A brief overview of the evolution and main features of the biotechnology industry

This paper offers an overview of the origin, evolution and main features of the biotechnology industry, putting particular emphasis on the behaviour of one key actor – the dedicated biotechnology firm. It starts with a brief historical background detailing the origin and dynamics of the industry, which is followed by a more detailed examination of the firms’ strategies, business models and networking behaviour. It concludes with a discussion on the constraints and opportunities faced by firms operating outside the main centres of knowledge production and business in biotechnology, as is the case of dedicated biotechnology firms located in Portugal. Adapted from Chapter 5 in Salavisa, I. and M. Fontes (Eds) Social Networks, Innovation and the Knowledge Economy, London: Routledge. A brief overview of the evolution and main features of the biotechnology industry _____________________________________________________________________________ 3 DINÂMIA’CET – IUL, Centro de Estudos sobre a Mudanca Socioeconomica e o Territorio ISCTE-IUL – Av. das Forcas Armadas, 1649-026 Lisboa, PORTUGAL Tel. 217938638 Fax. 217940042 E-mail: dinamia@iscte.pt http://dinamiacet.iscte-iul.pt/

[1]  Anna Nosella,et al.  Characteristics of the Italian biotechnology industry and new business models: the initial results of an empirical study , 2005 .

[2]  Benjamin Coriat,et al.  Does Biotech Reflect a New Science-based Innovation Regime? , 2003 .

[3]  F. Malerba Sectoral Systems of Innovation: Concepts, Issues and Analyses of Six Major Sectors in Europe , 2009 .

[4]  W. Powell,et al.  Interorganizational Collaboration and the Locus of Innovation: Networks of Learning in Biotechnology. , 1996 .

[5]  M. Mckelvey,et al.  What drives innovation processes in modern biotechnology and open source software? , 2005 .

[6]  Edward B. Roberts,et al.  Overcoming Weak Entrepreneurial Infrastructures for Academic Spin-Off Ventures , 2004 .

[7]  Meric S. Gertler,et al.  Local Nodes in Global Networks: The Geography of Knowledge Flows in Biotechnology Innovation , 2005 .

[8]  Terttu Luukkonen,et al.  Variability in organisational forms of biotechnology firms , 2005 .

[9]  Margarida Fontes,et al.  Technological Entrepreneurship and Capability Building in Biotechnology , 2007, Technol. Anal. Strateg. Manag..

[10]  Massimo Riccaboni,et al.  Technological change and network dynamics: Lessons from the pharmaceutical industry , 2001 .

[11]  A. Caruana,et al.  Global alliance networks : A comparison of biotech SMEs in Sweden and Australia , 2006 .

[12]  L. Willemstein,et al.  Dynamics in business models: An empirical analysis of medical biotechnology firms in the Netherlands , 2007 .

[13]  A. Arora,et al.  Markets for Technology and Their Implications for Corporate Strategy , 2000 .

[14]  F. Pammolli,et al.  The productivity crisis in pharmaceutical R&D , 2011, Nature Reviews Drug Discovery.

[15]  Cristina Sousa,et al.  Knowledge access and location decisions in biotechnology: the spatial dimension of social networks , 2009 .

[16]  Michael Gilding,et al.  'The tyranny of distance': Biotechnology networks and clusters in the antipodes , 2008 .

[17]  L. Orsenigo,et al.  A Critical Assessment of Regional Innovation Policy in Pharmaceutical Biotechnology , 2008 .

[18]  Shiri M. Breznitz,et al.  Cluster Sustainability in Peripheral Regions: A case study on Israel's and Finland's biotechnology industries , 2010 .

[19]  A. Cumbers,et al.  Beyond clusters: the implications of life science commodity chains for less-favoured regions , 2009 .

[20]  Tomas McKelvey Health Biotechnology: Emerging Business Models and Institutional Drivers , 2008 .

[21]  Steven c. Blank Insiders' Views on Business Models Used by Small Agricultural Biotechnology Firms: Economic Implications for the Emerging Global Industry , 2008 .

[22]  Maureen McKelvey,et al.  Pharmaceuticals Analyzed through the Lens of a Sectoral Innovation System , 2004 .

[23]  Paul Nightingale,et al.  The myth of the biotech revolution: An assessment of technological, clinical and organisational change , 2007 .

[24]  J. Gans,et al.  The Product Market and the Market for 'Ideas': Commercialization Strategies for Technology Entrepreneurs , 2002 .

[25]  M. Fontes Distant networking: The knowledge acquisition strategies of 'out-cluster' biotechnology firms , 2005 .

[26]  Terttu Luukkonen,et al.  Living up to the Expectations Set by ICT? The Case of Biotechnology Commercialisation in Finland , 2007, Technol. Anal. Strateg. Manag..

[27]  K. Eisenhardt,et al.  Organizational Growth: Linking Founding Team, Strategy, Environment, and Growth among U.S. Semiconductor Ventures, 1978-1988. , 1990 .

[28]  Dan Kaufmann,et al.  ‘The Biosciences Knowledge Value Chain and Comparative Incubation Models’ , 2006 .

[29]  David Finegold,et al.  Adapting a foreign direct investment strategy to the knowledge economy: the case of Singapore's emerging biotechnology cluster , 2004 .

[30]  B. Kogut,et al.  INTERFIRM COOPERATION AND STARTUP INNOVATION IN THE BIOTECHNOLOGY INDUSTRY. , 1993 .

[31]  Michel Quéré,et al.  KNOWLEDGE DYNAMICS: BIOTECHNOLOGY’S INCURSION INTO THE PHARMACEUTICAL INDUSTRY , 2003 .

[32]  V. Mangematin,et al.  Development of SMEs and heterogeneity of trajectories: the case of biotechnology in France , 2003 .

[33]  H. Gottinger,et al.  Organizational Entrepreneurship: A Historical Overview on Industry Alliances in Biotech and Pharmaceuticals , 2011 .

[34]  Meric S. Gertler,et al.  Life Sciences and Regional Innovation: One Path or Many? , 2009 .

[35]  Shaker A. Zahra,et al.  The effects of business-university alliances on innovative output and financial performance: a study of publicly traded biotechnology companies , 2002 .

[36]  Vincent Mangematin,et al.  The future of drug discovery and development: Shifting emphasis towards personalized medicine , 2010 .

[37]  J. Gans,et al.  The Product Market and the Market for 'Ideas': Commercialization Strategies for Technology Entrepreneurs , 2002 .

[38]  N. Lowe,et al.  Building on Diversity: Institutional Foundations of Hybrid Strategies in Toronto's Life Sciences Complex , 2009 .

[39]  Steven Casper,et al.  NATIONAL INSTITUTIONAL FRAMEWORKS AND THE HYBRIDIZATION OF ENTREPRENEURIAL BUSINESS MODELS: THE GERMAN AND UK BIOTECHNOLOGY SECTORS , 2001 .

[40]  Luigi Orsenigo,et al.  The emergence of biotechnology , 1989 .

[41]  Kelley A. Packalen,et al.  Organizational and Institutional Genesis: The Emergence of High-Tech Clusters in the Life Sciences , 2010 .

[42]  Walter W. Powell,et al.  A Comparison of U.S. and European University-Industry Relations in the Life Sciences , 2001 .

[43]  W. Powell,et al.  Network Dynamics and Field Evolution: The Growth of Interorganizational Collaboration in the Life Sciences1 , 2005, American Journal of Sociology.

[44]  Margarida Fontes,et al.  The commercialisation decisions of research-based spin-off: Targeting the market for technologies , 2012 .

[45]  Nadine Roijakkers,et al.  Inter-firm R&D partnering in pharmaceutical biotechnology since 1975: Trends, patterns, and networks , 2006 .

[46]  M. Dowling,et al.  Commercialization strategies of young biotechnology firms: An empirical analysis of the U.S. industry , 2008 .

[47]  Noel P. Greis,et al.  External partnering as a response to innovation barriers and global competition in biotechnology , 1995 .

[48]  R. Merges,et al.  The Control of Technology Alliances: An Empirical Analysis of the Biotechnology Industry , 2003 .

[49]  Finn Valentin,et al.  DISCONTINUITIES AND DISTRIBUTED INNOVATION:THE CASE OF BIOTECHNOLOGY IN FOOD PROCESSING , 2003 .

[50]  G. Pisano Can science be a business? Lessons from biotech. , 2006, Harvard business review.

[51]  A. Arora,et al.  Evaluating technological information and utilizing it: Scientific knowledge, technological capability, and external linkages in biotechnology , 1994 .

[52]  Maryann Feldman,et al.  Small-Firm Strategic Research Partnerships: The Case of Biotechnology , 2003, Technol. Anal. Strateg. Manag..

[53]  Elizabeth Garnsey,et al.  Do Academic Spin-Outs Differ and Does it Matter? , 2004 .

[54]  Knowledge intensive sectors in moderate innovative countries in Europe: overcoming the missing links, stepping over barriers , 2012 .

[55]  Walter W. Powell,et al.  Amphibious entrepreneurs and the emergence of organizational forms , 2012 .

[56]  Gary P. Pisano,et al.  The Evolution of Science-Based Business: Innovating How We Innovate , 2010 .

[57]  Salih Zeki Ozdemir,et al.  Vertical alliance networks: The case of university–biotechnology–pharmaceutical alliance chains , 2007 .

[58]  Conceptualizing and Measuring Modern Biotechnology , 2004 .

[59]  Anna Nosella,et al.  Business models in Italian biotechnology industry: a quantitative analysis , 2005 .

[60]  S. Bartholomew National Systems of Biotechnology Innovation: Complex Interdependence in the Global System , 1997 .

[61]  F. Rothaermel Complementary Assets, Strategic Alliances, and the Incumbent's Advantage: An Empirical Study of Industry and Firm Effects in the Biopharmaceutical Industry , 2001 .