I. DEDICATION II. PREFACE III. ACKNOWLEDGMENTS IV. CONTENTS SECTION 1: STRUCTURE 1 Anatomy Robert T. Burks and Mark G. Luker 2 The Knee as a Biologic Transmission Scott F. Dye 3 Ligament Biochemistry and Physiology Monti Khatod and David Amiel 4 Effects of Anatomic and Developmental Variation on Evaluation and Treatment of Knee Conditions Glenn C. Terry and Stephanie Silberberg SECTION 2: FUNCTION 5 Mobility of the Knee John O'Connor, Jennifer Feikes, Richie Gill, and Amy Zavatsky 6 Ligament Cutting Studies: Methodology Eric C. McCarty, Clemente Ibarra, Peter A. Torzilli, and and Results Russell F. Warren 7 Ligament Mechanics: Structural Behavior and Material Properties of Normal and Injured Ligaments Nigel G. Shrive, Gail M. Thornton, David A. Hart, and Cyril B. Frank 8 Articular Cartilage its Exacting Characteristics: The Benchmark for all Attempts to Achieve Articular Cartilage Regeneration or Repair Wayne H. Akeson 9 Joint Mechanoreceptors and Knee Function Tom Hogervorst, Richard A. Brand 10 Stability of the Knee John O'Connor, Amy Zavatsky, and Richie Gill 11 Ligment Injury and Repair Monti Khatod, Wayne H. Akeson, and David Amiel 12 Cell Adhesion and the Signaling Biology of Ligament Healing K-L. Paul Sung, Wayne H. Akeson, and Adam H. Hsieh 13 Arthrofibrosis the Mechanism of Proliferative Scar Production and Potential Therapeutic Remedies to Modulate the Healing Response Wayne H. Akeson 14 Cartilage Therapies: Chondrocyte Constance R. Chu Transplantation, Osteochondral Allografts and Autografts 15 Meniscus Injury and Repair Albert Tsai and Robert A. Pedowitz 16 Experimental Design and Statistical Analysis Richard L.Lieber 17 In-Vivo Measurement of ACL and ACL Graft Strain Braden C. Fleming, Bruce D. Beynnon, Per A. Renstrom, and Robert J. Johnson SECTION 3: INJURY AND REPAIR: CLINICAL 18 Epidemiology of Knee Ligament Injury William Ohara, Liz W. Paxton, and Donald C. Fithian 19 Diagnosis of Ligament Injury: Part A: History and Physical Exam William F. Luetzow Part B: Imaging Paul N. Grooff, Jean P. Schils, and Donald L. Resnick Part C: Instrumented Laxity Studies Donald C. Fithian, Mary Lou Stone, and Mark D. Shaieb 20 The Anterior Cruciate Ligament Deficient Knee: Natural History and the Effects of Non-Surgical Treatment Donald C. Fithian David H. Goltz, and T. Tadashi Funahashi 21 Principles of Surgery: Part A: Graft Choices and the Biology of Graft Healing Choll W. Kim and Robert A. Pedowitz Part B: Anatomic Placement and Fixation John W. Miles Part C: ACL Reconstruction: Techniques Past and Present Peter D. Laimins and Scott E. Powell 22 Rehabilitation after Anterior Cruciate Ligament Reconstruction K. Donald Shelbourne and Thomas E. Klootwyk 23 Treatment of Specific Injuries: Part A: Collateral Ligament Injuries T. Tadashi Funahashi, Diane C. Hillard-Sembell, and Donald C. Fithian Part B: Isolated and Combined PCL and Posterolateral Corner Injuries: Evaluation and Management Christopher C. Annunziata, J. Robert Giffin,