Heritability of erythrocyte Na+-Li+ countertransport in relation to essential hypertension.

The Na+-Li+ countertransport system in erythrocytes was investigated in patients with essential hypertension and control subjects. Furthermore, studies on the pairs of parent-offspring and husband-wife were added in order to evaluate heritability of the countertransport. The Na+-Li+ countertransport of patients with essential hypertension and normotensive subjects with the family history of hypertension was significantly increased in comparison with that of normotensive subjects without the family history. The correlation coefficient of the countertransport in pairs of parent-offspring was significant but not between husband-wife. These results support the concept of a genetic determinant for the countertransport system.

[1]  D. Tosteson,et al.  Red Cell Lithium‐Sodium Countertransport and Sodium‐Potassium Cotransport in Patients with Essential Hypertension , 1982, Hypertension.

[2]  H. A. Jensen,et al.  Essential hypertension: sodium-lithium countertransport in erythrocytes from patients and from children having one hypertensive parent. , 1982, Hypertension.

[3]  D. Tosteson,et al.  Increased sodium-lithium countertransport in red cells of patients with essential hypertension. , 1980, The New England journal of medicine.

[4]  J. Elghozi,et al.  Laboratory distinction between essential and secondary hypertension by measurement of erythrocyte cation fluxes. , 1980, The New England journal of medicine.

[5]  D. Tosteson,et al.  Lithium transport in human red blood cells: genetic and clinical aspects. , 1979, Archives of general psychiatry.

[6]  R. Garay,et al.  A NEW TEST SHOWING ABNORMAL NET Na+ AND K+ FLUXES IN ERYTHROCYTES OF ESSENTIAL HYPERTENSIVE PATIENTS , 1979, The Lancet.

[7]  D. Tosteson,et al.  A heritable disorder of lithium transport in erythrocytes of a subpopulation of manic-depressive patients. , 1978, The American journal of psychiatry.

[8]  D. Cusi,et al.  Familial aggregation of cation transport abnormalities and essential hypertension. , 1981, Clinical and experimental hypertension.

[9]  J. Davis,et al.  Lithium transport across the RBC membrane. A study of genetic factors. , 1980, Archives of general psychiatry.

[10]  J. Mendels,et al.  A pilot study of racial differences in erythrocyte lithium transport. , 1980, The American journal of psychiatry.