MEDICAMENTOS OFF LABEL

Introduction: The use of off-label drugs is common in special populations, such as children and pregnant women, as clinical trials are generally not performed in these populations. This theme is increasingly in the context of public health, especially when referring to the discussion on the rational use of medicines, involving consumer safety and the prescriptions of off-label medicines that have been on a large scale in the country. Objectives: to analyze the role of the pharmacist regarding the consumption of off-label medicines. We also sought to analyze the main risks to patient health associated with the use of prescription drugs off-label. Methods: This is an integrative review with a qualitative research approach. The search for articles was carried out at the Virtual Health Library (VHL) in the Latin American and Caribbean Health Sciences (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE). Results: Drug safety is an ongoing process that begins before it is administered to humans and extends throughout the drug's life cycle. Conclusion: There are potential risks in the use of off-label drugs, due to the lack of conclusive information about the agents and drugs inserted in the drug. The pharmacist can weigh risks and benefits when opting for off label prescription.