Genetic determinants of plasma β2‐glycoprotein I levels: a genome‐wide association study in extended pedigrees from Spain

β2‐Glycoprotein I (β2‐GPI), also designated apolipoprotein H, is a 50‐kDa protein that circulates in blood at high concentrations, playing important roles in autoimmune diseases, hemostasis, atherogenesis, and angiogenesis, as well as in host defense against bacteria and in protein/cellular waste removal. Plasma β2‐GPI levels have a significant genetic component (heritability of ~ 80%).

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