The Evaluation of Body Composition: A Useful Tool for Clinical Practice

Undernutrition is insufficiently detected in in- and outpatients, and this is likely to worsen during the next decades. The increased prevalence of obesity together with chronic illnesses associated with fat-free mass (FFM) loss will result in an increased prevalence of sarcopenic obesity. In patients with sarcopenic obesity, weight loss and the body mass index lack accuracy to detect FFM loss. FFM loss is related to increasing mortality, worse clinical outcomes, and impaired quality of life. In sarcopenic obesity and chronic diseases, body composition measurement with dual-energy X-ray absorptiometry, bioelectrical impedance analysis, or computerized tomography quantifies the loss of FFM. It allows tailored nutritional support and disease-specific therapy and reduces the risk of drug toxicity. Body composition evaluation should be integrated into routine clinical practice for the initial assessment and sequential follow-up of nutritional status. It could allow objective, systematic, and early screening of undernutrition and promote the rational and early initiation of optimal nutritional support, thereby contributing to reducing malnutrition-induced morbidity, mortality, worsening of the quality of life, and global health care costs.

[1]  P. Preux,et al.  Phase angle is a prognostic factor for survival in amyotrophic lateral sclerosis , 2008, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

[2]  C. Pichard,et al.  Body composition in patients with chronic hypercapnic respiratory failure. , 2006, Respiratory medicine.

[3]  W. Leslie,et al.  Body mass and composition affect bone density in recently diagnosed inflammatory bowel disease: The Manitoba IBD cohort study , 2009, Inflammatory bowel diseases.

[4]  O. Ljungqvist,et al.  Health economic impact of managing patients following a community-based diagnosis of malnutrition in the UK. , 2011, Clinical nutrition.

[5]  C. Pichard,et al.  Comparison of body weight and composition measured by two different dual energy X-ray absorptiometry devices and three acquisition modes in obese women. , 2006, Clinical nutrition.

[6]  C. Pichard,et al.  Comparison of Four Bioelectrical Impedance Analysis Formulas in Healthy Elderly Subjects , 2001, Gerontology.

[7]  J. Grutsch,et al.  Bioelectrical impedance phase angle in clinical practice: implications for prognosis in stage IIIB and IV non-small cell lung cancer , 2009, BMC Cancer.

[8]  L. Mccargar,et al.  Sarcopenia as a Determinant of Chemotherapy Toxicity and Time to Tumor Progression in Metastatic Breast Cancer Patients Receiving Capecitabine Treatment , 2009, Clinical Cancer Research.

[9]  M. Elia,et al.  Bioelectrical impedance analysis-part II: utilization in clinical practice. , 2004, Clinical nutrition.

[10]  M. Elia,et al.  Bioelectrical impedance analysis--part I: review of principles and methods. , 2004, Clinical nutrition.

[11]  A. Sohlström,et al.  Changes in total body fat during the human reproductive cycle as assessed by magnetic resonance imaging, body water dilution, and skinfold thickness: a comparison of methods. , 1997, The American journal of clinical nutrition.

[12]  J. Cleland,et al.  Body mass indices and outcome in patients with chronic heart failure , 2011, European journal of heart failure.

[13]  R. Thibault,et al.  [Assessment of nutritional status and body composition in patients with COPD: comparison of several methods]. , 2010, Revue des maladies respiratoires.

[14]  D. Kotler,et al.  Severity of human immunodeficiency virus infection is associated with decreased phase angle, fat mass and body cell mass in adults with pulmonary tuberculosis infection in Uganda. , 2001, The Journal of nutrition.

[15]  E. Marini,et al.  Bioelectrical impedance vector analysis detects low body cell mass and dehydration in patients with Alzheimer’s disease , 2010, The journal of nutrition, health & aging.

[16]  P. Kornprat,et al.  Serum albumin, subjective global assessment, body mass index and the bioimpedance analysis in the assessment of malnutrition in patients up to 15 years after liver transplantation , 2011, Clinical transplantation.

[17]  D. Tibboel,et al.  Measuring body composition and energy expenditure in children with severe neurologic impairment and intellectual disability. , 2011, The American journal of clinical nutrition.

[18]  M. Elia,et al.  ESPEN guidelines for nutrition screening 2002. , 2003, Clinical nutrition.

[19]  B. Nordestgaard,et al.  Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study. , 2006, American journal of respiratory and critical care medicine.

[20]  C. Pichard,et al.  Body composition changes over 9 years in healthy elderly subjects and impact of physical activity. , 2011, Clinical nutrition.

[21]  R. Rizzoli,et al.  Longitudinal follow-up of body composition in hematopoietic stem cell transplant patients , 2005, Bone Marrow Transplantation.

[22]  G. Hill Jonathan E. Rhoads Lecture. Body composition research: implications for the practice of clinical nutrition. , 1992, JPEN. Journal of parenteral and enteral nutrition.

[23]  Claude Pichard,et al.  Body composition interpretation. Contributions of the fat-free mass index and the body fat mass index. , 2003, Nutrition.

[24]  Y Schutz,et al.  Fat-free mass index and fat mass index percentiles in Caucasians aged 18–98 y , 2002, International Journal of Obesity.

[25]  B. Magnuson,et al.  Hypocaloric considerations in patients with potentially hypometabolic disease States. , 2011, Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.

[26]  Y. Lacasse,et al.  Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease. , 2002, American journal of respiratory and critical care medicine.

[27]  Lisa Martin,et al.  Sarcopenia in an Overweight or Obese Patient Is an Adverse Prognostic Factor in Pancreatic Cancer , 2009, Clinical Cancer Research.

[28]  C. Pichard,et al.  Assessment of food intake in hospitalised patients: a 10-year comparative study of a prospective hospital survey. , 2011, Clinical nutrition.

[29]  S. Heymsfield,et al.  The five-level model: a new approach to organizing body-composition research. , 1992, The American journal of clinical nutrition.

[30]  M. Samore,et al.  Effects of body size and body composition on survival in hemodialysis patients. , 2003, Journal of the American Society of Nephrology : JASN.

[31]  C. Pichard,et al.  Energy expenditure in anorexia nervosa: can fat-free mass as measured by bioelectrical impedance predict energy expenditure in hospitalized patients? , 1996, Clinical nutrition.

[32]  C. Pichard,et al.  Treatment of cachexia with recombinant growth hormone in a patient before lung transplantation: a case report. , 1999, Critical care medicine.

[33]  M. Manary,et al.  Supplementary feeding with either ready-to-use fortified spread or corn-soy blend in wasted adults starting antiretroviral therapy in Malawi: randomised, investigator blinded, controlled trial , 2009, BMJ : British Medical Journal.

[34]  F. Moore Reliable Bioelectrical Impedance Analysis Estimate of Fat-free Mass in Liver , Lung , and Heart Transplant Patients , 2022 .

[35]  A. Barros,et al.  Standardized phase angle from bioelectrical impedance analysis as prognostic factor for survival in patients with cancer , 2011, Supportive Care in Cancer.

[36]  A. R. Frisancho,et al.  New norms of upper limb fat and muscle areas for assessment of nutritional status. , 1981, The American journal of clinical nutrition.

[37]  M. Elia,et al.  Phase angle from bioelectrical impedance analysis remains an independent predictive marker in HIV-infected patients in the era of highly active antiretroviral treatment. , 2000, The American journal of clinical nutrition.

[38]  J. Reynolds,et al.  Enteral Nutrition Enriched With Eicosapentaenoic Acid (EPA) Preserves Lean Body Mass Following Esophageal Cancer Surgery: Results of a Double-Blinded Randomized Controlled Trial , 2009, Annals of surgery.

[39]  L. Birdsell,et al.  Association of skeletal muscle wasting with treatment with sorafenib in patients with advanced renal cell carcinoma: results from a placebo-controlled study. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[40]  D. Volkert,et al.  Bioelectric impedance phase angle is associated with hospital mortality of geriatric patients. , 2010, Archives of gerontology and geriatrics.

[41]  C. Pichard,et al.  Increased length of hospital stay in underweight and overweight patients at hospital admission: a controlled population study. , 2005, Clinical nutrition.

[42]  Tony Reiman,et al.  Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. , 2008, The Lancet. Oncology.

[43]  M. Brindisi,et al.  Body fluid retention and body weight change in anorexia nervosa patients during refeeding. , 2010, Clinical nutrition.

[44]  C. Pichard,et al.  Underweight patients with anorexia nervosa: comparison of bioelectrical impedance analysis using five equations to dual X-ray absorptiometry. , 2011, Clinical Nutrition.

[45]  A. Ionescu,et al.  Associated loss of fat-free mass and bone mineral density in chronic obstructive pulmonary disease. , 2004, American journal of respiratory and critical care medicine.

[46]  R. Hyzy,et al.  Bioelectrical impedance assessment of nutritional status in critically ill patients. , 1993, The American journal of clinical nutrition.

[47]  F. Slinde,et al.  Body composition by bioelectrical impedance predicts mortality in chronic obstructive pulmonary disease patients. , 2005, Respiratory medicine.

[48]  P. Preux,et al.  Alteration of nutritional status at diagnosis is a prognostic factor for survival of amyotrophic lateral sclerosis patients , 2010, Journal of Neurology, Neurosurgery & Psychiatry.

[49]  J. Grutsch,et al.  Bioelectrical impedance phase angle in clinical practice: implications for prognosis in advanced colorectal cancer. , 2004, The American journal of clinical nutrition.

[50]  C. Pichard,et al.  Lack of effects of recombinant growth hormone on muscle function in patients requiring prolonged mechanical ventilation: a prospective, randomized, controlled study. , 1996, Critical care medicine.

[51]  P. Angeli,et al.  Malnutrition in alcoholic and virus-related cirrhosis. , 1996, The American journal of clinical nutrition.

[52]  P. Fein,et al.  Extracellular mass/body cell mass ratio is an independent predictor of survival in peritoneal dialysis patients. , 2010, Kidney international. Supplement.

[53]  Dorothee Volkert,et al.  The German hospital malnutrition study. , 2006, Clinical nutrition.

[54]  L. Birdsell,et al.  Low body mass index and sarcopenia associated with dose-limiting toxicity of sorafenib in patients with renal cell carcinoma. , 2010, Annals of oncology : official journal of the European Society for Medical Oncology.

[55]  R. Barr,et al.  Reproducibility of DXA measurements of bone mineral density and body composition in children , 2009, Pediatric Radiology.

[56]  Tony Reiman,et al.  Body composition in patients with non-small cell lung cancer: a contemporary view of cancer cachexia with the use of computed tomography image analysis. , 2010, The American journal of clinical nutrition.

[57]  D. Menon,et al.  Quantification of lean and fat tissue repletion following critical illness: a case report , 2008, Critical care.

[58]  J. Wang,et al.  Body potassium by four-pi 40K counting: an anthropometric correction. , 1984, The American journal of physiology.

[59]  K. Westerterp,et al.  Body composition by bioelectrical-impedance analysis compared with deuterium dilution and skinfold anthropometry in patients with chronic obstructive pulmonary disease. , 1991, The American journal of clinical nutrition.

[60]  E. Wouters,et al.  Body composition and mortality in chronic obstructive pulmonary disease. , 2005, American Journal of Clinical Nutrition.

[61]  W. Fawzi,et al.  Nutritional status and mortality among HIV-infected patients receiving antiretroviral therapy in Tanzania. , 2011, The Journal of infectious diseases.

[62]  J. Grutsch,et al.  Bioelectrical impedance phase angle as a prognostic indicator in advanced pancreatic cancer. , 2004, The British journal of nutrition.

[63]  F. Slinde,et al.  Body composition by bioelectrical impedance predicts mortality in chronic obstructive pulmonary disease patients. , 2005, Respiratory medicine.

[64]  C. Pichard,et al.  Contribution of body composition to nutritional assessment at hospital admission in 995 patients: a controlled population study , 2001, British Journal of Nutrition.

[65]  M. Jaffrin Body composition determination by bioimpedance: an update , 2009, Current opinion in clinical nutrition and metabolic care.

[66]  A. Barros,et al.  Bioelectric impedance and individual characteristics as prognostic factors for post-operative complications. , 2003, Clinical nutrition.

[67]  M. Martínez-García,et al.  Mid-arm muscle area is a better predictor of mortality than body mass index in COPD. , 2006, Chest.

[68]  C. Pichard,et al.  Multimodal nutritional rehabilitation improves clinical outcomes of malnourished patients with chronic respiratory failure: a randomised controlled trial , 2011, Thorax.

[69]  M. Sawyer,et al.  Two faces of drug therapy in cancer: drug-related lean tissue loss and its adverse consequences to survival and toxicity , 2011, Current opinion in clinical nutrition and metabolic care.

[70]  H. V. van Stel,et al.  The impact of critical illness on perceived health-related quality of life during ICU treatment, hospital stay, and after hospital discharge: a long-term follow-up study. , 2008, Chest.

[71]  A. Covic,et al.  Nutritional status evaluation and survival in haemodialysis patients in one centre from Romania. , 2009, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[72]  Tony Reiman,et al.  Body Composition as an Independent Determinant of 5-Fluorouracil–Based Chemotherapy Toxicity , 2007, Clinical Cancer Research.

[73]  L. Ferrucci,et al.  Sarcopenic obesity: definition, cause and consequences , 2008, Current opinion in clinical nutrition and metabolic care.

[74]  C. Pichard,et al.  Single prediction equation for bioelectrical impedance analysis in adults aged 20--94 years. , 2001, Nutrition.

[75]  P. Iversen,et al.  Body composition in older acute stroke patients after treatment with individualized, nutritional supplementation while in hospital , 2010, BMC geriatrics.

[76]  L. Caregaro,et al.  Nutrition and survival in patients with liver cirrhosis. , 2001, Nutrition.

[77]  C. Pichard,et al.  Body composition measurements: interpretation finally made easy for clinical use , 2003, Current opinion in clinical nutrition and metabolic care.

[78]  C. Pichard,et al.  New bioelectrical impedance formula for patients with respiratory insufficiency: comparison to dual-energy X-ray absorptiometry. , 1998, The European respiratory journal.

[79]  M. Arad,et al.  Body mass index (BMI), body composition and mortality of nursing home elderly residents. , 2010, Archives of gerontology and geriatrics.

[80]  M. Palma,et al.  Prevalence and influence of malnutrition on quality of life and performance status in patients with locally advanced head and neck cancer before treatment , 2010, Supportive Care in Cancer.

[81]  J. Durnin,et al.  Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 Years , 1974, British Journal of Nutrition.

[82]  R. Mushnick,et al.  Relationship of bioelectrical impedance parameters to nutrition and survival in peritoneal dialysis patients. , 2003, Kidney international. Supplement.

[83]  C. Pichard,et al.  Fat-free and fat mass percentiles in 5225 healthy subjects aged 15 to 98 years. , 2001, Nutrition.

[84]  E. Smit,et al.  Oral nutritional supplements containing (n-3) polyunsaturated fatty acids affect the nutritional status of patients with stage III non-small cell lung cancer during multimodality treatment. , 2010, The Journal of nutrition.

[85]  T. Amaral,et al.  The economic impact of disease-related malnutrition at hospital admission. , 2007, Clinical nutrition.

[86]  C. Pichard,et al.  Body composition measurements during wasting diseases. , 1998, Current opinion in clinical nutrition and metabolic care.

[87]  Tony Reiman,et al.  A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. , 2008, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[88]  R. Ross,et al.  Abdominal obesity, liver fat, and muscle composition in survivors of childhood acute lymphoblastic leukemia. , 2007, The Journal of clinical endocrinology and metabolism.

[89]  C. Montagnese,et al.  Prognostic significance of bioelectrical impedance phase angle in advanced cancer: preliminary observations. , 2009, Nutrition (Burbank, Los Angeles County, Calif.).

[90]  O. Selberg,et al.  Norms and correlates of bioimpedance phase angle in healthy human subjects, hospitalized patients, and patients with liver cirrhosis , 2002, European Journal of Applied Physiology.

[91]  A. Fürstenberg,et al.  Assessment of Body Composition in Peritoneal Dialysis Patients Using Bioelectrical Impedance and Dual-Energy X-Ray Absorptiometry , 2011, American Journal of Nephrology.

[92]  Shumei S. Sun,et al.  Bioelectrical Impedance Analysis , 2005 .

[93]  S Burastero,et al.  Prediction of body cell mass, fat-free mass, and total body water with bioelectrical impedance analysis: effects of race, sex, and disease. , 1996, The American journal of clinical nutrition.

[94]  A. Forbes,et al.  ESPEN Guidelines on Parenteral Nutrition: intensive care. , 2006, Clinical nutrition.

[95]  G. Van den Berghe,et al.  ESPEN Guidelines on Enteral Nutrition: Intensive care. , 2006, Clinical nutrition.

[96]  C. Pichard,et al.  Nutritional assessment: lean body mass depletion at hospital admission is associated with an increased length of stay. , 2004, The American journal of clinical nutrition.