Naloxone does not affect ventilatory responses to hypoxia and hypercapnia in rats.

Ventilatory responses (tidal volume, respiratory frequency, and minute ventilation) to steady-state hypoxia and steady-state hypercapnia were measured plethysmographically in awake unrestrained adult rats, before and after subcutaneous injection of placebo (saline) naloxone in doses up to 5.0 mg/kg. Naloxone did not alter the ventilatory responses to hypoxia or hypercapnia.

[1]  F. N. David,et al.  Principles and procedures of statistics. , 1961 .

[2]  C. Soutar,et al.  Clinical studies of workers exposed to polyvinylchloride dust. , 1983, Thorax.

[3]  M. Grunstein,et al.  Effect of naloxone on ventilation in newborn rabbits. , 1981, Journal of applied physiology: respiratory, environmental and exercise physiology.

[4]  G. Isom,et al.  Naloxone-induced enhancement of carbon dioxide stimulated respiration. , 1982, Life sciences.

[5]  E. Scarpelli,et al.  Generation and regulation of breathing in utero: fetal CO2 response test. , 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

[6]  J P Jacky,et al.  A plethysmograph for long-term measurements of ventilation in unrestrained animals. , 1978, Journal of applied physiology: respiratory, environmental and exercise physiology.

[7]  J. Hempstead,et al.  Disposition of naloxone: use of a new radioimmunoassay. , 1975, The Journal of pharmacology and experimental therapeutics.

[8]  T. Waldrop,et al.  Naloxone enhances respiratory output in cats. , 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

[9]  R. A. Epstein,et al.  A theoretical analysis of the barometric method for measurement of tidal volume. , 1978, Respiration physiology.

[10]  P. Barnes,et al.  Endogenous opiates and the control of breathing in normal subjects and patients with chronic airflow obstruction. , 1982, Thorax.

[11]  T. B. Waggener,et al.  No effect of naloxone on hypoxia-induced ventilatory depression in adults. , 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

[12]  J. Hempstead,et al.  Pharmacokinetics of Naloxone in Rats and in Man: Basis for Its Potency and Short Duration of Action , 1976, Anesthesiology.

[13]  M. Grunstein,et al.  Respiratory control during hypoxia in newborn rabbits: implied action of endorphins. , 1981, Journal of applied physiology: respiratory, environmental and exercise physiology.

[14]  S. Tenney,et al.  Control of breathing in experimental anemia. , 1970, Respiration physiology.

[15]  V. Chernick,et al.  NALOXONE DECREASES THE DURATION OF PRIMARY APNEA WITH NEONATAL ASPHYXIA , 1980, Pediatric Research.

[16]  T. V. Santiago,et al.  Endorphins and the control of breathing. Ability of naloxone to restore flow-resistive load compensation in chronic obstructive pulmonary disease. , 1981, The New England journal of medicine.

[17]  J P Jacky,et al.  Barometric measurement of tidal volume: effects of pattern and nasal temperature. , 1980, Journal of applied physiology: respiratory, environmental and exercise physiology.

[18]  J. Farber,et al.  Naloxone administration and ventilation in awake cats , 1983, Brain Research.