Imaging of haemophilic arthropathy in growing joints: pitfalls in ultrasound and MRI

The purpose of this review was to summarize the current knowledge on the utilization of magnetic resonance imaging (MRI) and ultrasound (US) for assessing arthropathy in children and adolescents with haemophilia and to recognize the limitations of each imaging modality and pitfalls in the diagnosis of soft tissue and osteochondral abnormalities. Awareness of MRI and US limitations and pitfalls in the assessment of joints in persons with haemophilia is essential for accurate diagnosis and optimal management of haemophilic arthropathy.

[1]  A. Tagliafico,et al.  Point‐of‐care ultrasound in haemophilic arthropathy: will the HEAD‐US system supplement or replace physical examination? , 2016, Haemophilia : the official journal of the World Federation of Hemophilia.

[2]  R. Moineddin,et al.  Ultrasound and magnetic resonance imaging of healthy paediatric ankles and knees: a baseline for comparison with haemophilic joints , 2015 .

[3]  R. Moineddin,et al.  Diagnostic accuracy of ultrasound for assessment of hemophilic arthropathy: MRI correlation. , 2015, AJR. American journal of roentgenology.

[4]  R. Ljung,et al.  Definitions in hemophilia: communication from the SSC of the ISTH , 2014, Journal of thrombosis and haemostasis : JTH.

[5]  C. Hermans,et al.  Optimal management of hemophilic arthropathy and hematomas , 2014, Journal of blood medicine.

[6]  V. Blanchette,et al.  A systematic review of MR imaging as a tool for evaluating haemophilic arthropathy in children , 2013, Haemophilia : the official journal of the World Federation of Hemophilia.

[7]  Walter Grassi,et al.  Doppler ultrasound imaging techniques for assessment of synovial inflammation , 2013 .

[8]  Young Cheol Yoon,et al.  Knee derangements: comparison of isotropic 3D fast spin-echo, isotropic 3D balanced fast field-echo, and conventional 2D fast spin-echo MR imaging. , 2013, Radiology.

[9]  M. Morfini,et al.  Development and definition of a simplified scanning procedure and scoring method for Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) , 2013, Thrombosis and Haemostasis.

[10]  P. Babyn,et al.  Magnetic resonance imaging and joint outcomes in boys with severe hemophilia A treated with tailored primary prophylaxis in Canada , 2012, Journal of Thrombosis and Haemostasis.

[11]  R. Moineddin,et al.  An MRI scale for assessment of haemophilic arthropathy from the International Prophylaxis Study Group , 2012, Haemophilia : the official journal of the World Federation of Hemophilia.

[12]  B. Feldman,et al.  Outcome assessment and limitations , 2012, Haemophilia : the official journal of the World Federation of Hemophilia.

[13]  J Aarnio,et al.  Diagnostic performance of knee ultrasonography for detecting degenerative changes of articular cartilage. , 2012, Osteoarthritis and cartilage.

[14]  S. Riva,et al.  Ultrasonography of haemophilic arthropathy , 2012, Haemophilia : the official journal of the World Federation of Hemophilia.

[15]  M. Badr,et al.  Correlation between musculoskeletal function and radiological joint scores in haemophilia A adolescents , 2011, Haemophilia : the official journal of the World Federation of Hemophilia.

[16]  Fikri M Abu-Zidan,et al.  Clinical ultrasound physics , 2011, Journal of emergencies, trauma, and shock.

[17]  A. Goyal,et al.  Musculoskeletal manifestations of hemophilia: imaging features. , 2011, Current problems in diagnostic radiology.

[18]  R. Engelbert,et al.  Validation of a new pediatric joint scoring system from the International Hemophilia Prophylaxis Study Group: Validity of the hemophilia joint health score , 2011, Arthritis care & research.

[19]  M. Cerinic,et al.  Ultrasound detects joint damage and bleeding in haemophilic arthropathy: a proposal of a score , 2011, Haemophilia : the official journal of the World Federation of Hemophilia.

[20]  L. Valentino,et al.  Blood‐induced joint disease: the pathophysiology of hemophilic arthropathy , 2010, Journal of thrombosis and haemostasis : JTH.

[21]  A. Doria.  State‐of‐the‐art imaging techniques for the evaluation of haemophilic arthropathy: present and future , 2010, Haemophilia : the official journal of the World Federation of Hemophilia.

[22]  Seungbum Koo,et al.  Recent advances in MRI of articular cartilage. , 2009, AJR. American journal of roentgenology.

[23]  A. Mohanta,et al.  Refinement of a sonographic protocol for assessment of haemophilic arthropathy , 2009, Haemophilia : the official journal of the World Federation of Hemophilia.

[24]  Bejoy Thomas,et al.  Principles, techniques, and applications of T2*-based MR imaging and its special applications. , 2009, Radiographics : a review publication of the Radiological Society of North America, Inc.

[25]  R. Adler,et al.  Power Doppler sonography in the diagnosis of hemophilic synovitis – a promising tool , 2008, Journal of thrombosis and haemostasis : JTH.

[26]  F. Lafeber,et al.  Understanding haemophilic arthropathy: an exploration of current open issues , 2008, British journal of haematology.

[27]  P. Babyn,et al.  Reliability and construct validity of the compatible MRI scoring system for evaluation of elbows in haemophilic children , 2008, Haemophilia : the official journal of the World Federation of Hemophilia.

[28]  Alan R. Cohen,et al.  Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia. , 2007, The New England journal of medicine.

[29]  F. Ståhlberg,et al.  Gadolinium contrast agent is of limited value for magnetic resonance imaging assessment of synovial hypertrophy in hemophiliacs , 2007, Acta radiologica.

[30]  P. Babyn,et al.  Sonography for assessment of haemophilic arthropathy in children: a systematic protocol , 2007, Haemophilia : the official journal of the World Federation of Hemophilia.

[31]  C. Manigandan,et al.  Functional Independence Score in Haemophilia: a new performance‐based instrument to measure disability , 2005, Haemophilia : the official journal of the World Federation of Hemophilia.

[32]  P. Babyn,et al.  Reliability of progressive and additive MRI scoring systems for evaluation of haemophilic arthropathy in children: Expert MRI Working Group of the International Prophylaxis Study Group , 2005, Haemophilia : the official journal of the World Federation of Hemophilia.

[33]  P. Babyn,et al.  Compatible scales for progressive and additive MRI assessments of haemophilic arthropathy , 2005, Haemophilia : the official journal of the World Federation of Hemophilia.

[34]  R. Ljung,et al.  A new magnetic resonance imaging scoring method for assessment of haemophilic arthropathy , 2004, Haemophilia : the official journal of the World Federation of Hemophilia.

[35]  J. Bijlsma,et al.  Immature articular cartilage is more susceptible to blood-induced damage than mature articular cartilage: an in vivo animal study. , 2003, Arthritis and rheumatism.

[36]  R. Nuss,et al.  Radiological Evaluation of Hemophilic Arthropathy , 2003, Seminars in thrombosis and hemostasis.

[37]  J. Bijlsma,et al.  Blood-induced joint damage: longterm effects in vitro and in vivo. , 2003, The Journal of rheumatology.

[38]  A. Ferrández,et al.  Value of magnetic resonance imaging for the diagnosis and follow‐up of haemophilic arthropathy , 2003, Haemophilia : the official journal of the World Federation of Hemophilia.

[39]  T. Wallny,et al.  Clinical and radiographic scores in haemophilic arthropathies: how well do these correlate to subjective pain status and daily activities? , 2002, Haemophilia : the official journal of the World Federation of Hemophilia.

[40]  R. Soler,et al.  Hemophilic arthropathy. A scoring system for magnetic resonance imaging , 2002, European Radiology.

[41]  A. Klukowska,et al.  Correlation between clinical, radiological and ultrasonographical image of knee joints in children with haemophilia , 2001, Haemophilia : the official journal of the World Federation of Hemophilia.

[42]  M. Manco‐Johnson,et al.  MRI findings in haemophilic joints treated with radiosynoviorthesis with development of an MRI scale of joint damage , 2000, Haemophilia : the official journal of the World Federation of Hemophilia.

[43]  H. Imhof,et al.  Magnetic resonance imaging in hemophilic children: value of gradient echo and contrast-enhanced imaging. , 1999, Magnetic resonance imaging.

[44]  H. Pettersson,et al.  A radiologic classification of hemophilic arthropathy. , 1980, Clinical orthopaedics and related research.

[45]  M. Hilgartner,et al.  Hemophilic arthropathy. Current concepts of pathogenesis and management. , 1977, The Journal of bone and joint surgery. American volume.

[46]  A. Tagliafico,et al.  Hemosiderin Detection With Ultrasound: Reality or Myth? , 2016, AJR. American journal of roentgenology.

[47]  A. von Drygalski,et al.  Advances and challenges in hemophilic arthropathy. , 2016, Seminars in hematology.

[48]  A. Doria,et al.  Reply to "Hemosiderin Detection With Ultrasound: Reality or Myth?". , 2016, AJR. American journal of roentgenology.

[49]  MCh S. S. Baldawa MS,et al.  Susceptibility-Weighted Imaging , 2011, Clinical Neuroradiology.

[50]  J. Bijlsma,et al.  Exposure of human cartilage tissue to low concentrations of blood for a short period of time leads to prolonged cartilage damage: an in vitro study. , 2007, Arthritis and rheumatism.

[51]  Mark Brooker,et al.  The world federation of hemophilia , 2000, Haemophilia : the official journal of the World Federation of Hemophilia.