[Kisspeptins in human ovarian tissue during ontogenesis.]

The article presents the results of studies of the expression hormones-kisspeptins and their receptors in human ovarian tissues during ontogenesis of this organ. Kisspeptins regulate the hypothalamic-pituitary-gonadal axis, the most important function of which is to launch the mechanism of puberty. Verification of kisspeptins and their receptors in ovarian tissue, suggests that they promote ovulation, as well as controls the expression of matrix metalloproteinases involved in tissue remodeling. The KISS1/KISS1R system begins be active in the period of prenatal development, so that already at week 22 a positive reaction with antibodies to kisspeptin was recorded in the ovarian tissue. It has been established that, at reproductive age, the expression of kisspeptins remains at a consistently high level, whereas during menopause, the expression of kisspeptins in the ovaries has its peak, which may be due to a compensatory mechanism for reducing the synthesis of ovarian estrogens. In postmenopausal period defined minimum values. Further studies of the metabolism of kisspeptins during menopause will contribute to the expansion of knowledge about their mechanism and the possibility of using them as targeted therapeutic agents.