Structural remodeling of mouse gracilis artery after chronic alteration in blood supply.

The goals of this study were to determine the time course and spatial dependence of structural diameter changes in the mouse gracilis artery after a redistribution of blood flow and to compare the observations with predictions of computational models for structural adaptation. Diameters were measured 1, 2, 7, 14, 21, 28, and 56 days after resection of one of the two blood supplies to the artery. Overall average diameter, normalized with respect to diameters in untreated vessels, increased slightly during the first 7 days, then increased more rapidly, reaching a peak around day 21, and then decreased. This transient increase in diameter was spatially nonuniform, being largest toward the point of resection. A previously developed theoretical model, in which diameter varies in response to stimuli derived from local metabolic and hemodynamic conditions, was extended to include effects of time-delayed remodeling stimuli in regions of reduced perfusion. Predictions of this model were consistent with observed diameter changes, including the transient increase in diameters near the point of resection, when a remodeling stimulus with a time delay of approximately 7 days was included. The results suggest that delayed stimuli significantly influence the dynamic characteristics of vascular remodeling resulting from reduced blood supply.

[1]  Axel R Pries,et al.  Information Transfer in Microvascular Networks , 2002, Microcirculation.

[2]  I. Buschmann,et al.  The pathophysiology of the collateral circulation (arteriogenesis) , 2000, The Journal of pathology.

[3]  Axel R Pries,et al.  Angioadaptation: keeping the vascular system in shape. , 2002, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

[4]  H. Burkhart,et al.  Early collateral and microvascular adaptations to intestinal artery occlusion in rat. , 1996, The American journal of physiology.

[5]  John A. Nelder,et al.  A Simplex Method for Function Minimization , 1965, Comput. J..

[6]  M. Mulvany Resistance vessel structure in hypertension: growth or remodeling? , 1993, Journal of cardiovascular pharmacology.

[7]  I. Buschmann,et al.  Influence of Inflammatory Cytokines on Arteriogenesis , 2003, Microcirculation.

[8]  W. Risau,et al.  Mechanisms of angiogenesis , 1997, Nature.

[9]  Langille Bl,et al.  Arterial responses to compromised blood flow. , 1990 .

[10]  S. Werner,et al.  Differential regulation of pro-inflammatory cytokines during wound healing in normal and glucocorticoid-treated mice. , 1996, Cytokine.

[11]  P. Sipkema,et al.  Differential structural adaptation to haemodynamics along single rat cremaster arterioles , 2003, The Journal of physiology.

[12]  R L Prewitt,et al.  Microvascular density changes during wound-healing. , 1987, International journal of microcirculation, clinical and experimental.

[13]  S. Cross,et al.  Angiogenesis induction and regression in human surgical wounds , 2002, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[14]  M. Laughlin,et al.  Exercise training-induced coronary vascular adaptation. , 1992, Journal of applied physiology.

[15]  E. vanBavel,et al.  Organoid culture of cannulated rat resistance arteries: effect of serum factors on vasoactivity and remodeling. , 2000, American journal of physiology. Heart and circulatory physiology.

[16]  Armin Helisch,et al.  Arteriogenesis The Development and Growth of Collateral Arteries , 2003, Microcirculation.

[17]  Ji Song,et al.  Stimulation of Arteriogenesis in Skeletal Muscle by Microbubble Destruction With Ultrasound , 2002, Circulation.

[18]  Armin Helisch,et al.  Contribution of arteriogenesis and angiogenesis to postocclusive hindlimb perfusion in mice. , 2002, Journal of molecular and cellular cardiology.

[19]  W. Schaper,et al.  Arteriogenesis, a new concept of vascular adaptation in occlusive disease , 2004, Angiogenesis.

[20]  S. Segal,et al.  Cell-to-cell communication coordinates blood flow control. , 1994, Hypertension.

[21]  R. Prewitt,et al.  Alterations of mature arterioles associated with chronically reduced blood flow. , 1993, The American journal of physiology.

[22]  D. Scholz,et al.  Angiogenesis and myogenesis as two facets of inflammatory post-ischemic tissue regeneration , 2002, Molecular and Cellular Biochemistry.

[23]  S. L. Lim,et al.  Possible equilibration of portal venous and central venous pressures during circulatory arrest. , 1993, The American journal of physiology.

[24]  M. Fini,et al.  Matrix Metalloproteinase-9 Is Required for Adequate Angiogenic Revascularization of Ischemic Tissues: Potential Role in Capillary Branching , 2004, Circulation research.

[25]  W. Schaper,et al.  Collateral Artery Growth (Arteriogenesis) After Experimental Arterial Occlusion Is Impaired in Mice Lacking CC-Chemokine Receptor-2 , 2004, Circulation research.

[26]  L. Langille,et al.  Remodeling of Developing and Mature Arteries: Endothelium, Smooth Muscle, and Matrix , 1993, Journal of cardiovascular pharmacology.

[27]  A. Pries,et al.  Design principles of vascular beds. , 1995, Circulation research.

[28]  B. Reglin,et al.  Structural Adaptation of Vascular Networks: Role of the Pressure Response , 2001, Hypertension.

[29]  Hemodynamic Stresses and Structural Remodeling of Anastomosing Arteriolar Networks: Design Principles of Collateral Arterioles , 2002, Microcirculation.

[30]  R. Berne,et al.  Propagated Vasodilation in the Microcirculation of the Hamster Cheek Pouch , 1970, Circulation research.

[31]  T. Skalak,et al.  The Role of Mechanical Stresses in Microvascular Remodeling , 1996, Microcirculation.

[32]  A. Pries,et al.  Structural adaptation and stability of microvascular networks: theory and simulations. , 1998, The American journal of physiology.

[33]  T. Doetschman,et al.  Targeted disruption of the Fgf2 gene does not affect vascular growth in the mouse ischemic hindlimb. , 2002, Journal of applied physiology.

[34]  W. Schaper,et al.  Factors Regulating Arteriogenesis , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[35]  K. Moore Cell biology of chronic wounds: the role of inflammation. , 1999, Journal of wound care.

[36]  H. Bohlen,et al.  Functional adaptations of rat skeletal muscle arterioles to aerobic exercise training. , 1992, Journal of applied physiology.

[37]  M. Mulvany,et al.  Small artery structure in hypertension. Dual processes of remodeling and growth. , 1993, Hypertension.

[38]  M. Voskuil,et al.  CD44 Regulates Arteriogenesis in Mice and Is Differentially Expressed in Patients With Poor and Good Collateralization , 2004, Circulation.

[39]  J. Hoying,et al.  Flow-Dependent Remodeling in the Carotid Artery of Fibroblast Growth Factor-2 Knockout Mice , 2002, Arteriosclerosis, thrombosis, and vascular biology.