Protein kinases as targets for anti-parasitic chemotherapy.
暂无分享,去创建一个
[1] M. Noble,et al. Structures of P. falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition. , 2003, Structure.
[2] D. Chakrabarti,et al. Identification and Initial Characterization of Three Novel Cyclin-related Proteins of the Human Malaria Parasite Plasmodium falciparum* , 2003, Journal of Biological Chemistry.
[3] Daniel Kuhn,et al. Protein Kinase Involved in Flagellar-Length Control , 2003, Eukaryotic Cell.
[4] J. Mottram,et al. Stage-specific Differences in Cell Cycle Control in Trypanosoma brucei Revealed by RNA Interference of a Mitotic Cyclin* , 2003, Journal of Biological Chemistry.
[5] R. Azziz. The evaluation and management of hirsutism. , 2003, Obstetrics and gynecology.
[6] M. Dumas,et al. Treatment perspectives for human African trypanosomiasis , 2003, Fundamental & clinical pharmacology.
[7] R. Chakrabarti,et al. Potential Involvement of Extracellular Signal-regulated Kinase 1 and 2 in Encystation of a Primitive Eukaryote, Giardia lamblia , 2003, The Journal of Biological Chemistry.
[8] J. Endicott,et al. Cyclin-dependent kinase homologues of Plasmodium falciparum. , 2002, International journal for parasitology.
[9] E. Vassella,et al. Stage-specific requirement of a mitogen-activated protein kinase by Trypanosoma brucei. , 2002, Molecular biology of the cell.
[10] Zhijian J. Chen,et al. Hijacking of Host Cell IKK Signalosomes by the Transforming Parasite Theileria , 2002, Science.
[11] Jian Wang,et al. The Genome Sequence of the Malaria Mosquito Anopheles gambiae , 2002, Science.
[12] Jonathan E. Allen,et al. Genome sequence of the human malaria parasite Plasmodium falciparum , 2002, Nature.
[13] Jane A. Endicott,et al. Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor , 2002, Nature Structural Biology.
[14] S. Castanys,et al. Two casein kinase 1 isoforms are differentially expressed in Trypanosoma cruzi. , 2002, Molecular and biochemical parasitology.
[15] Laurent Meijer,et al. Protein kinases as drug targets in parasitic protozoa. , 2002, Trends in parasitology.
[16] L. Meijer,et al. Intracellular Targets of Paullones , 2002, The Journal of Biological Chemistry.
[17] D. Nolan,et al. A protein kinase specifically associated with proliferative forms of Trypanosoma brucei is functionally related to a yeast kinase involved in the co‐ordination of cell shape and division , 2002, Molecular microbiology.
[18] B. Nare,et al. Toxoplasma gondii Cyclic GMP-Dependent Kinase: Chemotherapeutic Targeting of an Essential Parasite Protein Kinase , 2002, Eukaryotic Cell.
[19] Wensheng Deng,et al. A novel cyclic GMP‐dependent protein kinase is expressed in the ring stage of the Plasmodium falciparum life cycle , 2002, Molecular microbiology.
[20] M. Shahabuddin,et al. Inhibition of Ca2+/Calmodulin-dependent Protein Kinase Blocks Morphological Differentiation of Plasmodium gallinaceum Zygotes to Ookinetes* , 2002, The Journal of Biological Chemistry.
[21] P. Liberator,et al. The role of a parasite-specific allosteric site in the distinctive activation behavior of Eimeria tenella cGMP-dependent protein kinase. , 2002, Biochemistry.
[22] P. Cohen. Protein kinases — the major drug targets of the twenty-first century? , 2002, Nature reviews. Drug discovery.
[23] J. Sachs,et al. The economic and social burden of malaria , 2002, Nature.
[24] Robert G. Ridley,et al. Medical need, scientific opportunity and the drive for antimalarial drugs , 2002, Nature.
[25] B. Greenwood,et al. Malaria in 2002 , 2002, Nature.
[26] D. Roos,et al. Daughter cell assembly in the protozoan parasite Toxoplasma gondii. , 2002, Molecular biology of the cell.
[27] W. Souza. Basic cell biology of Trypanosoma cruzi. , 2002 .
[28] M. Barrett,et al. Chemotherapy of human African trypanosomiasis. , 2002, Current pharmaceutical design.
[29] Fabienne Thomarat,et al. Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi , 2001, Nature.
[30] N. Waters,et al. Design and synthesis of Pfmrk inhibitors as potential antimalarial agents. , 2001, Bioorganic & medicinal chemistry letters.
[31] D. Goldberg,et al. Localization of the Plasmodium falciparumPfNT1 Nucleoside Transporter to the Parasite Plasma Membrane* , 2001, The Journal of Biological Chemistry.
[32] L. Meijer,et al. Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum. , 2001, Biochemical pharmacology.
[33] J. Harper,et al. Cyclin-dependent kinases. , 2001, Chemical reviews.
[34] R. Carter,et al. Current developments in malaria transmission-blocking vaccines , 2001, Expert opinion on biological therapy.
[35] L. Meijer,et al. Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum Biochemical properties and possible involvement in MAPK regulation. , 2001, European journal of biochemistry.
[36] K. Gull. The biology of kinetoplastid parasites: insights and challenges from genomics and post-genomics. , 2001, International journal for parasitology.
[37] J. Mottram,et al. The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana. , 2001, Molecular and biochemical parasitology.
[38] Anthony C. Bishop,et al. Magic bullets for protein kinases. , 2001, Trends in cell biology.
[39] R. Chakrabarti,et al. Possible Roles of Protein Kinase A in Cell Motility and Excystation of the Early Diverging Eukaryote Giardia lamblia * , 2001, The Journal of Biological Chemistry.
[40] A. Sharma. Protein tyrosine kinase activity in human malaria parasite Plasmodium falciparum. , 2000, Indian journal of experimental biology.
[41] W. Doolittle,et al. A kingdom-level phylogeny of eukaryotes based on combined protein data. , 2000, Science.
[42] G L Snyder,et al. Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. , 2000, European journal of biochemistry.
[43] M. Blackman,et al. Host cell invasion by malaria parasites. , 2000, Parasitology today.
[44] P. Cohen,et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors , 2000 .
[45] M. Chaussepied,et al. Constitutive PI3‐K activity is essential for proliferation, but not survival, of Theileria parva‐transformed B cells , 2000, Cellular microbiology.
[46] G. McConkey,et al. Identification of a nucleoside/nucleobase transporter from Plasmodium falciparum, a novel target for anti-malarial chemotherapy. , 2000, The Biochemical journal.
[47] J Mottram,et al. Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors. , 2000, Chemistry & biology.
[48] L. Aravind,et al. Chitinases of the Avian Malaria Parasite Plasmodium gallinaceum, a Class of Enzymes Necessary for Parasite Invasion of the Mosquito Midgut* , 2000, The Journal of Biological Chemistry.
[49] V. Heussler,et al. Theileria parva: taking control of host cell proliferation and survival mechanisms , 2000, Cellular microbiology.
[50] D. Chakrabarti,et al. PfPK6, a novel cyclin-dependent kinase/mitogen-activated protein kinase-related protein kinase from Plasmodium falciparum. , 2000, The Biochemical journal.
[51] B. Hall,et al. Dual Role for Transforming Growth Factor β-Dependent Signaling in Trypanosoma cruzi Infection of Mammalian Cells , 2000, Infection and Immunity.
[52] Barbara Kappes,et al. Activation of a Plasmodium falciparum cdc2-related Kinase by Heterologous p25 and Cyclin H , 2000, The Journal of Biological Chemistry.
[53] S. Prigge,et al. Cyclin H activation and drug susceptibility of the Pfmrk cyclin dependent protein kinase from Plasmodium falciparum. , 2000, Molecular and biochemical parasitology.
[54] G. Feng,et al. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP , 1999, Journal of immunology.
[55] B. Kappes,et al. An overview of Plasmodium protein kinases. , 1999, Parasitology today.
[56] D. Parzy,et al. An Atypical Mitogen-activated Protein Kinase (MAPK) Homologue Expressed in Gametocytes of the Human Malaria ParasitePlasmodium falciparum , 1999, The Journal of Biological Chemistry.
[57] R. Williams. A compartmentalised model for the estimation of the cost of coccidiosis to the world's chicken production industry. , 1999, International journal for parasitology.
[58] L. Meijer,et al. Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. , 1999, Journal of medicinal chemistry.
[59] L Meijer,et al. Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. , 1999, Cancer research.
[60] K. Matsumoto,et al. Molecular Cloning and Expression of a Stress-responsive Mitogen-activated Protein Kinase-related Kinase from Tetrahymena Cells* , 1999, The Journal of Biological Chemistry.
[61] G L Johnson,et al. Organization and regulation of mitogen-activated protein kinase signaling pathways. , 1999, Current opinion in cell biology.
[62] S. Sunkin,et al. Leishmania major Friedlin chromosome 1 has an unusual distribution of protein-coding genes. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[63] R A Musrati,et al. Malate dehydrogenase: distribution, function and properties. , 1998, General physiology and biophysics.
[64] S H Kim,et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. , 1998, Science.
[65] M. Wiese. A mitogen‐activated protein (MAP) kinase homologue of Leishmania mexicana is essential for parasite survival in the infected host , 1998, The EMBO journal.
[66] J. Mottram,et al. The crk3 Gene of Leishmania mexicanaEncodes a Stage-regulated cdc2-related Histone H1 Kinase That Associates with p12 cks1 * , 1998, The Journal of Biological Chemistry.
[67] D. Chakrabarti,et al. Identification, Cloning, and Mutational Analysis of the Casein Kinase 1 cDNA of the Malaria Parasite, Plasmodium falciparum , 1997, The Journal of Biological Chemistry.
[68] R. Ménard,et al. Gene targeting in malaria parasites. , 1997, Methods.
[69] J. Mottram,et al. Gene disruptions indicate an essential function for the LmmCRK1 cdc2‐related kinase of Leishmania mexicana , 1996, Molecular microbiology.
[70] J. Donelson,et al. Leishmania chagasi:A Gene Encoding a Protein Kinase with a Catalytic Domain Structurally Related to MAP Kinase☆ , 1996 .
[71] J. Mottram,et al. A family of trypanosome cdc2-related protein kinases. , 1995, Gene.
[72] G. Ward,et al. Staurosporine inhibits invasion of erythrocytes by malarial merozoites. , 1994, Experimental parasitology.
[73] Y. Zhao,et al. Plasmodium falciparum calcium-dependent protein kinase phosphorylates proteins of the host erythrocytic membrane. , 1994, Molecular and biochemical parasitology.
[74] A. Chishti,et al. Phosphorylation of protein 4.1 in Plasmodium falciparum-infected human red blood cells. , 1994, Blood.
[75] Y. Zhao,et al. Calcium-binding properties of a calcium-dependent protein kinase from Plasmodium falciparum and the significance of individual calcium-binding sites for kinase activation. , 1994, Biochemistry.
[76] L. Banaszak,et al. Refined crystal structure of mitochondrial malate dehydrogenase from porcine heart and the consensus structure for dicarboxylic acid oxidoreductases. , 1994, Biochemistry.
[77] J. E. Hyde,et al. Microtubular organization visualized by immunofluorescence microscopy during erythrocytic schizogony in Plasmodium falciparum and investigation of post-translational modifications of parasite tubulin , 1993, Parasitology.
[78] M. Parsons,et al. Protein kinases in divergent eukaryotes: identification of protein kinase activities regulated during trypanosome development. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[79] S. I. Becker,et al. Leishmanial protein kinases phosphorylate components of the complement system. , 1991, The EMBO journal.
[80] G. Schieven,et al. Distinct patterns of tyrosine phosphorylation during the life cycle of Trypanosoma brucei. , 1991, Molecular and biochemical parasitology.
[81] R. Sinden,et al. Possible roles of Ca2+ and cGMP as mediators of the exflagellation of Plasmodium berghei and Plasmodium falciparum. , 1990, Molecular and biochemical parasitology.
[82] L. Banaszak,et al. Refined crystal structure of cytoplasmic malate dehydrogenase at 2.5-A resolution. , 1989, Biochemistry.
[83] L. Banaszak,et al. Comparison of the molecular structures of cytoplasmic and mitochondrial malate dehydrogenase. , 1989, Biochemical Society transactions.
[84] G. H. Coombs,et al. Purification of particulate malate dehydrogenase and phosphoenolpyruvate carboxykinase from Leishmania mexicana mexicana. , 1985, Biochimica et biophysica acta.
[85] J. Mottram,et al. The cell cycle of parasitic protozoa: potential for chemotherapeutic exploitation. , 2003, Progress in cell cycle research.
[86] Susan S. Taylor,et al. Classification and Phylogenetic Analysis of the cAMP-Dependent Protein Kinase Regulatory Subunit Family , 2002, Journal of Molecular Evolution.
[87] D. Chakrabarti,et al. The cell cycle in protozoan parasites. , 2000, Progress in cell cycle research.
[88] D. Roos,et al. The apicoplast as a potential therapeutic target in Toxoplasma and other apicomplexan parasites: some additional thoughts. , 1999, Parasitology today.
[89] T. Hunter,et al. The protein kinases of budding yeast: six score and more. , 1997, Trends in biochemical sciences.
[90] R. Carter,et al. A MAP kinase homologue from the human malaria parasite, Plasmodium falciparum. , 1996, Gene.
[91] A. Waters. The ribosomal RNA genes of Plasmodium. , 1994, Advances in parasitology.
[92] N. Lang-Unnasch,et al. Purification and properties of Plasmodium falciparum malate dehydrogenase. , 1992, Molecular and biochemical parasitology.