Lipotoxicity: when tissues overeat
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[1] M. Reitman,et al. Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes. , 2001, Diabetes.
[2] M. Reitman,et al. WY14,643, a Peroxisome Proliferator-activated Receptor α (PPARα) Agonist, Improves Hepatic and Muscle Steatosis and Reverses Insulin Resistance in Lipoatrophic A-ZIP/F-1 Mice* , 2002, The Journal of Biological Chemistry.
[3] Mark E. Thomas,et al. Fatty acids exacerbate tubulointerstitial injury in protein-overload proteinuria. , 2002, American journal of physiology. Renal physiology.
[4] J. D. de Vries,et al. Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes. , 1997, Journal of lipid research.
[5] H. Nawata,et al. Effects of free fatty acids on β-cell functions: A possible involvement of peroxisome proliferator-activated receptors α or pancreatic/duodenal homeobox , 2001 .
[6] G. Shulman,et al. Prevention of fat-induced insulin resistance by salicylate. , 2001, The Journal of clinical investigation.
[7] D. Eizirik,et al. Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. , 2001, Diabetes.
[8] J. Ibdah,et al. Lack of mitochondrial trifunctional protein in mice causes neonatal hypoglycemia and sudden death. , 2001, The Journal of clinical investigation.
[9] J. McGarry,et al. Fatty acids, lipotoxicity and insulin secretion , 1999, Diabetologia.
[10] E. Bollano,et al. Overexpression of Apolipoprotein B in the Heart Impedes Cardiac Triglyceride Accumulation and Development of Cardiac Dysfunction in Diabetic Mice* , 2002, The Journal of Biological Chemistry.
[11] G. Zimmerman,et al. Intracellular unesterified arachidonic acid signals apoptosis. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[12] L. Orci,et al. Lipotoxic heart disease in obese rats: implications for human obesity. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[13] M. Laakso,et al. Serum lipids and lipoproteins in middle-aged non-insulin-dependent diabetics. , 1985, Atherosclerosis.
[14] S. Rabkin,et al. Palmitate-induced cardiac apoptosis is mediated through CPT-1 but not influenced by glucose and insulin. , 2002, American journal of physiology. Heart and circulatory physiology.
[15] K. Petersen,et al. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. , 2002, The Journal of clinical investigation.
[16] C. Newgard,et al. Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. , 1998, The Journal of biological chemistry.
[17] J. McGarry,et al. Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats. , 2001, Diabetes.
[18] G. Reach,et al. Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration. , 2000, Metabolism: clinical and experimental.
[19] P. Clayton,et al. Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion. , 2001, The Journal of clinical investigation.
[20] J. Björkegren,et al. Lipoprotein Secretion and Triglyceride Stores in the Heart* , 2001, The Journal of Biological Chemistry.
[21] G. Shulman,et al. On Diabetes: Insulin Resistance Cellular Mechanisms of Insulin Resistance , 2022 .
[22] D. Stump,et al. Oleic acid uptake and binding by rat adipocytes define dual pathways for cellular fatty acid uptake. , 2001, Journal of lipid research.
[23] T. Honjo,et al. Inhibition of Carnitine Palmitoyltransferase I Augments Sphingolipid Synthesis and Palmitate-induced Apoptosis* , 1997, The Journal of Biological Chemistry.
[24] M. Cnop,et al. Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity. , 2002, Biochemical pharmacology.
[25] K. Maedler,et al. Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function. , 2001, Diabetes.
[26] C. Schmitz‐Peiffer,et al. Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate* , 1999, The Journal of Biological Chemistry.
[27] C. Wrede,et al. Protein Kinase B/Akt Prevents Fatty Acid-induced Apoptosis in Pancreatic β-Cells (INS-1)* , 2002, The Journal of Biological Chemistry.
[28] P. Herrero,et al. A novel mouse model of lipotoxic cardiomyopathy. , 2001, The Journal of clinical investigation.
[29] A. Svanborg,et al. Gas chromatographic analysis of the fatty acid composition of the plasma lipids in normal and diabetic subjects. , 1960, The Journal of clinical investigation.
[30] M. Prentki,et al. Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects. , 2000, Cancer Research.
[31] Michele Purrello,et al. Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress. , 2002, Metabolism: clinical and experimental.
[32] K. Petersen,et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. , 2002, The Journal of clinical investigation.
[33] M. Bennett,et al. Abnormal myocardial lipid composition in an infant with type II glutaric aciduria. , 1987, Journal of lipid research.
[34] W. Dowhan,et al. Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis. , 2001, The Journal of biological chemistry.
[35] D. Kurtz,et al. Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[36] J. Schaffer. Fatty acid transport: the roads taken. , 2002, American journal of physiology. Endocrinology and metabolism.
[37] M. Sajan,et al. Skeletal muscle insulin resistance in obesity-associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota. , 2002, Diabetes.
[38] Robert V Farese,et al. Triglyceride accumulation protects against fatty acid-induced lipotoxicity , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[39] D. Hale,et al. Molecular basis of inherited medium-chain acyl-CoA dehydrogenase deficiency causing sudden child death , 1992, Journal of Inherited Metabolic Disease.
[40] Michael Karin,et al. Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ , 2001, Science.
[41] G. Shulman,et al. Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle* , 2002, The Journal of Biological Chemistry.
[42] Xianlin Han,et al. The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. , 2002, The Journal of clinical investigation.
[43] Yun-ping Zhou,et al. Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans. , 1995, The Journal of clinical endocrinology and metabolism.
[44] L. Scorrano,et al. Arachidonic Acid Causes Cell Death through the Mitochondrial Permeability Transition , 2000, The Journal of Biological Chemistry.
[45] R. Unger,et al. Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[46] E. Kraegen,et al. Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. , 1997, Diabetes.
[47] T. Utsumi,et al. Roles of long chain fatty acids and carnitine in mitochondrial membrane permeability transition. , 2001, Biochemical pharmacology.
[48] Daniel S. Ory,et al. Palmitate-induced Apoptosis Can Occur through a Ceramide-independent Pathway* , 2001, The Journal of Biological Chemistry.
[49] N. Ruderman,et al. Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α , 2002 .
[50] L. Buja,et al. A metabolic role for mitochondria in palmitate-induced cardiac myocyte apoptosis. , 2000, American journal of physiology. Heart and circulatory physiology.
[51] B. Zinman,et al. The metabolic response to the euglycemic insulin clamp in type I diabetes and normal humans. , 1985, Metabolism: clinical and experimental.
[52] L. Orci,et al. Diseases of liporegulation: new perspective on obesity and related disorders , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[53] M. Reitman,et al. Leptin-replacement therapy for lipodystrophy. , 2002, The New England journal of medicine.
[54] U. Boggi,et al. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. , 2002, Diabetes.
[55] S. Homma,et al. Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy. , 2003, The Journal of clinical investigation.
[56] A. Garg,et al. Editorial: Hepatic steatosis, insulin resistance, and adipose tissue disorders , 2002 .
[57] L. Orci,et al. Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[58] J. Spann,et al. Defective lipid metabolism in the failing heart. , 1968, The Journal of clinical investigation.
[59] R. Unger,et al. Liporegulation in Diet-induced Obesity , 2001, The Journal of Biological Chemistry.
[60] M. Prentki,et al. Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion. , 1992, The Journal of biological chemistry.
[61] G. Shulman,et al. Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects. , 2002, Diabetes.
[62] M. Prentki,et al. Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. , 2002, Diabetes.
[63] N. Nurjhan,et al. Fat metabolism in human obesity. , 1994, The American journal of physiology.