Changes in the metabolic footprint of placental explant-conditioned culture medium identifies metabolic disturbances related to hypoxia and pre-eclampsia.

[1]  D. Kell,et al.  Mass Spectrometry Tools and Metabolite-specific Databases for Molecular Identification in Metabolomics , 2009 .

[2]  Joshua D. Knowles,et al.  Development of a robust and repeatable UPLC-MS method for the long-term metabolomic study of human serum. , 2009, Analytical chemistry.

[3]  D. Kell,et al.  Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers. , 2008, Placenta.

[4]  D. Kell,et al.  Detection and Identification of Novel Metabolomic Biomarkers in Preeclampsia , 2008, Reproductive Sciences.

[5]  J. Kiang,et al.  Inhibition of Inducible Nitric-Oxide Synthase Protects Human T Cells from Hypoxia-Induced Apoptosis , 2008, Molecular Pharmacology.

[6]  Terry J. Smith,et al.  Expression Levels of mRNA for Rho A/Rho Kinase and Its Role in Isoprostane-Induced Vasoconstriction of Human Placental and Maternal Vessels , 2008, Reproductive Sciences.

[7]  I. Crocker,et al.  Effects of oxygen on cell turnover and expression of regulators of apoptosis in human placental trophoblast. , 2008, Placenta.

[8]  I. Crocker,et al.  Oxygen and the liberation of placental factors responsible for vascular compromise , 2008, Laboratory Investigation.

[9]  N. Serkova,et al.  Metabolic Markers of Hypoxia: Systems Biology Application in Biomedicine , 2008, Toxicology mechanisms and methods.

[10]  I. Crocker,et al.  Formation of syncytial knots is increased by hyperoxia, hypoxia and reactive oxygen species. , 2007, Placenta.

[11]  P. Sedlmayr.  Indoleamine 2,3-dioxygenase in materno-fetal interaction. , 2007, Current drug metabolism.

[12]  A. Toker,et al.  Placental tissue cyclo‐oxygenase 1 and 2 in pre‐eclamptic and normal pregnancy , 2006, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[13]  J. Kingdom,et al.  Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1. , 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

[14]  S. Yeh,et al.  Effect of physiologic levels of glutamine on ICAM-1 expression in endothelial cells activated by preeclamptic plasma. , 2006, The Journal of reproductive medicine.

[15]  C. Yeh,et al.  Effect of glutamine on cell adhesion molecule expression and leukocyte transmigration in endothelial cells stimulated by preeclamptic plasma. , 2005, Nutrition.

[16]  Douglas B. Kell,et al.  Novel biomarkers for pre-eclampsia detected using metabolomics and machine learning , 2005, Metabolomics.

[17]  D. Kell,et al.  Metabolic footprinting and systems biology: the medium is the message , 2005, Nature Reviews Microbiology.

[18]  B Huppertz,et al.  Human placental explants in culture: approaches and assessments. , 2005, Placenta.

[19]  I. Sargent,et al.  Latest Advances in Understanding Preeclampsia , 2005, Science.

[20]  R. Ness,et al.  Early Occurrence of Metabolic Syndrome After Hypertension in Pregnancy , 2005, Obstetrics and gynecology.

[21]  G. Mires,et al.  In Preeclampsia, the Circulating Factors Capable of Altering In Vitro Endothelial Function Precede Clinical Disease , 2005, Hypertension.

[22]  F. Prefumo,et al.  OC065: Uterine artery resistance at 10–14 weeks of gestation is correlated with trophoblast apoptosis , 2004 .

[23]  D. Kell,et al.  Metabolomics by numbers: acquiring and understanding global metabolite data. , 2004, Trends in biotechnology.

[24]  J. Kingdom,et al.  Pre-eclampsia : Current Perspectives on Management , 2003 .

[25]  T. Libermann,et al.  Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. , 2003, The Journal of clinical investigation.

[26]  I. Sargent,et al.  Decreased tryptophan catabolism by placental indoleamine 2,3-dioxygenase in preeclampsia. , 2003, American journal of obstetrics and gynecology.

[27]  I. Crocker,et al.  Differences in apoptotic susceptibility of cytotrophoblasts and syncytiotrophoblasts in normal pregnancy to those complicated with preeclampsia and intrauterine growth restriction. , 2003, The American journal of pathology.

[28]  T. Lawrence,et al.  Anti-inflammatory lipid mediators and insights into the resolution of inflammation , 2002, Nature Reviews Immunology.

[29]  D. Sahota,et al.  Increased placental apoptosis in pregnancies complicated by preeclampsia. , 2001, American journal of obstetrics and gynecology.

[30]  I. Sargent,et al.  Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre‐eclamptic pregnancies , 1998, British journal of obstetrics and gynaecology.

[31]  V. Gujrati,et al.  Novel appearance of placental nuclear monoamine oxidase: biochemical and histochemical evidence for hyperserotonomic state in preeclampsia-eclampsia. , 1996, American journal of obstetrics and gynecology.

[32]  J. Sun,et al.  [Determination of serum free amino acids and ammonia in pregnant women with severe pregnancy induced hypertension]. , 1996, Zhonghua fu chan ke za zhi.

[33]  W. Vach,et al.  [Changes in serotonin metabolism in pre-eclampsia]. , 1996, Geburtshilfe und Frauenheilkunde.

[34]  T. Imai,et al.  [Quantitative changes in leukotriene B4 release in neutrophilic leukocytes activated by Ca ionophore during pregnancy--normal pregnancy and preeclampsia]. , 1996, Nihon Sanka Fujinka Gakkai zasshi.

[35]  L. Dinkelborg,et al.  Transport and metabolism of L-glutamate during oxygenation, anoxia, and reoxygenation of rat cardiac myocytes. , 1996, The American journal of physiology.

[36]  R. Pijnenborg,et al.  A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre‐eclamptic pregnancies , 1994, British journal of obstetrics and gynaecology.

[37]  W. Piering,et al.  Preeclampsia related to a functioning extrauterine placenta: report of a case and 25-year follow-up. , 1993, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[38]  A. Koller,et al.  Prostaglandins mediate arteriolar dilation to increased blood flow velocity in skeletal muscle microcirculation. , 1990, Circulation research.

[39]  I. Macgillivray,et al.  The classification and definition of the hypertensive disorders of pregnancy. , 1988, American journal of obstetrics and gynecology.

[40]  R. A. Coleman,et al.  Comparison of the potencies of some prostaglandins as vasodilators in three vascular beds of the anaesthetised dog. , 1982, European journal of pharmacology.

[41]  E. Norwitz.  Defective implantation and placentation: laying the blueprint for pregnancy complications. , 2007, Reproductive biomedicine online.

[42]  D. Kell,et al.  Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era. , 2004, BioEssays : news and reviews in molecular, cellular and developmental biology.

[43]  D. Walker,et al.  Regional changes in kynurenic acid, quinolinic acid, and glial fibrillary acidic protein concentrations in the fetal sheep brain after experimentally induced placental insufficiency. , 2001, American journal of obstetrics and gynecology.

[44]  E. Morel,et al.  Observations on 138 molar pregnancies. , 1969, American journal of obstetrics and gynecology.