A Scoping Review of Available Tools in Measurement of the Effectiveness of Conservative Treatment in Lipoedema

(1) Background: Due to insufficient knowledge of lipoedema, the treatment of this disease is undoubtedly challenging. However, more and more researchers attempt to incorporate the most effective lipoedema treatment methods. When assessing a new therapeutic method, choosing correct, objective tools to measure the therapeutic outcome is very important. This article aims to present possible instruments that may be used in the evaluation of therapeutic effects in patients with lipoedema. (2) Methods: The data on therapeutic outcome measurements in lipoedema were selected in February 2022, using the Medical University of Gdansk Main Library multi-search engine. (3) Results: In total, 10 papers on this topic have been identified according to inclusion criteria. The tools evaluating the therapeutic outcomes used in the selected studies were: volume and circumference measurement, body mass index, waist-to-hip ratio, ultrasonography and various scales measuring the quality of life, the level of experiencing pain, the severity of symptoms, functional lower extremity scales, and a 6 min walk test. (4) Conclusion: The tools currently used in evaluating the effectiveness of conservative treatment in women with lipoedema are: volume and circumference measurement, waist-to-hip ratio, body fat percentage, ultrasonography, VAS scale, quality of life scales (SF-36, RAND-36), symptom severity questionnaire (QuASiL), Lower Extremity Functional Scale and 6 min walk. Choosing a proper tool to measure the treatment outcome is essential to objectively rate the effectiveness of therapeutic method.

[1]  E. Cione,et al.  Management of Lipedema with Ketogenic Diet: 22-Month Follow-Up , 2021, Life.

[2]  D. A. Benitti,et al.  Lipedema Can Be Treated Non-Surgically: A Report of 5 Cases , 2021, The American journal of case reports.

[3]  M. Foster,et al.  Lipedema and the Potential Role of Estrogen in Excessive Adipose Tissue Accumulation , 2021, International journal of molecular sciences.

[4]  R. Hansdorfer-Korzon,et al.  Lipoedema as a Social Problem. A Scoping Review , 2021, International journal of environmental research and public health.

[5]  D. Saucedo,et al.  Ultrasound criteria for lipedema diagnosis , 2021, Phlebology.

[6]  W. Białaszek,et al.  Quality of life, its factors, and sociodemographic characteristics of Polish women with lipedema , 2021, BMC Women's Health.

[7]  T. Atan,et al.  The Effects of Complete Decongestive Therapy or Intermittent Pneumatic Compression Therapy or Exercise Only in the Treatment of Severe Lipedema: A Randomized Controlled Trial. , 2020, Lymphatic research and biology.

[8]  B. Gower,et al.  Ketogenic diet as a potential intervention for lipedema. , 2020, Medical hypotheses.

[9]  G. Erbacher,et al.  Lipoedema: a paradigm shift and consensus. , 2020, Journal of wound care.

[10]  G. Yazici,et al.  The Effects of Complex Decongestive Physiotherapy Applications on Lower Extremity Circumference and Volume in Patients with Lipedema. , 2020, Lymphatic research and biology.

[11]  Ricardo Virgínio dos Santos,et al.  Translation, cultural adaptation, and validation of a lipedema symptoms questionnaire , 2020, Jornal vascular brasileiro.

[12]  K. Herbst,et al.  Aldo-Keto Reductase 1C1 (AKR1C1) as the First Mutated Gene in a Family with Nonsyndromic Primary Lipedema , 2020, International journal of molecular sciences.

[13]  F. Angst,et al.  Cross-sectional validity and specificity of comprehensive measurement in lymphedema and lipedema of the lower extremity: a comparison of five outcome instruments , 2020, Health and Quality of Life Outcomes.

[14]  L. Prantl,et al.  Lipedema-Pathogenesis, Diagnosis, and Treatment Options. , 2020, Deutsches Arzteblatt international.

[15]  Alexandre Campos Moraes Amato,et al.  Tradução, adaptação cultural e validação do questionário de avaliação sintomática do lipedema (QuASiL) , 2020 .

[16]  P. Moog,et al.  New Insights on Lipedema: The Enigmatic Disease of the Peripheral Fat. , 2019, Plastic and reconstructive surgery.

[17]  L. Mazzolai,et al.  Lipedema: A Call to Action! , 2019, Obesity.

[18]  Garry R Cooper-Stanton Flat knit hosiery: purpose, selection and application in chronic oedema and lipoedema. , 2019, British journal of community nursing.

[19]  K. Herbst,et al.  Subcutaneous adipose tissue therapy reduces fat by dual X‐ray absorptiometry scan and improves tissue structure by ultrasound in women with lipoedema and Dercum disease , 2018, Clinical obesity.

[20]  U. Wollina,et al.  Lipoedema is not lymphoedema: A review of current literature , 2018, International wound journal.

[21]  R. Schneider Low-frequency vibrotherapy considerably improves the effectiveness of manual lymphatic drainage (MLD) in patients with lipedema: A two-armed, randomized, controlled pragmatic trial , 2018, Physiotherapy theory and practice.

[22]  M. D. de Rooij,et al.  Exploration of Patient Characteristics and Quality of Life in Patients with Lipoedema Using a Survey , 2018, Dermatology and Therapy.

[23]  P. Ostaszewski,et al.  Depression and appearance-related distress in functioning with lipedema , 2018, Psychology, health & medicine.

[24]  M. Donahue,et al.  Tissue sodium content is elevated in the skin and subcutaneous adipose tissue in women with lipedema , 2017, Obesity.

[25]  Dominic Furniss,et al.  Measuring Limb Volume: Accuracy and Reliability of Tape Measurement Versus Perometer Measurement. , 2017, Lymphatic research and biology.

[26]  K. Herbst,et al.  Pilot study: whole body manual subcutaneous adipose tissue (SAT) therapy improved pain and SAT structure in women with lipedema , 2018, Hormone molecular biology and clinical investigation.

[27]  Amy J. Fetzer Specialist approaches to managing lipoedema. , 2016, British journal of community nursing.

[28]  Christy N. Wise,et al.  Living with lipoedema: reviewing different self-management techniques. , 2015, British journal of community nursing.

[29]  T. Kottmann,et al.  Treatment of lipoedema using liposuction Therapie des Lipödems mittels Liposuktion im Rahmen eines umfassenden Behandlungs – konzeptes , 2015, Phlebologie.

[30]  K. Herbst,et al.  Lipedema Fat and Signs and Symptoms of Illness, Increase with Advancing Stage , 2015 .

[31]  L. Kemény,et al.  Lipedema: an overview of its clinical manifestations, diagnosis and treatment of the disproportional fatty deposition syndrome – systematic review , 2012, Clinical obesity.

[32]  K. Herbst Rare adipose disorders (RADs) masquerading as obesity , 2012, Acta Pharmacologica Sinica.

[33]  L. Kemény,et al.  Lymphedema treatment decreases pain intensity in lipedema. , 2011, Lymphology.

[34]  M. Podda,et al.  Liposuction is an effective treatment for lipedema–results of a study with 25 patients , 2011, Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.

[35]  J. Bosman Lipoedema: poor knowledge, neglect or disinterest? , 2011 .

[36]  A. Child,et al.  Lipedema: An inherited condition , 2010, American journal of medical genetics. Part A.

[37]  T. Nijsten,et al.  Lipoedema: from clinical presentation to therapy. A review of the literature , 2009, The British journal of dermatology.

[38]  L. Kemény,et al.  Complete decongestive physiotherapy with and without pneumatic compression for treatment of lipedema: a pilot study. , 2008, Lymphology.

[39]  L. Kemény,et al.  Complex decongestive physiotherapy decreases capillary fragility in lipedema. , 2008, Lymphology.

[40]  E. Hines,et al.  Lipedema of the legs; a syndrome characterized by fat legs and edema. , 1951, Annals of internal medicine.