One‐Pot Synthesis of Tetrahydropyrimidines Catalyzed by Zeolite

A simple one‐pot synthesis of various tetrahydro pyrimidines in the presence of NaY zeolite, as an efficient catalyst, is reported. The multicomponent reaction was carried out by a three‐component coupling of 1,3‐diketone, aldehyde and urea/thiourea in the presence of the catalyst to give 1(a–k). The catalyst could be reused several times. Further reaction of these pyrimidines with phosphorus oxychloride gave corresponding N‐formylated compounds.

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