Dermoscopy: distinguishing malignant tumors from benign

Dermoscopy has dramatically developed, becoming a well-established routine technique in many countries in the mid-1980s. Dermoscopy allows physicians to observe structures and colors otherwise not visible to unaided eyes, increasing melanoma diagnostic accuracy by up to 35%. Moreover, dermoscopy allows for increases in the number of diagnosed and excised melanomas together with a reduction in the number of unnecessary excisions. New data are continuously acquired mostly on melanoma diagnosis, follow-up of melanocytic lesions and nevogenesis. Short-term 3-month follow-up is the optimum time interval for identifying minimal changes in featureless melanomas. Nevertheless, long-term follow-up is similarly useful for the recognition of changes in melanomas with very low rates of growth. In the last few years a huge number of publications on dermoscopy have been published. The aim of this review is to summarize the most important recent advances in dermoscopy.

[1]  H. Cabo,et al.  Dermoscopy of Cylindroma , 2010, Dermatology research and practice.

[2]  I. Zalaudek,et al.  Seven‐point checklist of dermoscopy revisited , 2011, The British journal of dermatology.

[3]  R. De Angelis,et al.  The specific dermoscopical criteria of Bowen's disease , 2006, Journal of the European Academy of Dermatology and Venereology : JEADV.

[4]  Michael Binder,et al.  Limitations of dermoscopy in the recognition of melanoma. , 2005, Archives of dermatology.

[5]  V. de Giorgi,et al.  Dermoscopy in black people , 2006, The British journal of dermatology.

[6]  Cesare Massone,et al.  Dermoscopy for skin cancer detection , 2005, Current opinion in oncology.

[7]  W. Stolz,et al.  The ABCD rule of dermatoscopy. High prospective value in the diagnosis of doubtful melanocytic skin lesions. , 1994, Journal of the American Academy of Dermatology.

[8]  M. Carulla,et al.  Dermoscopy of pyogenic granuloma: a morphological study , 2010, The British journal of dermatology.

[9]  R. Hofmann-Wellenhof,et al.  Dermoscopy for diagnosis and treatment monitoring of pediculosis capitis. , 2006, Journal of the American Academy of Dermatology.

[10]  J. Malvehy,et al.  Dermoscopy of sebaceous hyperplasia. , 2005, Archives of dermatology.

[11]  J. Malvehy,et al.  Dermoscopic findings in pyogenic granuloma , 2006, The British journal of dermatology.

[12]  C Massone,et al.  Teledermoscopy: education, discussion forums, teleconsulting and mobile teledermoscopy. , 2010, Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia.

[13]  K. Peris,et al.  Vascular patterns in basal cell carcinoma , 2011, Journal of the European Academy of Dermatology and Venereology : JEADV.

[14]  Giovanni Pellacani,et al.  Reflectance Confocal Microscopy for In Vivo Skin Imaging † , 2008, Photochemistry and photobiology.

[15]  A. Marghoob,et al.  Re: Differentiating vessels from globules on dermoscopy. , 2005, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[16]  H. Koga,et al.  Dermoscopy of pigmented lesions on mucocutaneous junction and mucous membrane , 2009, The British journal of dermatology.

[17]  H. Haenssle,et al.  Selection of patients for long-term surveillance with digital dermoscopy by assessment of melanoma risk factors. , 2010, Archives of dermatology.

[18]  A. Marghoob,et al.  The significance of crystalline/chrysalis structures in the diagnosis of melanocytic and nonmelanocytic lesions. , 2012, Journal of the American Academy of Dermatology.

[19]  G. Argenziano,et al.  Amelanotic/hypomelanotic melanoma: clinical and dermoscopic features , 2004, The British journal of dermatology.

[20]  N. Prose,et al.  Clinical and dermoscopic features of 88 scalp naevi in 39 children , 2011, The British journal of dermatology.

[21]  Rory Wolfe,et al.  Rate of growth in melanomas: characteristics and associations of rapidly growing melanomas. , 2006, Archives of dermatology.

[22]  B. N. Akay,et al.  Dermatoscopy of flat pigmented facial lesions: diagnostic challenge between pigmented actinic keratosis and lentigo maligna , 2010, The British journal of dermatology.

[23]  P. Tschandl,et al.  Growth rate of melanoma in vivo and correlation with dermatoscopic and dermatopathologic findings , 2001, Dermatology practical & conceptual.

[24]  P. Carli,et al.  Pattern analysis, not simplified algorithms, is the most reliable method for teaching dermoscopy for melanoma diagnosis to residents in dermatology , 2003, The British journal of dermatology.

[25]  J. Malvehy,et al.  Development of a two-step method for the diagnosis of melanoma by reflectance confocal microscopy. , 2009, Journal of the American Academy of Dermatology.

[26]  H. Koga,et al.  Dermoscopy of Pigmented Poromas , 2010, Dermatology.

[27]  E. Warshaw,et al.  Dermatoscopy use by US dermatologists: a cross-sectional survey. , 2010, Journal of the American Academy of Dermatology.

[28]  H. Kittler,et al.  Follow-up of melanocytic skin lesions with digital epiluminescence microscopy: patterns of modifications observed in early melanoma, atypical nevi, and common nevi. , 2000, Journal of the American Academy of Dermatology.

[29]  I. Zalaudek,et al.  Dermoscopy of Superficial Basal Cell Carcinoma , 2005, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[30]  Claus Garbe,et al.  Epidemiology of melanoma and nonmelanoma skin cancer--the role of sunlight. , 2008, Advances in experimental medicine and biology.

[31]  A. Marghoob,et al.  Pathways to involution of nevi: insights from dermoscopic follow-up. , 2010, Archives of dermatology.

[32]  S. Cramer,et al.  On the Development of Neurocutaneous Units—Implications for the Histogenesis of Congenital, Acquired, and Dysplastic Nevi , 2012, The American Journal of dermatopathology.

[33]  Jennifer L. Schwartz,et al.  Vulvar melanoma: a report of 20 cases and review of the literature. , 2004, Journal of the American Academy of Dermatology.

[34]  L. Thomas,et al.  Dermoscopic examination of nail pigmentation. , 2002, Archives of dermatology.

[35]  R. Botella-Estrada,et al.  Videomicroscopy of Venular Malformations (Port‐Wine Stain Type): Prediction of Response to Pulsed Dye Laser , 2004, Pediatric dermatology.

[36]  G. Argenziano,et al.  Dermoscopic classification of Spitz/Reed nevi. , 2002, Clinics in dermatology.

[37]  I. Zalaudek,et al.  Natural Evolution of Spitz Nevi , 2011, Dermatology.

[38]  F. Vazquez-Lopez,et al.  USEFULNESS OF THE DERMOSCOPE FOR EVALUATING THE DEPTH OF VENULAR MALFORMATIONS , 2005, Pediatric dermatology.

[39]  T. Saida,et al.  In vivo observation of magnified features of pigmented lesions on volar skin using video macroscope. Usefulness of epiluminescence techniques in clinical diagnosis. , 1995, Archives of dermatology.

[40]  J. Avilés-Izquierdo,et al.  [Dermoscopic features of eccrine poroma]. , 2009, Actas dermo-sifiliograficas.

[41]  D. Rigel,et al.  The rationale of the ABCDs of early melanoma. , 1993, Journal of the American Academy of Dermatology.

[42]  M. Mazumdar,et al.  Changes in the presentation of nodular and superficial spreading melanomas over 35 years , 2008, Cancer.

[43]  Toshiaki Saida,et al.  Significance of dermoscopic patterns in detecting malignant melanoma on acral volar skin: results of a multicenter study in Japan. , 2004, Archives of dermatology.

[44]  C‐S. Wu,et al.  Rainbow pattern in Kaposi’s sarcoma under polarized dermoscopy: a dermoscopic pathological study , 2009, The British journal of dermatology.

[45]  P. Carli,et al.  Dermoscopic Features of Mucosal Melanosis , 2004, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[46]  W. Stolz,et al.  Dermatoscopy for facial pigmented skin lesions. , 2002, Clinics in dermatology.

[47]  R. Cabrera,et al.  Dermoscopy in the diagnosis of tungiasis , 2009, The British journal of dermatology.

[48]  N. Cassano,et al.  Dermoscopic Features of Cutaneous Lymphangioma Circumscriptum , 2006, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[49]  A. Blum,et al.  Dermoscopic features of common melanocytic nevi of the junctional, compound and dermal type , 2004 .

[50]  Ken Kobayashi,et al.  Accuracy in melanoma detection: a 10-year multicenter survey. , 2012, Journal of the American Academy of Dermatology.

[51]  W. Bergman,et al.  The impact of dermoscopy on the management of pigmented lesions in everyday clinical practice of general dermatologists: a prospective study , 2010, The British journal of dermatology.

[52]  Telfer Nr,et al.  Guidelines for the management of basal cell carcinoma. British Association of Dermatologists. , 1999 .

[53]  R. Hofmann-Wellenhof,et al.  Dermoscopy patterns of halo nevi. , 2006, Archives of dermatology.

[54]  I. Zalaudek,et al.  Lupus Vulgaris: A New Look at an Old Symptom – The Lupoma Observed with Dermoscopy , 2008, Dermatology.

[55]  I. Zalaudek,et al.  The dermoscopic variability of pigment network in melanoma in situ , 2012, Melanoma research.

[56]  J. Malvehy,et al.  Dermoscopy of cutaneous leishmaniasis , 2009, The British journal of dermatology.

[57]  H. Kerl,et al.  Epidemiology and aetiology of basal cell carcinoma , 2007, The British journal of dermatology.

[58]  C. Longo,et al.  The impact of in vivo reflectance confocal microscopy for the diagnostic accuracy of melanoma and equivocal melanocytic lesions. , 2007, The Journal of investigative dermatology.

[59]  Milind Rajadhyaksha,et al.  Polarized and nonpolarized dermoscopy: the explanation for the observed differences. , 2008, Archives of dermatology.

[60]  H. Rabinovitz,et al.  White shiny structures: dermoscopic features revealed under polarized light , 2011, Journal of the European Academy of Dermatology and Venereology : JEADV.

[61]  V. De Giorgi,et al.  Non-invasive analysis of melanoma thickness by means of dermoscopy: a retrospective study , 2001, Melanoma research.

[62]  L. Thomas,et al.  Melanoma: early diagnosis using in vivo reflectance confocal microscopy , 2011, Clinical and experimental dermatology.

[63]  Giuseppe Micali,et al.  Cutaneous vascular patterns in psoriasis , 2010, International journal of dermatology.

[64]  S. Seidenari,et al.  Reflectance-mode confocal microscopy of pigmented skin lesions--improvement in melanoma diagnostic specificity. , 2005, Journal of the American Academy of Dermatology.

[65]  J. Malvehy,et al.  Dermoscopy of molluscum contagiosum: a useful tool for clinical diagnosis in adulthood , 2006, Journal of the European Academy of Dermatology and Venereology : JEADV.

[66]  S. Bottini,et al.  Dermoscopic vascular patterns in nodular "pure" amelanotic melanoma. , 2007, Archives of dermatology.

[67]  I. Zalaudek,et al.  What dermoscopy tells us about nevogenesis , 2011, The Journal of dermatology.

[68]  Michael P Schön,et al.  Seven-point checklist for dermatoscopy: performance during 10 years of prospective surveillance of patients at increased melanoma risk. , 2010, Journal of the American Academy of Dermatology.

[69]  A. Oakley,et al.  Better, sooner, more convenient: A successful teledermoscopy service , 2012, The Australasian journal of dermatology.

[70]  N. Pérez-Oliva,et al.  Dermoscopy of active lichen planus. , 2007, Archives of dermatology.

[71]  S. Menzies,et al.  The significance of eccentric and central hyperpigmentation, multifocal hyper/hypopigmentation, and the multicomponent pattern in melanocytic lesions lacking specific dermoscopic features of melanoma. , 2008, Archives of dermatology.

[72]  C. Longo,et al.  The impact of in vivo reflectance confocal microscopy on the diagnostic accuracy of lentigo maligna and equivocal pigmented and nonpigmented macules of the face. , 2010, The Journal of investigative dermatology.

[73]  C. Morton,et al.  Guidelines for the management of basal cell carcinoma , 2008, The British journal of dermatology.

[74]  R. Hofmann-Wellenhof,et al.  The epidermal and dermal origin of melanocytic tumors: theoretical considerations based on epidemiologic, clinical, and histopathologic findings. , 2008, The American Journal of dermatopathology.

[75]  Josep Malvehy,et al.  Time required for a complete skin examination with and without dermoscopy: a prospective, randomized multicenter study. , 2008, Archives of dermatology.

[76]  C. Longo,et al.  In vivo confocal microscopic and histopathologic correlations of dermoscopic features in 202 melanocytic lesions. , 2008, Archives of dermatology.

[77]  J. Kreusch,et al.  How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part I. Melanocytic skin tumors. , 2010, Journal of the American Academy of Dermatology.

[78]  T. Saida,et al.  Characteristic epiluminescent microscopic features of early malignant melanoma on glabrous skin. A videomicroscopic analysis. , 1998, Archives of dermatology.

[79]  L. Thomas,et al.  Reflectance confocal microscopy accurately discriminates between benign and malignant melanocytic lesions exhibiting a ‘dermoscopic island’ , 2013, Journal of the European Academy of Dermatology and Venereology : JEADV.

[80]  K Wolff,et al.  In vivo epiluminescence microscopy of pigmented skin lesions. II. Diagnosis of small pigmented skin lesions and early detection of malignant melanoma. , 1987, Journal of the American Academy of Dermatology.

[81]  Giovanni Pellacani,et al.  In vivo reflectance confocal microscopy enhances secondary evaluation of melanocytic lesions. , 2009, The Journal of investigative dermatology.

[82]  I Zalaudek,et al.  Slow‐growing melanoma: a dermoscopy follow‐up study , 2010, The British journal of dermatology.

[83]  A. Marghoob,et al.  Diagnosis and management of nail pigmentations. , 2007, Journal of the American Academy of Dermatology.

[84]  Milind Rajadhyaksha,et al.  Differences between polarized light dermoscopy and immersion contact dermoscopy for the evaluation of skin lesions. , 2007, Archives of dermatology.

[85]  K. Puttgen,et al.  No biopsy needed for eclipse and cockade nevi found on the scalps of children. , 2009, Archives of dermatology.

[86]  A. Lallas,et al.  Dermoscopy of early stage mycosis fungoides , 2013, Journal of the European Academy of Dermatology and Venereology : JEADV.

[87]  P. Coto-Segura,et al.  Dermoscopy of port-wine stains. , 2007, Archives of Dermatology.

[88]  Josep Malvehy,et al.  Historical, clinical, and dermoscopic characteristics of thin nodular melanoma. , 2010, Archives of dermatology.

[89]  Ashfaq A Marghoob,et al.  Observation of chrysalis structures with polarized dermoscopy. , 2009, Archives of dermatology.

[90]  R. Hofmann-Wellenhof,et al.  An additional dermoscopic feature of tungiasis. , 2005, Archives of dermatology.

[91]  D.Y. Lee,et al.  The use of dermoscopy for the diagnosis of plantar wart , 2009, Journal of the European Academy of Dermatology and Venereology : JEADV.

[92]  G. Filosa,et al.  Dermoscopy of lichen planus‐like keratosis: a model of inflammatory regression , 2007, Journal of the European Academy of Dermatology and Venereology : JEADV.

[93]  A. Marghoob,et al.  Clinical and dermoscopic stability and volatility of melanocytic nevi in a population-based cohort of children in Framingham school system , 2011, The Journal of investigative dermatology.

[94]  S. Menzies,et al.  Surface microscopy of pigmented basal cell carcinoma. , 2000, Archives of dermatology.

[95]  C. Dunton,et al.  Vulvar melanoma, biologically different from other cutaneous melanomas , 1999, The Lancet.

[96]  S. M. Stricklin,et al.  Cloudy and starry milia‐like cysts: how well do they distinguish seborrheic keratoses from malignant melanomas? , 2011, Journal of the European Academy of Dermatology and Venereology : JEADV.

[97]  Iris Zalaudek,et al.  非色素皮膚腫瘍の診断法:デルモスコピーで観察された血管構造の展望:I.メラニン細胞性皮膚腫瘍 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター , 2010 .

[98]  H. Koga,et al.  Key point in dermoscopic differentiation between early nail apparatus melanoma and benign longitudinal melanonychia , 2011, The Journal of dermatology.

[99]  I. Zalaudek,et al.  Dermoscopy of Eccrine Poroma , 2007, Dermatology.

[100]  Toshiaki Saida,et al.  Dermoscopy for acral pigmented skin lesions. , 2002, Clinics in dermatology.

[101]  A. Marghoob,et al.  Dermoscopic rainbow pattern in non‐Kaposi sarcoma lesions , 2009, The British journal of dermatology.

[102]  I. Zalaudek,et al.  Spitz nevus: an evolving clinicopathologic concept. , 2010, The American Journal of dermatopathology.

[103]  R. Schwartz,et al.  Dermatoscopy: alternative uses in daily clinical practice. , 2011, Journal of the American Academy of Dermatology.

[104]  Lidia Rudnicka,et al.  Trichoscopy: a new method for diagnosing hair loss. , 2008, Journal of drugs in dermatology : JDD.

[105]  Harold S Rabinovitz,et al.  Dermoscopy of pigmented skin lesions. , 2005, Journal of the American Academy of Dermatology.

[106]  R. Hofmann-Wellenhof,et al.  Entodermoscopy: A New Tool for Diagnosing Skin Infections and Infestations , 2007, Dermatology.

[107]  M. G. Fleming,et al.  Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet. , 2003, Journal of the American Academy of Dermatology.

[108]  Josep Malvehy,et al.  Dermoscopy of solitary angiokeratomas: a morphological study. , 2007, Archives of dermatology.

[109]  A. Marghoob,et al.  Differences in Dermoscopic Images from Nonpolarized Dermoscope and Polarized Dermoscope Influence the Diagnostic Accuracy and Confidence Level: A Pilot Study , 2008, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[110]  G. P. Lozzi,et al.  Early melanomas dermoscopically characterized by reticular depigmentation. , 2007, Archives of dermatology.

[111]  S. Menzies,et al.  Impact of dermoscopy and short‐term sequential digital dermoscopy imaging for the management of pigmented lesions in primary care: a sequential intervention trial , 2009, The British journal of dermatology.

[112]  I. Zalaudek,et al.  The many faces of blue nevus: A clinicopathologic study , 2007, Journal of cutaneous pathology.

[113]  G. Argenziano,et al.  Dermatoscopic pitfalls in differentiating pigmented Spitz naevi from cutaneous melanomas , 1999, The British journal of dermatology.

[114]  Emma Altobelli,et al.  Dermoscopic patterns of acral melanocytic nevi and melanomas in a white population in central Italy. , 2006, Archives of dermatology.

[115]  C. Berking,et al.  Reflectance confocal microscopy in the diagnosis of partially and completely amelanotic melanoma: report on seven cases , 2013, Journal of the European Academy of Dermatology and Venereology : JEADV.

[116]  B. Piraccini,et al.  In Situ Melanoma of the Nail Unit in Children: Report of Two Cases in Fair‐Skinned Caucasian Children , 2012, Pediatric dermatology.

[117]  A. Marghoob,et al.  Dermoscopy in skin self-examination: A useful tool for select patients. , 2011, Archives of dermatology.

[118]  V. de Giorgi,et al.  Dermoscopy pattern of cutaneous angiosarcoma. , 2011, European journal of dermatology : EJD.

[119]  R. Hofmann-Wellenhof,et al.  Shiny white streaks: An additional dermoscopic finding in melanomas viewed using contact polarised dermoscopy , 2010, The Australasian journal of dermatology.

[120]  L. Thomas,et al.  Features of pigmented vulval lesions on dermoscopy , 2011, The British journal of dermatology.

[121]  H. Wolff,et al.  Diagnosis of scabies with dermoscopy , 2008, Canadian Medical Association Journal.

[122]  Giovanni Pellacani,et al.  Dermoscopic island: a new descriptor for thin melanoma. , 2010, Archives of dermatology.

[123]  H. Ko,et al.  The use of dermatoscopy to differentiate vestibular papillae, a normal variant of the female external genitalia, from condyloma acuminata. , 2009, Journal of the American Academy of Dermatology.

[124]  A. Scope,et al.  Dermoscopic patterns of naevi in fifth grade children of the Framingham school system , 2008, The British journal of dermatology.

[125]  P. Buccini,et al.  Vulvar melanoma: a report of 10 cases and review of the literature , 2008, Melanoma research.

[126]  D. Velázquez-Tarjuelo,et al.  Características dermatoscópicas del poroma ecrino , 2009 .

[127]  A. Kopf,et al.  Early detection of malignant melanoma: The role of physician examination and self‐examination of the skin , 1985, CA: a cancer journal for clinicians.

[128]  K. Peris,et al.  Dermoscopy in the diagnosis and management of non-melanoma skin cancers. , 2012, European journal of dermatology : EJD.

[129]  W. Bergman,et al.  Impact of dermoscopy on the management of high-risk patients from melanoma families: a prospective study. , 2011, Acta dermato-venereologica.

[130]  A. Marghoob,et al.  Proposal for a revised 2-step algorithm for the classification of lesions of the skin using dermoscopy. , 2010, Archives of dermatology.

[131]  T. Akalın,et al.  Variations in the dermoscopic features of acquired acral melanocytic nevi. , 2007, Archives of dermatology.

[132]  A. Marghoob,et al.  Frequency of dermoscopic nevus subtypes by age and body site: a cross-sectional study. , 2011, Archives of dermatology.

[133]  Giuseppe Argenziano,et al.  Three-Point Checklist of Dermoscopy , 2004, Dermatology.

[134]  P. Buccini,et al.  Eccrine poroma: a clinical-dermoscopic study of seven cases. , 2009, Acta dermato-venereologica.

[135]  A. Marghoob,et al.  Dermoscopy: what's new? , 2009, Clinics in dermatology.

[136]  J. Bae,et al.  Differential diagnosis of plantar wart from corn, callus and healed wart with the aid of dermoscopy , 2009, The British journal of dermatology.

[137]  I Zalaudek,et al.  Changes observed in slow‐growing melanomas during long‐term dermoscopic monitoring , 2012, The British journal of dermatology.

[138]  R Hofmann-Wellenhof,et al.  Proposal of a new classification system for melanocytic naevi , 2007, The British journal of dermatology.

[139]  G. Argenziano,et al.  Diagnosis of pigmented skin lesions by dermoscopy: web‐based training improves diagnostic performance of non‐experts , 2003, The British journal of dermatology.

[140]  H. Ustun,et al.  Bonbon toffee sign: a new dermatoscopic feature for sebaceous hyperplasia , 2008, Journal of the European Academy of Dermatology and Venereology : JEADV.

[141]  A. Chuh,et al.  Diagnosis of Pediculosis pubis: a novel application of digital epiluminescence dermatoscopy , 2007, Journal of the European Academy of Dermatology and Venereology : JEADV.

[142]  I. Zalaudek,et al.  Pediatric Atypical Spitzoid Neoplasms: A Review with Emphasis on ‘Red’ (‘Spitz’) Tumors and ‘Blue’ (‘Blitz’) Tumors , 2010, Dermatology.

[143]  S. Menzies,et al.  Assessment of the optimal interval for and sensitivity of short-term sequential digital dermoscopy monitoring for the diagnosis of melanoma. , 2008, Archives of dermatology.

[144]  I. Zalaudek,et al.  Dermoscopy subpatterns of inflammatory skin disorders. , 2006, Archives of dermatology.

[145]  M. Oliviero,et al.  Dermoscopic pattern of pigmented basal cell carcinoma, blue-white variant. , 2006, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[146]  Jürgen Kreusch,et al.  Auflichtmikroskopische Charakterisierung von Gefäßmustern in Hauttumoren , 1996, Der Hautarzt.

[147]  Vitaly Terushkin,et al.  Analysis of the benign to malignant ratio of lesions biopsied by a general dermatologist before and after the adoption of dermoscopy. , 2011, Archives of dermatology.

[148]  G. Cevenini,et al.  Differentiation between pigmented Spitz naevus and melanoma by digital dermoscopy and stepwise logistic discriminant analysis , 2001, Melanoma research.

[149]  Cesare Massone,et al.  Mobile teledermoscopy--melanoma diagnosis by one click? , 2009, Seminars in cutaneous medicine and surgery.

[150]  G. Jemec,et al.  Diagnosis of Nonmelanoma Skin Cancer/Keratinocyte Carcinoma: A Review of Diagnostic Accuracy of Nonmelanoma Skin Cancer Diagnostic Tests and Technologies , 2007, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[151]  J. Kreusch,et al.  How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part II. Nonmelanocytic skin tumors. , 2010, Journal of the American Academy of Dermatology.

[152]  R. Braun,et al.  Diagnostic Pitfall: Pigmented Lesion of the Nipple – Correlation between Dermoscopy, Reflectance Confocal Microscopy and Histopathology , 2010, Dermatology.

[153]  J. Kelly Nodular melanoma: how current approaches to early detection are failing. , 2005, Journal of Drugs in Dermatology.

[154]  S. Menzies,et al.  Frequency and morphologic characteristics of invasive melanomas lacking specific surface microscopic features. , 1996, Archives of dermatology.

[155]  R. Hofmann-Wellenhof,et al.  Frequency, clinical and dermoscopic features of benign papillomatous melanocytic naevi (Unna type) , 2009, The British journal of dermatology.

[156]  G. Argenziano,et al.  Epiluminescence microscopy for the diagnosis of doubtful melanocytic skin lesions. Comparison of the ABCD rule of dermatoscopy and a new 7-point checklist based on pattern analysis. , 1998, Archives of dermatology.

[157]  K. Peris,et al.  Unusual clinical and dermoscopic features in two cases of pigmented basal cell carcinoma. , 2005, Journal of the American Academy of Dermatology.

[158]  B. Piraccini,et al.  Dealing with melanonychia. , 2009, Seminars in cutaneous medicine and surgery.

[159]  R. Hofmann-Wellenhof,et al.  Superficial Black Network: An Additional Dermoscopic Clue for the Diagnosis of Pigmented Spindle and/or Epithelioid Cell Nevus , 2001, Dermatology.

[160]  A. Marghoob,et al.  Dermoscopy of pigmented Spitz and Reed nevi: the starburst pattern. , 2005, Archives of dermatology.

[161]  J. André,et al.  In situ amelanotic melanoma of the nail unit mimicking lichen planus: report of 3 cases. , 2010, Archives of dermatology.

[162]  K Wolff,et al.  In vivo epiluminescence microscopy of pigmented skin lesions. I. Pattern analysis of pigmented skin lesions. , 1987, Journal of the American Academy of Dermatology.

[163]  K Wolff,et al.  In vivo epiluminescence microscopy: improvement of early diagnosis of melanoma. , 1993, The Journal of investigative dermatology.

[164]  R. Hofmann-Wellenhof,et al.  Dermoscopy of facial nonpigmented actinic keratosis , 2006, The British journal of dermatology.

[165]  Milind Rajadhyaksha,et al.  Basic principles of reflectance confocal microscopy , 2008 .

[166]  H. Cabo,et al.  Dermoscopy of pigmented lesions of the mucosa and the mucocutaneous junction: results of a multicenter study by the International Dermoscopy Society (IDS). , 2011, Archives of dermatology.

[167]  K. Peris,et al.  Pigmented reticular structures in basal cell carcinoma and collision tumours , 2010, The British journal of dermatology.

[168]  Melanosis of the areola in dermoscopy. , 2004, Journal of the American Academy of Dermatology.

[169]  I. Zalaudek,et al.  Dermoscopic features of melanoma on the scalp. , 2004, Journal of the American Academy of Dermatology.

[170]  Gianluca Petrillo,et al.  Vascular structures in skin tumors: a dermoscopy study. , 2004, Archives of dermatology.

[171]  I Zalaudek,et al.  Blue‐black rule: a simple dermoscopic clue to recognize pigmented nodular melanoma , 2011, The British journal of dermatology.

[172]  A. Marghoob,et al.  Reflectance confocal microscopy and features of melanocytic lesions: an internet-based study of the reproducibility of terminology. , 2009, Archives of dermatology.

[173]  Riccardo Bono,et al.  Dermoscopic evaluation of amelanotic and hypomelanotic melanoma. , 2008, Archives of dermatology.

[174]  J. Malvehy,et al.  Dermoscopic patterns of benign volar melanocytic lesions in patients with atypical mole syndrome. , 2004, Archives of dermatology.

[175]  M. Oliviero,et al.  Dermoscopic differentiation of a superficial basal cell carcinoma and squamous cell carcinoma in situ. , 2006, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[176]  C‐S. Wu,et al.  Dermoscopy of Kaposi's sarcoma: Areas exhibiting the multicoloured ‘rainbow pattern’ , 2009, Journal of the European Academy of Dermatology and Venereology : JEADV.

[177]  R. Hofmann-Wellenhof,et al.  Dermoscopy of Clear-Cell Acanthoma Differs from Dermoscopy of Psoriasis , 2004, Dermatology.

[178]  J. Grob,et al.  Melanoma and tumor thickness: challenges of early diagnosis. , 1999, Archives of dermatology.

[179]  L. Thomas,et al.  Dermoscopy of lentigo maligna melanoma: report of 125 cases , 2012, The British journal of dermatology.

[180]  I. Zalaudek,et al.  The spectrum of Spitz nevi: a clinicopathologic study of 83 cases. , 2005, Archives of dermatology.

[181]  G. Girolomoni,et al.  Videocapillaroscopic alterations in erythematotelangiectatic rosacea. , 2006, Journal of the American Academy of Dermatology.

[182]  G. P. Lozzi,et al.  Eccrine poroma in an unusual site: a clinical and dermoscopic simulator of amelanotic melanoma. , 2005, Journal of the American Academy of Dermatology.

[183]  M. Binder,et al.  Epiluminescence microscopy. A useful tool for the diagnosis of pigmented skin lesions for formally trained dermatologists. , 1995, Archives of dermatology.

[184]  David Whiting,et al.  The role of scalp dermoscopy in the diagnosis of alopecia areata incognita. , 2008, Journal of the American Academy of Dermatology.

[185]  Ralph Braun,et al.  Dermoscopy in General Dermatology , 2005, Dermatology.

[186]  J. Malvehy,et al.  Early stages of melanoma on the limbs of high-risk patients: clinical, dermoscopic, reflectance confocal microscopy and histopathological characterization for improved recognition. , 2011, Acta dermato-venereologica.

[187]  Michael Bailey,et al.  Dermatoscopy aids in the diagnosis of the solitary red scaly patch or plaque-features distinguishing superficial basal cell carcinoma, intraepidermal carcinoma, and psoriasis. , 2008, Journal of the American Academy of Dermatology.

[188]  A. Marghoob,et al.  Dermoscopy vs capillaroscopy of nontumoral dermatoses. , 2004, Archives of dermatology.

[189]  S. Menzies,et al.  Dermoscopy compared with naked eye examination for the diagnosis of primary melanoma: a meta‐analysis of studies performed in a clinical setting , 2008, The British journal of dermatology.

[190]  I. Zalaudek,et al.  Dermoscopy of Pigmented Lesions of the Vulva: A Retrospective Morphological Study , 2011, Dermatology.

[191]  Josep Malvehy,et al.  Dermoscopy report: proposal for standardization. Results of a consensus meeting of the International Dermoscopy Society. , 2007, Journal of the American Academy of Dermatology.

[192]  T. Saida,et al.  Clinical guidelines for the early detection of plantar malignant melanoma. , 1990, Journal of the American Academy of Dermatology.

[193]  Harald Kittler,et al.  Dermatoscopy of pigmented Bowen's disease. , 2010, Journal of the American Academy of Dermatology.

[194]  Giuseppe Argenziano,et al.  Dermoscopic criteria for melanoma in situ are similar to those for early invasive melanoma , 2001, Cancer.

[195]  Ana Morales,et al.  Dermoscopy of molluscum contagiosum. , 2005, Archives of dermatology.

[196]  Giuseppe Argenziano,et al.  Dermatoscopy of basal cell carcinoma: morphologic variability of global and local features and accuracy of diagnosis. , 2010, Journal of the American Academy of Dermatology.

[197]  R. Hofmann-Wellenhof,et al.  The AC Rule for melanoma: a simpler tool for the wider community. , 2011, Journal of the American Academy of Dermatology.

[198]  H. Cabo,et al.  Dermoscopic-pathologic correlation in an unusual case of pigmented basal cell carcinoma. , 2006, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].