Effect of radiologic stage III substage on nonsurgical therapy of non‐small cell lung cancer

Background. Patients with Stage III non–small cell lung cancer (NSCLC) whose cases are staged or treated surgically have different prognoses, depending on the substage (IIIa, IIIb). It is not known whether the prognostic differences apply to clinically staged nonsurgical cases. The authors wanted to determine whether radiologic Stage III substages, determined by computerized axial tomography (CT) scans, are prognostically important in these patients with NSCLC. In addition, they wanted to determine whether the observed superior survival of selected patients with Stage III NSCLC receiving chemotherapy in addition to radiation therapy (chemo‐RT) (Cancer and Leukemia Group B protocol 8433: N Engl J Med 1990; 323:940–5) was influenced by an imbalance in the radiologic Stage III substage.

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