The clinical use of brainstem reflexes and hand-muscle reflexes

Brainstem reflexes and hand-muscle reflexes can be elicited and recorded with routine EMG equipment. Not all these reflexes are useful in clinical neurology. But those that are - the subject of this review - exhibit distinct patterns of abnormality that have clinical diagnostic and localizing value in various diseases, including cranial neuropathies, focal lesions within the cervical cord, brainstem, and brain, movement disorders, and pain.

[1]  L. Bour,et al.  Blink reflex recovery curves in blepharospasm, torticollis spasmodica, and hemifacial spasm , 1996, Muscle & nerve.

[2]  Harding Ae Inherited movement disorders. , 1994 .

[3]  M. G. Leardi,et al.  Nociceptive quality of the orbicularis oculi reflexes as evaluated by distinct opiate- and benzodiazepine-induced changes in man , 1991, Brain Research.

[4]  J. Stevens,et al.  Trigeminal sensory neuropathy associated with connective tissue diseases , 1990, Neurology.

[5]  J. Kimura,et al.  Disorder of interneurons in Parkinsonism. The orbicularis oculi reflex to paired stimuli. , 1973, Brain : a journal of neurology.

[6]  M. Manfredi,et al.  Impairment of masticatory function in hemiplegia , 1988, Neurology.

[7]  P. Thompson,et al.  An exteroceptive reflex in the sternocleidomastoid muscle produced by electrical stimulation of the supraorbital nerve in normal subjects and patients with spasmodic torticollis , 1989, Neurology.

[8]  B W Ongerboer de Visser,et al.  Human reflexes and late responses. Report of an IFCN committee. , 1994, Electroencephalography and clinical neurophysiology.

[9]  J C Rothwell,et al.  New observations on the normal auditory startle reflex in man. , 1991, Brain : a journal of neurology.

[10]  M Manfredi,et al.  Assessment of trigeminal small‐fiber function: brain and reflex responses evoked by CO2‐laser stimulation , 1999, Muscle & nerve.

[11]  Á. Chamorro,et al.  Brain stem reflexes in patients with Wallenberg's syndrome: Correlation with clinical and magnetic resonance imaging (MRI) findings , 1996, Muscle & nerve.

[12]  [Corticobasal degeneration. The significance of clinical criteria for establishing the diagnosis]. , 1994, Der Nervenarzt.

[13]  M. Manfredi,et al.  Idiopathic and symptomatic trigeminal pain. , 1990, Journal of neurology, neurosurgery, and psychiatry.

[14]  M. V. Van Allen,et al.  Electrodiagnostic study of trigeminal nerve , 1970, Neurology.

[15]  J Kimura,et al.  Conduction abnormalities of the facial and trigeminal nerves in polyneuropathy. , 1982, Muscle & nerve.

[16]  P. Bawa,et al.  Contribution of joint and cutaneous afferents to longer-latency reflexes in man , 1981, Brain Research.

[17]  Changes of somatosensory evoked potentials in man as correlates of transcortical reflex mediation? , 1984, Neuroscience Letters.

[18]  G. Deuschl,et al.  Long-latency responses in human thenar muscles mediated by fast conducting muscle and cutaneous afferents , 1985, Neuroscience Letters.

[19]  J. Ellrich,et al.  Nociceptive masseter inhibitory reflexes evoked by laser radiant heat and electrical stimuli , 1997, Brain Research.

[20]  M. Hallett,et al.  Brainstem reflexes in patients with olivopontocerebellar atrophy , 1994, Muscle & nerve.

[21]  R. Rodnitzky,et al.  Electrophysiologic analysis of aberrant regeneration after facial nerve paralysis , 1975, Neurology.

[22]  T. Mima,et al.  Electrophysiological studies of early stage corticobasal degeneration , 1998, Movement disorders : official journal of the Movement Disorder Society.

[23]  J. Jenner,et al.  Cutaneous reflex responses and their central nervous pathways studied in man , 1982, The Journal of physiology.

[24]  M. Hayden,et al.  Silent periods, long-latency reflexes and cortical MEPs in Huntington's disease and at-risk relatives. , 1989, Electroencephalography and clinical neurophysiology.

[25]  J. Valls-Solé,et al.  Blink reflex excitability cycle in hemifacial spasm , 1989, Neurology.

[26]  B. Calancie,et al.  Effect of core cooling on short and long latency reflex responses , 1983, Brain Research.

[27]  T. Zeffiro,et al.  Cutaneous reflexes in Parkinson's disease , 1992, Muscle & nerve.

[28]  H. Hopf,et al.  Pontine lesions mimicking acute peripheral vestibulopathy , 1999, Journal of neurology, neurosurgery, and psychiatry.

[29]  R. G. Auger,et al.  Preservation of the masseter reflex in Friedreich's ataxia , 1992, Neurology.

[30]  B. O. D. Visser,et al.  Electromyographic and reflex study in idiopathic and symptomatic trigeminal neuralgias: latency of the jaw and blink reflexes , 1974, Journal of neurology, neurosurgery, and psychiatry.

[31]  H. Kuypers,et al.  Late blink reflex changes in lateral medullary lesions. An electrophysiological and neuro-anatomical study of Wallenberg's Syndrome. , 1978, Brain : a journal of neurology.

[32]  T. Sand,et al.  The Blink Reflex in Chronic Tension-Type Headache, Migraine, and Cervicogenic Headache , 1994, Cephalalgia : an international journal of headache.

[33]  J. Spillane,et al.  Isolated trigeminal neuropathy. A report of 16 cases. , 1959, Brain : a journal of neurology.

[34]  C. Marsden,et al.  Stretch reflex and servo action in a variety of human muscles. , 1976, The Journal of physiology.

[35]  J. Noth,et al.  Different mechanisms underlie the long‐latency stretch reflex response of active human muscle at different joints. , 1991, The Journal of physiology.

[36]  G M Murray,et al.  Electromyographic recordings of human jaw-jerk reflex characteristics evoked under standardized conditions. , 1984, Archives of oral biology.

[37]  E. Tolosa,et al.  Blink reflex studies in focal dystonias: Enhanced excitability of brainstem interneurons in cranial dystonia and spasmodic torticollis , 1988, Movement disorders : official journal of the Movement Disorder Society.

[38]  K. Holroyd,et al.  Central and peripheral mechanisms in chronic tension-type headache , 1996, Pain.

[39]  Á. Esteban,et al.  BLINK REFLEX IN HUNTINGTON'S CHOREA AND PARKINSON'S DISEASE , 1975 .

[40]  B. Day,et al.  The blink reflex in patients with idiopathic torsion dystonia. , 1990, Archives of neurology.

[41]  G. Pavesi,et al.  Impairment of corneal pain perception in cluster headache , 1991, Pain.

[42]  P Bawa,et al.  Firing patterns of human flexor carpi radialis motor units during the stretch reflex. , 1985, Journal of neurophysiology.

[43]  E. Favale,et al.  Early trigeminal evoked potentials in tumours of the base of the skull and trigeminal neuralgia. , 1988, Electroencephalography and clinical neurophysiology.

[44]  M. de Tommaso,et al.  Clinical Neurophysiology in Childhood Headache , 1999, Cephalalgia : an international journal of headache.

[45]  M. Manfredi,et al.  Neurophysiologic assessment of trigeminal function after surgery for trigeminal neuralgia , 1987, Neurology.

[46]  A. De Laat,et al.  The masseteric post-stimulus electromyographic-complex in people with dysfunction of the mandibular joint. , 1985, Archives of oral biology.

[47]  R. G. Auger,et al.  Hemifacial spasm , 1979, Neurology.

[48]  M. Manfredi,et al.  Recovery cycle of the masseter inhibitory reflex in man , 1984, Neuroscience Letters.

[49]  R. G. Robinson,et al.  PATHWAY FOR THE JAW–JERK IN MAN , 1959 .

[50]  D. Kömpf,et al.  Long-latency reflexes, somatosensory evoked potentials and transcranial magnetic stimulation: relation of the three methods in multiple sclerosis. , 1993, Electroencephalography and clinical neurophysiology.

[51]  B. Shahani,et al.  Assessing segmented excitability after acute rostral lesions , 1979, Neurology.

[52]  J C Rothwell,et al.  Long latency reflexes of human arm muscles in health and disease. , 1990, Electroencephalography and clinical neurophysiology. Supplement.

[53]  P. Thompson,et al.  The myoclonus in corticobasal degeneration. Evidence for two forms of cortical reflex myoclonus. , 1994, Brain : a journal of neurology.

[54]  Alfredo Berardelli,et al.  Pathophysiology of chorea and bradykinesia in Huntington's disease , 1999, Movement disorders : official journal of the Movement Disorder Society.

[55]  E. Bollen,et al.  Brainstem reflexes and brainstem auditory evoked responses in Huntington's chorea. , 1986, Journal of neurology, neurosurgery, and psychiatry.

[56]  T. Sand,et al.  Exteroceptive Suppression of Temporalis Muscle Activity: A Blind Study of Tension‐Type Headache, Migraine, and Cervicogenic Headache , 1995, Headache.

[57]  Y. Sharav,et al.  Masseter inhibitory periods and sensations evoked by electrical tooth pulp stimulation in patients with oral-facial pain and mandibular dysfunction. , 1982, Archives of oral biology.

[58]  J C Rothwell,et al.  Central EMG and tests of motor control. Report of an IFCN committee. , 1994, Electroencephalography and clinical neurophysiology.

[59]  G. Holstege,et al.  The late blink reflex response abnormality due to lesion of the lateral tegmental field. , 1997, Brain : a journal of neurology.

[60]  Christopher O'Brien,et al.  Motor Disturbances II , 1991 .

[61]  J. Valls-Solé,et al.  Normal proprioceptive trigeminal afferents in patients with Sjögren's syndrome and sensory neuronopathy , 1990, Annals of neurology.

[62]  C H Lücking,et al.  Essential tremor: electrophysiological and pharmacological evidence for a subdivision. , 1987, Journal of neurology, neurosurgery, and psychiatry.

[63]  P. Thompson,et al.  Focal dystonia of the jaw and the differential diagnosis of unilateral jaw and masticatory spasm. , 1986, Journal of neurology, neurosurgery, and psychiatry.

[64]  C. Jerge Organization and function of the trigeminal mensencephalic nucleus. , 1963, Journal of neurophysiology.

[65]  C. Marsden,et al.  Reliability and efficacy of the long‐latency stretch reflex in the human thumb. , 1981, The Journal of physiology.

[66]  J. Noth,et al.  Changes in the short‐ and long‐latency stretch reflex components of the triceps surae muscle during ischaemia in man. , 1993, The Journal of physiology.

[67]  H. Klawans,et al.  Chorea in childhood. , 1993, Pediatric annals.

[68]  J. Noth,et al.  Long-loop reflexes in small hand muscles studied in normal subjects and in patients with Huntington's disease. , 1985, Brain : a journal of neurology.

[69]  V. Nielsen Pathophysiology of hemifacial spasm , 1984, Neurology.

[70]  J A Stephens,et al.  The maturation of cutaneous reflexes studied in the upper limb in man. , 1983, The Journal of physiology.

[71]  P. Delwaide,et al.  Blink reflex studies in patients with Parkinsonism before and during therapy , 1971, Journal of neurology, neurosurgery, and psychiatry.

[72]  B. Shahani,et al.  The human blink reflex , 1970, Journal of neurology, neurosurgery, and psychiatry.

[73]  R. Hughes,et al.  Trigeminal sensory neuropathy. A study of 22 cases. , 1987, Brain : a journal of neurology.

[74]  M. Hallett,et al.  Cortical tremor , 1993, Neurology.

[75]  M. Manfredi,et al.  Histometric study of myelinated fibers in the human trigeminal nerve , 1991, Journal of the Neurological Sciences.

[76]  M. Manfredi,et al.  Excitability of the central masticatory pathways in patients with painful temporomandibular disorders , 1997, Pain.

[77]  J. Kimura,et al.  Orbicularis oculi reflex in the Wallenberg syndrome: alteration of the late reflex by lesions of the spinal tract and nucleus of the trigeminal nerve , 1972, Journal of Neurology Neurosurgery & Psychiatry.

[78]  B. W. Ongerboer de Visser,et al.  Jaw, blink and corneal reflex latencies in multiple sclerosis. , 1985, Journal of neurology, neurosurgery, and psychiatry.

[79]  T. Sand,et al.  Neurophysiological Studies in Chronic Paroxysmal Hemicrania and Hemicrania Continua , 1994, Headache.

[80]  Y. Agid,et al.  Diagnosis of “sporadic” Huntington's disease , 1995, Journal of the Neurological Sciences.

[81]  J. Bánk,et al.  The Blink Reflex in Migraine , 1992, Cephalalgia : an international journal of headache.

[82]  M. Manfredi,et al.  Mandibular nerve involvement in diabetic polyneuropathy and chronic inflammatory demyelinating polyneuropathy , 1998, Muscle & nerve.

[83]  A. McComas,et al.  Cutaneous reflexes in small muscles of the hand , 1973, Journal of neurology, neurosurgery, and psychiatry.

[84]  J. Noth Long loop reflexes: concepts and consequences. , 1986, Applied neurophysiology.

[85]  G. Lavigne,et al.  Clinical Science Human Factors in the Measurement of the Masseteric Silent Period , 1983, Journal of dental research.

[86]  J. Ellrich,et al.  Pain‐evoked blink reflex , 1997, Muscle & nerve.

[87]  R. Dengler,et al.  Recruitment of single motor units in the human blink reflex , 1982, Neuroscience Letters.

[88]  I. Ferguson Electrical study of jaw and orbicularis oculi reflexes after trigeminal nerve surgery. , 1978, Journal of neurology, neurosurgery, and psychiatry.

[89]  G. Deuschl,et al.  Spontaneous and reflex activity of facial muscles in dystonia, Parkinson’s disease, and in normal subjects , 1998, Journal of neurology, neurosurgery, and psychiatry.

[90]  A. Berardelli,et al.  Correlation between facial involuntary movements and abnormalities of blink and corneal reflexes in Huntington's chorea , 1988, Movement disorders : official journal of the Movement Disorder Society.

[91]  N. Accornero,et al.  The orbicularis oculi response after hemispheral damage. , 1983, Journal of neurology, neurosurgery, and psychiatry.

[92]  J. Schoenen,et al.  Reduction of temporalis exteroceptive suppression by peripheral electrical stimulation in migraine and tension-type headaches , 1994, Pain.

[93]  H. Hopf,et al.  Isolated cranial nerve palsies in multiple sclerosis , 1997, Journal of neurology, neurosurgery, and psychiatry.

[94]  P. Cheney Role of cerebral cortex in voluntary movements. A review. , 1985, Physical therapy.

[95]  Ongerboer de Visser Bw Comparative study of corneal and blink reflex latencies in patients with segmental or with cerebral lesions. , 1983 .

[96]  J. M. Minderhoud Neurologie, in praxis und klinik Band I re-edited by H.Ch. Hopf, K. Poeck, H. Schliack 1983 XXVII, Georg Thieme Verlag Stuttgart — New York ISBN 3 13 597801 X 42 p., 345 Fig., 68 TableS. Dm 440, - , 1983, Clinical Neurology and Neurosurgery.

[97]  D. Steenberghe,et al.  Electromyography of jaw reflexes in man : proceedings of the I.A.D.R. satellite symposium held at the Catholic University Leuven , 1989 .

[98]  L. Arendt-Nielsen,et al.  Sensory-motor interactions of human experimental unilateral jaw muscle pain: a quantitative analysis , 1996, Pain.

[99]  J. Kimura,et al.  Blink reflex in patients with hemispheric cerebrovascular accident (CVA) Blink reflex in CVA , 1985, Journal of the Neurological Sciences.

[100]  C. Marsden,et al.  Pathophysiology of blepharospasm and oromandibular dystonia. , 1985, Brain : a journal of neurology.

[101]  H. Hopf Topodiagnostic value of brain stem reflexes , 1994, Muscle & nerve.

[102]  C Molin,et al.  Vertical isometric muscle forces of the mandible. A comparative study of subjects with and without manifest mandibular pain dysfunction syndrome. , 1972, Acta odontologica Scandinavica.

[103]  P. McManis,et al.  Trigeminal sensory neuropathy associated with decreased oral sensation and impairment of the masseter inhibitory reflex , 1990, Neurology.

[104]  A. Laat Reflexes elicitable in jaw muscles and their role during jaw function and dysfunction: a review of the literature. Part III. Reflexes in human jaw muscles during function and dysfunction of the masticatory system , 1987 .

[105]  J. Olesen,et al.  Exteroceptive Suppression of Temporal Muscle Activity is Normal in Chronic Tension-Type Headache and Not Related To Actual Headache State , 1996, Cephalalgia : an international journal of headache.

[106]  T. Lidsky,et al.  Basal ganglia influences on brain stem trigeminal neurons , 1979, Experimental Neurology.

[107]  T. Mima,et al.  Familial cortical myoclonic tremor as a unique form of cortical reflex myoclonus , 1997, Movement disorders : official journal of the Movement Disorder Society.

[108]  A. Møller,et al.  On the origin of synkinesis in hemifacial spasm: results of intracranial recordings. , 1984, Journal of neurosurgery.

[109]  E. Evarts,et al.  Transcortical reflexes and servo control of movement. , 1981, Canadian journal of physiology and pharmacology.

[110]  G. Deuschl,et al.  Physiology and clinical applications of hand muscle reflexes. , 1990, Electroencephalography and clinical neurophysiology. Supplement.

[111]  M. Manfredi,et al.  Effects of brainstem lesions on the masseter inhibitory reflex. Functional mechanisms of reflex pathways. , 1990, Brain : a journal of neurology.

[112]  P. Delwaide,et al.  Exteroceptive suppression of temporalis muscle activity in chronic headache , 1987, Neurology.

[113]  A. Eisen,et al.  Electromyography in Disorders of Muscle Tone , 1987, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[114]  G. Deuschl,et al.  The diagnostic significance of long-latency reflexes in multiple sclerosis. , 1988, Electroencephalography and clinical neurophysiology.

[115]  M. Naumann,et al.  Long-latency reflexes of hand muscles in idiopathic focal dystonia and their modification by botulinum toxin. , 1997, Brain : a journal of neurology.

[116]  H Shibasaki,et al.  Cortical tremor , 1990, Neurology.

[117]  F. Valldeoriola,et al.  Neurophysiological investigations in patients with head tremor , 1997, Movement disorders : official journal of the Movement Disorder Society.

[118]  L M Harrison,et al.  Maturation of the cutaneomuscular reflex recorded from the first dorsal interosseous muscle in man. , 1990, The Journal of physiology.

[119]  G. Cruccu,et al.  Jaw-opening reflex after CO2 laser stimulation of the perioral region in man , 1998, Experimental Brain Research.

[120]  G. Deuschl,et al.  Hand muscle reflexes following electrical stimulation in choreatic movement disorders. , 1989, Journal of neurology, neurosurgery, and psychiatry.

[121]  K. Digre,et al.  Hemifacial spasm: differential diagnosis, mechanism, and treatment. , 1988, Advances in neurology.

[122]  K. Holroyd,et al.  Pericranial Muscle Tenderness and Exteroceptive Suppression of Temporalis Muscle Activity: A Blind Study of Chronic Tension‐Type Headache , 1997, Headache.

[123]  A. Berardelli,et al.  Masseter inhibitory reflex in movement disorders. Huntington's chorea, Parkinson's disease, dystonia, and unilateral masticatory spasm. , 1991, Electroencephalography and clinical neurophysiology.

[124]  J. Dichgans,et al.  Exteroceptive suppression of temporalis muscle activity in patients with fibromyalgia, tension-type headache, and normal controls. , 1998, Electroencephalography and clinical neurophysiology.

[125]  W. Halliday,et al.  Long-latency reflex activity in squirrel monkeys with occlusion of the middle cerebral artery. , 1987, Electroencephalography and clinical neurophysiology.

[126]  Heteronymous H-reflex in Temporal Muscle Motor Units , 1998, Journal of dental research.

[127]  P. Ashby,et al.  Stimulus-sensitive myoclonus in akinetic-rigid syndromes. , 1992, Brain : a journal of neurology.

[128]  F. Raudino,et al.  The Blink Reflex in Cluster Headache , 1990, Headache.

[129]  F. Glocker,et al.  Hemifacial spasm due to posterior fossa tumors: The impact of tumor location on electrophysiological findings , 1998, Clinical Neurology and Neurosurgery.