Achieving improved permeability by hydrogen bond donor modulation in a series of MGAT2 inhibitors
暂无分享,去创建一个
Philip A. MacFaul | Graeme R. Robb | Andrew G. Leach | David S. Clarke | Hayley S. Brown | James S. Scott | P. Macfaul | G. Robb | David J. Berry | Linda K. Buckett | Kristin Goldberg | Julian A. Hudson | Piotr Raubo | P. Raubo | J. Hudson | D. S. Clarke | K. Goldberg | L. Buckett | D. J. Berry
[1] R. Coleman,et al. Enzymes of glycerolipid synthesis in eukaryotes. , 1980, Annual review of biochemistry.
[2] Robert V Farese,et al. MGAT2, a Monoacylglycerol Acyltransferase Expressed in the Small Intestine* , 2003, The Journal of Biological Chemistry.
[3] Peter W. Kenny,et al. Prediction of hydrogen bond basicity from computed molecular electrostatic properties: implications for comparative molecular field analysis , 1994 .
[4] Robert V Farese,et al. Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding , 2009, Nature Medicine.
[5] P. Coleman,et al. Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoprotein. , 2007, Bioorganic & medicinal chemistry letters.
[6] Peter W. Kenny,et al. Hydrogen Bonding, Electrostatic Potential, and Molecular Design , 2009, J. Chem. Inf. Model..
[7] Malin Lemurell,et al. Identification and design of a novel series of MGAT2 inhibitors. , 2013, Bioorganic & medicinal chemistry letters.
[8] P. Artursson,et al. Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories. , 2008, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[9] Yongxin Han,et al. Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents. , 2011, Bioorganic & medicinal chemistry letters.
[10] M. Waring. Lipophilicity in drug discovery , 2010, Expert Opinion on Drug Discovery.
[11] C. L. Yen,et al. Deficiency of MGAT2 increases energy expenditure without high-fat feeding and protects genetically obese mice from excessive weight gain , 2011, Journal of Lipid Research.
[12] Matthew P. Jacobson,et al. Predicting and improving the membrane permeability of peptidic small molecules. , 2012, Journal of medicinal chemistry.
[13] M. Waring. Defining optimum lipophilicity and molecular weight ranges for drug candidates-Molecular weight dependent lower logD limits based on permeability. , 2009, Bioorganic & medicinal chemistry letters.
[14] Thomas J. Raub,et al. How hydrogen bonds impact P-glycoprotein transport and permeability. , 2012, Bioorganic & medicinal chemistry letters.
[15] P. Leeson,et al. The influence of drug-like concepts on decision-making in medicinal chemistry , 2007, Nature Reviews Drug Discovery.