. , 1954, Journal of the National Cancer Institute.

[248]  E. Montanya,et al.  Interleukin-1beta and inducible form of nitric oxide synthase expression in early syngeneic islet transplantation. , 2007, The Journal of endocrinology.

[249]  Giovanni Luca,et al.  Microencapsulated pancreatic islet allografts into nonimmunosuppressed patients with type 1 diabetes: first two cases. , 2006, Diabetes care.

[250]  A. Vasconcellos,et al.  Transplantation of micro- and macroencapsulated piglet islets into mice and monkeys. , 2005, Transplantation proceedings.

[251]  E. Kiseleva,et al.  Receptors of the PAR Family as a Link between Blood Coagulation and Inflammation , 2004, Biochemistry (Moscow).

[252]  R. Schnettler,et al.  Alginate coating of islets of Langerhans: in vitro studies on a new method for microencapsulation for immuno-isolated transplantation , 2004, Acta Diabetologica.

[253]  S. Bonner-Weir,et al.  Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice. , 2003, Diabetes.

[254]  P. de Vos,et al.  Long-term biocompatibility, chemistry, and function of microencapsulated pancreatic islets. , 2003, Biomaterials.

[255]  John M. Lachin,et al.  Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study. , 2003, JAMA.

[256]  R. van Schilfgaarde,et al.  Response of Encapsulated Rat Pancreatic Islets to Hypoxia , 2003, Cell Transplantation.

[257]  P. Allavena,et al.  Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation. , 2002, Diabetes.

[258]  E. Montanya,et al.  Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia. , 2002, Diabetes.

[259]  J. Corbett,et al.  Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production. , 2002, Diabetes.

[260]  D. Emerich,et al.  Immunoisolation cell therapy for CNS diseases. , 2001, Critical reviews in therapeutic drug carrier systems.

[261]  B. Kulseng,et al.  Poly-L-Lysine induces fibrosis on alginate microcapsules via the induction of cytokines. , 2001, Cell transplantation.

[262]  Ames,et al.  Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen , 2000 .

[263]  E L Chaikof,et al.  Engineering and material considerations in islet cell transplantation. , 1999, Annual review of biomedical engineering.

[264]  R. Lanza,et al.  Cell Encapsulation Technology and Therapeutics , 1999, Birkhäuser Boston.

[265]  D. Ecker,et al.  Transplantation of islets using microencapsulation: studies in diabetic rodents and dogs , 1999, Journal of Molecular Medicine.

[266]  R. Robitaille,et al.  Studies on small (<350 microm) alginate-poly-L-lysine microcapsules. III. Biocompatibility Of smaller versus standard microcapsules. , 1999, Journal of biomedical materials research.

[267]  E. Chaikof,et al.  Long-Term Survival of Poly-L-Lysine-Alginate Microencapsulated Islet Xenografts in Spontaneously Diabetic NOD Mice , 1999 .

[268]  R. Gill Antigen presentation pathways for immunity to islet transplants. Relevance to immunoisolation. , 1999, Annals of the New York Academy of Sciences.

[269]  Ales Prokop,et al.  Water Soluble Polymersfor Immunoisolation I: Complex Coacervation and Cytotoxicity , 1998 .

[270]  Efrat Development of engineered pancreatic beta-cell lines for cell therapy of diabetes. , 1998, Advanced drug delivery reviews.

[271]  D. Gray Encapsulated islet cells: the role of direct and indirect presentation and the relevance to xenotransplantation and autoimmune recurrence. , 1997, British medical bulletin.

[272]  Y. Mullen,et al.  Protection of mouse islet isografts from nonspecific inflammatory damage by recipient treatment with nicotinamide and 15-deoxyspergualin. , 1996, Cell transplantation.

[273]  E. Doherty,et al.  Transport characterization of membranes for immunoisolation. , 1996, Biomaterials.

[274]  R. Berber,et al.  Oxygen diffusivity in calcium alginate gel beads containing Gluconobacter suboxydans. , 1996, Artificial cells, blood substitutes, and immobilization biotechnology.

[275]  R. Padera,et al.  Time course of membrane microarchitecture-driven neovascularization. , 1996, Biomaterials.

[276]  P. Aebischer,et al.  Immunoisolated xenogenic chromaffin cell therapy for chronic pain. Initial clinical experience. , 1996, Anesthesiology.

[277]  P. de Vos,et al.  Kinetics of intraperitoneally infused insulin in rats. Functional implications for the bioartificial pancreas. , 1996, Diabetes.

[278]  P. Brunetti,et al.  Method for fabrication of coherent microcapsules: a new, potential immunoisolatory barrier for pancreatic islet transplantation , 1995 .

[279]  E. Dejana,et al.  Thrombin-induced endothelial cell dysfunction. , 1994, British medical bulletin.

[280]  J. A. Hubbell,et al.  Poly(ethylene oxide)-graft-poly(L-lysine) copolymers to enhance the biocompatibility of poly(L-lysine)-alginate microcapsule membranes. , 1992, Biomaterials.

[281]  N. Ziats,et al.  In vitro and in vivo interactions of cells with biomaterials. , 1988, Biomaterials.

[282]  Robert E. Wilson,et al.  Fundamentals of momentum, heat, and mass transfer , 1969 .